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An in-depth understanding of intracellular signaling may hold the key to the relationship of both conventional drugs and nanoparticles. Within these strategies, first, nanotechnology has become an essential tool in oncotherapy, improving biopharmaceutical properties and providing new immunomodulatory profiles to conventional drugs mediated by activation of endoplasmic reticulum (ER) stress. Secondly, functional proteomics techniques based on microarrays have proven to be a successful method for high throughput screening of proteins and profiling of biomolecule mechanisms of action. Here, we conducted a systematic characterization of the antitumor profile of a platinum compound conjugated with iron oxide nanoparticles (IONPs). As a result of the nano-conjugation, cytotoxic and proteomics profiles revealed a significant improvement in the antitumor properties of the starting material, providing selectivity in certain tumor cell lines tested. Moreover, cell death patterns associated with immunogenic cell death (ICD) response have also been identified when ER signaling pathways have been triggered. The evaluation in several tumor cell lines and the analysis by functional proteomics techniques have shown novel perspectives on the design of new cisplatin-derived conjugates, the high value of IONPs as drug delivery systems and ICD as a rewarding approach for targeted oncotherapy and onco-immunotherapies.<\/jats:p>","DOI":"10.3390\/cancers15123204","type":"journal-article","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T02:02:20Z","timestamp":1686880940000},"page":"3204","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Enhancement of Tumor Cell Immunogenicity and Antitumor Properties Derived from Platinum-Conjugated Iron Nanoparticles"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5585-9918","authenticated-orcid":false,"given":"\u00c1ngela-Patricia","family":"Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Department of Medicine and General Cytometry Service-Nucleus, CIBERONC CB16\/12\/00400, Cancer Research Centre (IBMCC\/CSIC\/USAL\/IBSAL), IBSAL, University of Salamanca-CSIC, Campus Miguel de Unamuno, s\/n, 37007 Salamanca, Spain"},{"name":"Department of Pharmaceutical Sciences, Organic Chemistry Section, Faculty of Pharmacy, University of Salamanca, Campus Miguel de Unamuno, s\/n, 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Iglesias-Anciones","sequence":"additional","affiliation":[{"name":"Department of Medicine and General Cytometry Service-Nucleus, CIBERONC CB16\/12\/00400, Cancer Research Centre (IBMCC\/CSIC\/USAL\/IBSAL), IBSAL, University of Salamanca-CSIC, Campus Miguel de Unamuno, s\/n, 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Javier","family":"Vaquero-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Medicine and General Cytometry Service-Nucleus, CIBERONC CB16\/12\/00400, Cancer Research Centre (IBMCC\/CSIC\/USAL\/IBSAL), IBSAL, University of Salamanca-CSIC, Campus Miguel de Unamuno, s\/n, 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7625-4806","authenticated-orcid":false,"given":"Rafael","family":"Pi\u00f1ol","sequence":"additional","affiliation":[{"name":"Institute of Nanoscience and Materials of Aragon (INMA), CSIC-University of Zaragoza, 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio J.","family":"Criado","sequence":"additional","affiliation":[{"name":"Department of Inorganic Chemistry, Faculty of Chemical Sciences, Plaza de los Ca\u00eddos, s\/n, 37008 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Inorganic Chemistry, Faculty of Chemical Sciences, Plaza de los Ca\u00eddos, s\/n, 37008 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9435-2952","authenticated-orcid":false,"given":"Pablo","family":"Juanes-Velasco","sequence":"additional","affiliation":[{"name":"Department of Medicine and General Cytometry Service-Nucleus, CIBERONC CB16\/12\/00400, Cancer Research Centre (IBMCC\/CSIC\/USAL\/IBSAL), IBSAL, University of Salamanca-CSIC, Campus Miguel de Unamuno, s\/n, 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina L.","family":"Garc\u00eda-Vaquero","sequence":"additional","affiliation":[{"name":"Department of Medicine and General Cytometry Service-Nucleus, CIBERONC CB16\/12\/00400, Cancer Research Centre (IBMCC\/CSIC\/USAL\/IBSAL), IBSAL, University of Salamanca-CSIC, Campus Miguel de Unamuno, s\/n, 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlota","family":"Arias-Hidalgo","sequence":"additional","affiliation":[{"name":"Department of Medicine and General Cytometry Service-Nucleus, CIBERONC CB16\/12\/00400, Cancer Research Centre (IBMCC\/CSIC\/USAL\/IBSAL), IBSAL, University of Salamanca-CSIC, Campus Miguel de Unamuno, s\/n, 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0007-7230","authenticated-orcid":false,"given":"Alberto","family":"Orfao","sequence":"additional","affiliation":[{"name":"Department of Medicine and General Cytometry Service-Nucleus, CIBERONC CB16\/12\/00400, Cancer Research Centre (IBMCC\/CSIC\/USAL\/IBSAL), IBSAL, University of Salamanca-CSIC, Campus Miguel de Unamuno, s\/n, 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0828-3212","authenticated-orcid":false,"given":"\u00c1ngel","family":"Mill\u00e1n","sequence":"additional","affiliation":[{"name":"Institute of Nanoscience and Materials of Aragon (INMA), CSIC-University of Zaragoza, 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7305-3766","authenticated-orcid":false,"given":"Manuel","family":"Fuentes","sequence":"additional","affiliation":[{"name":"Department of Medicine and General Cytometry Service-Nucleus, CIBERONC CB16\/12\/00400, Cancer Research Centre (IBMCC\/CSIC\/USAL\/IBSAL), IBSAL, University of Salamanca-CSIC, Campus Miguel de Unamuno, s\/n, 37007 Salamanca, Spain"},{"name":"Proteomics Unit, Cancer Research Centre (IBMCC\/CSIC\/USAL\/IBSAL), 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"21829","DOI":"10.1002\/anie.202004317","article-title":"Developing New Cancer Nanomedicines by Repurposing Old Drugs","volume":"59","author":"Yang","year":"2020","journal-title":"Angew. 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Technol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"16192","DOI":"10.1007\/s10853-022-07649-z","article-title":"Advanced cisplatin nanoformulations as targeted drug delivery platforms for lung carcinoma treatment: A review","volume":"57","author":"Pavan","year":"2022","journal-title":"J. Mater. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.jconrel.2022.03.049","article-title":"Targeted nanomedicine in cisplatin-based cancer therapeutics","volume":"345","author":"Han","year":"2022","journal-title":"J. Control. Release"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Acebes-Fernandez, V., Landeira-Vinuela, A., Juanes-Velasco, P., Hernandez, A.-P., Otazo-Perez, A., Manzano-Roman, R., Gongora, R., and Fuentes, M. (2020). Nanomedicine and Onco-Immunotherapy: From the Bench to Bedside to Biomarkers. Nanomaterials, 10.","DOI":"10.3390\/nano10071274"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"114680","DOI":"10.1016\/j.ejmech.2022.114680","article-title":"The role of Platinum(IV)-based antitumor drugs and the anticancer immune response in medicinal inorganic chemistry. A systematic review from 2017 to 2022","volume":"243","author":"Su","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Hernandez, A.P., Juanes-Velasco, P., Landeira-Vinuela, A., Bareke, H., Montalvillo, E., Gongora, R., and Fuentes, M. (2021). Restoring the Immunity in the Tumor Microenvironment: Insights into Immunogenic Cell Death in Onco-Therapies. 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Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1038\/s41419-020-03221-2","article-title":"Detection of immunogenic cell death and its relevance for cancer therapy","volume":"11","author":"Fucikova","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_14","first-page":"738","article-title":"Magnetic nanoparticles in cancer diagnosis, drug delivery and treatment","volume":"7","author":"Wu","year":"2017","journal-title":"Mol. Clin. Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.lfs.2020.117361","article-title":"Effect of superparamagnetic iron oxide nanoparticles on glucose homeostasis on type 2 diabetes experimental model","volume":"245","author":"Ali","year":"2020","journal-title":"Life Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"14153","DOI":"10.1039\/C8NR03084G","article-title":"PEG-copolymer-coated iron oxide nanoparticles that avoid the reticuloendothelial system and act as kidney MRI contrast agents","volume":"10","author":"Puigivila","year":"2018","journal-title":"Nanoscale"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3134","DOI":"10.1021\/acsnano.5b00059","article-title":"Joining Time-Resolved Thermometry and Magnetic-Induced Heating in a Single Nanoparticle Unveils Intriguing Thermal Properties","volume":"9","author":"Pinol","year":"2015","journal-title":"ACS Nano"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.addr.2020.06.025","article-title":"Cancer therapy with iron oxide nanoparticles: Agents of thermal and immune therapies","volume":"163","author":"Soetaert","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.actbio.2021.10.048","article-title":"Synergistic interventional photothermal therapy and immunotherapy using an iron oxide nanoplatform for the treatment of pancreatic cancer","volume":"138","author":"Wang","year":"2022","journal-title":"Acta Biomater."