{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:29:27Z","timestamp":1790688567306,"version":"4.1.0"},"reference-count":59,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T00:00:00Z","timestamp":1681862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"GIRCI"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Ophthalmic malignancies include various rare neoplasms involving the conjunctiva, the uvea, or the periocular area. These tumors are characterized by their scarcity as well as their histological, and sometimes genetic, diversity. Uveal melanoma (UM) is the most common primary intraocular malignancy. UM raises three main challenges highlighting the specificity of ophthalmic malignancies. First, UM is a very rare malignancy with an estimated incidence of 6 cases per million inhabitants. Second, tissue biopsy is not routinely recommended due to the risk of extraocular dissemination. Third, UM is an aggressive cancer because it is estimated that about 50% of patients will experience metastatic spread without any curative treatment available at this stage. These challenges better explain the two main objectives in the creation of a dedicated UM biobank. First, collecting UM samples is essential due to tissue scarcity. Second, large-scale translational research programs based on stored human samples will help to better determine UM pathogenesis with the aim of identifying new biomarkers, allowing for early diagnosis and new targeted treatment modalities. Other periocular malignancies, such as conjunctival melanomas or orbital malignancies, also raise specific concerns. In this context, the number of biobanks worldwide dedicated to ocular malignancies is very limited. The aims of this article were (i) to describe the specific challenges raised by a dedicated ocular malignancy biobank, (ii) to report our experience in setting up such a biobank, and (iii) to discuss future perspectives in this field.<\/jats:p>","DOI":"10.3390\/cancers15082372","type":"journal-article","created":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T04:22:51Z","timestamp":1681878171000},"page":"2372","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Need for a Dedicated Ophthalmic Malignancy Clinico-Biological Biobank: The Nice Ocular MAlignancy (NOMA) Biobank"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3836-7126","authenticated-orcid":false,"given":"Arnaud","family":"Martel","sequence":"first","affiliation":[{"name":"Ophthalmology Department, Nice University Hospital, 06001 Nice, France"},{"name":"Institute of Research on Cancer and Aging in Nice (IRCAN), Team 4, Centre Antoine Lacassagne, Centre National de la Recherche Scientifique (CNRS), Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), F\u00e9d\u00e9ration Hospitalo-Universitaire (FHU) OncoAge, C\u00f4te d\u2019Azur University, 06189 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauris","family":"Gastaud","sequence":"additional","affiliation":[{"name":"Oncology Department, Antoine Lacassagne Cancer Centre, 06000 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christelle","family":"Bonnetaud","sequence":"additional","affiliation":[{"name":"Hospital-Integrated Biobank (BB-0033-00025), Centre Hospitalier Universitaire de Nice, F\u00e9d\u00e9ration Hospitalo-Universitaire (FHU) OncoAge, C\u00f4te d\u2019Azur University, CEDEX 1, 06001 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2274-0256","authenticated-orcid":false,"given":"Sacha","family":"Nahon-Esteve","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Nice University Hospital, 06001 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Washetine","sequence":"additional","affiliation":[{"name":"Hospital-Integrated Biobank (BB-0033-00025), Centre Hospitalier Universitaire de Nice, F\u00e9d\u00e9ration Hospitalo-Universitaire (FHU) OncoAge, C\u00f4te d\u2019Azur University, CEDEX 1, 06001 Nice, France"},{"name":"Laboratory of Clinical and Experimental Pathology, Centre Hospitalier Universitaire de Nice, F\u00e9d\u00e9ration Hospitalo-Universitaire (FHU) OncoAge, C\u00f4te d\u2019Azur University, 06000 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Bordone","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical