{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:57:16Z","timestamp":1760147836511,"version":"build-2065373602"},"reference-count":36,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T00:00:00Z","timestamp":1678147200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003500","name":"University of Padova, Italy","doi-asserted-by":"publisher","award":["DOR2215418\/22"],"award-info":[{"award-number":["DOR2215418\/22"]}],"id":[{"id":"10.13039\/501100003500","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Basaloid squamous cell carcinoma (BSCC) is a subtype of squamous cell carcinoma (SCC) associated with a poor prognosis. Tumor\u2013stroma ratio (TSR) has been introduced as a prognostic feature in many solid tumors. TSR was investigated in a series of laryngeal BSCCs and compared with a group of stage-matched conventional SCCs (cSCCs), in both preoperative and surgical specimens, with the intent of ascertaining the more aggressive behavior of BSCC and verifying the presence of stromal-related causes. A series of 14 consecutive laryngeal BSCCs and a control group of 28 stage-matched conventional cSCCs were analyzed. A higher nodal metastasis presence was found in BSCCs (57.1% vs. 28.6%). The recurrence rate was 33.5% and 63.6% in the cSCC and BSCC groups; disease-free survival (DFS) was higher, though not significantly, in patients with cSCC. TSR, large cell nests, and tumor budding showed a moderate to very good agreement, and stroma type a good to very good agreement between biopsies and surgical specimens in the cSCC group. In the BSCC group, agreement was poor to very good for TSR and stroma type, and good to very good for large cell nests and tumor budding. Age was the only feature significant in predicting recurrence in the BSCC group (p = 0.0235). In cSCC, TSR low\/stroma rich cases, when evaluated on biopsies or surgical specimens, were associated with lower DFS (p = 0.0036; p = 0.0041, respectively). Laryngeal BSCCs showed a lower DFS than cSCCs, even if statistical significance was not reached. TSR, evaluated in laryngeal biopsies and excised tumors, was prognostic in terms of DFS in cSCC but not in BSCC cases.<\/jats:p>","DOI":"10.3390\/cancers15061645","type":"journal-article","created":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T01:58:22Z","timestamp":1678240702000},"page":"1645","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Tumor-Stroma Ratio in Basaloid and Conventional Laryngeal Squamous Cell Carcinoma: Prognostic Significance and Concordance in Paired Biopsies and Surgical Samples"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8751-0588","authenticated-orcid":false,"given":"Gino","family":"Marioni","sequence":"first","affiliation":[{"name":"Otolaryngology Section, Department of Neuroscience DNS, University of Padova, 35100 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Taboni","sequence":"additional","affiliation":[{"name":"Otolaryngology Section, Department of Neuroscience DNS, University of Padova, 35100 Padova, Italy"},{"name":"Guided Therapeutics (GTx) Program International Scholarship, University Health Network (UHN), Toronto, ON M5G1L7, Canada"},{"name":"Artificial Intelligence in Medicine and Innovation in Clinical Research and Methodology, Department of Clinical and Experimental Sciences, University of Brescia, 25100 Brescia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Sbaraglia","sequence":"additional","affiliation":[{"name":"Pathological Anatomy Unit, Department of Medicine DIMED, University of Padova, 35100 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2306-4088","authenticated-orcid":false,"given":"Leonardo","family":"Franz","sequence":"additional","affiliation":[{"name":"Otolaryngology Section, Department of Neuroscience DNS, University of Padova, 35100 Padova, Italy"},{"name":"Guided Therapeutics (GTx) Program International Scholarship, University Health Network (UHN), Toronto, ON M5G1L7, Canada"},{"name":"Artificial Intelligence in Medicine and Innovation in Clinical Research and Methodology, Department of Clinical and Experimental Sciences, University of Brescia, 25100 Brescia, Italy"},{"name":"Phoniatrics and Audiology Unit, Department of Neuroscience DNS, University of Padova, 31100 Treviso, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tommaso","family":"Saccardo","sequence":"additional","affiliation":[{"name":"Otolaryngology Section, Department of Neuroscience DNS, University of Padova, 35100 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Colombo","sequence":"additional","affiliation":[{"name":"Otolaryngology Section, Department of Neuroscience DNS, University of Padova, 35100 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla","family":"Zimello","sequence":"additional","affiliation":[{"name":"Otolaryngology Section, Department of Neuroscience DNS, University of Padova, 35100 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9705-4459","authenticated-orcid":false,"given":"Anna Chiara","family":"Frigo","sequence":"additional","affiliation":[{"name":"Department of Cardiac-Thoracic-Vascular Sciences and Public Health, University of Padova, 35100 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4023-0121","authenticated-orcid":false,"given":"Marco","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Otolaryngology Section, Department of Neuroscience DNS, University of Padova, 35100 Padova, Italy"},{"name":"Guided Therapeutics (GTx) Program International Scholarship, University Health Network (UHN), Toronto, ON M5G1L7, Canada"},{"name":"Technology for Health, Department of Information Engineering, University of Brescia, 25100 Brescia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lara","family":"Alessandrini","sequence":"additional","affiliation":[{"name":"Pathological Anatomy Unit, Department of Medicine DIMED, University of Padova, 35100 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s12105-021-01405-6","article-title":"Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Hypopharynx, larynx, trachea and parapharyngeal space","volume":"16","author":"Zidar","year":"2022","journal-title":"Head Neck Pathol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1016\/S0046-8177(86)80422-1","article-title":"Basaloid-squamous carcinoma of the tongue, hypopharynx, and larynx: Report of 10 cases","volume":"17","author":"Wain","year":"1986","journal-title":"Hum. 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