{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T01:10:37Z","timestamp":1789521037986,"version":"build-2803163510"},"reference-count":34,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T00:00:00Z","timestamp":1678838400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"German Research Foundation Projekt","award":["512648189"],"award-info":[{"award-number":["512648189"]}]},{"name":"Open Access Publication Fund of the Thueringer Universitaets- und Landesbibliothek Jena","award":["512648189"],"award-info":[{"award-number":["512648189"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Investigations on the association between patient\u2019s age and head and neck cancer (HNC) treatment decision are sparse. Nationwide diagnoses-related group-based data of 1,226,357 cases hospitalized with primary HNC in Germany from 2005 to 2018 were included. Negative binomial regression was performed to study the development of the treatment rates over time. For all treatment options, i.e., biopsies, surgery, radiotherapy, and chemotherapy\/biologicals, increases in the treatment rates were seen in patients &gt;80 years (surgery: oral cavity: relative risk [RR]: 1.2, CI: 1.13\u20131.20; oropharynx: RR: 1.2, CI: 1.15\u20131.34; hypopharynx: RR: 1.1, CI: 1.02\u20131.17; larynx: RR: 1.1, CI: 1.04\u20131.12; radiotherapy: oral cavity: RR: 1.1, CI: 1.07\u20131.23; oropharynx: RR: 1.3, CI: 1.16\u20131.49; hypopharynx: RR: 1.3, CI: 1.21\u20131.46; larynx: RR 1.2, CI: 1.03\u20131.29; chemotherapy: oral cavity: RR: 1.2, CI: 1.06\u20131.31; salivary glands: RR: 1.3, CI: 1.09\u20131.50; oropharynx: RR: 1.4, CI: 1.12\u20131.83; hypopharynx: RR: 1.3, CI: 1.06\u20131.48; larynx: RR: 1.3, CI: 1.08\u20131.52, all p &lt; 0.05). Older age cohorts (\u226580 years) need more awareness as they are mainly responsible for the increase in the rates of surgery, radiotherapy, and chemotherapy\/biologics in HNC patients.<\/jats:p>","DOI":"10.3390\/cancers15061780","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T05:53:44Z","timestamp":1678859624000},"page":"1780","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The Association between Patient\u2019s Age and Head and Neck Cancer Treatment Decision\u2014A Population-Based Diagnoses-Related Group-Based Nationwide Study in Germany"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4822-907X","authenticated-orcid":false,"given":"Mussab","family":"Kouka","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Jena University Hospital, 07747 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Hermanns","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Jena University Hospital, 07747 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7420-7707","authenticated-orcid":false,"given":"Peter","family":"Schlattmann","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics, Computer Sciences and Data Sciences, Jena University Hospital, 07743 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9671-0784","authenticated-orcid":false,"given":"Orlando","family":"Guntinas-Lichius","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Jena University Hospital, 07747 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1016\/j.joms.2017.05.008","article-title":"Epidemiological Trends of Head and Neck Cancer in the United States: A SEER Population Study","volume":"75","author":"Mourad","year":"2017","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_2","unstructured":"Federal Statistical Office (2021, November 04). German Centre for Cancer Registry Data, Robert Koch Institute: Database Query with Estimates for Cancer Incidence, Prevalence and Survival in Germany, Based on Data of the Population Based Cancer Registries; Federal Statistical Office. Available online: www.krebsdaten.de\/database."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1093\/jnci\/djh306","article-title":"Randomized phase III trial of neoadjuvant chemotherapy in head and neck cancer: 10-year follow-up","volume":"96","author":"Zorat","year":"2004","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Tsukahara, K., Kubota, A., Hasegawa, Y., Takemura, H., Terada, T., Taguchi, T., Nagahara, K., Nakatani, H., Yoshino, K., and Higaki, Y. (2015). Randomized phase III trial of adjuvant chemotherapy with S-1 after curative treatment in patients with squamous-cell carcinoma of the head and neck (ACTS-HNC). PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0116965"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3266","DOI":"10.1200\/JCO.19.00555","article-title":"Phase III Randomized Trial of Chemotherapy With or Without Bevacizumab in Patients With Recurrent or Metastatic Head and Neck Cancer","volume":"37","author":"Argiris","year":"2019","journal-title":"J. Clin. Oncol."