{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T11:24:10Z","timestamp":1783164250775,"version":"3.54.6"},"reference-count":30,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T00:00:00Z","timestamp":1686182400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Electrochemotherapy has been proven to be an efficient treatment for cutaneous metastases of various cancers. Data on breast cancer (BC) patients with cutaneous metastases were retrieved from the INSPECT database. Patients were divided by their receptor status: HER2+, HR+ (ER\/PgR+), and TN (triple negative). Groups were similar for histological subtype and location of the nodules. Most patients were previously treated with surgery\/systemic therapy\/radiotherapy. We found no differences in the three groups in terms of response ratio (OR per patient 86% HER2+, 80% HR+, 76% TN, p = 0.8664). The only factor positively affecting the complete response rate in all groups was small tumor size (&lt;3 cm, p = 0.0105, p = 0.0001, p = 0.0266, respectively). Local progression-free survival was positively impacted by the achievement of complete response in HER2+ (p = 0.0297) and HR+ (p = 0.0094), while overall survival was affected by time to local progression in all groups (p = 0.0065 in HER2+, p &lt; 0.0001 in HR+, p = 0.0363 in TN). ECT treatment is equally effective among groups, despite different receptor status. Response and local tumor control seem to be better in multiple small lesions than in big armor-like lesions, suggesting that treating smaller, even multiple, lesions at the time of occurrence is more effective than treating bigger long-lasting armor-like cutaneous lesions.<\/jats:p>","DOI":"10.3390\/cancers15123116","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T02:03:18Z","timestamp":1686276198000},"page":"3116","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Efficacy of Electrochemotherapy in Breast Cancer Patients of Different Receptor Status: The INSPECT Experience"],"prefix":"10.3390","volume":"15","author":[{"given":"Claudia","family":"Di Prata","sequence":"first","affiliation":[{"name":"Department of Surgery, Oncology and Gastroenterology (DISCOG), University of Padua, 35128 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2036-8721","authenticated-orcid":false,"given":"Matteo","family":"Mascherini","sequence":"additional","affiliation":[{"name":"Department of Surgery, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alastair MacKenzie","family":"Ross","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, St Thomas\u2019 Hospital, London SE1 7EH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Silvestri","sequence":"additional","affiliation":[{"name":"Oncology and Haematology Unit, Azienda Unit\u00e0 Sanitaria Locale Socio Sanitaria (AULSS) 3 Serenissima-Mirano, 30035 Venice, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Kis","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology, University of Szeged, H-6720 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joy","family":"Odili","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, St. Georges University Hospitals NHS Trust, London SW17 0QT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Fabrizio","sequence":"additional","affiliation":[{"name":"Unit of Plastic Surgery, Centro di Riferimento Oncologico della Basilicata (IRCCS-CROB), 85028 Rionero in Vulture, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rowan Pritchard","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Edge Hill University, Ormskirk L39 4QP, UK"},{"name":"Department of Plastic Surgery, University of Liverpool, Liverpool L7 8TX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Kunte","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Dermatochirurgie und Dermatologie, Artemed Fachklinik M\u00fcnchen, 80336 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Orlando","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Southmead Hospital, North Bristol NHS Trust, Bristol BS10 5NB, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1309-837X","authenticated-orcid":false,"given":"James","family":"Clover","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Cork University Hospital, T12 DC4A Cork, Ireland"},{"name":"Cancer Reseach@UCC, University College Cork, T12 YN60 Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siva","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Queen Victoria Hospital National Health Service (NHS) Foundation Trust, East Grinstead RH19 3DZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Russano","sequence":"additional","affiliation":[{"name":"Soft-Tissue, Peritoneum and Melanoma Surgical Oncology Unit, Veneto Institute of Oncology IOV\u2014IRCCS, 35128 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0594-1577","authenticated-orcid":false,"given":"Paolo","family":"Matteucci","sequence":"additional","affiliation":[{"name":"Hull University Teaching Hospitals NHS Trust, Hull HU3 2JZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobian","family":"Muir","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, James Cook