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It remains unclear as to what has led to an increase in incidences of NHL, however, chemical substance exposure is known to be one of the risk factors for the disease. Therefore, we performed a systematic review and meta-analysis including case-control, cohort, and cross-sectional observational epidemiological studies to verify the association between occupational exposure to carcinogens and NHL risk. Articles between the years 2000 and 2020 were collected. Two different reviewers performed a blind selection of the studies using the Rayyan QCRI web app. Post-completion, the selected articles were extracted and analyzed via the RedCap platform. Our review resulted in 2719 articles, of which 51 were included in the meta-analysis, resulting in an overall OR of 1.27 (95% CI 1.04\u20131.55). Furthermore, it was observed that the main occupation associated with the increased risk of NHL was that in which workers are exposed to pesticides. We therefore conclude that the evidence synthesis of the epidemiological literature supports an increased risk for NHL, regardless of subtype, considering occupational exposure to certain chemical compounds, mainly pesticides, benzene, and trichlorethylene, and certain classes of work, primarily in the field of agriculture.<\/jats:p>","DOI":"10.3390\/cancers15092600","type":"journal-article","created":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T02:08:42Z","timestamp":1683252522000},"page":"2600","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Occupational Exposures and Risks of Non-Hodgkin Lymphoma: A Meta-Analysis"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0211-6659","authenticated-orcid":false,"given":"Luiza Flavia Veiga","family":"Francisco","sequence":"first","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-390, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rog\u00e9rio Nunes","family":"da Silva","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Environment and Health, University of Cuiab\u00e1, Cuiab\u00e1 78008-000, MT, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Ant\u00f4nio","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-390, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martins Fideles","family":"dos Santos Neto","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-390, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iara Zapparoli","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Hematology Department, Barretos Cancer Hospital, Barretos 14784-390, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5616-6710","authenticated-orcid":false,"given":"M\u00e1rcia M. C.","family":"Marques","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-390, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8607-6206","authenticated-orcid":false,"given":"Henrique C. S.","family":"Silveira","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-390, SP, Brazil"},{"name":"Postgraduate Program in Environment and Health, University of Cuiab\u00e1, Cuiab\u00e1 78008-000, MT, Brazil"},{"name":"Campus S\u00e3o Paulo, University of Anhanguera, S\u00e3o Paulo 04119-901, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/j.mayocp.2015.04.025","article-title":"Non-Hodgkin Lymphoma: Diagnosis and Treatment","volume":"90","author":"Ansell","year":"2015","journal-title":"Mayo Clin. 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