{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T09:11:18Z","timestamp":1783588278272,"version":"3.55.0"},"reference-count":122,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T00:00:00Z","timestamp":1672012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Until now, morphological assessment with an optical or electronic microscope, fluorescence in situ hybridization, DNA sequencing, flow cytometry, polymerase chain reactions, and immunohistochemistry have been employed for leukemia identification. Nevertheless, despite their numerous different vantages, it is difficult to recognize leukemic cells correctly. Recently, the electrochemical evaluation with a nano-sensing interface seems an attractive alternative. Electrochemical biosensors measure the modification in the electrical characteristics of the nano-sensing interface, which is modified by the contact between a biological recognition element and the analyte objective. The implementation of nanosensors is founded not on single nanomaterials but rather on compilating these components efficiently. Biosensors able to identify the molecules of deoxyribonucleic acid are defined as DNA biosensors. Our review aimed to evaluate the literature on the possible use of electrochemical biosensors for identifying hematological neoplasms such as acute promyelocytic leukemia, acute lymphoblastic leukemia, and chronic myeloid leukemia. In particular, we focus our attention on using DNA electrochemical biosensors to evaluate leukemias.<\/jats:p>","DOI":"10.3390\/cancers15010146","type":"journal-article","created":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T02:53:11Z","timestamp":1672109591000},"page":"146","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Electrochemical Biosensors in the Diagnosis of Acute and Chronic Leukemias"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6156-8239","authenticated-orcid":false,"given":"Alessandro","family":"Allegra","sequence":"first","affiliation":[{"name":"Division of Hematology, Department of Human Pathology in Adulthood and Childhood \u201cGaetano Barresi\u201d, University of Messina, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6910-0160","authenticated-orcid":false,"given":"Claudia","family":"Petrarca","sequence":"additional","affiliation":[{"name":"Department of Medicine and Aging Sciences, G. D\u2019Annunzio University, 66100 Chieti, Italy"},{"name":"Center for Advanced Studies and Technology, G. D\u2019Annunzio University, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9224-5886","authenticated-orcid":false,"given":"Mario","family":"Di Gioacchino","sequence":"additional","affiliation":[{"name":"Institute for Clinical Immunotherapy and Advanced Biological Treatments, 65100 Pescara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Mirabile","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Human Pathology in Adulthood and Childhood \u201cGaetano Barresi\u201d, University of Messina, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiano","family":"Gangemi","sequence":"additional","affiliation":[{"name":"Unit of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, School of Allergy and Clinical Immunology, University of Messina, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/978-3-031-04039-9_12","article-title":"Coupling Micro-Physiological Systems and Biosensors for Improving Cancer Biomarkers Detection","volume":"1379","author":"Brancato","year":"2022","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"123419","DOI":"10.1016\/j.talanta.2022.123419","article-title":"Recent advances in inorganic functional nanomaterials based flexible electrochemical sensors","volume":"244","author":"Yuan","year":"2022","journal-title":"Talanta"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1351\/pac199163091247","article-title":"Chemical sensors: Definitions and classification","volume":"63","author":"Hulanicki","year":"1991","journal-title":"Pure Appl. Chem."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aca.2012.05.048","article-title":"Recent advances in ZnO nanostructures and thin films for biosensor applications: Review","volume":"737","author":"Arya","year":"2012","journal-title":"Anal. Chim. Acta"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"4212","DOI":"10.3390\/s150204212","article-title":"Sol-gel deposition of iridium oxide for biomedical micro-devices","volume":"15","author":"Nguyen","year":"2015","journal-title":"Sensors"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0003-2670(99)00572-3","article-title":"Sol\u2013gel materials for electrochemical biosensors","volume":"399","author":"Wang","year":"1999","journal-title":"Anal. Chim. Acta"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1021\/ac401563m","article-title":"Electrochemical sensing and biosensing