{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:27:55Z","timestamp":1791581275853,"version":"4.3.4"},"reference-count":85,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:00:00Z","timestamp":1671753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Hereditary non-polyposis colorectal cancer is also known as Lynch syndrome. Lynch syndrome is associated with pathogenetic variants in one of the mismatch repair (MMR) genes. In addition to colorectal cancer, the inefficiency of the MMR system leads to a greater predisposition to cancer of the endometrium and other cancers of the abdominal sphere. Molecular diagnosis is performed to identify pathogenetic variants in MMR genes. However, for many patients with clinically suspected Lynch syndrome, it is not possible to identify a pathogenic variant in MMR genes. Molecular diagnosis is essential for referring patients to specific surveillance to prevent the development of tumors related to Lynch syndrome. This review summarizes the main aspects of Lynch syndrome and recent advances in the field and, in particular, emphasizes the factors that can lead to the loss of expression of MMR genes.<\/jats:p>","DOI":"10.3390\/cancers15010075","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T03:26:25Z","timestamp":1671765985000},"page":"75","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Hereditary Colorectal Cancer: State of the Art in Lynch Syndrome"],"prefix":"10.3390","volume":"15","author":[{"given":"Antonio","family":"Nolano","sequence":"first","affiliation":[{"name":"CEINGE Advanced Biotechnologies Scarl, \u201cFrancesco Salvatore\u201d Napoli, Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1701-5060","authenticated-orcid":false,"given":"Alessia","family":"Medugno","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5164-332X","authenticated-orcid":false,"given":"Silvia","family":"Trombetti","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, 80131 Naples, Italy"},{"name":"Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, 80137 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2221-5825","authenticated-orcid":false,"given":"Raffaella","family":"Liccardo","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4752-5678","authenticated-orcid":false,"given":"Marina","family":"De Rosa","sequence":"additional","affiliation":[{"name":"CEINGE Advanced Biotechnologies Scarl, \u201cFrancesco Salvatore\u201d Napoli, Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, 80131 Naples, Italy"},{"name":"Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1549-0615","authenticated-orcid":false,"given":"Paola","family":"Izzo","sequence":"additional","affiliation":[{"name":"CEINGE Advanced Biotechnologies Scarl, \u201cFrancesco Salvatore\u201d Napoli, Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, 80131 Naples, Italy"},{"name":"Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0787-6182","authenticated-orcid":false,"given":"Francesca","family":"Duraturo","sequence":"additional","affiliation":[{"name":"CEINGE Advanced Biotechnologies Scarl, \u201cFrancesco Salvatore\u201d Napoli, Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, 80131 Naples, Italy"},{"name":"Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,23]]},"reference":[{"key":"ref_1","first-page":"971","article-title":"Worldwide prevalence of Lynch syndrome in patients with colorectal cancer: Systematic review and meta-analysis","volume":"24","author":"Kaushik","year":"2022","journal-title":"Anesthesia Analg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.3892\/or.2015.4108","article-title":"Genetics, diagnosis and management of colorectal cancer (Review)","volume":"34","author":"Marina","year":"2015","journal-title":"Oncol. 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