{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T15:50:43Z","timestamp":1788709843210,"version":"build-2803163510"},"reference-count":52,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T00:00:00Z","timestamp":1677542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: iron deficiency (ID) is frequent in older patients. Purpose: to evaluate the association between ID and survival in patients \u2265 75 years old with confirmed solid tumors. Methods: a retrospective monocentric study including patients between 2009 and 2018. ID, absolute ID (AID) and functional ID (FID) were defined according to the European Society for Medical Oncology (ESMO) criteria. Severe ID was defined by a ferritin level &lt; 30 \u00b5g\/L. Results: in total, 556 patients were included, the mean age was 82 (\u00b14.6) years, 56% were male, the most frequent cancer was colon cancer (19%, n = 104), and metastatic cancers were found in 38% (n = 211). Median follow-up time: 484 [190\u20131377] days. In anemic patients, ID and FID were independently associated with an increased risk of mortality (respectively, HR 1.51; p = 0.0065 and HR 1.73; p = 0.0007). In non-anemic patients, FID was independently associated with better survival (HR 0.65; p = 0.0495). Conclusion: in our study, ID was significantly associated with survival, and with better survival for patients without anemia. These results suggest that attention should be paid to the iron status in older patients with tumors and raise questions about the prognostic value of iron supplementation for iron-deficient patients without anemia.<\/jats:p>","DOI":"10.3390\/cancers15051533","type":"journal-article","created":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T01:36:09Z","timestamp":1677634569000},"page":"1533","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association between Iron Deficiency and Survival in Older Patients with Cancer"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9039-3829","authenticated-orcid":false,"given":"Julie","family":"Tisserand","sequence":"first","affiliation":[{"name":"Geriatrics Department, Poitiers University Hospital, 86000 Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0155-1766","authenticated-orcid":false,"given":"Violaine","family":"Randrian","sequence":"additional","affiliation":[{"name":"ProDiCeT, CHU Poitiers, Universit\u00e9 de Poitiers, 86000 Poitiers, France"},{"name":"Gastroenterology and Hepatology Department, Poitiers University Hospital, 86000 Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Paccalin","sequence":"additional","affiliation":[{"name":"Geriatrics Department, Poitiers University Hospital, 86000 Poitiers, France"},{"name":"University Hospital Poitiers, University of Poitiers, INSERM CIC 1402, 2 rue de la Mil\u00e9trie, CEDEX, 86021 Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Jean","family":"Saulnier","sequence":"additional","affiliation":[{"name":"University Hospital Poitiers, University of Poitiers, INSERM CIC 1402, 2 rue de la Mil\u00e9trie, CEDEX, 86021 Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Arviset","sequence":"additional","affiliation":[{"name":"Geriatrics Department, Poitiers University Hospital, 86000 Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Fourmy","sequence":"additional","affiliation":[{"name":"Geriatrics Department, Poitiers University Hospital, 86000 Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Arriudarr\u00e9","sequence":"additional","affiliation":[{"name":"Geriatrics Department, Poitiers University Hospital, 86000 Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lie","family":"Jamet","sequence":"additional","affiliation":[{"name":"Geriatrics Department, Poitiers University Hospital, 86000 Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvan","family":"Moreno","sequence":"additional","affiliation":[{"name":"Geriatrics Department, Poitiers University Hospital, 86000 Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Val\u00e9ro","sequence":"additional","affiliation":[{"name":"Geriatrics Department, Poitiers University Hospital, 86000 Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2758-5064","authenticated-orcid":false,"given":"Evelyne","family":"Liuu","sequence":"additional","affiliation":[{"name":"Geriatrics Department, Poitiers University Hospital, 86000 Poitiers, France"},{"name":"University Hospital Poitiers, University of Poitiers, INSERM CIC 1402, 2 rue de la Mil\u00e9trie, CEDEX, 86021 Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1182\/blood-2004-05-1812","article-title":"Prevalence of anemia in persons 65 years and older in the United States: Evidence for a high rate of unexplained anemia","volume":"104","author":"Guralnik","year":"2004","journal-title":"Blood"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1186\/s13054-014-0542-9","article-title":"Prevalence of iron deficiency on ICU discharge and its relation with fatigue: A multicenter prospective study","volume":"18","author":"Lasocki","year":"2014","journal-title":"Crit. 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