{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T03:46:16Z","timestamp":1780371976027,"version":"3.54.1"},"reference-count":45,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T00:00:00Z","timestamp":1675123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Objective: Hypoparathyroidism is a known complication of total laryngectomy, although parathyroid preservation and\/or reimplantation are not routine. Autofluorescence is a new technique for identifying parathyroid glands intraoperatively. The aim of this study was to evaluate the feasibility of autofluorescence in this context. Materials and Methods: A retrospective study of patients undergoing total laryngectomy\/pharyngectomy with concomitant thyroidectomy using the Fluobeam\u00ae (Fluoptics, Grenoble, France) and frozen section of a parathyroid fragment in case of reimplantation. The rates of identification using autofluorescence, reimplantation, and hypoparathyroidism were evaluated. Results: Eighteen patients (16 males, median age 67) underwent total laryngectomy\/pharyngectomy with total thyroidectomy (n = 12) or hemithyroidectomy (n = 6). A median of 2 parathyroid glands were identified per patient. Ninety-two percent were identified by autofluorescence before visualisation. All parathyroids were reimplanted due to devascularization. Temporary hypoparathyroidism occurred in nine patients, and was permanent in one patient. After 34 months of median follow-up (range 1\u201349), no tumor recurrence was observed in the reimplantation sites. Conclusions: To our knowledge, this is the largest study to evaluate autofluorescence during total laryngectomy with thyroidectomy. No tumor recurrence occurred in the sites of parathyroid reimplantation.<\/jats:p>","DOI":"10.3390\/cancers15030875","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T05:33:53Z","timestamp":1675229633000},"page":"875","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Intraoperative Autofluorescence Imaging for Parathyroid Gland Identification during Total Laryngectomy with Thyroidectomy"],"prefix":"10.3390","volume":"15","author":[{"given":"Ra\u00efs","family":"Obongo Anga","sequence":"first","affiliation":[{"name":"Department of Head and Neck Oncology, Gustave Roussy Cancer Campus, 94805 Villejuif, France"},{"name":"Department of Head and Neck Cancer and ENT Surgery, Henri Becquerel Cancer Center, 76038 Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8408-8868","authenticated-orcid":false,"given":"Muriel","family":"Abbaci","sequence":"additional","affiliation":[{"name":"Plateforme d\u2019Imagerie et de Cytom\u00e9trie, UMS AMMICa, Gustave-Roussy Cancer Campus\u2014Grand Paris, Universit\u00e9 Paris-Saclay, 94805 Villejuif, France; Laboratoire d\u2019Imagerie Biom\u00e9dicale Multimodale Paris Saclay, Universit\u00e9 Paris-Saclay, CEA, CNRS, Inserm, 91401 Orsay, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Guerlain","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology, Gustave Roussy Cancer Campus, 94805 Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Breuskin","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology, Gustave Roussy Cancer Campus, 94805 Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odile","family":"Casiraghi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Gustave Roussy Cancer Campus, 94805 Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9437-0744","authenticated-orcid":false,"given":"Alix","family":"Marhic","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology, Gustave Roussy Cancer Campus, 94805 Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Benmoussa-Rebibo","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology, Gustave Roussy Cancer Campus, 94805 Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9lo\u00efse","family":"de Kermadec","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology, Gustave Roussy Cancer Campus, 94805 Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1260-1762","authenticated-orcid":false,"given":"Antoine","family":"Moya-Plana","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology, Gustave Roussy Cancer Campus, 94805 Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Temam","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology, Gustave Roussy Cancer Campus, 94805 Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7604-4964","authenticated-orcid":false,"given":"Philippe","family":"Gorphe","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology, Gustave Roussy Cancer Campus, 94805 Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1161-5628","authenticated-orcid":false,"given":"Dana M.","family":"Hartl","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology, Gustave Roussy Cancer Campus, 94805 Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e1202","DOI":"10.1097\/SLA.0000000000003800","article-title":"Risk of Permanent Hypoparathyroidism After Total Thyroidectomy for Benign Disease: A Nationwide Population-based Cohort Study From Sweden","volume":"274","author":"Anneback","year":"2021","journal-title":"Ann. 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