{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T23:45:23Z","timestamp":1783813523216,"version":"3.55.0"},"reference-count":54,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T00:00:00Z","timestamp":1681344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Haihe Laboratory of Cell Ecosystem Innovation Fund","award":["HH22KYZX0030"],"award-info":[{"award-number":["HH22KYZX0030"]}]},{"name":"Haihe Laboratory of Cell Ecosystem Innovation Fund","award":["82130006"],"award-info":[{"award-number":["82130006"]}]},{"name":"Haihe Laboratory of Cell Ecosystem Innovation Fund","award":["82170202"],"award-info":[{"award-number":["82170202"]}]},{"name":"Haihe Laboratory of Cell Ecosystem Innovation Fund","award":["2022ZZTS0225"],"award-info":[{"award-number":["2022ZZTS0225"]}]},{"name":"Natural Science Foundation of China","award":["HH22KYZX0030"],"award-info":[{"award-number":["HH22KYZX0030"]}]},{"name":"Natural Science Foundation of China","award":["82130006"],"award-info":[{"award-number":["82130006"]}]},{"name":"Natural Science Foundation of China","award":["82170202"],"award-info":[{"award-number":["82170202"]}]},{"name":"Natural Science Foundation of China","award":["2022ZZTS0225"],"award-info":[{"award-number":["2022ZZTS0225"]}]},{"name":"Fundamental Research Fund for Graduate of Central South University","award":["HH22KYZX0030"],"award-info":[{"award-number":["HH22KYZX0030"]}]},{"name":"Fundamental Research Fund for Graduate of Central South University","award":["82130006"],"award-info":[{"award-number":["82130006"]}]},{"name":"Fundamental Research Fund for Graduate of Central South University","award":["82170202"],"award-info":[{"award-number":["82170202"]}]},{"name":"Fundamental Research Fund for Graduate of Central South University","award":["2022ZZTS0225"],"award-info":[{"award-number":["2022ZZTS0225"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Hematological malignancies are diverse, with high malignancy characteristics, poor prognoses, and high mortality rates. The development of hematological malignancies is driven by genetic factors, tumor microenvironment factors, or metabolic factors; however, even when considering all of these factors, one still cannot fully estimate the risk of hematological malignancies. Several recent studies have demonstrated an intimate connection between intestinal microbes and the progression of hematological malignancies, and gut microbes play a primary role in the initiation and progression of hematological tumors through direct and indirect mechanisms. Thus, we summarize the correlation between intestinal microbes and hematological malignancies\u2019 onset, progression, and therapeutic effect in order to better understand how intestinal microbes affect their initiation and progression, especially in leukemia, lymphoma, and multiple myeloma, which may provide potential therapeutic targets for improving the survival of patients with hematological malignancies.<\/jats:p>","DOI":"10.3390\/cancers15082284","type":"journal-article","created":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T01:32:03Z","timestamp":1681435923000},"page":"2284","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Intestinal Microbes and Hematological Malignancies"],"prefix":"10.3390","volume":"15","author":[{"given":"Yinghong","family":"Zhu","sequence":"first","affiliation":[{"name":"Haihe Laboratory of Cell Ecosystem, State Key Laboratory of Experimental Hematology, National Clinical Research Center for Geriatric Disorders, Department of Hematology, Xiangya Hospital, Central South University, Changsha 410008, China"},{"name":"Key Laboratory for Carcinogenesis and Invasion, Chinese Ministry of Education, Key Laboratory of Carcinogenesis, Chinese Ministry of Health, Cancer Research Institute, School of Basic Medical Sciences, Central South University, Changsha 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaohui","family":"Yang","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Human Stem and Reproductive Engineering, School of Basic Medical Science, Central South University, Changsha 410205, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1226-3671","authenticated-orcid":false,"given":"Qin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Third Xiangya Hospital, Central South University, Changsha 410013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjuan","family":"He","sequence":"additional","affiliation":[{"name":"Haihe Laboratory of Cell Ecosystem, State Key Laboratory of Experimental Hematology, National Clinical Research Center for Geriatric Disorders, Department of Hematology, Xiangya Hospital, Central South University, Changsha 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0834-9306","authenticated-orcid":false,"given":"Wen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Haihe Laboratory of Cell Ecosystem, State Key Laboratory of Experimental Hematology, National Clinical Research Center for Geriatric Disorders, Department of Hematology, Xiangya Hospital, Central South University, Changsha 410008, China"},{"name":"Key Laboratory for Carcinogenesis and Invasion, Chinese Ministry of Education, Key Laboratory of Carcinogenesis, Chinese Ministry of Health, Cancer Research Institute, School of Basic Medical Sciences, Central South University, Changsha 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1182\/blood-2016-01-643569","article-title":"The 2016 revision of the World Health Organization classification of lymphoid neoplasms","volume":"127","author":"Swerdlow","year":"2016","journal-title":"Blood"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1038\/480S33a","article-title":"Multiple myeloma","volume":"480","author":"Brody","year":"2011","journal-title":"Nature"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/modpathol.3880035","article-title":"The World Health Organization classification of hematological malignancies report of the Clinical Advisory Committee Meeting, Airlie House, Virginia, November 1997","volume":"13","author":"Harris","year":"2000","journal-title":"Mod. 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