{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T11:14:36Z","timestamp":1793272476697,"version":"4.5.0"},"reference-count":29,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T00:00:00Z","timestamp":1684195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Wellcome\/EPSRC Centre for Interventional and Surgical Sciences","award":["203145\/Z\/16\/Z"],"award-info":[{"award-number":["203145\/Z\/16\/Z"]}]},{"name":"UCLH\/UCL Biomedical Research Centre","award":["203145\/Z\/16\/Z"],"award-info":[{"award-number":["203145\/Z\/16\/Z"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Post-operative endocrine outcomes in patients with non-functioning pituitary adenoma (NFPA) are variable. The aim of this study was to use machine learning (ML) models to better predict medium- and long-term post-operative hypopituitarism in patients with NFPAs. We included data from 383 patients who underwent surgery with or without radiotherapy for NFPAs, with a follow-up period between 6 months and 15 years. ML models, including k-nearest neighbour (KNN), support vector machine (SVM), and decision tree models, showed a superior ability to predict panhypopituitarism compared with non-parametric statistical modelling (mean accuracy: 0.89; mean AUC-ROC: 0.79), with SVM achieving the highest performance (mean accuracy: 0.94; mean AUC-ROC: 0.88). Pre-operative endocrine function was the strongest feature for predicting panhypopituitarism within 1 year post-operatively, while endocrine outcomes at 1 year post-operatively supported strong predictions of panhypopituitarism at 5 and 10 years post-operatively. Other features found to contribute to panhypopituitarism prediction were age, volume of tumour, and the use of radiotherapy. In conclusion, our study demonstrates that ML models show potential in predicting post-operative panhypopituitarism in the medium and long term in patients with NFPM. Future work will include incorporating additional, more granular data, including imaging and operative video data, across multiple centres.<\/jats:p>","DOI":"10.3390\/cancers15102771","type":"journal-article","created":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T02:27:04Z","timestamp":1684204024000},"page":"2771","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Post-Operative Medium- and Long-Term Endocrine Outcomes in Patients with Non-Functioning Pituitary Adenomas\u2014Machine Learning Analysis"],"prefix":"10.3390","volume":"15","author":[{"given":"Ziad","family":"Hussein","sequence":"first","affiliation":[{"name":"Department of Diabetes & Endocrinology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield S10 2JF, UK"},{"name":"Department of Diabetes & Endocrinology, University College London Hospital, London NW1 2BU, UK"},{"name":"Centre for Obesity & Metabolism, Department of Experimental & Translational Medicine, Division of Medicine, University College London, London WC1N 3BG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"Slack","sequence":"additional","affiliation":[{"name":"Wellcome\/EPSRC Centre for Interventional and Surgical Sciences, University College London, London W1W 7TY, UK"},{"name":"Department of Medical Physics and Biomedical Engineering, University College London, London WC1E 6BT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8000-392X","authenticated-orcid":false,"given":"Hani J.","family":"Marcus","sequence":"additional","affiliation":[{"name":"Wellcome\/EPSRC Centre for Interventional and Surgical Sciences, University College London, London W1W 7TY, UK"},{"name":"Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London NW1 2BU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0357-5996","authenticated-orcid":false,"given":"Evangelos B.","family":"Mazomenos","sequence":"additional","affiliation":[{"name":"Wellcome\/EPSRC Centre for Interventional and Surgical Sciences, University College London, London W1W 7TY, UK"},{"name":"Department of Medical Physics and Biomedical Engineering, University College London, London WC1E 6BT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie E.","family":"Baldeweg","sequence":"additional","affiliation":[{"name":"Department of Diabetes & Endocrinology, University College London Hospital, London NW1 2BU, UK"},{"name":"Centre for Obesity & Metabolism, Department of Experimental & Translational Medicine, Division of Medicine, University College London, London WC1N 3BG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s11102-018-0869-3","article-title":"Epidemiology, clinical presentation and diagnosis of non-functioning pituitary adenomas","volume":"21","author":"Ntali","year":"2018","journal-title":"Pituitary"},{"key":"ref_2","unstructured":"Snyder, P.J. (2011). The Pituitary, Academic Press."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1159\/000339823","article-title":"Natural History of Postoperative Nonfunctioning Pituitary Adenomas: A Systematic Review and Meta-Analysis","volume":"96","author":"Chen","year":"2012","journal-title":"Neuroendocrinology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00701-003-0174-3","article-title":"Impact of primary surgery on pituitary function in patients with non-functioning pituitary adenomas\u2014A study on 721 patients","volume":"146","author":"Nomikos","year":"2004","journal-title":"Acta Neurochir."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1210\/jcem-62-6-1173","article-title":"Reversible Hypopituitarism in Patients with Large Nonfunctioning Pituitary Adenomas","volume":"62","author":"Arafah","year":"1986","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1159\/000522090","article-title":"Systematic Review Endocrine Function after Transsphenoidal Surgery in Patients with Non-Functioning Pituitary Adenomas: A Systematic Review and Meta-Analysis","volume":"112","author":"Pedersen","year":"2022","journal-title":"Neuroendocrinology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"589","DOI":"10.3171\/2015.1.JNS141543","article-title":"Improved versus worsened endocrine function after transsphenoidal surgery for nonfunctional pituitary adenomas: Rate, time course, and radiological analysis","volume":"124","author":"Jahangiri","year":"2016","journal-title":"J. Neurosurg."