{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:52:42Z","timestamp":1760147562793,"version":"build-2065373602"},"reference-count":61,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T00:00:00Z","timestamp":1676246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>A recent study reported that the occurrence of depapillated mucosa surrounding oral tongue squamous cell carcinomas (OTSCC) is associated with perineural invasion (PNI). The present study evaluates the reliability of depapillation as a PNI predictor and how it could affect narrow-band imaging (NBI) performance. This is thus a retrospective study on patients affected by OTSCC submitted to radical surgery. The preoperative endoscopy was evaluated to identify the presence of depapillation. Differences in distribution between depapillation and clinicopathological variables were analyzed. NBI vascular patterns were reported, and the impact of depapillation on those was studied. We enrolled seventy-six patients. After evaluation of the preoperative endoscopies, 40 (53%) patients had peritumoral depapillation, while 59 (78%) had a positive NBI pattern. Depapillation was strongly correlated to PNI, 54% vs. 28% (p = 0.022). Regarding the NBI pattern, there was no particular association with depapillation-associated tumors. The presence of depapillation did not affect the intralesional pattern detected by the NBI, while no NBI-positive pattern was found in the depapillation area. Finally, the NBI-guided resection margins were not affected by depapillation. Peritumoral depapillation is a reliable feature for PNI in OTSCC. NBI margin detection is not impaired by depapillation.<\/jats:p>","DOI":"10.3390\/cancers15041196","type":"journal-article","created":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T01:41:06Z","timestamp":1676338866000},"page":"1196","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Role of Peritumoral Depapillation and Its Impact on Narrow-Band Imaging in Oral Tongue Squamous Cell Carcinoma"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1187-3045","authenticated-orcid":false,"given":"Andrea","family":"Iandelli","sequence":"first","affiliation":[{"name":"IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7699-2291","authenticated-orcid":false,"given":"Claudio","family":"Sampieri","sequence":"additional","affiliation":[{"name":"IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy"},{"name":"Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genova, 16126 Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7997-964X","authenticated-orcid":false,"given":"Filippo","family":"Marchi","sequence":"additional","affiliation":[{"name":"IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy"},{"name":"Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genova, 16126 Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9946-0650","authenticated-orcid":false,"given":"Alessia","family":"Pennacchi","sequence":"additional","affiliation":[{"name":"IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy"},{"name":"Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genova, 16126 Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea Luigi Camillo","family":"Carobbio","sequence":"additional","affiliation":[{"name":"Section of Otorhinolaryngology\u2014Head and Neck Surgery, Department of Neurosciences, University of Padua\u2014\u201cAzienda Ospedaliera di Padova\u201d, 35128 Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Lovino Camerino","sequence":"additional","affiliation":[{"name":"IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy"},{"name":"Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genova, 16126 Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6000-3006","authenticated-orcid":false,"given":"Marta","family":"Filauro","sequence":"additional","affiliation":[{"name":"IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giampiero","family":"Parrinello","sequence":"additional","affiliation":[{"name":"IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Peretti","sequence":"additional","affiliation":[{"name":"IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy"},{"name":"Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genova, 16126 Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1002\/cncr.32802","article-title":"Annual report to the nation on the status of cancer, part I: National cancer statistics","volume":"126","author":"Henley","year":"2020","journal-title":"Cancer"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s00428-021-03063-z","article-title":"The prognostic role of histologic grade, worst pattern of invasion, and tumor budding in early oral tongue squamous cell carcinoma: A comparative study","volume":"479","author":"Xu","year":"2021","journal-title":"Virchows Arch."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/lary.29674","article-title":"The Prognostic Value of Lymph Node Burden in Oral Cavity Cancer: Systematic Review and Meta-Analysis","volume":"132","author":"Tsai","year":"2022","journal-title":"Laryngoscope"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.oraloncology.2019.02.001","article-title":"Survival outcomes after treatment of cancer of the oral cavity (1985\u20132015)","volume":"90","author":"Zanoni","year":"2019","journal-title":"Oral Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1177\/0194599812439664","article-title":"Isolated skip nodal metastasis is rare in T1 and T2 oral tongue squamous cell carcinoma","volume":"147","author":"Balasubramanian","year":"2012","journal-title":"Otolaryngol. \u2013Head Neck Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.mayocp.2015.12.017","article-title":"Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment","volume":"91","author":"Marur","year":"2016","journal-title":"Mayo Clin. Proc."