{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:35:46Z","timestamp":1787027746771,"version":"build-2736575974"},"reference-count":153,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T00:00:00Z","timestamp":1675123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Kaposi\u2019s sarcoma (KS) is a common neoplasm in Eastern and central Africa reflecting the spread of human gammaherpesvirus-8 (HHV-8), now considered a necessary causal agent for the development of KS. The endemic KS subtype can follow an aggressive clinical course with ulcerative skin lesions with soft tissue invasion or even bone or visceral involvement. In the latter cases, a thorough imaging work-up and better follow-up schedules are warranted. As KS is a chronic disease, the therapeutic goal is to obtain sustainable remission in cutaneous and visceral lesions and a good quality of life. Watchful monitoring may be sufficient in localized cutaneous forms. Potential therapeutic modalities for symptomatic advanced KS include systemic chemotherapies, immunomodulators, immune checkpoint inhibitors, and antiangiogenic drugs.<\/jats:p>","DOI":"10.3390\/cancers15030872","type":"journal-article","created":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T02:27:56Z","timestamp":1675132076000},"page":"872","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Endemic Kaposi\u2019s Sarcoma"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9477-7392","authenticated-orcid":false,"given":"Perla El","family":"Zeinaty","sequence":"first","affiliation":[{"name":"Department of Dermato-Oncology, AP-HP H\u00f4pital Saint-Louis, F-75010 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9leste","family":"Lebb\u00e9","sequence":"additional","affiliation":[{"name":"Department of Dermato-Oncology, AP-HP H\u00f4pital Saint-Louis, F-75010 Paris, France"},{"name":"INSERM U976, Universit\u00e9 Paris Cit\u00e9, F-75010 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4557-3377","authenticated-orcid":false,"given":"Julie","family":"Delyon","sequence":"additional","affiliation":[{"name":"Department of Dermato-Oncology, AP-HP H\u00f4pital Saint-Louis, F-75010 Paris, France"},{"name":"INSERM U976, Universit\u00e9 Paris Cit\u00e9, F-75010 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1056\/NEJM199505043321801","article-title":"Detection of herpesvirus-like DNA sequences in Kaposi\u2019s sarcoma in patients with and those without HIV infection","volume":"332","author":"Moore","year":"1995","journal-title":"N. 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