and Experimental Pathology, Centre Hospitalier Universitaire de Nice, F\u00e9d\u00e9ration Hospitalo-Universitaire (FHU) OncoAge, C\u00f4te d\u2019Azur University, 06000 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Salah","sequence":"additional","affiliation":[{"name":"Hospital-Integrated Biobank (BB-0033-00025), Centre Hospitalier Universitaire de Nice, F\u00e9d\u00e9ration Hospitalo-Universitaire (FHU) OncoAge, C\u00f4te d\u2019Azur University, CEDEX 1, 06001 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Tanga","sequence":"additional","affiliation":[{"name":"Hospital-Integrated Biobank (BB-0033-00025), Centre Hospitalier Universitaire de Nice, F\u00e9d\u00e9ration Hospitalo-Universitaire (FHU) OncoAge, C\u00f4te d\u2019Azur University, CEDEX 1, 06001 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Fayada","sequence":"additional","affiliation":[{"name":"Hospital-Integrated Biobank (BB-0033-00025), Centre Hospitalier Universitaire de Nice, F\u00e9d\u00e9ration Hospitalo-Universitaire (FHU) OncoAge, C\u00f4te d\u2019Azur University, CEDEX 1, 06001 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Lespinet","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical and Experimental Pathology, Centre Hospitalier Universitaire de Nice, F\u00e9d\u00e9ration Hospitalo-Universitaire (FHU) OncoAge, C\u00f4te d\u2019Azur University, 06000 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryline","family":"Allegra","sequence":"additional","affiliation":[{"name":"Hospital-Integrated Biobank (BB-0033-00025), Centre Hospitalier Universitaire de Nice, F\u00e9d\u00e9ration Hospitalo-Universitaire (FHU) OncoAge, C\u00f4te d\u2019Azur University, CEDEX 1, 06001 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salome","family":"Lalvee","sequence":"additional","affiliation":[{"name":"Hospital-Integrated Biobank (BB-0033-00025), Centre Hospitalier Universitaire de Nice, F\u00e9d\u00e9ration Hospitalo-Universitaire (FHU) OncoAge, C\u00f4te d\u2019Azur University, CEDEX 1, 06001 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Zahaf","sequence":"additional","affiliation":[{"name":"Hospital-Integrated Biobank (BB-0033-00025), Centre Hospitalier Universitaire de Nice, F\u00e9d\u00e9ration Hospitalo-Universitaire (FHU) OncoAge, C\u00f4te d\u2019Azur University, CEDEX 1, 06001 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1700-8570","authenticated-orcid":false,"given":"Stephanie","family":"Baillif","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Nice University Hospital, 06001 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corine","family":"Bertolotto","sequence":"additional","affiliation":[{"name":"C3M, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), C\u00f4te d\u2019Azur University, 06200 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1025-3429","authenticated-orcid":false,"given":"Baharia","family":"Mograbi","sequence":"additional","affiliation":[{"name":"Institute of Research on Cancer and Aging in Nice (IRCAN), Team 4, Centre Antoine Lacassagne, Centre National de la Recherche Scientifique (CNRS), Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), F\u00e9d\u00e9ration Hospitalo-Universitaire (FHU) OncoAge, C\u00f4te d\u2019Azur University, 06189 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Lassalle","sequence":"additional","affiliation":[{"name":"Institute of Research on Cancer and Aging in Nice (IRCAN), Team 4, Centre Antoine Lacassagne, Centre National de la Recherche Scientifique (CNRS), Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), F\u00e9d\u00e9ration Hospitalo-Universitaire (FHU) OncoAge, C\u00f4te d\u2019Azur University, 06189 Nice, France"},{"name":"Hospital-Integrated Biobank (BB-0033-00025), Centre Hospitalier Universitaire de Nice, F\u00e9d\u00e9ration Hospitalo-Universitaire (FHU) OncoAge, C\u00f4te d\u2019Azur University, CEDEX 1, 06001 Nice, France"},{"name":"Laboratory of Clinical and Experimental Pathology, Centre Hospitalier Universitaire de Nice, F\u00e9d\u00e9ration Hospitalo-Universitaire (FHU) OncoAge, C\u00f4te d\u2019Azur University, 06000 