{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T22:52:31Z","timestamp":1788303151464,"version":"build-2803163510"},"reference-count":208,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T00:00:00Z","timestamp":1682121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European\u2019s Union Horizon 2020 research and innovation program","award":["860245"],"award-info":[{"award-number":["860245"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Radiotherapy is one of the standard treatment approaches used against thoracic cancers, occasionally combined with chemotherapy, immunotherapy and molecular targeted therapy. However, these cancers are often not highly sensitive to standard of care treatments, making the use of high dose radiotherapy necessary, which is linked with high rates of radiation-induced adverse effects in healthy tissues of the thorax. These tissues remain therefore dose-limiting factors in radiation oncology despite recent technological advances in treatment planning and delivery of irradiation. Polyphenols are metabolites found in plants that have been suggested to improve the therapeutic window by sensitizing the tumor to radiotherapy, while simultaneously protecting normal cells from therapy-induced damage by preventing DNA damage, as well as having anti-oxidant, anti-inflammatory or immunomodulatory properties. This review focuses on the radioprotective effect of polyphenols and the molecular mechanisms underlying these effects in the normal tissue, especially in the lung, heart and esophagus.<\/jats:p>","DOI":"10.3390\/cancers15092412","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T02:06:11Z","timestamp":1682301971000},"page":"2412","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Polyphenols as Potential Protectors against Radiation-Induced Adverse Effects in Patients with Thoracic Cancer"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2834-967X","authenticated-orcid":false,"given":"\u00c8lia","family":"Prades-Sagarra","sequence":"first","affiliation":[{"name":"The M-Lab, Department of Precision Medicine, GROW\u2014School for Oncology and Reproduction, Maastricht University, 6229 ER Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3900-5314","authenticated-orcid":false,"given":"Ala","family":"Yaromina","sequence":"additional","affiliation":[{"name":"The M-Lab, Department of Precision Medicine, GROW\u2014School for Oncology and Reproduction, Maastricht University, 6229 ER Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8887-4137","authenticated-orcid":false,"given":"Ludwig J.","family":"Dubois","sequence":"additional","affiliation":[{"name":"The M-Lab, Department of Precision Medicine, GROW\u2014School for Oncology and Reproduction, Maastricht University, 6229 ER Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.addr.2017.01.004","article-title":"Radiotherapy for Cancer: Present and Future","volume":"109","author":"Allen","year":"2017","journal-title":"Adv. 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