{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T04:05:01Z","timestamp":1791777901078,"version":"4.3.4"},"reference-count":68,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T00:00:00Z","timestamp":1685318400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Positron emission tomography with computed tomography (PET\/CT) and magnetic resonance imaging (MRI) could improve accuracy in target volume determination for gastrointestinal cancers. A systematic search of the PubMed database was performed, focusing on studies published within the last 20 years. Articles were considered eligible for the review if they included patients with anal canal, esophageal, rectal or pancreatic cancer, as well as PET\/CT or MRI for radiotherapy treatment planning, and if they reported interobserver variability or changes in treatment planning volume due to different imaging modalities or correlation between the imaging modality and histopathologic specimen. The search of the literature retrieved 1396 articles. We retrieved six articles from an additional search of the reference lists of related articles. Forty-one studies were included in the final review. PET\/CT seems indispensable for target volume determination of pathological lymph nodes in esophageal and anal canal cancer. MRI seems appropriate for the delineation of primary tumors in the pelvis as rectal and anal canal cancer. Delineation of the target volumes for radiotherapy of pancreatic cancer remains challenging, and additional studies are needed.<\/jats:p>","DOI":"10.3390\/cancers15112967","type":"journal-article","created":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T02:04:21Z","timestamp":1685412261000},"page":"2967","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The Role of MRI and PET\/CT in Radiotherapy Target Volume Determination in Gastrointestinal Cancers\u2014Review of the Literature"],"prefix":"10.3390","volume":"15","author":[{"given":"Ajra","family":"Secerov Ermenc","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Institute of Oncology Ljubljana, 1000 Ljubljana, Slovenia"},{"name":"Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Segedin","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Institute of Oncology Ljubljana, 1000 Ljubljana, Slovenia"},{"name":"Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,29]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization International Agency for Research on Cancer (IARC) (2023, January 20). GLOBOCAN 2020: Estimated Cancer Incidence, Mortality and Prevalence Worldwide in 2020. Available online: http:\/\/globocan.iarc.fr\/."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/s41416-019-0412-y","article-title":"How rapid advances in imaging are defining the future of precision radiation oncology","volume":"120","author":"Beaton","year":"2019","journal-title":"Br. J. Cancer"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"614008","DOI":"10.3389\/fonc.2020.614008","article-title":"Trimodality PET\/CT\/MRI and Radiotherapy: A Mini-Review","volume":"10","author":"Decazes","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.radonc.2010.07.019","article-title":"Clinical evidence on PET-CT for radiation therapy planning in gastro-intestinal tumors","volume":"96","author":"Lambrecht","year":"2010","journal-title":"Radiother. Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1259\/bjr.20170370","article-title":"PET imaging in anal canal cancer: A systematic review and meta-analysis","volume":"90","author":"Mahmud","year":"2017","journal-title":"Br. J. Radiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.critrevonc.2016.08.015","article-title":"Impact of PET\/CT on radiation treatment in patients with esophageal cancer: A systematic review","volume":"107","author":"Lu","year":"2016","journal-title":"Crit. Rev. Oncol.\/Hematol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.dld.2015.02.005","article-title":"Role of fluorine 18 fluorodeoxyglucose positron emission tomography\/computed tomography in gastrointestinal cancers","volume":"47","author":"Cacheux","year":"2015","journal-title":"Dig. Liver Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0360-3016(00)00467-3","article-title":"Towards multidimensional radiotherapy (MD-CRT): Biological imaging and biological conformality","volume":"47","author":"Ling","year":"2000","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.clon.2015.06.008","article-title":"Functional Imaging Biomarkers: Potential to Guide an Individualised Approach to Radiotherapy","volume":"27","author":"Prestwich","year":"2015","journal-title":"Clin. Oncol. (R. Coll. Radiol.)"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"801","DOI":"10.2967\/jnumed.119.227967","article-title":"68Ga-FAPI PET\/CT: Tracer Uptake in 28 Different Kinds of Cancer","volume":"60","author":"Kratochwil","year":"2019","journal-title":"J. Nucl. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.crad.2014.07.017","article-title":"Imaging of oesophageal cancer with FDG-PET\/CT and MRI","volume":"70","author":"Lips","year":"2015","journal-title":"Clin. Radiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"429","DOI":"10.7785\/tcrt.2012.500342","article-title":"The potential for an enhanced role for MRI in radiation-therapy treatment planning","volume":"12","author":"Metcalfe","year":"2013","journal-title":"Technol. Cancer Res. Treat."