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1002\/hed.23994","article-title":"Oral squamous cell carcinoma of the tongue: Prospective and objective speech evaluation of patients undergoing surgical therapy","volume":"38","author":"Riemann","year":"2016","journal-title":"Head Neck"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.oraloncology.2008.05.008","article-title":"Survival following primary surgery for oral cancer","volume":"45","author":"Rogers","year":"2009","journal-title":"Oral Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Brierley, J., Gospodarowicz, M., and Wittekind, C. (2016). TNM Classification of Malignant Tumours, Union for International Cancer Control. [8th ed.].","DOI":"10.1002\/9780471420194.tnmc26.pub3"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Iandelli, A., Marchi, F., Chen, A.-C., Young, C.-K., Liao, C.-T., Tsao, C.-K., Kang, C.-J., Wang, H.-M., Chang, T.-C.J., and Huang, S.-F. (2022). Adequacy of Disease Control by Supraomohyoid Neck Dissection in cT1\/T2 Tongue Cancer. J. Pers. Med., 12.","DOI":"10.3390\/jpm12091535"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"17","DOI":"10.14639\/0392-100X-N1653","article-title":"Prognostic impact of perineural invasion in oral cancer: A systematic review","volume":"42","author":"Quintana","year":"2022","journal-title":"Acta Otorhinolaryngol. Ital."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1055\/s-0036-1571837","article-title":"Pathology of Perineural Spread","volume":"77","author":"Brown","year":"2016","journal-title":"J. Neurol.Surg. Part B Skull Base"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1002\/hed.21846","article-title":"Risks and clinical implications of perineural invasion in T1-2 oral tongue squamous cell carcinoma","volume":"34","author":"Tai","year":"2012","journal-title":"Head Neck"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"619","DOI":"10.2174\/1874210601610010619","article-title":"Diagnosis of Lingual Atrophic Conditions: Associations with Local and Systemic Factors. A Descriptive Review","volume":"10","author":"Erriu","year":"2016","journal-title":"Open Dent. J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.tripleo.2003.10.014","article-title":"Prognostic significance of perineural invasion in oral and oropharyngeal carcinoma","volume":"97","author":"Rahima","year":"2004","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endodontology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1002\/hed.25170","article-title":"Perineural invasion: Independent prognostic factor in oral cancer that warrants adjuvant treatment","volume":"40","author":"Nair","year":"2018","journal-title":"Head Neck"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.oooo.2019.12.016","article-title":"The impact of peritumoral depapillation in cancers of the tongue","volume":"129","author":"Singh","year":"2020","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.ijom.2010.01.007","article-title":"Detecting early oral cancer: Narrowband imaging system observation of the oral mucosa microvasculature","volume":"39","author":"Takano","year":"2010","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/odi.12430","article-title":"Narrow band imaging: Clinical applications in oral and oropharyngeal cancer","volume":"22","author":"Vu","year":"2016","journal-title":"Oral Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.oraloncology.2010.01.020","article-title":"Narrow band imaging and high definition television in evaluation of oral and oropharyngeal squamous cell cancer: A prospective study","volume":"46","author":"Piazza","year":"2010","journal-title":"Oral Oncol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1002\/hed.23989","article-title":"Improved surgical margin definition by narrow band imaging for resection of oral squamous cell carcinoma: A prospective gene expression profiling study","volume":"38","author":"Farah","year":"2016","journal-title":"Head Neck"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.oraloncology.2015.07.005","article-title":"Narrow band imaging in the intra-operative defini-tion of resection margins in oral cavity and oropharyngeal cancer","volume":"51","author":"Tirelli","year":"2015","journal-title":"Oral Oncol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1002\/hed.21964","article-title":"Value of narrow band imaging endoscopy in early mucosal head and neck cancer","volume":"34","author":"Lin","year":"2012","journal-title":"Head Neck"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1007\/s00405-016-3925-5","article-title":"The diagnostic value of narrow band imaging in different oral and oropharyngeal subsites","volume":"273","author":"Piazza","year":"2016","journal-title":"Eur. Arch. Oto-Rhino-Laryngol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1590\/abd1806-4841.20164288","article-title":"Geographic tongue and psoriasis: Clinical, histopathological, immunohistochemical and genetic correlation\u2014A literature review","volume":"91","author":"Picciani","year":"2016","journal-title":"An. Bras. Dermatol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1097\/MOO.0b013e328344b3ed","article-title":"\u201cBiologic endoscopy\u201d: Optimization of upper aerodigestive tract cancer