platform based on biomass-derived macroporous carbon materials","volume":"86","author":"Wang","year":"2014","journal-title":"Anal. Chem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"8129","DOI":"10.1002\/anie.201302958","article-title":"A two-channel ratiometric electrochemical biosensor for in vivo monitoring of copper ions in a rat brain using gold truncated octahedral microcages","volume":"52","author":"Chai","year":"2013","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.1166\/jnn.2015.10037","article-title":"A DNA Aptasensor for Electrochemical Detection of Vascular Endothelial Growth Factor","volume":"15","author":"Ravalli","year":"2015","journal-title":"J. Nanosci. Nanotechnol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.bios.2013.11.077","article-title":"Ultrasensitive electrochemical DNA sensor based on the target induced structural switching and surface-initiated enzymatic polymerization","volume":"55","author":"Wan","year":"2014","journal-title":"Biosens. Bioelectron."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"112878","DOI":"10.1016\/j.bios.2020.112878","article-title":"A facile strategy for quantitative sensing of glycans on cell surface using organic electrochemical transistors","volume":"175","author":"Chen","year":"2020","journal-title":"Biosens. Bioelectron."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"5576","DOI":"10.1021\/ac0107148","article-title":"Metal nanoparticle based electrochemical stripping potentiometric detection of DNA hybridization","volume":"73","author":"Wang","year":"2001","journal-title":"Anal. Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"669","DOI":"10.2174\/187152011796817682","article-title":"Nanoparticles in oncology: The new theragnostic molecules","volume":"11","author":"Allegra","year":"2011","journal-title":"Anti-Cancer Agents Med. Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.bios.2015.05.073","article-title":"Phage-AgNPs complex as SERS probe for U937 cell identification","volume":"74","author":"Lentini","year":"2015","journal-title":"Biosens. Bioelectron."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.bioelechem.2004.12.002","article-title":"Covalent attachment of glucose oxidase to an Au electrode modified with gold nanoparticles for use as glucose biosensor","volume":"67","author":"Zhang","year":"2005","journal-title":"Bioelectrochemistry"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/elan.200403113","article-title":"Carbon\u2013nanotube based electrochemical biosensors: A review","volume":"17","author":"Wang","year":"2005","journal-title":"Electroanalysis"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Pawar, R.S., Upadhaya, P.G., and Patravale, V.B. (2018). Quantum Dots: Novel Realm in Biomedical and Pharmaceutical Industry. Handbook of Nanomaterials for Industrial Applications, Elsevier.","DOI":"10.1016\/B978-0-12-813351-4.00035-3"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Bakirhan, N.K., and Ozkan, S.A. (2018). Quantum Dots as a New Generation Nanomaterials and Their Electrochemical Applications. In: Pharmaceutical Industry. Handbook of Nanomaterials for Industrial Applications, Elsevier.","DOI":"10.1016\/B978-0-12-813351-4.00029-8"},{"key":"ref_19","first-page":"1","article-title":"Nanobiosensors: The future for diagnosis of disease","volume":"3","author":"Prasad","year":"2014","journal-title":"Nanobiosen. Dis. Dig."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.aca.2016.12.031","article-title":"Synthesis of palladium@gold nanoalloys\/nitrogen and sulphur-functionalized multiple graphene aerogel for electrochemical detection of dopamine","volume":"954","author":"Li","year":"2017","journal-title":"Anal. Chim. Acta"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.bios.2017.12.031","article-title":"Electrochemical sensor and biosensor platforms based on advanced nanomaterials for biological and biomedical applications","volume":"103","author":"Maduraiveeran","year":"2018","journal-title":"Biosens. Bioelectron."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Khalil, I., Julkapli, N.M., Yehye, W.A., Basirun, W.J., and Bhargava, S.K. (2016). Graphene-Gold Nanoparticles Hybrid-Synthesis, Functionalization, and Application in a Electrochemical and Surface-Enhanced Raman Scattering Biosensor. Materials, 9.","DOI":"10.3390\/ma9060406"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Yu, S.H., Lee, C.S., and Kim, T.H. (2019). Electrochemical Detection of Ultratrace Lead Ion through Attaching and Detaching DNA Aptamer from Electrochemically Reduced Graphene Oxide Electrode. Nanomaterials, 9.","DOI":"10.3390\/nano9060817"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"4563","DOI":"10.1039\/c1an15486a","article-title":"A novel nitrite sensor based on graphene\/polypyrrole\/chitosan