{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T16:33:16Z","timestamp":1777566796510,"version":"3.51.4"},"reference-count":59,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T00:00:00Z","timestamp":1680048000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007388","name":"Compagnia San Paolo","doi-asserted-by":"publisher","award":["ID ROL 20207"],"award-info":[{"award-number":["ID ROL 20207"]}],"id":[{"id":"10.13039\/100007388","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007388","name":"Compagnia San Paolo","doi-asserted-by":"publisher","award":["MSALRC23"],"award-info":[{"award-number":["MSALRC23"]}],"id":[{"id":"10.13039\/100007388","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Italian Ministry of Health, RICERCA CORRENTE 2023","award":["ID ROL 20207"],"award-info":[{"award-number":["ID ROL 20207"]}]},{"name":"Italian Ministry of Health, RICERCA CORRENTE 2023","award":["MSALRC23"],"award-info":[{"award-number":["MSALRC23"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Neuroblastoma (NB) is a tumor affecting the peripheral sympathetic nervous system that substantially contributes to childhood cancer mortality. Despite recent advances in understanding the complexity of NB, the mechanisms determining its progression are still largely unknown. Some recurrent segmental chromosome aberrations (SCA) have been associated with poor survival. However, the prognostic role of most SCA has not yet been investigated. We examined a cohort of 260 NB primary tumors at disease onset for the loss of chromosome 10q, by array-comparative genomic hybridization (a-CGH) and Single Nucleotide Polymorphism (SNP) array and we found that 26 showed 10q loss, while the others 234 displayed different SCA. We observed a lower event-free survival for NB patients displaying 10q loss compared to patients with tumors carrying other SCA. Furthermore, analyzing the region of 10q loss, we identified a cluster of 75 deleted genes associated with poorer outcome. Low expression of six of these genes, above all CCSER2, was significantly correlated to worse survival using in silico data from 786 NB patients. These potential tumor suppressor genes can be partly responsible for the poor prognosis of NB patients with 10q loss.<\/jats:p>","DOI":"10.3390\/cancers15072035","type":"journal-article","created":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T01:05:26Z","timestamp":1680138326000},"page":"2035","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Multiple Genes with Potential Tumor Suppressive Activity Are Present on Chromosome 10q Loss in Neuroblastoma and Are Associated with Poor Prognosis"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3698-9319","authenticated-orcid":false,"given":"Marzia","family":"Ognibene","sequence":"first","affiliation":[{"name":"U.O.C. Genetica Medica, IRCCS Istituto Giannina Gaslini, 16147 Genova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8498-3750","authenticated-orcid":false,"given":"Patrizia","family":"De Marco","sequence":"additional","affiliation":[{"name":"U.O.C. Genetica Medica, IRCCS Istituto Giannina Gaslini, 16147 Genova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1950-4754","authenticated-orcid":false,"given":"Loredana","family":"Amoroso","sequence":"additional","affiliation":[{"name":"U.O.C. Oncologia Pediatrica, IRCCS Istituto Giannina Gaslini, 16147 Genova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Cangelosi","sequence":"additional","affiliation":[{"name":"Unit\u00e0 di Bioinformatica Clinica, IRCCS Istituto Giannina Gaslini, 16147 Genova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9744-5222","authenticated-orcid":false,"given":"Federico","family":"Zara","sequence":"additional","affiliation":[{"name":"U.O.C. Genetica Medica, IRCCS Istituto Giannina Gaslini, 16147 Genova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9193-1622","authenticated-orcid":false,"given":"Stefano","family":"Parodi","sequence":"additional","affiliation":[{"name":"Direzione Scientifica, IRCCS Giannina Gaslini, 16147 Genova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6321-5701","authenticated-orcid":false,"given":"Annalisa","family":"Pezzolo","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Giannina Gaslini, 16147 Genova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3389\/fnmol.2019.00009","article-title":"Neuroblastoma-A Neural Crest Derived Embryonal Malignancy","volume":"12","author":"Johnsen","year":"2019","journal-title":"Front. Mol. Neurosci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jpedsurg.2018.09.004","article-title":"APSA Cancer committee. Update on neuroblastoma","volume":"54","author":"Newman","year":"2019","journal-title":"J. Pediatr. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00441-017-2747-0","article-title":"Neuroblastoma pathogenesis: Deregulation of embryonic neural crest development","volume":"372","author":"Tomolonis","year":"2018","journal-title":"Cell Tissue Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrc3526","article-title":"Neuroblastoma: Developmental biology, cancer genomics and immunotherapy","volume":"13","author":"Cheung","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"16078","DOI":"10.1038\/nrdp.2016.78","article-title":"Neuroblastoma","volume":"2","author":"Matthay","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1146\/annurev-med-011514-023121","article-title":"Neuroblastoma: Molecular pathogenesis and therapy","volume":"66","author":"Louis","year":"2015","journal-title":"Ann. Rev. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"5183","DOI":"10.1038\/s41467-020-18987-4","article-title":"Pan-neuroblastoma analysis reveals age- and signature-associated driver alterations","volume":"11","author":"Brady","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/ng.2529","article-title":"The genetic landscape of high-risk neuroblastoma","volume":"45","author":"Pugh","year":"2013","journal-title":"Nat. Genet."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1053\/j.sempedsurg.2016.09.007","article-title":"Recent biologic and genetic advances in neuroblastoma: Implications for diagnostic, risk stratification, and treatment strategies","volume":"25","author":"Newman","year":"2016","journal-title":"Semin. Pediatr. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/cncr.29706","article-title":"Advances in the translational genomics of neuroblastoma: From improving risk stratification and revealing novel biology to identifying actionable genomic alterations","volume":"122","author":"Bosse","year":"2016","journal-title":"Cancer"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1001\/jama.2012.228","article-title":"Association of age at diagnosis and genetic mutations in patients with neuroblastoma","volume":"307","author":"Cheung","year":"2012","journal-title":"J. Am. Med. Assoc."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1200\/JCO.2008.16.0630","article-title":"Overall genomic pattern is a predictor of outcome in neuroblastoma","volume":"27","author":"Schleiermacher","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1093\/jnci\/djy022","article-title":"Genomic Amplifications and Distal 6q Loss: Novel Markers for Poor Survival in High-risk Neuroblastoma Patients","volume":"110","author":"Depuydt","year":"2018","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/gcc.22827","article-title":"Genomic co-amplification of CDK4\/MDM2\/FRS2 is associated with very poor prognosis and atypical clinical features in neuroblastoma patients","volume":"59","author":"Amoroso","year":"2020","journal-title":"Genes Chromosomes Cancer"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Ognibene, M., Amoroso, L., Melchionda, F., Cangelosi, D., Zara, F., Parodi, S., and Pezzolo, A. (2021). High Grade of Amplification of Six Regions on Chromosome 2p in a Neuroblastoma Patient with Very Poor Outcome: The Putative New Oncogene TSSC1. Cancers, 13.","DOI":"10.3390\/cancers13225792"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Ognibene, M., and Pezzolo, A. (2020). Ezrin interacts with the tumor suppressor CHL1 and promotes neuronal differentiation of human neuroblastoma. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0244069"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1080\/15384047.2019.1704122","article-title":"Identification of a minimal region of loss on chromosome 6q27 associated with poor survival of high-risk neuroblastoma patients","volume":"21","author":"Ognibene","year":"2020","journal-title":"Cancer Biol. Ther."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"25903","DOI":"10.18632\/oncotarget.25403","article-title":"CHL1 gene acts as a tumor suppressor in human neuroblastoma","volume":"9","author":"Ognibene","year":"2018","journal-title":"Oncotarget"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41525-020-0125-4","article-title":"19p loss is significantly enriched in older age neuroblastoma patients and correlates with poor prognosis","volume":"5","author":"Lasorsa","year":"2020","journal-title":"NPJ Genom Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e27635","DOI":"10.1002\/pbc.27635","article-title":"Loss of whole chromosome X predicts prognosis of neuroblastoma patients with numerical genomic profile","volume":"66","author":"Parodi","year":"2019","journal-title":"Pediatr Blood Cancer."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Brandetti, E., Focaccetti, C., Pezzolo, A., Ognibene, M., Folgiero, V., Cotugno, N., Benvenuto, M., Palma, P., Manzari, V., and Rossi, P. (2021). Enhancement of Neuroblastoma NK-Cell-Mediated Lysis through NF-kB p65 Subunit-Induced Expression of FAS and PVR, the Loss of Which Is Associated with Poor Patient Outcome. Cancers, 13.","DOI":"10.3390\/cancers13174368"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/(SICI)1098-2264(199707)19:3<176::AID-GCC7>3.0.CO;2-V","article-title":"Novel regions of chromosomal loss in familial neuroblastoma by comparative genomic hybridization","volume":"19","author":"Altura","year":"1997","journal-title":"Genes Chromosom. Cancer"},{"key":"ref_23","first-page":"1829","article-title":"Allelotype of neuroblastoma","volume":"11","author":"Takita","year":"1995","journal-title":"Oncogene"},{"key":"ref_24","first-page":"311","article-title":"Different karyotypic patterns in early and advanced stage