evaluation","volume":"19","author":"Piazza","year":"2011","journal-title":"Curr. Opin. Otolaryngol. Head Neck Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.otohns.2007.12.034","article-title":"The value of narrow band imaging endoscope for early head and neck cancers","volume":"138","author":"Watanabe","year":"2018","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/S1542-3565(05)00262-4","article-title":"Narrow band imaging: A new diagnostic approach to visualize angiogenesis in superficial neoplasia","volume":"3","author":"Muto","year":"2005","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/j.1365-2559.2010.03512.x","article-title":"Microvascular irregularities are associated with composition of squamous epithelial lesions and correlate with subepithelial invasion of superficial-type pharyngeal squamous cell carcinoma","volume":"56","author":"Fuji","year":"2010","journal-title":"Histopathology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"E112","DOI":"10.1177\/0145561319848669","article-title":"Tumor Budding and Worse Pattern of Invasion Can Predict Nodal Metastasis in Oral Cancers and Associated with Poor Survival in Early-Stage Tumors","volume":"98","author":"Chatterjee","year":"2019","journal-title":"Ear Nose Throat J."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s00428-020-03008-y","article-title":"Biopsy pattern of invasion type to determine the surgical approach in early-stage oral squamous cell carcinoma","volume":"479","author":"Pu","year":"2021","journal-title":"Virchows Arch."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3322\/caac.21388","article-title":"The Eighth Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population-based to a more \u201cpersonalized\u201d approach to cancer staging","volume":"67","author":"Amin","year":"2017","journal-title":"CA Cancer J. Clin."},{"key":"ref_33","unstructured":"(2022, November 07). International Agency for Research on Cancer. Available online: https:\/\/screening.iarc.fr\/atlasoralglossdef.php?key=depapillation&img."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1002\/hed.25163","article-title":"Role of adverse pathological features in surgically treated early oral cavity carcinomas with adequate margins and the development of a scoring system to predict local control","volume":"40","author":"Subramaniam","year":"2018","journal-title":"Head Neck"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1002\/hed.26554","article-title":"Predictive nomograms for oral tongue squamous cell carcinoma applying the American Joint Committee on Cancer\/Union Internationale Contre le Cancer 8th edition staging system","volume":"43","author":"Balasubramanian","year":"2021","journal-title":"Head Neck"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/cncr.23142","article-title":"Salvage therapy in relapsed squamous cell carcinoma of the oral cavity: How and when?","volume":"112","author":"Liao","year":"2008","journal-title":"Cancer"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"106210","DOI":"10.1016\/j.oraloncology.2022.106210","article-title":"Oncological outcomes of compartmental surgery and wide local excision in oral tongue and floor of the mouth cancer","volume":"135","author":"Missale","year":"2022","journal-title":"Oral Oncol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.3389\/fonc.2019.01571","article-title":"Magnetic Resonance vs. Intraoral Ultrasonography in the Preoperative Assessment of Oral Squamous Cell Carcinoma : A Systematic Review and Meta-Analysis","volume":"9","author":"Marchi","year":"2020","journal-title":"Front. Oncol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Caprioli, S., Casaleggio, A., Tagliafico, A.S., Conforti, C., Borda, F., Fiannacca, M., Filauro, M., Iandelli, A., Marchi, F., and Parrinello, G. (2022). High-Frequency Intraoral Ultrasound for Preoperative Assessment of Depth of Invasion for Early Tongue Squamous Cell Carcinoma : Radiological\u2013Pathological Correlations. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph192214900"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1007\/s00405-020-06421-w","article-title":"Intraoral ultrasonography in the assessment of DOI in oral cavity squamous cell carcinoma: A comparison with magnetic resonance and histopathology","volume":"278","author":"Filauro","year":"2020","journal-title":"Eur. Arch. Oto-Rhino-Laryngol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1002\/hed.25633","article-title":"Depth of invasion alone as an indication for postoperative radiotherapy in small oral squamous cell carcinomas: An International Collaborative Study","volume":"41","author":"Ebrahimi","year":"2019","journal-title":"Head Neck"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1002\/lary.28241","article-title":"Beyond Depth of Invasion: Adverse Pathologic Tumor Features in Early Oral Tongue Squamous Cell Carcinoma","volume":"130","author":"Larson","year":"2020","journal-title":"Laryngoscope"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1016\/j.ejso.2019.05.018","article-title":"Predictors of locoregional control in stage I\/II oral squamous cell carcinoma classi fi ed by AJCC 8th edition","volume":"45","author":"Subramaniam","year":"2019","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1002\/hed.24724","article-title":"Correlating the depth of invasion at specific anatomic locations with the risk for regional metastatic disease to lymph nodes in the neck for oral squamous cell carcinoma Hans","volume":"39","author":"Brockhoff","year":"2017","journal-title":"Head