nanocomposite modified glassy carbon electrode","volume":"136","author":"Ye","year":"2011","journal-title":"Analyst"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Lee, C.S., Yu, S.H., and Kim, T.H. (2017). One-Step Electrochemical Fabrication of Reduced Graphene Oxide\/Gold Nanoparticles Nanocomposite-Modified Electrode for Simultaneous Detection of Dopamine, Ascorbic Acid, and Uric Acid. Nanomaterials, 8.","DOI":"10.3390\/nano8010017"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Wu, B., Zhao, N., Hou, S., and Zhang, C. (2016). Electrochemical Synthesis of Polypyrrole, Reduced Graphene Oxide, and Gold Nanoparticles Composite and Its Application to Hydrogen Peroxide Biosensor. Nanomaterials, 6.","DOI":"10.3390\/nano6110220"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1021\/ac202878q","article-title":"Electrochemical sensors and biosensors","volume":"84","author":"Kimmel","year":"2011","journal-title":"Anal. Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ab.2011.12.047","article-title":"Label-free electrochemical immunosensor based on graphene\/methylene blue nanocomposite","volume":"422","author":"Mao","year":"2012","journal-title":"Anal. Biochem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2930","DOI":"10.1016\/j.biomaterials.2011.01.002","article-title":"A graphene functionalized electrochemical aptasensor for selective label-free detection of cancer cell","volume":"32","author":"Feng","year":"2011","journal-title":"Biomaterial"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1007\/s00216-011-5696-6","article-title":"Electrochemically synthesized polymers in molecular imprinting for chemical sensing","volume":"402","author":"Sharma","year":"2012","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1016\/j.bios.2010.08.008","article-title":"Impedimetric immunosensor doped with reduced graphene sheets fabricated by controllable electrodeposition for the non-labelled detection of bacteria","volume":"26","author":"Wan","year":"2011","journal-title":"Biosens. Bioelectron."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1007\/s10529-009-0076-4","article-title":"Advances in enzyme immobilisation","volume":"31","author":"Brady","year":"2009","journal-title":"Biotechnol. Lett."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1021\/ac1032929","article-title":"\u201cOff\u2013On\u201d electrochemical hairpin-dna-based genosensor for cancer diagnostics","volume":"83","author":"Farjami","year":"2011","journal-title":"Anal. Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.trac.2004.11.007","article-title":"New materials for electrochemical sensing v: Nanoparticles for DNA labelling","volume":"24","author":"Merkoci","year":"2005","journal-title":"TrAC Trend Anal. Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.bios.2012.08.021","article-title":"Electrochemical detection of hepatitis B and papilloma virus DNAs using SWCNT array coated with gold nanoparticles","volume":"41","author":"Wang","year":"2013","journal-title":"Biosens. Bioelectron."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.aca.2006.09.004","article-title":"Nucleic acid biosensor for detection of hepatitis B virus using 2,9-dimethyl-1,10-phenanthroline copper complex as electrochemical indicator","volume":"582","author":"Li","year":"2007","journal-title":"Anal. Chim. Acta"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.talanta.2006.01.027","article-title":"Immobilization of streptavidin in sol-gel films: Application on the diagnosis of hepatitis C virus","volume":"70","author":"Dahmouche","year":"2006","journal-title":"Talanta"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ab.2006.12.039","article-title":"A DNA electrochemical sensor based on nanogold-modified poly-2,6-pyridinedicarboxylic acid film and detection of PAT gene fragment","volume":"365","author":"Yang","year":"2007","journal-title":"Anal. Biochem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.bios.2004.07.025","article-title":"Direct electrochemical sensor for fast reagent-free DNA detection","volume":"21","author":"Komarova","year":"2005","journal-title":"Biosens. Bioelectron."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"11751","DOI":"10.1021\/bi034637h","article-title":"DNA sequence recognition by bispyrazinonaphthalimides antitumor agents","volume":"42","author":"Carrasco","year":"2003","journal-title":"Biochemistry"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.talanta.2006.11.015","article-title":"Electrochemical DNA biosensor for the detection of short DNA species of Chronic Myelogenous Leukemia by using methylene blue","volume":"72","author":"Lin","year":"2007","journal-title":"Talanta"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0039-9140(01)00650-6","article-title":"Electrochemical DNA biosensor for the detection of TT and Hepatitis B virus from PCR amplified real samples by using methylene blue","volume":"56","author":"Meric","year":"2002","journal-title":"Talanta"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3698","DOI":"10.1021\/ac011148j","article-title":"DNA sensor with a dipyridophenazine complex of osmium(lI) as an electrochemical probe","volume":"74","author":"Maruyama","year":"2002","journal-title":"Anal. Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1016\/j.jinorgbio.2005.08.016","article-title":"Studies on the interaction mechanism between hexakis(imidazole) manganese(II) terephthalate and DNA and preparation of DNA electrochemical sensor","volume":"99","author":"Zhang","year":"2005","journal-title":"J. Inorg. Biochem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.talanta.2006.11.019","article-title":"Study of interactions between actinomycin D and oligonucleotides by microchip electrophoresis and ESI-MS","volume":"72","author":"Zhou","year":"2007","journal-title":"Talanta"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0302-4598(99)00061-6","article-title":"Tuning the redox potential of riboflavin by zirconium phosphate in carbon paste electrodes","volume":"49","author":"Malinauskas","year":"1999","journal-title":"Bioelectrochem. Bioenerg."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.bios.2004.05.014","article-title":"Molecularly imprinted polypyrrole-based synthetic receptor for direct detection of bovine leukemia virus glycoproteins","volume":"20","author":"Ramanaviciene","year":"2004","journal-title":"Biosens. Bioelectron."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1021\/ja017365j","article-title":"Direct-writing of polymer nanostructures: Poly(thiophene) nanowires on semiconducting and insulating surfaces","volume":"124","author":"Maynor","year":"2002","journal-title":"J. Am. Chem. Soc."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1126\/science.264.5166.1757","article-title":"Conducting polyaniline filaments in a mesoporous channel host","volume":"264","author":"Wu","year":"1994","journal-title":"Science"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.bios.2010.08.053","article-title":"Electrochemical DNA hybridization sensors applied to real and complex biological samples","volume":"26","author":"Tozer","year":"2010","journal-title":"Biosens. Bioelectron."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e65","DOI":"10.1093\/nar\/gkn299","article-title":"Electrochemical detection of low-copy number salivary RNA based on specific signal amplification with a hairpin probe","volume":"36","author":"Wei","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1182\/blood.V99.3.759","article-title":"Acute promyelocytic leukemia: Evolving therapeutic strategies","volume":"99","author":"Tallman","year":"2002","journal-title":"Blood"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.cancergencyto.2005.12.006","article-title":"A complex, four-way variant t(15;17) in acute promyelocytic leukemia","volume":"167","author":"Yoo","year":"2006","journal-title":"Cancer Genet. Cytogenet."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0165-4608(01)00504-0","article-title":"Fluorescence in situ hybridization: A highly efficient technique of molecular diagnosis and predication for disease course in patients with myeloid leukemias","volume":"131","author":"Amare","year":"2001","journal-title":"Cancer Genet. Cytogenet."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0165-4608(03)00027-X","article-title":"Cytogenetic and molecular analysis of an unusual case of acute promyelocytic leukemia with a t(15;17;17)(q22;q23;q21)","volume":"145","author":"Tirado","year":"2003","journal-title":"Cancer Genet. Cytogenet."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.leukres.2006.05.011","article-title":"Identification of PML-RARA rearrangement by RT-PCR and sequencing in an acute promyelocytic leukemia without t(15;17) on G-banding and FISH","volume":"31","author":"Han","year":"2007","journal-title":"Leuk. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1016\/j.bios.2010.01.032","article-title":"Nanostructured rough gold electrodes for the development of lactate oxidase-based biosensors","volume":"25","author":"Gamero","year":"2010","journal-title":"Biosens. Bioelectron."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"3812","DOI":"10.1016\/j.bios.2011.02.039","article-title":"Electrochemical biosensor based on nanoporous gold electrode for detection of PML\/RAR\u03b1 fusion gene","volume":"26","author":"Zhong","year":"2011","journal-title":"Biosens. Bioelectron."