{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T12:01:33Z","timestamp":1784808093333,"version":"3.55.0"},"reference-count":60,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T00:00:00Z","timestamp":1673913600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The AIRC program","award":["24285"],"award-info":[{"award-number":["24285"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Enhanced recovery after surgery (ERAS) program refers to a multimodal intervention to reduce the length of stay and postoperative complications; it has been effective in different kinds of major surgery including colorectal, gynaecologic and gastric cancer surgery. Its impact in terms of safety and efficacy in the treatment of peritoneal surface malignancies is still unclear. A systematic review and a meta-analysis were conducted to evaluate the effect of ERAS after cytoreductive surgery with or without HIPEC for peritoneal metastases. MEDLINE, PubMed, EMBASE, Google Scholar and Cochrane Database were searched from January 2010 and December 2021. Single and double-cohort studies about ERAS application in the treatment of peritoneal cancer were considered. Outcomes included the postoperative length of stay (LOS), postoperative morbidity and mortality rates and the early readmission rate. Twenty-four studies involving 5131 patients were considered, 7 about ERAS in cytoreductive surgery (CRS) + HIPEC and 17 about cytoreductive alone; the case histories of two Italian referral centers in the management of peritoneal cancer were included. ERAS adoption reduced the LOS (\u22123.17, 95% CrI \u22124.68 to \u22121.69 in CRS + HIPEC and \u22121.65, 95% CrI \u22122.32 to \u20131.06 in CRS alone in the meta-analysis including 6 and 17 studies respectively. Non negligible lower postoperative morbidity was also in the meta-analysis including the case histories of two Italian referral centers. Implementation of an ERAS protocol may reduce LOS, postoperative complications after CRS with or without HIPEC compared to conventional recovery.<\/jats:p>","DOI":"10.3390\/cancers15030570","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T02:31:11Z","timestamp":1674009071000},"page":"570","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Enhanced Recovery after Surgery (ERAS) Program for Patients with Peritoneal Surface Malignancies Undergoing Cytoreductive Surgery with or without HIPEC: A Systematic Review and a Meta-Analysis"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7676-9658","authenticated-orcid":false,"given":"Manuela","family":"Robella","sequence":"first","affiliation":[{"name":"Unit of Surgical Oncology, Candiolo Cancer Institute, FPO-IRCCS, 10060 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7190-2106","authenticated-orcid":false,"given":"Marco","family":"Tonello","sequence":"additional","affiliation":[{"name":"Advanced Surgical Oncology Unit, Surgical Oncology of the Esophagus and Digestive Tract, Veneto Institute of Oncology IOV-IRCCS, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5835-5638","authenticated-orcid":false,"given":"Paola","family":"Berchialla","sequence":"additional","affiliation":[{"name":"Center for Biostatistics, Epidemiology and Public Health (C-BEPH), Deptartment of Clinical and Biological Sciences, University of Torino, 10124 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0499-0131","authenticated-orcid":false,"given":"Veronica","family":"Sciannameo","sequence":"additional","affiliation":[{"name":"Center for Biostatistics, Epidemiology and Public Health (C-BEPH), Deptartment of Clinical and Biological Sciences, University of Torino, 10124 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba Maria","family":"Ilari Civit","sequence":"additional","affiliation":[{"name":"Unit of Surgical Oncology, Candiolo Cancer Institute, FPO-IRCCS, 10060 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5764-5606","authenticated-orcid":false,"given":"Antonio","family":"Sommariva","sequence":"additional","affiliation":[{"name":"Advanced Surgical Oncology Unit, Surgical Oncology of the Esophagus and Digestive Tract, Veneto Institute of Oncology IOV-IRCCS, 35128 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Sassaroli","sequence":"additional","affiliation":[{"name":"Abdominal Oncology Department, Fondazione Giovanni Pascale, IRCCS, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3981-1145","authenticated-orcid":false,"given":"Andrea","family":"Di Giorgio","sequence":"additional","affiliation":[{"name":"Surgical Unit of Peritoneum and Retroperitoneum, Fondazione Policlinico Universitario