{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T15:52:00Z","timestamp":1793721120527,"version":"4.6.1"},"reference-count":47,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T00:00:00Z","timestamp":1680134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Azienda USL-IRCCS of Reggio Emilia"},{"name":"Italian Ministry of Health"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: Key elements in cancer cachexia (CC) management are personalized and multimodal interventions, but it is hard for some patients to follow programs based on several components. We examined the feasibility of a bimodal intervention, including a psycho-educational component and exercises, to support patients and their caregivers in managing CC; Methods: Prospective mixed-methods pilot study explored feasibility data, changes in patient-reported outcomes, and performance outcomes over time in a convenient sample of 30 consecutive CC patients and their caregivers. Results: Twenty-four dyads consented to participate. Twenty dyads received at least two psycho-educational sessions, so the psycho-educational component was feasible for 83.3% of the sample. Six dyads participated in at least fourteen out of twenty-seven rehabilitation sessions, so the exercise program was feasible for 25.0% of the sample. Six dyads showed compliance greater than 50% for both components of the bimodal intervention. Conclusions: While we did not meet our primary feasibility endpoint and had mixed acceptability, our experience provides insight into the challenges and lessons learned in implementing a primary palliative care intervention for CC. More robust studies are needed to help clinicians understand the best exercise program for CC patients, to be included in a multimodal intervention.<\/jats:p>","DOI":"10.3390\/cancers15072063","type":"journal-article","created":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T01:37:02Z","timestamp":1680226622000},"page":"2063","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Psycho-Educational and Rehabilitative Intervention to Manage Cancer Cachexia (PRICC) for Advanced Patients and Their Caregivers: Lessons Learned from a Single-Arm Feasibility Trial"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3627-8691","authenticated-orcid":false,"given":"Loredana","family":"Buonaccorso","sequence":"first","affiliation":[{"name":"Scientific Directorate, Azienda USL-IRCSS di Reggio Emilia, 42122 Reggio Emilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6435-9504","authenticated-orcid":false,"given":"Stefania","family":"Fugazzaro","sequence":"additional","affiliation":[{"name":"Physical Medicine and Rehabilitation Unit, Azienda USL-IRCSS di Reggio Emilia, 42122 Reggio Emilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Autelitano","sequence":"additional","affiliation":[{"name":"Palliative Care Unit, Azienda USL-IRCSS di Reggio Emilia, 42122 Reggio Emilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9595-6384","authenticated-orcid":false,"given":"Elisabetta","family":"Bertocchi","sequence":"additional","affiliation":[{"name":"Palliative Care Unit, Azienda USL-IRCSS di Reggio Emilia, 42122 Reggio Emilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monia Allisen","family":"Accogli","sequence":"additional","affiliation":[{"name":"Physical Medicine and Rehabilitation Unit, Azienda USL-IRCSS di Reggio Emilia, 42122 Reggio Emilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Denti","sequence":"additional","affiliation":[{"name":"Physical Medicine and Rehabilitation Unit, Azienda USL-IRCSS di Reggio Emilia, 42122 Reggio Emilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4645-0336","authenticated-orcid":false,"given":"Stefania","family":"Costi","sequence":"additional","affiliation":[{"name":"Physical Medicine and Rehabilitation Unit, Azienda USL-IRCSS di Reggio Emilia, 42122 Reggio Emilia, Italy"},{"name":"Department of Surgery, Medicine, Dentistry and Morphological Sciences, University of Modena and Reggio Emilia, Via del Pozzo No. 74, 41100 Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6153-5525","authenticated-orcid":false,"given":"Gianfranco","family":"Martucci","sequence":"additional","affiliation":[{"name":"Local Network of Palliative Care, AUSL Modena, 41100 Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8225-2938","authenticated-orcid":false,"given":"Luca","family":"Braglia","sequence":"additional","affiliation":[{"name":"Scientific Directorate, Azienda USL-IRCSS di Reggio Emilia, 42122 Reggio Emilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Chiara","family":"Bassi","sequence":"additional","affiliation":[{"name":"Medical Library, Azienda USL-IRCSS di Reggio Emilia, 42122 Reggio Emilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5798-5064","authenticated-orcid":false,"given":"Silvia","family":"Tanzi","sequence":"additional","affiliation":[{"name":"Palliative Care Unit, Azienda USL-IRCSS di Reggio Emilia, 42122 Reggio Emilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nrclinonc.2012.209","article-title":"Understanding the Mechanisms and Treatment Options in Cancer Cachexia","volume":"10","author":"Fearon","year":"2013","journal-title":"Nat. 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