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.aca.2010.01.009","article-title":"Review: Carbon nanotube based electrochemical sensors for biomolecules","volume":"662","author":"Jacobs","year":"2010","journal-title":"Anal. Chim. Acta"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.bios.2012.10.052","article-title":"An enhanced sensing platform for ultrasensitive impedimetric detection of target genes based on ordered FePt nanoparticles decorated carbon nanotubes","volume":"42","author":"Zhang","year":"2013","journal-title":"Biosens. Bioelectron."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.elecom.2015.01.023","article-title":"Graphene and carbon quantum dots electrochemistry","volume":"52","author":"Lima","year":"2015","journal-title":"Electrochem. Commun."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"127490","DOI":"10.1016\/j.snb.2019.127490","article-title":"Synthesizing anode electrochemiluminescent self-catalyzed carbon dots-based nanocomposites and its application in sensitive ECL biosensor for microRNA detection","volume":"305","author":"Zhong","year":"2020","journal-title":"Sens. Actuator B Chem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"104093","DOI":"10.1016\/j.nanoen.2019.104093","article-title":"Carbon quantum dot-based composites for energy storage and electrocatalysis: Mechanism, applications and future prospects","volume":"66","author":"Hoang","year":"2019","journal-title":"Nano Energy"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.talanta.2017.09.082","article-title":"Enhanced electrochemical response of carbon quantum dot modified electrodes, applications and future prospects","volume":"178","author":"Algarra","year":"2018","journal-title":"Talanta"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Cai, Z.T., Ye, Y.B., Wan, X., Liu, J., Yang, S., Xia, Y., Li, G., and He, Q. (2019). Morphology-dependent electrochemical sensing properties of iron oxide-graphene oxide nanohybrids for dopamine and uric acid. Nanomaterials, 9.","DOI":"10.3390\/nano9060835"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s00604-018-2688-7","article-title":"Electrochemical determination of acetaminophen using a glassy carbon electrode modified with a hybrid material consisting of graphene aerogel and octadecylamine-functionalized carbon quantum dots","volume":"185","author":"Li","year":"2018","journal-title":"Microchim. Acta"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.aca.2015.11.021","article-title":"A quadruplet electrochemical platform for ultrasensitive and simultaneous detection of ascorbic acid, dopamine, uric acid and acetaminophen based on a ferrocene derivative functional Au NPs\/carbon dots nanocomposite and graphene","volume":"903","author":"Yang","year":"2015","journal-title":"Anal. Chim. Acta"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/j.snb.2017.08.156","article-title":"Preparation of highly sensitive Pt nanoparticles-carbon quantum dots\/ionic liquid functionalized graphene oxide nanocomposites and application for H2O2 detection","volume":"255","author":"Chen","year":"2018","journal-title":"Sens. Actuator B Chem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"3497","DOI":"10.2147\/IJN.S308258","article-title":"Efficient Determination of PML\/RAR\u03b1 Fusion Gene by the Electrochemical DNA Biosensor Based on Carbon Dots\/Graphene Oxide Nanocomposites","volume":"16","author":"Zhang","year":"2021","journal-title":"Int. J. Nanomed."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/j.talanta.2008.12.053","article-title":"An electrochemical biosensor for detection of PML\/RARA fusion gene using capture probe covalently immobilized onto poly-calcon carboxylic acid modified glassy carbon electrode","volume":"78","author":"Wei","year":"2009","journal-title":"Talanta"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0021-9673(99)00827-4","article-title":"Preparative isolation and purification of hydroxyanthraquinones from Rheum officinale Baill by high-speed counter-current chromatography using pH-modulated stepwise elution","volume":"858","author":"Yang","year":"1999","journal-title":"J. Chromatogr. A"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.talanta.2007.07.038","article-title":"Studies of the interaction between Aloe-emodin and DNA and preparation of DNA biosensor for detection of PML-RAR fusion gene in acute promyelocytic leukemia","volume":"74","author":"Lin","year":"2008","journal-title":"Talanta"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"4030","DOI":"10.1093\/nar\/gkm358","article-title":"Synthesis and investigation of deoxyribonucleic acid\/locked nucleic acid chimeric molecular beacons","volume":"35","author":"Yang","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"8028","DOI":"10.1021\/ac801040e","article-title":"Electrochemical biosensor for detection of BCR\/ABL fusion gene using locked nucleic acids on 4-aminobenzenesulfonic acid-modified glassy carbon electrode","volume":"80","author":"Chen","year":"2008","journal-title":"Anal. Chem."