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0431-9353","authenticated-orcid":false,"given":"Paul","family":"Hofman","sequence":"additional","affiliation":[{"name":"Institute of Research on Cancer and Aging in Nice (IRCAN), Team 4, Centre Antoine Lacassagne, Centre National de la Recherche Scientifique (CNRS), Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), F\u00e9d\u00e9ration Hospitalo-Universitaire (FHU) OncoAge, C\u00f4te d\u2019Azur University, 06189 Nice, France"},{"name":"Hospital-Integrated Biobank (BB-0033-00025), Centre Hospitalier Universitaire de Nice, F\u00e9d\u00e9ration Hospitalo-Universitaire (FHU) OncoAge, C\u00f4te d\u2019Azur University, CEDEX 1, 06001 Nice, France"},{"name":"Laboratory of Clinical and Experimental Pathology, Centre Hospitalier Universitaire de Nice, F\u00e9d\u00e9ration Hospitalo-Universitaire (FHU) OncoAge, C\u00f4te d\u2019Azur University, 06000 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Nahon-Est\u00e8ve, S., Bertolotto, C., Picard-Gauci, A., Gastaud, L., Baillif, S., Hofman, P., Groulier, A., Maschi, C., Caujolle, J.-P., and Lassalle, S. (2021). Small but Challenging Conjunctival Melanoma: New Insights, Paradigms and Future Perspectives. Cancers, 13.","DOI":"10.3390\/cancers13225691"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s41572-020-0158-0","article-title":"Uveal Melanoma","volume":"6","author":"Jager","year":"2020","journal-title":"Nat. Rev. Dis. Primer"},{"key":"ref_3","first-page":"241","article-title":"Uveal Melanoma: Relatively Rare but Deadly Cancer","volume":"31","author":"Kaliki","year":"2017","journal-title":"Eye Lond. Engl."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1136\/bjophthalmol-2016-309034","article-title":"Metastatic Disease from Uveal Melanoma: Treatment Options and Future Prospects","volume":"101","author":"Carvajal","year":"2017","journal-title":"Br. J. Ophthalmol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"7","DOI":"10.21037\/aes-21-30","article-title":"Animal Models of Uveal Melanoma","volume":"7","author":"Uner","year":"2022","journal-title":"Ann. Eye Sci."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Lamas, N.J., Martel, A., Nahon-Est\u00e8ve, S., Goffinet, S., Macocco, A., Bertolotto, C., Lassalle, S., and Hofman, P. (2021). Prognostic Biomarkers in Uveal Melanoma: The Status Quo, Recent Advances and Future Directions. Cancers, 14.","DOI":"10.3390\/cancers14010096"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1089\/bio.2013.0042","article-title":"Defining Biobank","volume":"11","author":"Hewitt","year":"2013","journal-title":"Biopreserv. Biobank"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s12967-019-1859-6","article-title":"FGB network The French Glioblastoma Biobank (FGB): A National Clinicobiological Database","volume":"17","author":"Clavreul","year":"2019","journal-title":"J. Transl. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"774624","DOI":"10.3389\/fmed.2021.774624","article-title":"The Xiangya Ocular Tumor Bank: A Disease-Specific Biobank for Advancing Translational Research into Ocular Tumors","volume":"8","author":"Gao","year":"2021","journal-title":"Front. Med."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Rodrigues, M., de Koning, L., Coupland, S.E., Jochemsen, A.G., Marais, R., Stern, M.-H., Valente, A., Barnhill, R., Cassoux, N., and Evans, A. (2019). So Close, yet so Far: Discrepancies between Uveal and Other Melanomas. A Position Paper from UM Cure 2020. Cancers, 11.","DOI":"10.3390\/cancers11071032"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1101\/gad.296962.117","article-title":"Focus on Cutaneous and Uveal Melanoma Specificities","volume":"31","author":"Pandiani","year":"2017","journal-title":"Genes Dev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1097\/ICU.0000000000000905","article-title":"Treatment of Metastatic Uveal Melanoma in 2022: Improved Treatment Regimens and Improved Prognosis","volume":"33","author":"Reichstein","year":"2022","journal-title":"Curr. Opin. Ophthalmol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s11912-017-0606-5","article-title":"Immunotherapy for the Treatment of Uveal Melanoma: Current Status and Emerging Therapies","volume":"19","author":"Komatsubara","year":"2017","journal-title":"Curr. Oncol. Rep."