{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:47:32Z","timestamp":1760244452366,"version":"build-2065373602"},"reference-count":48,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T00:00:00Z","timestamp":1672185600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"German Research Foundation","award":["DFG SFB 1074","B1","B2","70114291"],"award-info":[{"award-number":["DFG SFB 1074","B1","B2","70114291"]}]},{"name":"German Cancer Aid \u201cDeutsche Krebshilfe\u201d project","award":["DFG SFB 1074","B1","B2","70114291"],"award-info":[{"award-number":["DFG SFB 1074","B1","B2","70114291"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>WNT pathways play an important role in cancer development and progression, but WNT pathways can also inhibit growth in melanoma, prostate, and ovarian cancers. Chronic lymphocytic leukemia (CLL) is known for its overexpression of several WNT ligands and receptors. Canonical WNT signaling is \u03b2-catenin-dependent, whereas non-canonical WNT signaling is \u03b2-catenin-independent. Research on WNT in CLL focuses mainly on non-canonical signaling due to the high expression of the WNT-5a receptor ROR1. However, it was also shown that mutations in canonical WNT pathway genes can lead to WNT activation in CLL. The focus of this review is \u03b2-catenin-independent signaling and \u03b2-catenin-dependent signaling within CLL cells and the role of WNT in the leukemic microenvironment. The major role of WNT pathways in CLL pathogenesis also makes WNT a possible therapeutic target, directly or in combination with other drugs.<\/jats:p>","DOI":"10.3390\/cancers15010194","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T02:52:21Z","timestamp":1672282341000},"page":"194","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["To \u03b2 or Not to \u03b2: How Important Is \u03b2-Catenin Dependent and Independent WNT Signaling in CLL?"],"prefix":"10.3390","volume":"15","author":[{"given":"Karol D.","family":"Urbanek","sequence":"first","affiliation":[{"name":"Mechanisms of Leukemogenesis (B061), German Cancer Research Center, DKFZ, 69120 Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Stilgenbauer","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Center Ulm, Ulm University Medical Center, 89081 Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0227-7188","authenticated-orcid":false,"given":"Daniel","family":"Mertens","sequence":"additional","affiliation":[{"name":"Mechanisms of Leukemogenesis (B061), German Cancer Research Center, DKFZ, 69120 Heidelberg, Germany"},{"name":"Department of Internal Medicine III, University Hospital Ulm, 89081 Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrc3419","article-title":"WNT signalling pathways as therapeutic targets in cancer","volume":"13","author":"Anastas","year":"2013","journal-title":"Nat. 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