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/S0968-0896(00)00325-4","article-title":"2\u2032-O,4\u2032-C-Methylene bridged nucleic acid (2\u2032,4\u2032-BNA): Synthesis and triplex-forming properties","volume":"9","author":"Obika","year":"2001","journal-title":"Bioorg. Med. Chem."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.bios.2011.07.032","article-title":"Enzyme-amplified electrochemical biosensor for detection of PML-RAR\u03b1 fusion gene based on hairpin LNA probe","volume":"28","author":"Lin","year":"2011","journal-title":"Biosens. Bioelectron."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.bios.2015.04.071","article-title":"Dual-probe electrochemical DNA biosensor based on the \u201cY\u201d junction structure and restriction endonuclease assisted cyclic enzymatic amplification for detection of double-strand DNA of PML\/RAR\u03b1 related fusion gene","volume":"71","author":"Wang","year":"2015","journal-title":"Biosens. Bioelectron."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.bios.2018.04.012","article-title":"2\u2019-Fluoro ribonucleic acid modified DNA dual-probe sensing strategy for enzyme-amplified electrochemical detection of double-strand DNA of PML\/RAR\u03b1 related fusion gene","volume":"112","author":"Lei","year":"2018","journal-title":"Biosens. Bioelectron."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.3324\/haematol.2020.247031","article-title":"Pediatric acute lymphoblastic leukemia","volume":"105","author":"Inaba","year":"2020","journal-title":"Haematologica"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.bioelechem.2016.12.001","article-title":"Amplified detection of leukemia cancer cells using an aptamer-conjugated gold-coated magnetic nanoparticles on a nitrogen-doped graphene modified electrode","volume":"114","author":"Khoshfetrat","year":"2017","journal-title":"Bioelectrochemistry"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1084\/jem.20101947","article-title":"Ebf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia","volume":"208","author":"Willette","year":"2011","journal-title":"J. Exp. Med."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/leu.2008.306","article-title":"Incidence and diversity of PAX5 fusion genes in childhood acute lymphoblastic leukemia","volume":"23","author":"Nebral","year":"2009","journal-title":"Leukemia"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1038\/s41388-018-0573-9","article-title":"Chromosomal translocation-mediated evasion from miRNA induces strong MEF2D fusion protein expression, causing inhibition of PAX5 transcriptional activity","volume":"38","author":"Hirano","year":"2019","journal-title":"Oncogene"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/nrg3296","article-title":"DNA secondary structures: Stability and function of G-quadruplex structures","volume":"13","author":"Bochman","year":"2012","journal-title":"Nat. Rev. Genet."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nrd3428","article-title":"Targeting G-quadruplexes in gene promoters: A novel anticancer strategy?","volume":"10","author":"Balasubramanian","year":"2011","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1021\/ac5034903","article-title":"Versatile biosensing platform for DNA detection based on a DNAzyme and restriction-endonuclease-assisted recycling","volume":"87","author":"Yuan","year":"2015","journal-title":"Anal. Chem."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aca.2016.02.034","article-title":"Cascaded strand displacement for non-enzymatic target recycling amplification and label-free electronic detection of microRNA from tumor cells","volume":"916","author":"Shi","year":"2016","journal-title":"Anal. Chim. Acta"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"111593","DOI":"10.1016\/j.bios.2019.111593","article-title":"Ultra-sensitive label-free electrochemical detection of the acute leukaemia gene Pax-5a based on enzyme-assisted cycle amplification","volume":"143","author":"Zhao","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"3629","DOI":"10.1039\/c4an00420e","article-title":"An efficient nanomaterial-based electrochemical biosensor for sensitive recognition of drug-resistant leukemia cells","volume":"139","author":"Zhang","year":"2014","journal-title":"Analyst"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/S0140-6736(13)62120-0","article-title":"Chronic myeloid leukaemia","volume":"385","author":"Apperley","year":"2015","journal-title":"Lancet"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.talanta.2006.01.009","article-title":"A nano-porous CeO(2)\/Chitosan composite film as the immobilization matrix for colorectal cancer DNA sequence-selective electrochemical