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"vi51","DOI":"10.1093\/annonc\/mdt342","article-title":"Oesophageal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"24","author":"Stahl","year":"2013","journal-title":"Ann. Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.radonc.2014.04.013","article-title":"Anal cancer: ESMO-ESSO-ESTRO clinical practice guidelines for diagnosis, treatment and follow-up","volume":"111","author":"Nilsson","year":"2014","journal-title":"Radiother. Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.prro.2019.06.016","article-title":"Radiation Therapy for Pancreatic Cancer: Executive Summary of an ASTRO Clinical Practice Guideline","volume":"9","author":"Palta","year":"2019","journal-title":"Pract. Radiat. Oncol."},{"key":"ref_16","first-page":"iv22","article-title":"Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"28","author":"Wyrwicz","year":"2017","journal-title":"Ann. Oncol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"105906","DOI":"10.1016\/j.ijsu.2021.105906","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"88","author":"Page","year":"2021","journal-title":"Int. J. Surg."},{"key":"ref_18","unstructured":"National Comprehensive Cancer Network (2023, January 25). Anal Carcinoma (Version 1.2023). Available online: https:\/\/www.nccn.org\/guidelines\/guidelines-detail?category=1&id=1414."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1748-717X-5-10","article-title":"FDG-PET\/CT imaging for staging and target volume delineation in conformal radiotherapy of anal carcinoma","volume":"5","author":"Krengli","year":"2010","journal-title":"Radiat. Oncol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1080\/0284186X.2017.1325003","article-title":"PET-CT guided SIB-IMRT combined with concurrent 5-FU\/MMC for the treatment of anal cancer","volume":"56","author":"Zimmermann","year":"2017","journal-title":"Acta Oncol."},{"key":"ref_21","first-page":"2524","article-title":"FDG-PET\/CT in the Radiotherapy Treatment Planning of Locally Advanced Anal Cancer: A Monoinstitutional Experience","volume":"11","author":"Vicenzi","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.ijrobp.2009.09.029","article-title":"Squamous cell carcinoma of the anal canal: Patterns and predictors of failure and implications for intensity-modulated radiation treatment planning","volume":"78","author":"Wright","year":"2010","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/j.ijrobp.2011.12.058","article-title":"Australasian Gastrointestinal Trials Group (AGITG) contouring atlas and planning guidelines for intensity-modulated radiotherapy in anal cancer","volume":"83","author":"Ng","year":"2012","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.ijrobp.2008.08.070","article-title":"Elective clinical target volumes for conformal therapy in anorectal cancer: A radiation therapy oncology group consensus panel contouring atlas","volume":"74","author":"Myerson","year":"2009","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_25","unstructured":"Muirhead, R., Adams, R., Gilbert, D., Harrison, M., Glynne-Jones, R., and Sebag-Montefiore, D. (2020, August 20). National Guidance for IMRT in Anal Cancer. Available online: http:\/\/analimrtguidance.co.uk\/national-anal-imrt-guidance-v3.pdf."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Frennered, A., Scherman, J., Buchwald, P., Johnsson, A., Sartor, H., Zackrisson, S., Tr\u00e4g\u00e5rdh, E., and Nilsson, M.P. (2021). Patterns of pathologic lymph nodes in anal cancer: A PET-CT-based analysis with implications for radiotherapy treatment volumes. BMC Cancer, 21.","DOI":"10.1186\/s12885-021-08187-8"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Dapper, H., Schiller, K., M\u00fcnch, S., Peeken, J.C., Borm, K., Weber, W., and Combs, S.E. (2019). Have we achieved adequate recommendations for target volume definitions in anal cancer? A PET imaging based patterns of failure analysis in the context of established contouring guidelines. BMC Cancer, 19.","DOI":"10.1186\/s12885-019-5970-0"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.radonc.2020.05.018","article-title":"Patterns of inguinal lymph node metastases in anal canal cancer and recommendations for elective clinical target volume (CTV) delineation","volume":"149","author":"Garda","year":"2020","journal-title":"Radiother. Oncol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/acm2.13423","article-title":"The benefit of MR-only radiotherapy treatment planning for anal and rectal cancers: A planning study","volume":"22","author":"Bird","year":"2021","journal-title":"J. Appl. Clin. Med. Phys."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s13014-017-0883-z","article-title":"Target volume delineation of anal cancer based on magnetic resonance imaging or positron emission tomography","volume":"12","author":"Rusten","year":"2017","journal-title":"Radiat. Oncol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"6066","DOI":"10.21037\/jtd.2018.10.57","article-title":"Systematic review and meta-analysis of the accuracy of 18F-FDG PET\/CT for detection of regional lymph node metastasis in esophageal squamous cell carcinoma","volume":"10","author":"Jiang","year":"2018","journal-title":"J. Thorac. Dis."},{"key":"ref_32","unstructured":"National Comprehensive Cancer Network (2023, April 23). Esophageal and Esophagastric Junction Cancers (Version 2.2023). Available online: https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/esophageal.pdf."