{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:07:12Z","timestamp":1790176032809,"version":"4.1.0"},"reference-count":51,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T00:00:00Z","timestamp":1679616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI18\/01253"],"award-info":[{"award-number":["PI18\/01253"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: We examined cognitive, brain MRI, and lumbar infusion test (LIT) features to identify predictors of response to ventriculoperitoneal shunting (VPS) in long-term cancer survivors with suspected normal pressure hydrocephalus (NPH) following cranial radiotherapy (RT). Methods: Patients who completed cranial RT at least 2 years before with clinically suspected NPH and an Evans\u2019 index (EI) \u2265 0.30 underwent a cognitive and a cerebrospinal fluid (CSF) volumetric (MRI) analysis (n = 36). For those in whom VPS was placed (n = 14), we explored whether adding a CSF volumetric analysis to classical MRI and LIT (Tap Test) features would better identify VPS responders. Results: Nearly 80% exhibited cognitive impairment. The CSF volume at NPH diagnoses was significantly larger in the group of VPS responders (p = 0.04). The addition of CSF volume to NPH diagnoses increased accuracy to 93%, with a positive and negative predictive value of 91% and 100%, respectively. Conclusion: The addition of a quantitative MRI analysis of CSF volume to classical MRI and LIT NPH criteria, along with a high clinical suspicion of NPH, may help to identify VPS responders, thus improving the clinical management and prognosis of long-term survivors.<\/jats:p>","DOI":"10.3390\/cancers15071949","type":"journal-article","created":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T02:34:54Z","timestamp":1679625294000},"page":"1949","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Normal Pressure Hydrocephalus Following Cranial Radiation: Identification of Shunting Responders"],"prefix":"10.3390","volume":"15","author":[{"given":"Nuria","family":"Cayuela","sequence":"first","affiliation":[{"name":"Neurology Department, Complex Hospitalari Mois\u00e8s Broggi, 08970 Sant Joan Desp\u00ed, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Dom\u00ednguez-Lizarbe","sequence":"additional","affiliation":[{"name":"Neurology Department, Hospital Germans Trias i Pujol, Universitat Aut\u00f2noma de Barcelona, 08916 Badalona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Plans","sequence":"additional","affiliation":[{"name":"Neuro-Oncology Unit, Hospital Universitari de Bellvitge-Institut Catal\u00e0 d\u2019Oncologia l\u2019Hospitalet, Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (Oncobell Program), 08908 L\u2019Hospitalet de Llobregat, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Alemany","sequence":"additional","affiliation":[{"name":"Neuro-Oncology Unit, Hospital Universitari de Bellvitge-Institut Catal\u00e0 d\u2019Oncologia l\u2019Hospitalet, Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (Oncobell Program), 08908 L\u2019Hospitalet de Llobregat, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0677-3680","authenticated-orcid":false,"given":"Juan Jos\u00e9","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Institute for Diagnostic Imaging, Hospital Universitari de Bellvitge, 08907 L\u2019Hospitalet de Llobregat, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bego\u00f1a","family":"Andr\u00e9s","sequence":"additional","affiliation":[{"name":"Neuro-Oncology Unit, Hospital Universitari de Bellvitge-Institut Catal\u00e0 d\u2019Oncologia l\u2019Hospitalet, Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (Oncobell Program), 08908 L\u2019Hospitalet de Llobregat, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Lucas","sequence":"additional","affiliation":[{"name":"Neuro-Oncology Unit, Hospital Universitari de Bellvitge-Institut Catal\u00e0 d\u2019Oncologia l\u2019Hospitalet, Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (Oncobell Program), 08908 L\u2019Hospitalet de Llobregat, Barcelona, Spain"},{"name":"Radiation Oncology Department, Hospital Universitari de Bellvitge-Institut Catal\u00e0 d\u2019Oncologia l\u2019Hospitalet, 08908 L\u2019Hospitalet de Llobregat, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Bruna","sequence":"additional","affiliation":[{"name":"Neuro-Oncology Unit, Hospital Universitari de Bellvitge-Institut Catal\u00e0 d\u2019Oncologia l\u2019Hospitalet, Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (Oncobell Program), 08908 L\u2019Hospitalet de Llobregat, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6787-1949","authenticated-orcid":false,"given":"Marta","family":"Sim\u00f3","sequence":"additional","affiliation":[{"name":"Neuro-Oncology Unit, Hospital Universitari de Bellvitge-Institut Catal\u00e0 d\u2019Oncologia l\u2019Hospitalet, Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (Oncobell Program), 08908 L\u2019Hospitalet de Llobregat, Barcelona, Spain"},{"name":"Cognition and Brain Plasticity Group, Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge, 08908 L\u2019Hospitalet de Llobregat, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1056\/NEJMoa071780","article-title":"Prophylactic cranial irradiation in extensive small-cell lung cancer","volume":"357","author":"Slotman","year":"2007","journal-title":"N. 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