Neck"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1002\/lary.27490","article-title":"Does anatomic subsite influence oral cavity cancer mortality? A SEER database analysis","volume":"129","author":"Farhood","year":"2019","journal-title":"Laryngoscope"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Calabrese, L., Bizzoca, M.E., Grigolato, R., Maffini, F.A., Tagliabue, M., Negro, R., Leuci, S., Mignogna, M.D., and Muzio, L.L. (2020). From bench to bedside in tongue muscle cancer invasion and back again: Gross anatomy, microanatomy, surgical treatments and basic research. Life, 10.","DOI":"10.3390\/life10090197"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.anl.2020.05.023","article-title":"Letter to \u201cMedial lingual lymph node metastasis in carcinoma of the tongue\u201d","volume":"47","author":"Deganello","year":"2020","journal-title":"Auris Nasus Larynx"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"337","DOI":"10.5306\/wjco.v11.i6.337","article-title":"Lingual lymph nodes: Anatomy, clinical considerations, and oncological significance","volume":"11","author":"Gvetadze","year":"2020","journal-title":"World J. Clin. Oncol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.joms.2018.07.023","article-title":"Increased Presence of Perineural Invasion in the Tongue and Floor of the Mouth: Could It Represent a More Aggressive Oral Squamous Cell Carcinoma, or Do Larger Aggressive Tumors Cause Perineural Invasion?","volume":"77","author":"Kim","year":"2019","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"7451","DOI":"10.1038\/s41598-017-08022-w","article-title":"Pathological features and their prognostic impacts on oral cavity cancer patients among different subsites\u2014A singe institute\u2019s experience in Taiwan","volume":"7","author":"Liu","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1097\/PAS.0b013e318285f684","article-title":"Perineural invasion in T1 oral squamous cell carcinoma indicates the need for aggressive elective neck dissection","volume":"37","author":"Tai","year":"2013","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.ijrobp.2018.12.009","article-title":"Perineural Invasion and Perineural Tumor Spread in Head and Neck Cancer","volume":"103","author":"Bakst","year":"2019","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s12105-012-0412-1","article-title":"Validation of the Risk Model: High-Risk Classification and Tumor Pattern of Invasion Predict Outcome for Patients with Low-Stage Oral Cavity Squamous Cell Carcinoma","volume":"7","author":"Li","year":"2013","journal-title":"Head Neck Pathol."},{"key":"ref_54","unstructured":"National Comprehensive Cancer Network (2019). NCCN Guidelines Version 3, National Comprehensive Cancer Network."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.1007\/s00405-020-06578-4","article-title":"Narrow band imaging observed oral mucosa microvasculature as a tool to detect early oral cancer: An Indian experience","volume":"278","author":"Nair","year":"2021","journal-title":"Eur. Arch. Oto-Rhino-Laryngol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"E1156","DOI":"10.1002\/lary.29035","article-title":"Diagnostic Accuracy of Narrow Band Imaging in Patients with Oral Lichen Planus: A Prospective Study","volume":"131","author":"Deganello","year":"2021","journal-title":"Laryngoscope"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Guida, A., Maglione, M., Crispo, A., Perri, F., Villano, S., Pavone, E., Aversa, C., Longo, F., Feroce, F., and Botti, G. (2019). Oral lichen planus and other confounding factors in narrow band imaging (NBI) during routine inspection of oral cavity for early detection of oral squamous cell carcinoma: A retrospective pilot study. BMC Oral Health, 19.","DOI":"10.1186\/s12903-019-0762-0"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"900451","DOI":"10.3389\/fonc.2022.900451","article-title":"Videomics of the Upper Aero-Digestive Tract Cancer: Deep Learning Applied to White Light and Narrow Band Imaging for Automatic Segmentation of Endoscopic Images","volume":"12","author":"Azam","year":"2022","journal-title":"Front. Oncol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1002\/ijc.33352","article-title":"Epithelial-to-mesenchymal transition in oral squamous cell carcinoma: Challenges and opportunities","volume":"148","author":"Ling","year":"2021","journal-title":"Int. J. Cancer"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.jcms.2018.03.019","article-title":"The value of histological grading of biopsy and resection specimens in early stage oral squamous cell carcinomas","volume":"46","author":"Dik","year":"2018","journal-title":"J. Cranio-Maxillofac. Surg."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1309\/AJCPFIVHHH7Q3BLX","article-title":"Poor correlation of histologic parameters between biopsy and resection specimen in early stage oral squamous cell carcinoma","volume":"144","author":"Dik","year":"2015","journal-title":"Am. J. Clin. Pathol."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/15\/4\/1196\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:34:12Z","timestamp":1760121252000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/15\/4\/1196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,13]]},"references-count":61,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["cancers15041196"],"URL":"https:\/\/doi.org\/10.3390\/cancers15041196","relation":{},"ISSN":["2072-6694"],"issn-type":[{"type":"electronic","value":"2072-6694"}],"subject":[],"published":{"date-parts":[[2023,2,13]]}}}