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1056\/NEJMoa2103485","article-title":"Overall Survival Benefit with Tebentafusp in Metastatic Uveal Melanoma","volume":"385","author":"Nathan","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1016\/j.ophtha.2011.01.040","article-title":"Uveal Melanoma: Trends in Incidence, Treatment, and Survival","volume":"118","author":"Singh","year":"2011","journal-title":"Ophthalmology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"100800","DOI":"10.1016\/j.preteyeres.2019.100800","article-title":"Uveal Melanoma: Towards a Molecular Understanding","volume":"75","author":"Smit","year":"2020","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"St\u00e5lhammar, G., and Grossniklaus, H.E. (2021). Intratumor Heterogeneity in Uveal Melanoma BAP-1 Expression. Cancers, 13.","DOI":"10.3390\/cancers13051143"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1167\/iovs.08-2296","article-title":"Genomic Profiling and Identification of High-Risk Uveal Melanoma by Array CGH Analysis of Primary Tumors and Liver Metastases","volume":"50","author":"Trolet","year":"2009","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1016\/j.ophtha.2012.02.017","article-title":"Collaborative Ocular Oncology Group Report Number 1: Prospective Validation of a Multi-Gene Prognostic Assay in Uveal Melanoma","volume":"119","author":"Onken","year":"2012","journal-title":"Ophthalmology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"100971","DOI":"10.1016\/j.preteyeres.2021.100971","article-title":"Conjunctival Melanoma: New Insights in Tumour Genetics and Immunology, Leading to New Therapeutic Options","volume":"86","author":"Brouwer","year":"2022","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1159\/000480640","article-title":"Uveal Melanoma: 5-Year Update on Incidence, Treatment, and Survival (SEER 1973\u20132013)","volume":"4","author":"Aronow","year":"2018","journal-title":"Ocul. Oncol. Pathol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1038\/s41433-021-01422-3","article-title":"Ocular Surface Squamous Neoplasia: Management and Outcomes","volume":"35","author":"Williams","year":"2021","journal-title":"Eye"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1038\/s41433-019-0437-8","article-title":"National Incidence of Eyelid Cancer in Ireland (2005\u20132015)","volume":"33","author":"Quigley","year":"2019","journal-title":"Eye"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Frizziero, L., Midena, E., Trainiti, S., Londei, D., Bonaldi, L., Bini, S., and Parrozzani, R. (2019). Uveal Melanoma Biopsy: A Review. Cancers, 11.","DOI":"10.3390\/cancers11081075"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ajo.2016.02.027","article-title":"Outcomes after Proton Beam Therapy for Large Choroidal Melanomas in 492 Patients","volume":"165","author":"Bensoussan","year":"2016","journal-title":"Am. J. Ophthalmol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Martel, A., Baillif, S., Nahon-Esteve, S., Gastaud, L., Bertolotto, C., Rom\u00e9o, B., Mograbi, B., Lassalle, S., and Hofman, P. (2020). Liquid Biopsy for Solid Ophthalmic Malignancies: An Updated Review and Perspectives. Cancers, 12.","DOI":"10.3390\/cancers12113284"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"4469","DOI":"10.1158\/1078-0432.CCR-08-0012","article-title":"Visualization of Circulating Melanoma Cells in Peripheral Blood of Patients with Primary Uveal Melanoma","volume":"14","author":"Ulmer","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1002\/ijc.28436","article-title":"Detection Rate and Prognostic Value of Circulating Tumor Cells and Circulating Tumor DNA in Metastatic Uveal Melanoma","volume":"134","author":"Bidard","year":"2014","journal-title":"Int. J. Cancer"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1167\/tvst.8.2.13","article-title":"Aqueous Humor Markers in Retinoblastoma, a Review","volume":"8","author":"Ghiam","year":"2019","journal-title":"Transl. Vis. Sci. Technol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.ophtha.2019.10.026","article-title":"Aqueous Humor Is Superior to Blood as a Liquid Biopsy for Retinoblastoma","volume":"127","author":"Berry","year":"2020","journal-title":"Ophthalmology"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"4740","DOI":"10.1167\/iovs.19-28309","article-title":"Aqueous Humor Biomarkers Identify Three Prognostic Groups in Uveal Melanoma","volume":"60","author":"Wierenga","year":"2019","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Im, D.H., Peng, C.