{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T07:18:27Z","timestamp":1793085507213,"version":"4.5.0"},"reference-count":55,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T00:00:00Z","timestamp":1679529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: This study tested the diagnostic value of 18F-FDG PET\/CT (FDG-PET) volumetric and texture parameters in the histological differentiation of mediastinal bulky disease due to classical Hodgkin lymphoma (cHL), primary mediastinal B-cell lymphoma (PMBCL) and grey zone lymphoma (GZL), using machine learning techniques. Methods: We reviewed 80 cHL, 29 PMBCL and 8 GZL adult patients with mediastinal bulky disease and histopathological diagnoses who underwent FDG-PET pre-treatment. Volumetric and radiomic parameters were measured using FDG-PET both for bulky lesions (BL) and for all lesions (AL) using LIFEx software (threshold SUV \u2265 2.5). Binary and multiclass classifications were performed with various machine learning techniques fed by a relevant subset of radiomic features. Results: The analysis showed significant differences between the lymphoma groups in terms of SUVmax, SUVmean, MTV, TLG and several textural features of both first- and second-order grey level. Among machine learning classifiers, the tree-based ensembles achieved the best performance both for binary and multiclass classifications in histological differentiation. Conclusions: Our results support the value of metabolic heterogeneity as an imaging biomarker, and the use of radiomic features for early characterization of mediastinal bulky lymphoma.<\/jats:p>","DOI":"10.3390\/cancers15071931","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T04:37:28Z","timestamp":1679546248000},"page":"1931","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Characterization of Mediastinal Bulky Lymphomas with FDG-PET-Based Radiomics and Machine Learning Techniques"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9370-102X","authenticated-orcid":false,"given":"Elisabetta Maria","family":"Abenavoli","sequence":"first","affiliation":[{"name":"Nuclear Medicine Unit, Department of Experimental and Clinical Biomedical Sciences \u2018Mario Serio\u2019, University of Florence, 50139 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6704-6914","authenticated-orcid":false,"given":"Matteo","family":"Barbetti","sequence":"additional","affiliation":[{"name":"Department of Information Engineering, University of Florence, 50134 Florence, Italy"},{"name":"Istituto Nazionale di Fisica Nucleare (INFN), Florence Division, 50019 Sesto Fiorentino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Linguanti","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit, Department of Experimental and Clinical Biomedical Sciences \u2018Mario Serio\u2019, University of Florence, 50139 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Mungai","sequence":"additional","affiliation":[{"name":"Department of Radiology, Azienda Ospedaliero Universitaria Careggi, 50139 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Nassi","sequence":"additional","affiliation":[{"name":"Hematology Department, Azienda Ospedaliero Universitaria Careggi, University of Florence, 50139 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Puccini","sequence":"additional","affiliation":[{"name":"Hematology Department, Azienda Ospedaliero Universitaria Careggi, University of Florence, 50139 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5720-9807","authenticated-orcid":false,"given":"Ilaria","family":"Romano","sequence":"additional","affiliation":[{"name":"Hematology Department, Azienda Ospedaliero Universitaria Careggi, University of Florence, 50139 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Sordi","sequence":"additional","affiliation":[{"name":"Hematology Department, Azienda Ospedaliero Universitaria Careggi, University of Florence, 50139 Florence, Italy"},{"name":"Department of Experimental and Clinical Medicine, CRIMM, Center Research and Innovation of Myeloproliferative Neoplasms, Azienda Ospedaliera Universitaria Careggi, University of Florence, 50139 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5317-7533","authenticated-orcid":false,"given":"Raffaella","family":"Santi","sequence":"additional","affiliation":[{"name":"Pathology Section, Department of Health Sciences, University of Florence, 50139 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Passeri","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit, Department of Experimental and Clinical Biomedical Sciences \u2018Mario Serio\u2019, University of Florence, 50139 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Sciagr\u00e0","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit, Department of Experimental and Clinical Biomedical Sciences \u2018Mario Serio\u2019, University of Florence, 50139 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2955-6451","authenticated-orcid":false,"given":"Cinzia","family":"Talamonti","sequence":"additional","affiliation":[{"name":"Istituto Nazionale di Fisica Nucleare (INFN), Florence Division, 50019 Sesto Fiorentino, Italy"},{"name":"Medical Physics Unit, Department of Experimental and Clinical Biomedical Sciences \u2018Mario Serio\u2019, University of Florence, 50139 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8024-8425","authenticated-orcid":false,"given":"Angelina","family":"Cistaro","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department, Salus Alliance Medical, 16128 Genoa, Italy"},{"name":"Pediatric Study Group for Italian Association of Nuclear Medicine (AIMN), 20159 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro Maria","family":"Vannucchi","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, CRIMM, Center Research and Innovation of Myeloproliferative Neoplasms, Azienda Ospedaliera Universitaria Careggi, University of Florence, 50139 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9947-6559","authenticated-orcid":false,"given":"Valentina","family":"Berti","sequence":"additional","affiliation":[{"name":"Nuclear 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