A. Gemelli-IRCCS, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8471-710X","authenticated-orcid":false,"given":"Roberta","family":"Gelmini","sequence":"additional","affiliation":[{"name":"SC Chirurgia Generale d\u2019Urgenza ed Oncologica, AOU Policlinico di Modena, 41125 Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Ghirardi","sequence":"additional","affiliation":[{"name":"UOC Ovarian Carcinoma Fondazione Policlinico Universitario \u201cA. Gemelli\u201d IRCCS, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4122-1259","authenticated-orcid":false,"given":"Franco","family":"Roviello","sequence":"additional","affiliation":[{"name":"Unit of General Surgery and Surgical Oncology, Department of Medicine, Surgery, and Neurosciences, University of Siena, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Carboni","sequence":"additional","affiliation":[{"name":"Peritoneal Tumours Unit, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3671-3470","authenticated-orcid":false,"given":"Piero Vincenzo","family":"Lippolis","sequence":"additional","affiliation":[{"name":"General and Peritoneal Surgery, Hospital University Pisa, 56124 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3116-277X","authenticated-orcid":false,"given":"Shigeki","family":"Kusamura","sequence":"additional","affiliation":[{"name":"Peritoneal Surface Malignancies Unit, Fondazione Istituto Nazionale Tumori IRCCS Milano, 20133 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Vaira","sequence":"additional","affiliation":[{"name":"Unit of Surgical Oncology, Candiolo Cancer Institute, FPO-IRCCS, 10060 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1007\/DCR.0b013e3181b5504e","article-title":"Treatments and Outcomes of Peritoneal Surface Tumors Through a Centralized National Service (United Kingdom)","volume":"52","author":"Rout","year":"2009","journal-title":"Dis. Colon Rectum"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ejso.2004.09.011","article-title":"Perioperative morbidity and quality of life in long-term survivors following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy","volume":"31","author":"Schmidt","year":"2005","journal-title":"Eur. J. Surg. Oncol. (EJSO)"},{"key":"ref_3","first-page":"99","article-title":"Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: A review of factors contributing to morbidity and mortality","volume":"7","author":"Newton","year":"2016","journal-title":"J. Gastrointest. Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.jamcollsurg.2013.12.013","article-title":"Intraperitoneal Chemotherapy for Peritoneal Surface Malignancy: Experience with 1000 Patients","volume":"218","author":"Levine","year":"2013","journal-title":"J. Am. Coll. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"266","DOI":"10.3747\/co.23.2831","article-title":"Treatment of Peritoneal Surface Malignancies with Hyperthermic Intraperitoneal Chemotherapy\u2014Current Perspectives","volume":"23","author":"Spiliotis","year":"2016","journal-title":"Curr. Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1002\/bjs.9582","article-title":"Consensus guidelines for enhanced recovery after gastrectomy","volume":"101","author":"Mortensen","year":"2014","journal-title":"Br. J. Surg."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"The ERAS Compliance Group (2015). The Impact of Enhanced Recovery Protocol Compliance on Elective Colorectal Cancer Resection: Results from an International Registry. Ann. Surg., 261, 1153\u20131159.","DOI":"10.1097\/SLA.0000000000001029"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"237.e1","DOI":"10.1016\/j.ajog.2019.04.028","article-title":"International validation of Enhanced Recovery After Surgery Society guidelines on enhanced recovery for gynecologic surgery","volume":"221","author":"Wijk","year":"2019","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jclinepi.2021.03.001","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"134","author":"Page","year":"2021","journal-title":"J. Clin. Epidemiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/jrsm.1153","article-title":"A Bayesian missing data framework for generalized multiple outcome mixed treatment comparisons","volume":"7","author":"Hong","year":"2015","journal-title":"Res. Synth. Methods"},{"key":"ref_11","first-page":"1593","article-title":"The No-U-Turn Sampler: Adaptively Setting Path Lengths in Hamiltonian Monte Carlo","volume":"15","author":"Hoffman","year":"2014","journal-title":"J. Mach. Learn. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.3389\/fpsyg.2019.02767","article-title":"Indices of Effect Existence and Significance in the Bayesian Framework","volume":"10","author":"Makowski","year":"2019","journal-title":"Front. Psychol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Makowski, D., Ben-Shachar, M., and L\u00fcdecke, D. (2019). bayestestR: Describing Effects and their Uncertainty, Existence and Significance within the Bayesian Framework. J. Open Source Softw., 4.","DOI":"10.21105\/joss.01541"},{"key":"ref_14","unstructured":"R Core Team (2022). A Language and Environment for Statistical Computing, R Foundation for Statistical Computing. Available online: https:\/\/www.R-project.org\/."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v080.i05","article-title":"Performing Arm-Based Network Meta-Analysis in R with the pcnetmeta Package","volume":"80","author":"Lin","year":"2017","journal-title":"J. Stat. Softw."},{"key":"ref_16","unstructured":"Phillippo, D.M. (multinma: Network Meta-Analysis of Individual and Aggregate Data in Stan, 2022). multinma: Network Meta-Analysis of Individual and Aggregate Data in Stan, R Package Version 0.4.1."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1097\/AOG.0b013e31829aa780","article-title":"Enhanced Recovery in Gynecologic Surgery","volume":"122","author":"Kalogera","year":"2013","journal-title":"Obstet. Gynecol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.ygyno.2019.12.018","article-title":"Postoperative narcotic use in patients with ovarian cancer on an Enhanced Recovery After Surgery (ERAS) pathway","volume":"156","author":"Kay","year":"2020","journal-title":"Gynecol. Oncol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"543.e1","DOI":"10.1016\/j.ajog.2020.07.003","article-title":"Validation of an enhanced recovery after surgery protocol in gynecologic surgery: An Italian randomized study","volume":"223","author":"Ferrari","year":"2020","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_20","unstructured":"Azhar, H., Hafeez, M.H., and Ahmed, S.Z. (2022). Enhanced Recovery after Surgery (ERAS) versus Traditional Care in Patients Hospitalized for Colorectal Surgery: A Meta-Analysis. Arch. Surg. Res., 2."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s00404-021-06339-6","article-title":"The impact of Enhanced Recovery after Surgery (ERAS) pathways with regard to perioperative outcome in patients with ovarian cancer","volume":"306","author":"Reuter","year":"2021","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1245\/s10434-019-07900-z","article-title":"Implementation of an Enhanced Recovery After Surgery (ERAS) Program is Associated with Improved Outcomes in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy","volume":"27","author":"Webb","year":"2019","journal-title":"Ann. Surg. Oncol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1097\/IGC.0000000000001198","article-title":"The Impact of an Enhanced Recovery After Surgery Program on Patients Treated for Gynecologic Cancer in the Community Hospital Setting","volume":"28","author":"Mendivil","year":"2018","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.ejca.2020.06.011","article-title":"PROFAST: A randomised trial implementing enhanced recovery after surgery for highcomplexity advanced ovarian cancer surgery","volume":"136","author":"Clua","year":"2020","journal-title":"Eur. J. Cancer"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jss.2019.10.042","article-title":"Cytoreductive Surgery and HIPEC in an Enhanced Recovery After Surgery Program: A Feasibility Study","volume":"247","author":"Lu","year":"2019","journal-title":"J. Surg. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"5265","DOI":"10.1245\/s10434-020-09476-5","article-title":"Impact of Enhanced Recovery after Surgery on Postoperative Outcomes for Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy","volume":"28","author":"White","year":"2021","journal-title":"Ann. Surg. Oncol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.suronc.2016.08.001","article-title":"Effectiveness and failures of a fast track protocol after cytoreduction and hyperthermic intraoperative intraperitoneal chemotherapy in patients with peritoneal surface malignancies","volume":"25","author":"Gil","year":"2016","journal-title":"Surg. Oncol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.amjsurg.2019.06.019","article-title":"Feasibility and benefits of an enhanced recovery after surgery protocol for patients undergoing cytoreductive surgery and heated intraperitoneal chemotharpy: A single institution experience","volume":"219","author":"Siddharthan","year":"2019","journal-title":"Am. J. Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1136\/ijgc-2021-002495","article-title":"Enhanced recovery after surgery protocols improve time to return to intended oncology treatment following interval cytoreductive surgery for advanced gynecologic cancers","volume":"31","author":"Tankou","year":"2021","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1080\/00016340500408325","article-title":"The effect of accelerated rehabilitation on recovery after surgery for ovarian malignancy","volume":"85","author":"Marx","year":"2006","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.ygyno.2007.10.014","article-title":"A clinical pathway for patients undergoing primary cytoreductive surgery with rectosigmoid colectomy for advanced ovarian and primary peritoneal cancers","volume":"108","author":"Gerardi","year":"2008","journal-title":"Gynecol. Oncol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s00404-015-3934-4","article-title":"Implementation of enhanced recovery after surgery (ERAS) in gynaecological oncology","volume":"294","author":"Myriokefalitaki","year":"2015","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1097\/AOG.0000000000001555","article-title":"Enhanced Recovery Implementation in Major Gynecologic Surgeries","volume":"128","author":"Modesitt","year":"2016","journal-title":"Obstet. Gynecol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1136\/ijgc-2019-000268","article-title":"Compliance with enhanced recovery after surgery program in gynecology: Are all items of equal importance?","volume":"29","author":"Pache","year":"2019","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ygyno.2018.08.007","article-title":"Enhanced Recovery after Surgery (ERAS) in gynecologic oncology: System-wide implementation and audit leads to improved value and patient outcomes","volume":"151","author":"Bisch","year":"2018","journal-title":"Gynecol. Oncol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.ygyno.2018.09.009","article-title":"Impact of enhanced recovery after surgery (ERAS) protocol on gastrointestinal function in gynecologic oncology patients undergoing laparotomy","volume":"151","author":"Boitano","year":"2018","journal-title":"Gynecol. Oncol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1136\/ijgc-2018-000043","article-title":"A prospective study evaluating the impact of implementing the ERAS protocol on patients undergoing surgery for advanced ovarian cancer","volume":"29","author":"Agarwal","year":"2019","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.ygyno.2018.04.003","article-title":"Narcotics reduction, quality and safety in gynecologic oncology surgery in the first year of enhanced recovery after surgery protocol implementation","volume":"149","author":"Bergstrom","year":"2018","journal-title":"Gynecol. Oncol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/AOG.0000000000002735","article-title":"Effect of an Enhanced Recovery after Surgery Program on Opioid Use and Patient-Reported Outcomes","volume":"132","author":"Meyer","year":"2018","journal-title":"Obstet. Gynecol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/aogs.14009","article-title":"Thirty-day outcomes after gynecologic oncology surgery: A single-center experience of enhanced recovery after surgery pathways","volume":"100","author":"Bernard","year":"2020","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"331","DOI":"10.5455\/medarh.2019.73.331-337","article-title":"Evaluation of Enhanced Recovery after Following a Surgical Protocol for Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Carcinomatosis","volume":"73","author":"Duzgun","year":"2019","journal-title":"Med. Arch."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1016\/j.amjsurg.2020.08.041","article-title":"Enhanced recovery after surgery is safe for cytoreductive surgery with hyperthermic intraperitoneal chemotherapy","volume":"220","author":"Martin","year":"2020","journal-title":"Am. J. Surg."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ygyno.2020.12.035","article-title":"Outcomes of enhanced recovery after surgery (ERAS) in gynecologic oncology\u2014A systematic review and meta-analysis","volume":"161","author":"Bisch","year":"2020","journal-title":"Gynecol. Oncol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1016\/j.ejso.2020.07.041","article-title":"Guidelines for Perioperative Care in Cytoreductive Surgery (CRS) with or without hyperthermic IntraPEritoneal chemotherapy (HIPEC): Enhanced recovery after surgery (ERAS\u00ae) Society Recommendations\u2014Part I: Preoperative and intraoperative management","volume":"46","author":"Kusamura","year":"2020","journal-title":"Eur. J. Surg. Oncol. (EJSO)"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1016\/j.ejso.2020.08.006","article-title":"Guidelines