},{"key":"ref_6","first-page":"16","article-title":"Squamous cell carcinoma of the head and neck in the elderly","volume":"18","author":"Strojan","year":"2012","journal-title":"Rep. Pract. Oncol. Radiother."},{"key":"ref_7","unstructured":"Global Burden of Disease Cancer Collaboration, Fitzmaurice, C., Abate, D., Abbasi, N., Abbastabar, H., Abd-Allah, F., Abdel-Rahman, O., Abdelalim, A., Abdoli, A., and Abdollahpour, I. (2019). Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017: A Systematic Analysis for the Global Burden of Disease Study. JAMA Oncol., 5, 1749\u20131768."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.jgo.2021.03.011","article-title":"The impact of age on outcome in phase III NRG Oncology\/RTOG trials of radiotherapy (XRT) +\/\u2212 systemic therapy in locally advanced head and neck cancer","volume":"12","author":"Kish","year":"2021","journal-title":"J. Geriatr. Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1634\/theoncologist.2013-0325","article-title":"Elderly patients with squamous cell carcinoma of the head and neck and the benefit of multimodality therapy","volume":"20","author":"Moye","year":"2015","journal-title":"Oncologist"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s00405-006-0203-y","article-title":"The effect of age on survival and quality of life in elderly head and neck cancer patients: A long-term prospective study","volume":"264","author":"Derks","year":"2007","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1001\/jamaoncol.2016.1804","article-title":"Incidence of Oropharyngeal Cancer Among Elderly Patients in the United States","volume":"2","author":"Zumsteg","year":"2016","journal-title":"JAMA Oncol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Dittberner, A., Friedl, B., Wittig, A., Buentzel, J., Kaftan, H., Boeger, D., Mueller, A.H., Schultze-Mosgau, S., Schlattmann, P., and Ernst, T. (2020). Gender Disparities in Epidemiology, Treatment, and Outcome for Head and Neck Cancer in Germany: A Population-Based Long-Term Analysis from 1996 to 2016 of the Thuringian Cancer Registry. Cancers, 12.","DOI":"10.3390\/cancers12113418"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1387860","DOI":"10.1155\/2022\/1387860","article-title":"Mortality during In-Hospital Treatment for Head and Neck Cancer in Germany: A Diagnosis-Related Group-Based Nationwide Analysis, 2005\u20132018","volume":"2022","author":"Hermanns","year":"2022","journal-title":"J. Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Hermanns, I., Ziadat, R., Schlattmann, P., and Guntinas-Lichius, O. (2021). Trends in Treatment of Head and Neck Cancer in Germany: A Diagnosis-Related-Groups-Based Nationwide Analysis, 2005\u20132018. Cancers, 13.","DOI":"10.3390\/cancers13236060"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.otc.2018.03.004","article-title":"Head and Neck Cancer and the Elderly Patient","volume":"51","author":"Cervenka","year":"2018","journal-title":"Otolaryngol. Clin. N. Am."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1002\/ijc.33896","article-title":"Diverging incidence trends of oral tongue cancer compared to other head and neck cancers in young adults in France","volume":"150","author":"Deneuve","year":"2022","journal-title":"Int. J. Cancer"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3109\/0284186X.2012.742964","article-title":"The impact of comorbidity on outcome in 12 623 Danish head and neck cancer patients: A population based study from the DAHANCA database","volume":"52","author":"Dalton","year":"2013","journal-title":"Acta Oncol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3260","DOI":"10.1002\/cam4.882","article-title":"Role of comorbidity on outcome of head and neck cancer: A population-based study in Thuringia, Germany","volume":"5","author":"Inhestern","year":"2016","journal-title":"Cancer Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1097\/MLG.0b013e3180337827","article-title":"Factors that influence treatment decision in older patients with resectable head and neck cancer","volume":"117","author":"Sanabria","year":"2007","journal-title":"Laryngoscope"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00405-004-0744-x","article-title":"Reasons