{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T23:56:28Z","timestamp":1784764588200,"version":"3.55.0"},"reference-count":46,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T00:00:00Z","timestamp":1676419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Aim: To evaluate the evolution of addictions (tobacco and alcohol) and social precarity in head and neck squamous cell carcinoma survivors when these factors are addressed from the time of diagnosis. Methods: Addictions and social precarity in patients with a new diagnosis of HNSCC were assessed through the EPICES score, the Fagerstr\u00f6m score, and the CAGE questionnaire. When identified as precarious\/dependent, patients were referred to relevant addiction\/social services. Results: One hundred and eighty-two patients were included. At the time of diagnosis, an active tobacco consumption was associated with alcohol drinking (Fisher\u2019s exact test, p &lt; 0.001). Active smokers were more socially deprived (mean EPICES score = mES = 36.2 [\u00b122.1]) than former smokers (mES = 22.8 [\u00b117.8]) and never smokers (mES = 18.9 [\u00b114.5]; Kruskal-Wallis, p &lt; 0.001). The EPICES score was correlated to the Fagerstr\u00f6m score (Kruskal-Wallis, p &lt; 0.001). Active drinkers (mES = 34.1 [\u00b121.9]) and former drinkers (mES = 32.7 [\u00b121]) were more likely to be socially deprived than those who never drank (mES = 20.8 [\u00b117.1]; Krukal-Wallis, p &lt; 0.001). A Fagerstr\u00f6m score improvement at one year was associated to a CAGE score improvement (Fisher\u2019s exact test, p &lt; 0.001). Tobacco and alcohol consumption were more than halved one year after treatment. Patients who continued to smoke one year after diagnosis were significantly more likely to continue to drink (Fisher\u2019s exact test, p &lt; 0.001) and had a significantly higher initial EPICES score (Kruskal-Wallis, p &lt; 0.001). Conclusions: At one year, addictions and social deprivation tend to improve when taken care of from the diagnosis. The most dependent patients and those with multiple frailties are at highest risk of cessation failure.<\/jats:p>","DOI":"10.3390\/cancers15041231","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T03:37:24Z","timestamp":1676432244000},"page":"1231","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Addictions, Social Deprivation and Cessation Failure in Head and Neck Squamous Cell Carcinoma Survivors"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4090-7286","authenticated-orcid":false,"given":"Lara","family":"Nokovitch","sequence":"first","affiliation":[{"name":"Surgical Oncology Department, Centre L\u00e9on B\u00e9rard, UNICANCER, 69008 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonjae","family":"Kim","sequence":"additional","affiliation":[{"name":"Surgical Oncology Department, Centre L\u00e9on B\u00e9rard, UNICANCER, 69008 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Zrounba","sequence":"additional","affiliation":[{"name":"Surgical Oncology Department, Centre L\u00e9on B\u00e9rard, UNICANCER, 69008 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Eric","family":"Roux","sequence":"additional","affiliation":[{"name":"Surgical Oncology Department, Centre L\u00e9on B\u00e9rard, UNICANCER, 69008 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Poupart","sequence":"additional","affiliation":[{"name":"Surgical Oncology Department, Centre L\u00e9on B\u00e9rard, UNICANCER, 69008 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabiha","family":"Giagnorio","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Centre L\u00e9on B\u00e9rard, UNICANCER, 69008 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Triviaux","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Centre L\u00e9on B\u00e9rard, UNICANCER, 69008 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Maquet","sequence":"additional","affiliation":[{"name":"ENT Department, CHU de Rouen, 76000 Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0204-1426","authenticated-orcid":false,"given":"Jennifer","family":"Thollin","sequence":"additional","affiliation":[{"name":"Surgical Oncology Department, Centre L\u00e9on B\u00e9rard, UNICANCER, 69008 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Arantes","sequence":"additional","affiliation":[{"name":"Surgical Oncology Department, Centre L\u00e9on B\u00e9rard, UNICANCER, 69008 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Thomas","sequence":"additional","affiliation":[{"name":"Surgical Oncology Department, Centre L\u00e9on B\u00e9rard, UNICANCER, 69008 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3498-6499","authenticated-orcid":false,"given":"B\u00e9atrice","family":"Fervers","sequence":"additional","affiliation":[{"name":"Prevention Cancer Environment Department, Centre L\u00e9on B\u00e9rard, 28 Rue La\u00ebnnec, 69008 Lyon, France"},{"name":"Inserm, U1296 Unit, \u201cRadiation: Defense, Health and Environment\u201d, Centre L\u00e9on B\u00e9rard, 28 Rue La\u00ebnnec, 69008 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Deneuve","sequence":"additional","affiliation":[{"name":"Surgical Oncology Department, Centre L\u00e9on B\u00e9rard, UNICANCER, 69008 Lyon, France"},{"name":"Inserm, U1296 Unit, \u201cRadiation: Defense, Health and Environment\u201d, Centre L\u00e9on B\u00e9rard, 28 Rue La\u00ebnnec, 69008 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.coms.2018.06.001","article-title":"Epidemiology and Demographics of the Head and Neck Cancer Population","volume":"30","author":"Cohen","year":"2018","journal-title":"Oral Maxillofac. 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