University Hospital, Middlesbrough TS4 3BW, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2676-4549","authenticated-orcid":false,"given":"Francesca de","family":"Terlizzi","sequence":"additional","affiliation":[{"name":"IGEA S.p.A. Biophysics Department, 41012 Carpi, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3829-0210","authenticated-orcid":false,"given":"Julie","family":"Gehl","sequence":"additional","affiliation":[{"name":"Center for Experimental Drug and Gene Electrotransfer (C*EDGE), Department of Clinical Oncology and Palliative Care, Zealand University Hospital, 4000 Roskilde, Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva-Maria","family":"Grischke","sequence":"additional","affiliation":[{"name":"Department of Gynecology, University Hospital of T\u00fcbingen, 72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,8]]},"reference":[{"key":"ref_1","unstructured":"SEER (2022). Annual Report to the Nation 2022: Overall Cancer Statistics, SEER."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1365-4632.2012.05635.x","article-title":"Patterns of Skin Metastases: A Review of 25 Years\u2019 Experience at a Single Cancer Center: Patterns of Skin Metastases","volume":"53","author":"Wong","year":"2014","journal-title":"Int. J. Dermatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1111\/tbj.14049","article-title":"Treatment of Diffuse Cutaneous Metastases from Breast Cancer","volume":"26","author":"Sittenfeld","year":"2020","journal-title":"Breast. J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.2217\/fon.13.216","article-title":"Eribulin in Cutaneous Breast Cancer Metastasis Treatment: Clinical Activity and Symptom Control","volume":"9","author":"Moretti","year":"2013","journal-title":"Future Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1007\/s10549-012-2095-4","article-title":"The Activity and Safety of Electrochemotherapy in Persistent Chest Wall Recurrence from Breast Cancer after Mastectomy: A Phase-II Study","volume":"134","author":"Campana","year":"2012","journal-title":"Breast. Cancer Res. Treat."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.ejso.2020.10.037","article-title":"Outcomes of Older Adults Aged 90 and over with Cutaneous Malignancies after Electrochemotherapy with Bleomycin: A Matched Cohort Analysis from the InspECT Registry","volume":"47","author":"Sersa","year":"2021","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e909","DOI":"10.1016\/j.clbc.2018.03.007","article-title":"Electrochemotherapy for Breast Cancer\u2014Results from the INSPECT Database","volume":"18","author":"Matthiessen","year":"2018","journal-title":"Clin. Breast Cancer"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ejca.2020.06.020","article-title":"Electrochemotherapy in the Treatment of Cutaneous Malignancy: Outcomes and Subgroup Analysis from the Cumulative Results from the Pan-European International Network for Sharing Practice in Electrochemotherapy Database for 2482 Lesions in 987 Patients (2008\u20132019)","volume":"138","author":"Clover","year":"2020","journal-title":"Eur. J. Cancer"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1080\/0284186X.2018.1454602","article-title":"Updated Standard Operating Procedures for Electrochemotherapy of Cutaneous Tumours and Skin Metastases","volume":"57","author":"Gehl","year":"2018","journal-title":"Acta Oncol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1245\/s10434-015-4779-6","article-title":"Electrochemotherapy in the Treatment of Cutaneous Metastases from Breast Cancer: A Multicenter Cohort Analysis","volume":"22","author":"Cabula","year":"2015","journal-title":"Ann. Surg. Oncol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1188\/02.CJON.255-260","article-title":"Cutaneous Metastatic Breast Cancer","volume":"6","author":"Moore","year":"2002","journal-title":"Clin. J. Oncol. Nurs."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1111\/jdv.18456","article-title":"Health-related Quality of Life Trajectories in Melanoma Patients after Electrochemotherapy: Real-world Insights from the InspECT Register","volume":"36","author":"Campana","year":"2022","journal-title":"Acad. Derm. Venereol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Vestergaard, K., Vissing, M., Gehl, J., and Lindhardt, C.L. (2023). Qualitative Investigation of Experience and Quality of Life in Patients Treated with Calcium Electroporation for Cutaneous Metastases. Cancers, 15.","DOI":"10.3390\/cancers15030599"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"164","DOI":"10.2478\/raon-2022-0009","article-title":"Sunitinib Potentiates the Cytotoxic Effect of Electrochemotherapy in Pancreatic Carcinoma Cells","volume":"56","author":"Bosnjak","year":"2022","journal-title":"Radiol. Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1007\/s00262-016-1856-z","article-title":"Immune Checkpoint Blockade with Concurrent Electrochemotherapy in Advanced Melanoma: A Retrospective Multicenter Analysis","volume":"65","author":"Heppt","year":"2016","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"772144","DOI":"10.3389\/fonc.2021.772144","article-title":"The Role of Electrochemotherapy in the Cutaneous and Subcutaneous Metastases from Breast Cancer: Analysis of Predictive Factors to Treatment from an Italian Cohort of Patients","volume":"11","author":"Russano","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ejcsup.2006.08.003","article-title":"Standard Operating Procedures of the Electrochemotherapy: Instructions for the Use of Bleomycin or Cisplatin Administered Either Systemically or Locally and Electric Pulses Delivered by the CliniporatorTM by Means of Invasive or Non-Invasive Electrodes","volume":"4","author":"Mir","year":"2006","journal-title":"Eur. J. Cancer Suppl."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ejca.2008.10.026","article-title":"New Response Evaluation Criteria in Solid Tumours: Revised RECIST Guideline (Version 1.1)","volume":"45","author":"Eisenhauer","year":"2009","journal-title":"Eur. J. Cancer"},{"key":"ref_19","first-page":"108","article-title":"Electrochemotherapy for Treatment of Cutaneous Breast Cancer Metastases: A Review","volume":"3","author":"Banerjee","year":"2016","journal-title":"Arch. Breast Cancer"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1159\/000494093","article-title":"Electrochemotherapy in the Treatment of Breast Cancer Metastasis to the Skin and Subcutaneous Tissue\u2014Multicenter Experience","volume":"42","author":"Wichtowski","year":"2019","journal-title":"Oncol. Res. Treat."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1097\/CMR.0000000000000699","article-title":"Safety and Efficacy of Electrochemotherapy in a Series of Patients with Nonmetastasized Primary or Recurrent Anorectal Malignant Melanoma","volume":"31","author":"Farricha","year":"2021","journal-title":"Melanoma Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1245\/s10434-011-1860-7","article-title":"Electrochemotherapy in the Treatment of Kaposi Sarcoma Cutaneous Lesions: A Two-Center Prospective Phase II Trial","volume":"19","author":"Curatolo","year":"2012","journal-title":"Ann. Surg. Oncol."},{"key":"ref_23","first-page":"470","article-title":"Prospective Cohort Study by InspECT on Safety and Efficacy of Electrochemotherapy for Cutaneous Tumors and Metastases Depending on Ulceration","volume":"20","author":"Claussen","year":"2022","journal-title":"J. Dtsch. Derma Gesell."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.radonc.2010.10.020","article-title":"Durable Palliation of Breast Cancer Chest Wall Recurrence with Radiation Therapy, Hyperthermia, and Chemotherapy","volume":"97","author":"Zagar","year":"2010","journal-title":"Radiother. Oncol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"136","DOI":"10.3109\/02656730903341340","article-title":"Elective Re-Irradiation and Hyperthermia Following Resection of Persistent Locoregional Recurrent Breast Cancer: A Retrospective Study","volume":"26","author":"Oldenborg","year":"2010","journal-title":"Int. J. Hyperth."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1245\/s10434-008-0204-8","article-title":"Bleomycin-Based Electrochemotherapy: Clinical Outcome from a Single Institution\u2019s Experience with 52 Patients","volume":"16","author":"Campana","year":"2009","journal-title":"Ann. Surg. Oncol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1007\/s00432-014-1691-6","article-title":"Bleomycin Electrochemotherapy in Elderly Metastatic Breast Cancer Patients: Clinical Outcome and Management Considerations","volume":"140","author":"Campana","year":"2014","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s10549-016-4046-y","article-title":"Effective Treatment of Intractable Cutaneous Metastases of Breast Cancer with Electrochemotherapy: Ten-Year Audit of Single Centre Experience","volume":"161","author":"Bourke","year":"2017","journal-title":"Breast. Cancer Res. Treat."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Campana, L.G., Peric, B., Mascherini, M., Spina, R., Kunte, C., Kis, E., Rozsa, P., Quaglino, P., Jones, R.P., and Clover, A.J.P. (2021). Combination of Pembrolizumab with Electrochemotherapy in Cutaneous Metastases from Melanoma: A Comparative Retrospective Study from the InspECT and Slovenian Cancer Registry. Cancers, 13.","DOI":"10.3390\/cancers13174289"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1080\/0284186X.2017.1290274","article-title":"Electrochemotherapy and Calcium Electroporation Inducing a Systemic Immune Response with Local and Distant Remission of Tumors in a Patient with Malignant Melanoma\u2014A Case Report","volume":"56","author":"Falk","year":"2017","journal-title":"Acta Oncol."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/15\/12\/3116\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:51:07Z","timestamp":1760125867000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/15\/12\/3116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,8]]},"references-count":30,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,6]]}},"alternative-id":["cancers15123116"],"URL":"https:\/\/doi.org\/10.3390\/cancers15123116","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,8]]}}}