neuroblastomas","volume":"47","author":"Kaneko","year":"1987","journal-title":"Cancer Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1200\/JCO.2008.16.6785","article-title":"INRG Task Force. The International Neuroblastoma Risk Group (INRG) classification system: An INRG Task Force report","volume":"27","author":"Cohn","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1200\/JCO.2016.72.0177","article-title":"Revisions to the International neuroblastoma response criteria: A consensus statement from the National Cancer Institute clinical trials planning meeting","volume":"35","author":"Park","year":"2017","journal-title":"J. Clin. Oncol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1200\/JCO.2009.24.8351","article-title":"Improved survival of children with neuroblastoma between 1979 and 2005: A report of the Italian Neuroblastoma Registry","volume":"28","author":"Haupt","year":"2010","journal-title":"J. Clin. Oncol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Cangelosi, D., Morini, M., Zanardi, N., Sementa, A.R., Muselli, M., Conte, M., Garaventa, A., Pfeffer, U., Bosco, M.C., and Varesio, L. (2020). Hypoxia Predicts Poor Prognosis in Neuroblastoma Patients and Associates with Biological Mechanisms Involved in Telomerase Activation and Tumor Microenvironment Reprogramming. Cancers, 12.","DOI":"10.3390\/cancers12092343"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s13059-015-0694-1","article-title":"Comparison of RNA-seq and microarray-based models for clinical endpoint prediction","volume":"16","author":"Zhang","year":"2015","journal-title":"Genome Biol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1158\/1078-0432.CCR-14-0817","article-title":"Revised risk estimation and treatment stratification of low- and intermediate-risk neuroblastoma patients by integrating clinical and molecular prognostic markers","volume":"21","author":"Oberthuer","year":"2015","journal-title":"Clin. Cancer Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1158\/2159-8290.CD-16-0861","article-title":"Cross-cohort analysis identifies a TEAD4-MYCN positive feedback loop as the core regulatory element of high-risk neuroblastoma","volume":"8","author":"Rajbhandari","year":"2018","journal-title":"Cancer Discov."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Gibbons, J.D., and Chakraborti, S. (2010). Nonparametric Statistical Inference, CRC Press, Chapman & Hall. [5th ed.].","DOI":"10.1201\/9781439896129"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Hosmer, D.W., Lemeshow, S., and May, S. (2008). Applied Survival Analysis\u2014Regression Modelling of Time to Event Data, John Wiley & Sons, Inc.. [2nd ed.].","DOI":"10.1002\/9780470258019"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1200\/JCO.2005.06.104","article-title":"Unequivocal delineation of clinicogenetic subgroups and development of a new model for improved outcome prediction in neuroblastoma","volume":"23","author":"Vandesompele","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1038\/s41436-019-0545-7","article-title":"Technical laboratory standards for interpretation and reporting of acquired copy-number abnormalities and copy-neutral loss of heterozygosity in neoplastic disorders: A joint consensus recommendation from the American College of Medical Genetics and Genomics (ACMG) and the Cancer Genomics Consortium (CGC)","volume":"21","author":"Mikhail","year":"2019","journal-title":"Genet Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"7432","DOI":"10.1038\/sj.onc.1210552","article-title":"Identification of candidate genes involved in neuroblastoma progression by combining genomic and expression microarrays with survival data","volume":"26","author":"Lastowska","year":"2007","journal-title":"Oncogene"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/nrn3120","article-title":"Linking neurodevelopmental and synaptic theories of mental illness through DISC1","volume":"12","author":"Brandon","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nature09859","article-title":"DISC1-dependent switch from progenitor proliferation to migration in the developing cortex","volume":"473","author":"Ishizuka","year":"2011","journal-title":"Nature"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s13365-018-0692-7","article-title":"HERV-W env regulates calcium influx via activating TRPC3 channel together with depressing DISC1 in human neuroblastoma cells","volume":"25","author":"Chen","year":"2019","journal-title":"J. Neurovirol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1007\/s11064-018-2539-2","article-title":"Lead Neurotoxicity on Human Neuroblastoma Cell Line SH-SY5Y is Mediated via Transcription Factor EGR1\/Zif268 Induced Disrupted in Scherophernia-1 Activation","volume":"43","author":"You","year":"2018","journal-title":"Neurochem. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e2214507120","DOI":"10.1073\/pnas.2214507120","article-title":"Gcap14 is a microtubule plus-end-tracking protein coordinating microtubule-actin crosstalk during neurodevelopment","volume":"120","author":"Mun","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e1791","DOI":"10.1002\/cnr2.1791","article-title":"Cellular senescence-related long noncoding ribonucleic acids: Predicting prognosis in hepatocellular carcinoma","volume":"1","author":"Huang","year":"2023","journal-title":"Cancer Rep."