-C., Xu, L., Kim, M.E., Ostrow, D., Yellapantula, V., Bootwalla, M., Biegel, J.A., Gai, X., and Prabakar, R.K. (2022). Potential of Aqueous Humor as a Liquid Biopsy for Uveal Melanoma. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23116226"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Washetine, K., Heeke, S., Bonnetaud, C., Kara-Borni, M., Ili\u00e9, M., Lassalle, S., Butori, C., Long-Mira, E., Marquette, C.H., and Cohen, C. (2018). Establishing a Dedicated Lung Cancer Biobank at the University Center Hospital of Nice (France). Why and How?. Cancers, 10.","DOI":"10.3390\/cancers10070220"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"De Blasio, P., and Biunno, I. (2021). New Challenges for Biobanks: Accreditation to the New ISO 20387:2018 Standard Specific for Biobanks. BioTech, 10.","DOI":"10.3390\/biotech10030013"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/978-3-319-20579-3_3","article-title":"Sustainability of Biobanks in the Future","volume":"864","year":"2015","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1093\/jncimonographs\/lgr009","article-title":"Biobankonomics: Developing a Sustainable Business Model Approach for the Formation of a Human Tissue Biobank","volume":"2011","author":"Vaught","year":"2011","journal-title":"J. Natl. Cancer Inst. Monogr."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/978-1-4939-8935-5_2","article-title":"An Introduction to Starting a Biobank","volume":"Volume 1897","author":"Harati","year":"2019","journal-title":"Methods Molecular Biology"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00428-013-1524-z","article-title":"Public-Private Relationships in Biobanking: A Still Underestimated Key Component of Open Innovation","volume":"464","author":"Hofman","year":"2014","journal-title":"Virchows Arch. Int. J. Pathol."},{"key":"ref_39","first-page":"261fs45","article-title":"Public Biobanks: Calculation and Recovery of Costs","volume":"6","author":"Yuille","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.bulcan.2018.07.011","article-title":"Management of uveal melanomas, guidelines for oncologists","volume":"105","author":"Mathis","year":"2018","journal-title":"Bull. Cancer"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1684\/bdc.2014.2041","article-title":"Immunohistochemistry and personalised medicine in lung oncology: Advantages and limitations","volume":"101","author":"Hofman","year":"2014","journal-title":"Bull. Cancer"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1089\/bio.2022.0076","article-title":"Utilizing Modular Biobanking Software in Different Types of Biobanking Activities","volume":"20","author":"Jacotot","year":"2022","journal-title":"Biopreservation Biobanking"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1167\/iovs.13-13670","article-title":"The Prognostic Value of Extraocular Extension in Relation to Monosomy 3 and Gain of Chromosome 8q in Uveal Melanoma","volume":"55","author":"Koopmans","year":"2014","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.ophtha.2017.08.017","article-title":"Adjuvant Sunitinib in High-Risk Patients with Uveal Melanoma: Comparison with Institutional Controls","volume":"125","author":"Valsecchi","year":"2018","journal-title":"Ophthalmology"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"5956","DOI":"10.1167\/iovs.15-17092","article-title":"Radiation Treatment Affects Chromosome Testing in Uveal Melanoma","volume":"56","author":"Kroes","year":"2015","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1136\/bjophthalmol-2015-307057","article-title":"Concordant Chromosome 3 Results in Paired Choroidal Melanoma Biopsies and Subsequent Tumour Resection Specimens","volume":"99","author":"Coupland","year":"2015","journal-title":"Br. J. Ophthalmol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1136\/bjophthalmol-2019-315363","article-title":"Effects