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s13014-016-0731-6","article-title":"Distribution of FDG-avid nodes in esophageal cancer: Implications for radiotherapy target delineation","volume":"11","author":"Garcia","year":"2016","journal-title":"Radiat. Oncol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/1754-9485.12474","article-title":"Distribution of lymph node metastases on FDG-PET\/CT in inoperable or unresectable oesophageal cancer patients and the impact on target volume definition in radiation therapy","volume":"60","author":"Machiels","year":"2016","journal-title":"J. Med. Imaging Radiat. Oncol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1007\/s00066-020-01630-y","article-title":"Impact of 18F-FDG-PET\/CT on the identification of regional lymph node metastases and delineation of the primary tumor in esophageal squamous cell carcinoma patients","volume":"196","author":"Marr","year":"2020","journal-title":"Strahlenther. Onkol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1056\/NEJMoa1112088","article-title":"Preoperative Chemoradiotherapy for Esophageal or Junctional Cancer","volume":"366","author":"Hulshof","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.2147\/OTT.S130285","article-title":"Can involved-field irradiation replace elective nodal irradiation in chemoradiotherapy for esophgeal cancer? A systematic review and meta-analysis","volume":"10","author":"Wang","year":"2017","journal-title":"Onco Targets Ther."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1093\/jrr\/rry055","article-title":"Comparison of elective nodal irradiation and involved-field irradiation in esophageal squamous cell carcinoma: A meta-analysis","volume":"59","author":"Cheng","year":"2018","journal-title":"J. Radiat. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1007\/s12094-018-1879-3","article-title":"Radiotherapy volume delineation using 18F-FDG-PET\/CT modifies gross node volume in patients with oesophageal cancer","volume":"20","author":"Mateos","year":"2018","journal-title":"Clin. Transl. Oncol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1007\/s00066-017-1164-3","article-title":"Inclusion of PET-CT into planning of primary or neoadjuvant chemoradiotherapy of esophageal cancer improves prognosis","volume":"193","author":"Metzger","year":"2017","journal-title":"Strahlenther. Onkol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.radonc.2014.10.016","article-title":"Clinical validation of FDG-PET\/CT in the radiation treatment planning for patients with oesophageal cancer","volume":"113","author":"Muijs","year":"2014","journal-title":"Radiother. Oncol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.ijrobp.2009.07.1681","article-title":"Comparison of 18F-Fluorothymidine and 18F-Fluorodeoxyglucose PET\/CT in Delineating Gross Tumor Volume by Optimal Threshold in Patients with Squamous Cell Carcinoma of Thoracic Esophagus","volume":"76","author":"Han","year":"2010","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s12149-007-0040-0","article-title":"Pre-operative estimation of esophageal tumor metabolic length in FDG-PET images with surgical pathology confirmation","volume":"21","author":"Mamede","year":"2007","journal-title":"Ann. Nucl. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.ijrobp.2008.04.015","article-title":"Using 18F-Fluorodeoxyglucose Positron Emission Tomography to Estimate the Length of Gross Tumor in Patients with Squamous Cell Carcinoma of the Esophagus","volume":"73","author":"Zhong","year":"2009","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.clon.2008.06.004","article-title":"Improving observer variability in target delineation for gastro-oesophageal cancer\u2014The role of 18Ffluoro-2-deoxy-D-glucose positron emission tomography\/computed tomography","volume":"20","author":"Vesprini","year":"2008","journal-title":"Clin. Oncol. (R. Coll. Radiol.)"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/j.1442-2050.2009.01044.x","article-title":"Impact of 18-fluorodeoxyglucose positron emission tomography on computed tomography defined target volumes in radiation treatment planning of esophageal cancer: Reduction in geographic misses with equal inter-observer variability","volume":"23","author":"Schreurs","year":"2010","journal-title":"Dis. Esophagus"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ctro.2018.10.003","article-title":"Gross tumour delineation on computed tomography and positron emission tomography-computed tomography in oesophageal cancer: A nationwide study","volume":"14","author":"Nowee","year":"2018","journal-title":"Clin. Transl. Radiat. Oncol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1093\/jrr\/rrz004","article-title":"Impact of hybrid FDG-PET\/CT on gross tumor volume definition of cervical esophageal cancer: Reducing interobserver variation","volume":"60","author":"Toya","year":"2019","journal-title":"J. Radiat. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"817413","DOI":"10.3389\/fonc.2022.817413","article-title":"Inter-Observer and Intra-Observer Variability in Gross Tumor Volume Delineation of Primary Esophageal Carcinomas Based on Different Combinations of Diagnostic Multimodal Images","volume":"12","author":"Li","year":"2022","journal-title":"Front. Oncol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"550100","DOI":"10.3389\/fonc.2021.550100","article-title":"Comparison of the Gross Target Volumes Based on Diagnostic PET\/CT for Primary Esophageal Cancer","volume":"11","author":"Shi","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/1748-717X-8-169","article-title":"Improved longitudinal length accuracy of gross tumor volume delineation with diffusion weighted magnetic resonance imaging for esophageal squamous cell carcinoma","volume":"8","author":"Hou","year":"2013","journal-title":"Radiat. Oncol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.adro.2019.04.004","article-title":"Gross Tumor Delineation in Esophageal Cancer on MRI Compared With 18F-FDG-PET\/CT","volume":"4","author":"Vollenbrock","year":"2019","journal-title":"Adv. Radiat. Oncol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"844702","DOI":"10.3389\/fonc.2022.844702","article-title":"Value of 18F-FDG PET\/MRI in the Preoperative Assessment of Resectable Esophageal Squamous Cell Carcinoma: A Comparison With 18F-FDG PET\/CT, MRI, and Contrast-Enhanced CT","volume":"12","author":"Wang","year":"2022","journal-title":"Front. Oncol."},{"key":"ref_54","unstructured":"National Comprehensive Cancer Network (2023, April 23). Rectal Cancer (Version 2.2023). Available online: https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/rectal.pdf."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.radonc.2010.11.018","article-title":"FDG-PET provides the best correlation with the tumor specimen compared to MRI and CT in rectal cancer","volume":"98","author":"Buijsen","year":"2011","journal-title":"Radiother. Oncol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1259\/bjr\/60198873","article-title":"MR vs CT imaging: Low rectal cancer tumour delineation for three-dimensional conformal radiotherapy","volume":"82","author":"Salerno","year":"2009","journal-title":"Br. J. Radiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1111\/j.1754-9485.2010.02212.x","article-title":"The utility of multimodality imaging with CT and MRI in defining rectal tumour volumes for radiotherapy treatment planning: A pilot study","volume":"54","author":"Tan","year":"2010","journal-title":"J. Med. Imaging Radiat. Oncol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.radonc.2011.12.016","article-title":"FDG-PET-CT reduces the interobserver variability in rectal tumor delineation","volume":"102","author":"Buijsen","year":"2012","journal-title":"Radiother. Oncol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"e439","DOI":"10.1016\/j.ijrobp.2011.03.031","article-title":"Delineation of gross tumor volume (GTV) for radiation treatment planning of locally advanced rectal cancer using information from MRI or FDG-PET\/CT: A prospective study","volume":"81","author":"Hansson","year":"2011","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.ejrad.2014.02.007","article-title":"Rectal tumour volume (GTV) delineation using T2-weighted and diffusion-weighted MRI: Implications for radiotherapy planning","volume":"83","author":"Regini","year":"2014","journal-title":"Eur. J. Radiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.radonc.2015.10.030","article-title":"Inter-observer agreement of MRI-based tumor delineation for preoperative radiotherapy boost in locally advanced rectal cancer","volume":"118","author":"Burbach","year":"2016","journal-title":"Radiother. Oncol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"20200543","DOI":"10.1259\/bjr.20200543","article-title":"Manual and semi-automated delineation of locally advanced rectal cancer subvolumes with diffusion-weighted MRI","volume":"93","author":"Hearn","year":"2020","journal-title":"Br. J. Radiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.prro.2013.09.002","article-title":"Clinical utility of integrated positron emission tomography\/computed tomography imaging in the clinical management and radiation treatment planning of locally advanced rectal cancer","volume":"4","author":"Whaley","year":"2014","journal-title":"Pract. Radiat. Oncol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"424","DOI":"10.21873\/invivo.13095","article-title":"DWI-MR and PET-CT functional imaging for boost tumor volume delineation in neoadjuvant rectal cancer treatment","volume":"37","author":"Rosa","year":"2023","journal-title":"In Vivo"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.ijrobp.2014.02.035","article-title":"Variability of target and normal structure delineation using multimodality imaging for radiation therapy of pancreatic cancer","volume":"89","author":"Dalah","year":"2014","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"20140590","DOI":"10.1259\/bjr.20140590","article-title":"Consequences of additional use of contrast-enhanced 18F-FDG PET\/CT in target volume delineation and dose distribution for pancreatic cancer","volume":"88","author":"Li","year":"2015","journal-title":"Br. J. Radiol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1756-9966-27-41","article-title":"Comparison of CT and PET-CT based planning of radiation therapy in locally advanced pancreatic carcinoma","volume":"27","author":"Topkan","year":"2008","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Liermann, J., Syed, M., Ben-Josef, E., Schubert, K., Schlampp, I., Sprengel, S.D., Ristau, J., Weykamp, F., R\u00f6hrich, M., and Koerber, S.A. (2021). Impact of FAPI-PET\/CT on target volume definition in radiation therapy of locally recurrent pancreatic cancer. 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