for non-standard treatment in elderly patients with advanced head and neck cancer","volume":"262","author":"Derks","year":"2005","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1002\/hed.21897","article-title":"Impact of comorbidity on therapeutic decision-making in head and neck cancer: Audit from a comprehensive cancer center in India","volume":"34","author":"Baijal","year":"2012","journal-title":"Head Neck"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.radonc.2013.07.005","article-title":"Impact of comorbidity on treatment outcome in head and neck squamous cell carcinoma\u2014A systematic review","volume":"110","year":"2014","journal-title":"Radiother. Oncol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/hed.25408","article-title":"Influence of comorbidity on therapeutic decision making and impact on outcomes in patients with head and neck squamous cell cancers: Results from a prospective cohort study","volume":"41","author":"Agarwal","year":"2019","journal-title":"Head Neck"},{"key":"ref_24","first-page":"283","article-title":"Impact of comorbidity on survival for locally advanced head and neck cancer patients treated by radiotherapy or radiotherapy plus chemotherapy","volume":"33","author":"Liu","year":"2010","journal-title":"Chang. Gung Med. J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1001\/archotol.127.9.1089","article-title":"Head and neck squamous cell carcinoma in elderly patients: A long-term retrospective review of 273 cases","volume":"127","author":"Sarini","year":"2001","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1007\/s00520-019-04904-z","article-title":"Factors impacting on discordance with treatment plan in head and neck cancer patients: A retrospective, population-based cohort study","volume":"28","author":"Chang","year":"2020","journal-title":"Support Care Cancer"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/S0194-5998(98)70386-9","article-title":"Management of cancer in the elderly: Therapeutic dilemmas","volume":"118","author":"Hirano","year":"1998","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1001\/jamaoto.2022.2791","article-title":"Cetuximab-Based vs Carboplatin-Based Chemoradiotherapy for Patients With Head and Neck Cancer","volume":"148","author":"Sun","year":"2022","journal-title":"JAMA Otolaryngol. Head Neck Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1002\/cncr.32583","article-title":"Rising incidence of late-stage head and neck cancer in the United States","volume":"126","author":"Yetukuri","year":"2020","journal-title":"Cancer"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"723716","DOI":"10.3389\/fonc.2021.723716","article-title":"Patterns-of-Care Analysis for Radiotherapy of Elderly Head-and-Neck Cancer Patients: A Trinational Survey in Germany, Austria and Switzerland","volume":"11","author":"Haehl","year":"2022","journal-title":"Front. Oncol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1007\/s00066-018-1357-4","article-title":"Health services research in German radiation oncology: New opportunities to advance cancer care","volume":"194","author":"Medenwald","year":"2018","journal-title":"Strahlenther. Onkol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.critrevonc.2004.08.001","article-title":"Treatment of head and neck cancer in elderly patients: State of the art and guidelines","volume":"53","author":"Bernardi","year":"2005","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.semradonc.2012.05.002","article-title":"Impact of age and comorbidity on treatment and outcomes in elderly cancer patients","volume":"22","author":"Chen","year":"2012","journal-title":"Semin. Radiat. Oncol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1097\/01.coc.0000143049.05090.12","article-title":"The effects of age and comorbidity on treatment and outcomes in women with endometrial cancer","volume":"28","author":"Truong","year":"2005","journal-title":"Am. J. Clin. Oncol."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/15\/6\/1780\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:55:41Z","timestamp":1760122541000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/15\/6\/1780"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,15]]},"references-count":34,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["cancers15061780"],"URL":"https:\/\/doi.org\/10.3390\/cancers15061780","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,15]]}}}