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1126\/science.1231776","article-title":"Epigenetic Regulation by Long Noncoding RNAs","volume":"338","author":"Lee","year":"2012","journal-title":"Science"},{"key":"ref_44","first-page":"1551","article-title":"Astragaloside IV inhibits the progression of liver cancer by modulating macrophage polarization through the TLR4\/NF-\u03baB\/STAT3 signaling pathway","volume":"14","author":"Min","year":"2022","journal-title":"Am. J. Transl. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/s41420-021-00592-z","article-title":"Telocytes promote hepatocellular carcinoma by activating the ERK signaling pathway and miR-942-3p\/MMP9 axis","volume":"7","author":"Xu","year":"2021","journal-title":"Cell Death Discov."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"4207","DOI":"10.7150\/ijbs.64714","article-title":"Targeted Inhibition of LPL\/FABP4\/CPT1 fatty acid metabolic axis can effectively prevent the progression of nonalcoholic steatohepatitis to liver cancer","volume":"17","author":"Yang","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"383","DOI":"10.7150\/ijbs.17236","article-title":"Inhibition of Proteasome Activity Induces Aggregation of IFIT2 in the Centrosome and Enhances IFIT2-Induced Cell Apoptosis","volume":"13","author":"Chen","year":"2017","journal-title":"Int. J. Biol. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"200","DOI":"10.7150\/ijbs.5613","article-title":"Interferon induced IFIT family genes in host antiviral defense","volume":"9","author":"Zhou","year":"2013","journal-title":"Int. J. Biol. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.canlet.2015.10.016","article-title":"Blocking TNF-\u03b1 inhibits angiogenesis and growth of IFIT2-depleted metastatic oral squamous cell carcinoma cells","volume":"370","author":"Lai","year":"2016","journal-title":"Cancer Lett."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/tbj.12097","article-title":"Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) as a prognostic marker for local control in T1-2 N0 breast cancer treated with breast-conserving surgery and radiation therapy (BCS + RT)","volume":"19","author":"Danish","year":"2013","journal-title":"Breast J."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1080\/15384047.2016.1276129","article-title":"Curcumin induces apoptosis in human leukemic cell lines through an IFIT2-dependent pathway","volume":"18","author":"Zhang","year":"2017","journal-title":"Cancer Biol. Ther."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.humpath.2016.01.013","article-title":"High IFIT1 expression predicts improved clinical outcome, and IFIT1 along with MGMT more accurately predicts prognosis in newly diagnosed glioblastoma","volume":"52","author":"Zhang","year":"2016","journal-title":"Hum. Pathol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/hep.29156","article-title":"Hepatic IFIT3 predicts interferon-\u03b1 therapeutic response in patients of hepatocellular carcinoma","volume":"66","author":"Yang","year":"2017","journal-title":"Hepatology."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1007\/s00432-017-2351-4","article-title":"Elevated interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) is a poor prognostic marker in pancreatic ductal adenocarcinoma","volume":"143","author":"Zhao","year":"2017","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"148","DOI":"10.3389\/fmolb.2019.00148","article-title":"Emerging Functions of Human IFIT Proteins in Cancer","volume":"19","author":"Pidugu","year":"2019","journal-title":"Front. Mol. Biosci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/cdd.2015.107","article-title":"Heparan sulfation is essential for the prevention of cellular senescence","volume":"23","author":"Jung","year":"2016","journal-title":"Cell Death Differ."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1038\/nsmb.2669","article-title":"Transcriptional regulation by Polycomb group proteins","volume":"20","author":"Helin","year":"2013","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1038\/s41467-018-03781-0","article-title":"PCGF5 is required for neural differentiation of embryonic stem cells","volume":"9","author":"Yao","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"36293","DOI":"10.18632\/oncotarget.9202","article-title":"Unveiling MYCN regulatory networks in neuroblastoma via integrative analysis of heterogeneous genomics data","volume":"7","author":"Hsu","year":"2016","journal-title":"Oncotarget"}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/15\/7\/2035\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:06:03Z","timestamp":1760123163000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/15\/7\/2035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,29]]},"references-count":59,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023,4]]}},"alternative-id":["cancers15072035"],"URL":"https:\/\/doi.org\/10.3390\/cancers15072035","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,29]]}}}