{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:05:58Z","timestamp":1760148358148,"version":"build-2065373602"},"reference-count":50,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T00:00:00Z","timestamp":1682467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R21 OD026618","P20GM125503"],"award-info":[{"award-number":["1R21 OD026618","P20GM125503"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences of the National Institutes of Health","doi-asserted-by":"publisher","award":["1R21 OD026618","P20GM125503"],"award-info":[{"award-number":["1R21 OD026618","P20GM125503"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Multiple myeloma (MM) is the second most common hematological malignancy. It is a clonal B-cell disorder characterized by the proliferation of malignant plasma cells in the bone marrow, the presence of monoclonal serum immunoglobulin, and osteolytic lesions. An increasing amount of evidence shows that the interactions of MM cells and the bone microenvironment play a significant role, suggesting that these interactions may be good targets for therapy. The osteopontin-derived collagen-binding motif-bearing peptide NIPEP-OSS stimulates biomineralization and enhances bone remodeling dynamics. Due to its unique targeted osteogenic activity with a broad safety margin, we evaluated the potential of NIPEP-OSS for anti-myeloma activity using MM bone disease (MMBD) animal models. In a 5TGM1-engrafted NSG model, the survival rates of the control and treated groups were significantly different (p = 0.0014), with median survival times of 45 and 57 days, respectively. The bioluminescence analyses showed that myeloma slowly developed in the treated mice compared to the control mice in both models. NIPEP-OSS enhanced bone formation by increasing biomineralization in the bone. We also tested NIPEP-OSS in a well-established 5TGM1-engrafted C57BL\/KaLwRij model. Similar to the previous model, the median survival times of the control and treated groups were significantly different (p = 0.0057), with 46 and 63 days, respectively. In comparison with the control, an increase in p1NP was found in the treated mice. We concluded that NIPEP-OSS delays mouse myeloma progression via bone formation in MMBD mouse models.<\/jats:p>","DOI":"10.3390\/cancers15092473","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T04:42:54Z","timestamp":1682484174000},"page":"2473","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Synthetic Collagen-Binding Peptide NIPEP-OSS Delays Mouse Myeloma Progression"],"prefix":"10.3390","volume":"15","author":[{"given":"Syed Hassan","family":"Mehdi","sequence":"first","affiliation":[{"name":"Myeloma Center, The University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Austin C.","family":"Gentry","sequence":"additional","affiliation":[{"name":"Myeloma Center, The University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jue-Yeon","family":"Lee","sequence":"additional","affiliation":[{"name":"Research Institute, NIBEC Co., Ltd., 174 Yulgok-ro, Jongno-gu, Seoul 03170, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chong-Pyoung","family":"Chung","sequence":"additional","affiliation":[{"name":"Research Institute, NIBEC Co., Ltd., 174 Yulgok-ro, Jongno-gu, Seoul 03170, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donghoon","family":"Yoon","sequence":"additional","affiliation":[{"name":"Myeloma Center, The University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0267-6605(93)90082-I","article-title":"Design of synthetic polymeric structures for cell transplantation and tissue engineering","volume":"13","author":"Cohen","year":"1993","journal-title":"Clin. 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