of Plaque Brachytherapy and Proton Beam Radiotherapy on Prognostic Testing: A Comparison of Uveal Melanoma Genotyped by Microsatellite Analysis","volume":"104","author":"Thornton","year":"2020","journal-title":"Br. J. Ophthalmol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/s40265-022-01704-4","article-title":"Tebentafusp: First Approval","volume":"82","author":"Dhillon","year":"2022","journal-title":"Drugs"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Lassalle, S., Nahon-Esteve, S., Frouin, E., Boulagnon-Rombi, C., Josselin, N., Cassoux, N., Barnhill, R., Scheller, B., Baillif, S., and Hofman, P. (2020). PD-L1 Expression in 65 Conjunctival Melanomas and Its Association with Clinical Outcome. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21239147"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1038\/s41418-020-00730-7","article-title":"Single-Cell RNA Sequencing Reveals Intratumoral Heterogeneity in Primary Uveal Melanomas and Identifies HES6 as a Driver of the Metastatic Disease","volume":"28","author":"Pandiani","year":"2021","journal-title":"Cell Death Differ."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"4374","DOI":"10.7150\/thno.72966","article-title":"Recent Advances in Understanding the Role of HES6 in Cancers","volume":"12","author":"Krossa","year":"2022","journal-title":"Theranostics"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.survophthal.2021.01.008","article-title":"Orbital Exenteration: An Updated Review with Perspectives","volume":"66","author":"Martel","year":"2021","journal-title":"Surv. Ophthalmol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Martel, A., Lassalle, S., Picard-Gauci, A., Gastaud, L., Montaudie, H., Bertolotto, C., Nahon-Esteve, S., Poissonnet, G., Hofman, P., and Baillif, S. (2021). New Targeted Therapies and Immunotherapies for Locally Advanced Periocular Malignant Tumours: Towards a New \u201cEye-Sparing\u201d Paradigm?. Cancers, 13.","DOI":"10.3390\/cancers13112822"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1007\/s00417-021-05155-7","article-title":"Efficacy and Safety of an Artificial Dermal Graft for the Reconstruction of Exenterated Sockets: A Preliminary Report","volume":"259","author":"Monjanel","year":"2021","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"100968","DOI":"10.1016\/j.preteyeres.2021.100968","article-title":"Translation of Single-Cell Transcriptomic Analysis of Uveal Melanomas to Clinical Oncology","volume":"85","author":"Strub","year":"2021","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41420-020-0259-2","article-title":"Endoplasmic Reticulum Stress Mediates Resistance to BCL-2 Inhibitor in Uveal Melanoma Cells","volume":"6","author":"Bellini","year":"2020","journal-title":"Cell Death Discov."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Thariat, J., Martel, A., Matet, A., Loria, O., Kodjikian, L., Nguyen, A.-M., Rosier, L., Herault, J., Nahon-Est\u00e8ve, S., and Mathis, T. (2022). Non-Cancer Effects Following Ionizing Irradiation Involving the Eye and Orbit. Cancers, 14.","DOI":"10.3390\/cancers14051194"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1136\/bjophthalmol-2021-319091","article-title":"Phantom Vision after Eye Removal: Prevalence, Features and Related Risk Factors","volume":"106","author":"Martel","year":"2022","journal-title":"Br. J. Ophthalmol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.jfo.2017.11.027","article-title":"Clinical, radiological, pathological features, treatment and follow-up of periocular and\/or orbital amyloidosis: Report of 6 cases and literature review","volume":"41","author":"Martel","year":"2018","journal-title":"J. Fr. Ophtalmol."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/15\/8\/2372\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:18:45Z","timestamp":1760123925000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/15\/8\/2372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,19]]},"references-count":59,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2023,4]]}},"alternative-id":["cancers15082372"],"URL":"https:\/\/doi.org\/10.3390\/cancers15082372","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,19]]}}}