biosensor","volume":"70","author":"Feng","year":"2006","journal-title":"Talanta"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3109\/10408444.2010.529105","article-title":"Exposure, health and ecological effects review of engineered nanoscale cerium and cerium oxide associated with its use as a fuel additive","volume":"41","author":"Cassee","year":"2011","journal-title":"Crit. Rev. Toxicol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.colsurfb.2013.07.027","article-title":"Electrochemical determination of BCR\/ABL fusion gene based on in situ synthesized gold nanoparticles and cerium dioxide nanoparticles","volume":"112","author":"Li","year":"2013","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"108176","DOI":"10.1016\/j.bioelechem.2022.108176","article-title":"Electrochemical DNA biosensor for chronic myelocytic leukemia based on hybrid nanostructure","volume":"147","author":"Avelino","year":"2022","journal-title":"Bioelectrochemistry"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"5109","DOI":"10.1039\/C7CS00838D","article-title":"Two-dimensional transition metal carbides and nitrides (MXenes) for biomedical applications","volume":"47","author":"Huang","year":"2018","journal-title":"Chem. Soc. Rev."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1126\/science.1102896","article-title":"Electric field effect in atomically thin carbon films","volume":"306","author":"Novoselov","year":"2004","journal-title":"Science"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"3996","DOI":"10.1021\/acsnano.1c00248","article-title":"Ti3C2TX MXene for sensing applications: Recent progress, design principles, and future perspectives","volume":"15","author":"Pei","year":"2021","journal-title":"ACS Nano"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s12951-022-01317-9","article-title":"Novel Ti3C2TX MXene nanozyme with manageable catalytic activity and application to electrochemical biosensor","volume":"20","author":"Yu","year":"2022","journal-title":"J. Nanobiotechnology"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"8753","DOI":"10.1021\/la401431q","article-title":"Quantum dots self assembly based interface for blood cancer detection","volume":"29","author":"Sharma","year":"2013","journal-title":"Langmuir"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1007\/s00277-011-1212-5","article-title":"A novel mechanism of dasatinib-induced apoptosis in chronic myeloid leukemia; ceramide synthase and ceramide clearance genes","volume":"90","author":"Gencer","year":"2011","journal-title":"Ann. Hematol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"5609","DOI":"10.1021\/ac400994p","article-title":"Nanoarchitectured electrochemical cytosensors for selective detection of leukemia cells and quantitative evaluation of death receptor expression on cell surfaces","volume":"85","author":"Zheng","year":"2013","journal-title":"Anal. Chem."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"6207","DOI":"10.1038\/onc.2008.298","article-title":"The promise of cancer therapeutics targeting the TNF-related apoptosis-inducing ligand and TRAIL receptor pathway","volume":"27","author":"Wang","year":"2008","journal-title":"Oncogene"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.bios.2014.05.064","article-title":"Toward therapeutic effects evaluation of chronic myeloid leukemia drug: Electrochemical platform for caspase-3 activity sensing","volume":"61","author":"Zhou","year":"2014","journal-title":"Biosens. Bioelectron."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"136299","DOI":"10.1016\/j.chemosphere.2022.136299","article-title":"Nanoplastics: Focus on the role of microRNAs and long non-coding RNAs","volume":"308","author":"Banikazemi","year":"2022","journal-title":"Chemosphere"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.bios.2017.08.036","article-title":"Recent advances in signal amplification strategy based on oligonucleotide and nanomaterials for microRNA detection\u2014A review","volume":"99","author":"Chen","year":"2018","journal-title":"Biosens. Bioelectron."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"113478","DOI":"10.1016\/j.jpba.2020.113478","article-title":"New trends in the development of electrochemical biosensors for the quantification of microRNAs","volume":"189","author":"Mujica","year":"2020","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.coelec.2019.04.030","article-title":"Current advances in electrochemical genosensors for detecting microRNA cancer markers","volume":"16","author":"Mohammadi","year":"2019","journal-title":"Curr. Opin. Electrochem."