},{"key":"ref_8","unstructured":"Pekic, S., Miljic, D., Popovic, V., and Hypopituitarism Following Cranial Radiotherapy (2021, December 07). Endotext 2021, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK532082\/."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"748725","DOI":"10.3389\/fendo.2021.748725","article-title":"Machine-Learning Prediction of Postoperative Pituitary Hormonal Outcomes in Nonfunctioning Pituitary Adenomas: A Multicenter Study","volume":"12","author":"Fang","year":"2021","journal-title":"Front. Endocrinol."},{"key":"ref_10","first-page":"55","article-title":"Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD): The TRIPOD Statement","volume":"162","author":"Collins","year":"2015","journal-title":"BMC Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"972617","DOI":"10.1155\/2012\/972617","article-title":"Diagnosing Growth Hormone Deficiency in Adults","volume":"2012","author":"Glynn","year":"2012","journal-title":"Int. J. Endocrinol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1210\/edrv.19.2.0329","article-title":"The diagnosis of growth hormone deficiency in children and adults","volume":"19","author":"Shalet","year":"1998","journal-title":"Endocr. Rev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S0140-6736(21)00136-7","article-title":"Adrenal insufficiency","volume":"397","author":"Husebye","year":"2021","journal-title":"Lancet"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1016\/S0140-6736(03)13492-7","article-title":"Adrenal insufficiency","volume":"361","author":"Arlt","year":"2003","journal-title":"Lancet"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3888","DOI":"10.1210\/jc.2016-2118","article-title":"Hormonal Replacement in Hypopituitarism in Adults: An Endocrine Society Clinical Practice Guideline","volume":"101","author":"Fleseriu","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/cen.14633","article-title":"Society for Endocrinology guidelines for testosterone replacement therapy in male hypogonadism","volume":"96","author":"Jayasena","year":"2022","journal-title":"Clin. Endocrinol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1210\/jc.2012-3550","article-title":"Approach to the patient with hypogonadotropic hypogonadism","volume":"98","author":"Ferreira","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0950-351X(05)80321-0","article-title":"Radiation and hypothalamic-pituitary function","volume":"4","author":"Littley","year":"1990","journal-title":"Baillieres. Clin. Endocrinol. Metab."},{"key":"ref_19","first-page":"2825","article-title":"Scikit-Learn: Machine Learning in Python","volume":"12","author":"Pedregosa","year":"2011","journal-title":"J. Mach. Learn. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"443","DOI":"10.3803\/EnM.2015.30.4.443","article-title":"Diagnosis and Treatment of Hypopituitarism","volume":"30","author":"Kim","year":"2015","journal-title":"Endocrinol. Metab."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000207607","article-title":"Hypopituitarism following Radiotherapy Revisited","volume":"15","author":"Darzy","year":"2009","journal-title":"Endocr. Dev."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1210\/er.2009-0033","article-title":"Mortality in Patients with Pituitary Disease","volume":"31","author":"Sherlock","year":"2010","journal-title":"Endocr. Rev."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0140-6736(00)04006-X","article-title":"Association between premature mortality and hypopituitarism","volume":"357","author":"Tomlinson","year":"2001","journal-title":"Lancet"},{"key":"ref_24","unstructured":"Drummond, J.B., Ribeiro-Oliveira, J.A., Soares, B.S., and Non-Functioning Pituitary Adenomas (2021, February 21). Endotext 2018, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK534880\/."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1007\/s11102-019-00960-0","article-title":"Non-functioning pituitary adenomas: Indications for pituitary surgery and post-surgical management","volume":"22","author":"Esposito","year":"2019","journal-title":"Pituitary"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1097\/00006123-199702000-00001","article-title":"Complications of Transsphenoidal Surgery: Results of a National Survey, Review of the Literature, and Personal Experience","volume":"40","author":"Ivan","year":"1997","journal-title":"Neurosurgery"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1677\/ERC-08-0231","article-title":"Radiation-induced hypopituitarism","volume":"16","author":"Fernandez","year":"2009","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s11102-008-0088-4","article-title":"Hypopituitarism following radiotherapy","volume":"12","author":"Darzy","year":"2009","journal-title":"Pituitary"},{"key":"ref_29","first-page":"661","article-title":"Reduced hypothalamic blood flow after radiation treatment of nasopharyngeal cancer: SPECT studies in 34 patients","volume":"12","author":"Chieng","year":"1991","journal-title":"AJNR Am. J. Neuroradiol."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/15\/10\/2771\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:35:48Z","timestamp":1760124948000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/15\/10\/2771"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,16]]},"references-count":29,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["cancers15102771"],"URL":"https:\/\/doi.org\/10.3390\/cancers15102771","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,16]]}}}