{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:13:01Z","timestamp":1760148781296,"version":"build-2065373602"},"reference-count":111,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T00:00:00Z","timestamp":1685318400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["320030_182690"],"award-info":[{"award-number":["320030_182690"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Walter-Bruckerhoff Stiftung","award":["320030_182690"],"award-info":[{"award-number":["320030_182690"]}]},{"name":"Stiftung f\u00fcr Angewandte Krebsforchung","award":["320030_182690"],"award-info":[{"award-number":["320030_182690"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Recent high-throughput RNA sequencing technologies have confirmed that a large part of the non-coding genome is transcribed. The priority for further investigations is nevertheless generally given in cancer to coding sequences, due to the obvious interest of finding therapeutic targets. In addition, several RNA-sequencing pipelines eliminate repetitive sequences, which are difficult to analyze. In this review, we shall focus on endogenous retroviruses. These sequences are remnants of ancestral germline infections by exogenous retroviruses. These sequences represent 8% of human genome, meaning four-fold the fraction of the genome encoding for proteins. These sequences are generally mostly repressed in normal adult tissues, but pathological conditions lead to their de-repression. Specific mesothelioma-associated endogenous retrovirus expression and their association to clinical outcome is discussed.<\/jats:p>","DOI":"10.3390\/cancers15112969","type":"journal-article","created":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T02:04:21Z","timestamp":1685412261000},"page":"2969","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the Expression of the \u00abDark Matter\u00bb of the Genome in Mesothelioma for Potentially Predictive Biomarkers for Prognosis and Immunotherapy"],"prefix":"10.3390","volume":"15","author":[{"given":"Emanuela","family":"Felley-Bosco","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Oncology, Department of Thoracic Surgery, Z\u00fcrich University Hospital, 8091 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1021\/acs.chemrestox.8b00146","article-title":"Asbestos: Modern Insights for Toxicology in the Era of Engineered Nanomaterials","volume":"31","author":"MacFarlane","year":"2018","journal-title":"Chem. 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