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.3762\/bjnano.7.193","article-title":"A novel electrochemical nanobiosensor for the ultrasensitive and specific detection of femtomolar-level gastric cancer biomarker miRNA-106a","volume":"7","author":"Daneshpour","year":"2016","journal-title":"Beilstein J. Nanotechnol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"69334","DOI":"10.1039\/C5RA12373A","article-title":"Retracted Article: Graphene oxide\/DNA-decorated electrode for the fabrication of microRNA biosensor","volume":"5","author":"Sun","year":"2015","journal-title":"RSC Adv."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"111544","DOI":"10.1016\/j.bios.2019.111544","article-title":"Double signal amplification strategy for ultrasensitive electrochemical biosensor based on nuclease and quantum dot-DNA nanocomposites in the detection of breast cancer 1 gene mutation","volume":"142","author":"Yang","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.aca.2019.09.037","article-title":"An enzyme-free electrochemical biosensor for simultaneous detection of two hemophilia A biomarkers: Combining target recycling with quantum dots-encapsulated metal-organic frameworks for signal amplification","volume":"1092","author":"Rezaei","year":"2019","journal-title":"Anal. Chim. Acta"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.talanta.2018.09.110","article-title":"High performance electrochemical biosensor based on 3D nitrogen-doped reduced graphene oxide electrode and tetrahedral DNA nanostructure","volume":"194","author":"Tian","year":"2019","journal-title":"Talanta"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"11262","DOI":"10.1039\/C9NR02543J","article-title":"Exonuclease-assisted target recycling for ultrasensitive electrochemical detection of microRNA at vertically aligned carbon nanotubes","volume":"11","author":"Chen","year":"2019","journal-title":"Nanoscale"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s42250-019-00058-x","article-title":"A Highly Sensitive Electrochemical Biosensor Based on Carbon Black and Gold Nanoparticles Modified Pencil Graphite Electrode for microRNA-21 Detection","volume":"2","author":"Yammouri","year":"2019","journal-title":"Chem. Afr."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"El Aamri, M., Yammouri, G., Mohammadi, H., Amine, A., and Korri-Youssoufi, H. (2020). Electrochemical Biosensors for Detection of MicroRNA as a Cancer Biomarker: Pros and Cons. Biosensors, 10.","DOI":"10.3390\/bios10110186"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/elsc.202100170","article-title":"Fabrication of Au\/Fe3O4\/RGO based aptasensor for measurement of miRNA-128, a biomarker for acute lymphoblastic leukemia (ALL)","volume":"22","author":"Dinani","year":"2022","journal-title":"Eng. Life Sci."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.bios.2017.09.042","article-title":"Conducting electrospun fibres with polyanionic grafts as highly selective, label-free, electrochemical biosensor with a low detection limit for non-Hodgkin lymphoma gene","volume":"100","author":"Aydemira","year":"2018","journal-title":"Biosens. Bioelectron."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Allegra, A., Cancemi, G., Mirabile, G., Tonacci, A., Musolino, C., and Gangemi, S. (2022). Circulating tumour cells, cell free DNA and tumour-educated platelets as reliable diagnostic and management biomarkers for the liquid biopsy in multiple myeloma. Cancers, 14.","DOI":"10.3390\/cancers14174136"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.bios.2018.11.037","article-title":"Liquid biopsy of circulating tumor DNA and biosensor applications","volume":"126","author":"Li","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Li, W. (2022). Measurable Residual Disease Testing in Acute Leukemia: Technology and Clinical Significance. Leukemia, Exon Publications. Chapter 5.","DOI":"10.36255\/exon-publications-leukemia-measurable-residual-disease"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"138863","DOI":"10.1016\/j.electacta.2021.138863","article-title":"Electrochemical biosensors combining aptamers and enzymatic activity: Challenges and analytical opportunities","volume":"390","author":"Rhouati","year":"2021","journal-title":"Electrochim. Acta"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"114736","DOI":"10.1016\/j.ab.2022.114736","article-title":"Various types of electrochemical biosensors for leukemia detection and therapeutic approaches","volume":"654","author":"Chupradit","year":"2022","journal-title":"Anal. Biochem."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/15\/1\/146\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:52:06Z","timestamp":1760147526000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/15\/1\/146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,26]]},"references-count":122,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["cancers15010146"],"URL":"https:\/\/doi.org\/10.3390\/cancers15010146","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,26]]}}}