{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T04:56:25Z","timestamp":1775019385133,"version":"3.50.1"},"reference-count":36,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T00:00:00Z","timestamp":1677456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fundaci\u00f3n Madrile\u00f1a de Hematolog\u00eda y Hemoterapia and Fundaci\u00f3n Leucemia y Linfoma"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Mortality rates for COVID-19 have declined over time in the general population, but data in patients with hematologic malignancies are contradictory. We identified independent prognostic factors for COVID-19 severity and survival in unvaccinated patients with hematologic malignancies, compared mortality rates over time and versus non-cancer inpatients, and investigated post COVID-19 condition. Data were analyzed from 1166 consecutive, eligible patients with hematologic malignancies from the population-based HEMATO-MADRID registry, Spain, with COVID-19 prior to vaccination roll-out, stratified into early (February\u2013June 2020; n = 769 (66%)) and later (July 2020\u2013February 2021; n = 397 (34%)) cohorts. Propensity-score matched non-cancer patients were identified from the SEMI-COVID registry. A lower proportion of patients were hospitalized in the later waves (54.2%) compared to the earlier (88.6%), OR 0.15, 95%CI 0.11\u20130.20. The proportion of hospitalized patients admitted to the ICU was higher in the later cohort (103\/215, 47.9%) compared with the early cohort (170\/681, 25.0%, 2.77; 2.01\u20133.82). The reduced 30-day mortality between early and later cohorts of non-cancer inpatients (29.6% vs. 12.6%, OR 0.34; 0.22\u20130.53) was not paralleled in inpatients with hematologic malignancies (32.3% vs. 34.8%, OR 1.12; 0.81\u20131.5). Among evaluable patients, 27.3% had post COVID-19 condition. These findings will help inform evidence-based preventive and therapeutic strategies for patients with hematologic malignancies and COVID-19 diagnosis.<\/jats:p>","DOI":"10.3390\/cancers15051497","type":"journal-article","created":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T06:09:52Z","timestamp":1677564592000},"page":"1497","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["COVID-19 Severity and Survival over Time in Patients with Hematologic Malignancies: A Population-Based Registry Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7908-0063","authenticated-orcid":false,"given":"Joaqu\u00edn","family":"Mart\u00ednez-L\u00f3pez","sequence":"first","affiliation":[{"name":"Hematology Department, Hospital Universitario 12 de Octubre, imas12, Universidad Complutense, CNIO-ISCIII, CIBERONC, 28041 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"De la Cruz","sequence":"additional","affiliation":[{"name":"Research Institute, Hospital Universitario 12 de Octubre, imas12, 28041 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Gil-Manso","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario 12 de Octubre, imas12, Universidad Complutense, CNIO-ISCIII, CIBERONC, 28041 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2423-822X","authenticated-orcid":false,"given":"Adri\u00e1n","family":"Alegre","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario de La Princesa, IIS-HUP, 28006 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4945-9114","authenticated-orcid":false,"given":"Javier","family":"Ortiz","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario de La Princesa, IIS-HUP, 28006 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar","family":"Llamas","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Health Research Institute IIS-FJD, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1692-2248","authenticated-orcid":false,"given":"Yolanda","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Health Research Institute IIS-FJD, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4550-757X","authenticated-orcid":false,"given":"Jos\u00e9-\u00c1ngel","family":"Hern\u00e1ndez-Rivas","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario Infanta Leonor, 28031 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6329-1704","authenticated-orcid":false,"given":"Isabel","family":"Gonz\u00e1lez-Gasc\u00f3n","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario Infanta Leonor, 28031 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celina","family":"Benavente","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Cl\u00ednico San Carlos, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Estival Monteliu","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Cl\u00ednico San Carlos, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3937-3499","authenticated-orcid":false,"given":"V\u00edctor","family":"Jim\u00e9nez-Yuste","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario La Paz, 28046 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6550-2621","authenticated-orcid":false,"given":"Miguel","family":"Canales","sequence":"additional","affiliation":[{"name":"Hematology Department, Cl\u00ednica Universidad de Navarra, 28027 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9431-4646","authenticated-orcid":false,"given":"Mariana","family":"Bastos","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, 28007 Madrid, Spain"},{"name":"Department of Medicine, Universidad Complutense, 28223 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3855-7774","authenticated-orcid":false,"given":"Mi","family":"Kwon","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, 28007 Madrid, Spain"},{"name":"Department of Medicine, Universidad Complutense, 28223 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Valenciano","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario HM Sanchinarro, 28050 