{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:02:17Z","timestamp":1792519337183,"version":"4.5.0"},"reference-count":30,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T00:00:00Z","timestamp":1682467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>The Baveno VII criteria are used in patients with liver cirrhosis to predict high-risk varices in patients with liver cirrhosis. Yet its use in patients with advanced hepatocellular carcinoma (HCC) has not been validated. HCC alone is accompanied with a higher variceal bleeding risk due to its association with liver cirrhosis and portal vein thrombosis. The use of systemic therapy in advanced HCC has been thought to further augment this risk. Upper endoscopy is commonly used to evaluate for the presence of varices before initiation of treatment with systemic therapy. Yet it is associated with procedural risks, waiting time and limited availability in some localities which may delay the commencement of systemic therapy. Our study successfully validated the Baveno VI criteria with a 3.5% varices needing treatment (VNT) missed rate, also with acceptable &lt;5% VNT missed rates when considering alternative liver stiffness (LSM) and platelet cut-offs. The Baveno VII clinically significant portal hypertension rule-out criteria (LSM &lt; 15 kPa and platelet &gt;150 \u00d7 109\/L) also revealed a low frequency (2%) of hepatic events, whilst the rule-in criteria (LSM &gt; 25 kPa) was predictive of a higher proportion of hepatic events (14%). Therefore, our study has successfully validated the Baveno VII criteria as a non-invasive stratification of the risk of variceal bleeding and hepatic decompensation in the HCC population.<\/jats:p>","DOI":"10.3390\/cancers15092480","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T04:42:54Z","timestamp":1682484174000},"page":"2480","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Baveno VII Criteria Is an Accurate Risk Stratification Tool to Predict High-Risk Varices Requiring Intervention and Hepatic Events in Patients with Advanced Hepatocellular Carcinoma"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1401-0173","authenticated-orcid":false,"given":"Claudia Wing-Kwan","family":"Wu","sequence":"first","affiliation":[{"name":"Medical Data Analytics Centre, Hong Kong SAR, China"},{"name":"Department of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong SAR, China"},{"name":"Institute of Digestive Disease, Prince of Wales Hospital, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1277-9595","authenticated-orcid":false,"given":"Rashid Nok-Shun","family":"Lui","sequence":"additional","affiliation":[{"name":"Medical Data Analytics Centre, Hong Kong SAR, China"},{"name":"Department of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong SAR, China"},{"name":"Institute of Digestive Disease, Prince of Wales Hospital, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent Wai-Sun","family":"Wong","sequence":"additional","affiliation":[{"name":"Medical Data Analytics Centre, Hong Kong SAR, China"},{"name":"Department of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong SAR, China"},{"name":"Institute of Digestive Disease, Prince of Wales Hospital, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsz-Fai","family":"Yam","sequence":"additional","affiliation":[{"name":"Medical Data Analytics Centre, Hong Kong SAR, China"},{"name":"Department of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong SAR, China"},{"name":"Institute of Digestive Disease, Prince of Wales Hospital, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry Cheuk-Fung","family":"Yip","sequence":"additional","affiliation":[{"name":"Medical Data Analytics Centre, Hong Kong SAR, China"},{"name":"Department of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong SAR, China"},{"name":"Institute of Digestive Disease, Prince of Wales Hospital, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0453-3168","authenticated-orcid":false,"given":"Ken","family":"Liu","sequence":"additional","affiliation":[{"name":"AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5749-1598","authenticated-orcid":false,"given":"Jimmy Che-To","family":"Lai","sequence":"additional","affiliation":[{"name":"Medical Data Analytics Centre, Hong Kong SAR, China"},{"name":"Department of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong SAR, China"},{"name":"Institute of Digestive Disease, Prince of Wales Hospital, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yee-Kit","family":"Tse","sequence":"additional","affiliation":[{"name":"Medical Data Analytics Centre, Hong Kong SAR, China"},{"name":"Department of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong SAR, China"},{"name":"Institute of Digestive Disease, Prince of Wales Hospital, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony Shu-Kam","family":"Mok","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Translational Oncology, Department of Clinical Oncology, The Hong Kong Cancer Institute, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7790-1611","authenticated-orcid":false,"given":"Henry Lik-Yuen","family":"Chan","sequence":"additional","affiliation":[{"name":"Medical Data Analytics Centre, Hong Kong SAR, China"},{"name":"Union Hospital, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3679-6368","authenticated-orcid":false,"given":"Kelvin Kwok-Chai","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Surgery, The Chinese University of Hong Kong, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2863-9389","authenticated-orcid":false,"given":"Grace Lai-Hung","family":"Wong","sequence":"additional","affiliation":[{"name":"Medical Data Analytics Centre, Hong Kong SAR, China"},{"name":"Department of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong SAR, China"},{"name":"Institute of Digestive Disease, Prince of Wales Hospital, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8998-5480","authenticated-orcid":false,"given":"Stephen Lam","family":"Chan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Translational Oncology, Department of Clinical Oncology, The Hong Kong Cancer Institute, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.cgh.2006.08.011","article-title":"Prevalence and prognostic significance of the presence of esophageal varices in patients with hepatocellular carcinoma","volume":"4","author":"Giannini","year":"2006","journal-title":"Clin. 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