for Perioperative Care in Cytoreductive Surgery (CRS) with or without hyperthermic IntraPEritoneal chemotherapy (HIPEC): Enhanced Recovery After Surgery (ERAS\u00ae) Society Recommendations\u2014Part II: Postoperative management and special considerations","volume":"46","author":"Kusamura","year":"2020","journal-title":"Eur. J. Surg. Oncol. (EJSO)"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Mao, F., and Huang, Z. (2021). Enhanced Recovery After Surgery for Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: A Systematic Review and Meta-Analysis. Front. Surg., 8.","DOI":"10.3389\/fsurg.2021.713171"},{"key":"ref_47","first-page":"226","article-title":"Enhanced Recovery after Bariatric Surgery: Systematic Review and Meta-Analysis","volume":"27","author":"Piotr","year":"2016","journal-title":"Obes. Surg."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1097\/DCR.0b013e3182812842","article-title":"Enhanced Recovery After Surgery Programs Versus Traditional Care for Colorectal Surgery","volume":"56","author":"Zhuang","year":"2013","journal-title":"Dis. Colon Rectum"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/bjs.5468","article-title":"A protocol is not enough to implement an enhanced recovery programme for colorectal resection","volume":"94","author":"Maessen","year":"2007","journal-title":"Br. J. Surg."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1002\/bjs.5454","article-title":"Randomized clinical trial assessing the effect of Doppler-optimized fluid management on outcome after elective colorectal resection","volume":"93","author":"Noblett","year":"2006","journal-title":"Br. J. Surg."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1093\/bja\/aei223","article-title":"Intraoperative oesophageal Doppler guided fluid management shortens postoperative hospital stay after major bowel surgery","volume":"95","author":"Wakeling","year":"2005","journal-title":"Br. J. Anaesth."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1046\/j.1365-2044.2002.02708.x","article-title":"Randomised controlled trial investigating the influence of intravenous fluid titration using oesophageal Doppler monitoring during bowel surgery*","volume":"57","author":"Conway","year":"2002","journal-title":"Anaesthesia"},{"key":"ref_53","first-page":"695","article-title":"Fluid administration in cytoreductive surgery with hyperthermic intraperitoneal chemotherapy: Neither too much nor too little","volume":"72","author":"Garijo","year":"2021","journal-title":"Braz. J. Anesthesiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1245\/s10434-018-07092-y","article-title":"Restrictive Intraoperative Fluid Therapy is Associated with Decreased Morbidity and Length of Stay Following Hyperthermic Intraperitoneal Chemoperfusion","volume":"26","author":"Hendrix","year":"2018","journal-title":"Ann. Surg. Oncol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1017\/S0029665110001734","article-title":"A meta-analysis of randomised controlled trials of intravenous fluid therapy in major elective open abdominal surgery: Getting the balance right","volume":"69","author":"Varadhan","year":"2010","journal-title":"Proc. Nutr. Soc."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1111\/aogs.12423","article-title":"Implementing a structured Enhanced Recovery After Surgery (ERAS) protocol reduces length of stay after abdominal hysterectomy","volume":"93","author":"Wijk","year":"2014","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1007\/s00268-017-4054-z","article-title":"Enhanced Recovery After Surgery: Can We Rely on the Key Factors or Do We Need the Bel Ensemble?","volume":"41","author":"Jurt","year":"2017","journal-title":"World J. Surg."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1111\/codi.12200","article-title":"Adherence to Enhanced Recovery after Surgery and length of stay after colonic resection","volume":"15","author":"Cakir","year":"2013","journal-title":"Color. Dis."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1001\/archsurg.2010.309","article-title":"Adherence to the Enhanced Recovery after Surgery Protocol and Outcomes after Colorectal Cancer Surgery","volume":"146","author":"Gustafsson","year":"2011","journal-title":"Arch. Surg."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"O148","DOI":"10.1111\/codi.13002","article-title":"Factors predicting 30-day readmission after laparoscopic colorectal cancer surgery within an enhanced recovery programme","volume":"17","author":"Francis","year":"2015","journal-title":"Color. 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