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Callejas-Charavia","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario Pr\u00edncipe de Asturias, Universidad de Alcal\u00e1, Alcal\u00e1 de Henares, 28805 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2969-3002","authenticated-orcid":false,"given":"Javier","family":"L\u00f3pez-Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario Ram\u00f3n y Cajal, 28034 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4118-7110","authenticated-orcid":false,"given":"Pilar","family":"Herrera","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario Ram\u00f3n y Cajal, 28034 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Duarte","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario Puerta de Hierro Majadahonda, 28222 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc\u00eda","family":"N\u00fa\u00f1ez Mart\u00edn-Buitrago","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario Puerta de Hierro Majadahonda, 28222 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Sanchez Godoy","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario Severo Ochoa, 28911 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Jacome Yerovi","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario Severo Ochoa, 28911 Madrid, 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Defensa G\u00f3mez Ulla, 28047 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bel\u00e9n","family":"Rosado Sierra","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario Rey Juan Carlos, M\u00f3stoles, 28933 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Concepci\u00f3n","family":"Al\u00e1ez-Us\u00f3n","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital HLA Universitario Moncloa, 28027 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keina","family":"Quiroz-Cervantes","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario de M\u00f3stoles, 28935 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Mart\u00ednez-Chamorro","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario Quir\u00f3nsalud Madrid, Pozuelo de Alarc\u00f3n, 28223 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"P\u00e9rez-Oteyza","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario HM Sanchinarro, 28050 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Martos-Martinez","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario General de Villalba, Villalba, 28400 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina","family":"Herr\u00e1ez","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario Infanta Sof\u00eda, San Sebasti\u00e1n de Los Reyes, 28702 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"Gonz\u00e1lez-Santillana","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario de Fuenlabrada, 28942 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Francisco","family":"Del Campo","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario del Henares, Coslada, 28822 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arancha","family":"Alonso","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Ruber, 28006 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adolfo","family":"de la Fuente","sequence":"additional","affiliation":[{"name":"Hematology Department, MD Anderson Cancer Center Madrid, 28033 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Pascual","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario Infanta Elena, Valdemoro, 28340 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosal\u00eda","family":"Bustelos-Rodriguez","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario del Sureste, Arganda del Rey, 28500 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Sebrango","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario de Torrej\u00f3n, 28850 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario del Tajo, Aranjuez, 28300 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eriel Alexis","family":"Marcheco-Pupo","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario Infanta Cristina, Parla, 28980 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Grande","sequence":"additional","affiliation":[{"name":"Hematology Department, Cl\u00ednica Universidad de Navarra, 28027 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1ngel","family":"Cedillo","sequence":"additional","affiliation":[{"name":"Asociaci\u00f3n Madrile\u00f1a de Hematolog\u00eda y Hemoterapia (AMHH), 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Lumbreras","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9s","family":"Arroyo Barea","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario 12 de Octubre, imas12, Universidad Complutense, CNIO-ISCIII, CIBERONC, 28041 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6649-4301","authenticated-orcid":false,"given":"Jos\u00e9 Manuel","family":"Casas-Rojo","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Universitario Infanta Cristina, Parla, 28980 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Calbacho","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario 12 de Octubre, imas12, Universidad Complutense, CNIO-ISCIII, CIBERONC, 28041 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Luis","family":"Diez-Mart\u00edn","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, 28007 Madrid, Spain"},{"name":"Department of Medicine, Universidad Complutense, 28223 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"Garc\u00eda-Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital Universitario Pr\u00edncipe de Asturias, Universidad de Alcal\u00e1, Alcal\u00e1 de Henares, 28805 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,27]]},"reference":[{"key":"ref_1","unstructured":"(2022, September 07). 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