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1166\/jbn.2013.1637","article-title":"Hemostasis Disorders Caused by Polymer Coated Iron Oxide Nanoparticles","volume":"9","author":"Ali","year":"2013","journal-title":"J. Biomed. Nanotechnol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jinorgbio.2013.10.021","article-title":"Enhanced cytotoxic activity of bile acid cisplatin derivatives by conjugation with gold nanoparticles","volume":"131","author":"Milian","year":"2014","journal-title":"J. Inorg. Biochem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"9960","DOI":"10.1039\/C7NR02196H","article-title":"Functional insights into the cellular response triggered by a bile-acid platinum compound conjugated to biocompatible ferric nanoparticles using quantitative proteomic approaches","volume":"9","author":"Diez","year":"2017","journal-title":"Nanoscale"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1186\/s12951-022-01546-y","article-title":"Comprehensive and systematic characterization of multi-functionalized cisplatin nano-conjugate: From the chemistry and proteomic biocompatibility to the animal model","volume":"20","author":"Hernandez","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1021\/acsmedchemlett.7b00493","article-title":"New Hybrids Derived from Podophyllic Aldehyde and Diterpenylhydroquinones with Selectivity toward Osteosarcoma Cells","volume":"9","author":"Hernandez","year":"2018","journal-title":"ACS Med. Chem. Lett."},{"key":"ref_25","first-page":"776","article-title":"Linear Regression Analysis Part 14 of a Series on Evaluation of Scientific Publications","volume":"107","author":"Schneider","year":"2010","journal-title":"Dtsch. Arztebl. Int."},{"key":"ref_26","first-page":"73","article-title":"SARS-CoV-2 Infection Triggers Auto-Immune Response in ARDS","volume":"13","author":"Lecrevisse","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Landeira-Vinuela, A., Diez, P., Juanes-Velasco, P., Lecrevisse, Q., Orfao, A., de las Rivas, J., and Fuentes, M. (2021). Deepening into Intracellular Signaling Landscape through Integrative Spatial Proteomics and Transcriptomics in a Lymphoma Model. Biomolecules, 11.","DOI":"10.3390\/biom11121776"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ab.2014.01.002","article-title":"Evaluation of homo-and hetero-functionally activated glass surfaces for optimized antibody arrays","volume":"450","author":"Bartolome","year":"2014","journal-title":"Anal. Biochem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1021\/acs.jproteome.6b00980","article-title":"Screening and Validation of Novel Biomarkers in Osteoarticular Pathologies by Comprehensive Combination of Protein Array Technologies","volume":"16","author":"Lourido","year":"2017","journal-title":"J. Proteome Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/978-1-0716-1562-1_2","article-title":"Systematic and Rational Design of Protein Arrays in Noncontact Printers: Pipeline and Critical Aspects","volume":"2344","author":"Hernandez","year":"2021","journal-title":"Methods Mol. Biol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3390\/microarrays1020064","article-title":"Data Analysis Strategies for Protein Microarrays","volume":"1","author":"Diez","year":"2012","journal-title":"Microarrays"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1021\/bc049788r","article-title":"Intrinsically fluorescent cytotoxic cisplatin analogues as DNA marker molecules","volume":"16","author":"Criado","year":"2005","journal-title":"Bioconjugate Chem."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Lakowicz, J.R. (2006). Principles of Fluorescence Spectroscopy, Springer.","DOI":"10.1007\/978-0-387-46312-4"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"14951","DOI":"10.1002\/jcp.28334","article-title":"RAS\/MAPK signaling functions in oxidative stress, DNA damage response and cancer progression","volume":"234","author":"Rezatabar","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e955691","DOI":"10.4161\/21624011.2014.955691","article-title":"Consensus guidelines for the detection of immunogenic cell death","volume":"3","author":"Kepp","year":"2014","journal-title":"Oncoimmunology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1016\/j.bbamcr.2014.01.009","article-title":"The role of MAPK signalling pathways in the response to endoplasmic reticulum stress","volume":"1843","author":"Darling","year":"2014","journal-title":"Biochim. Biophys. Acta-Mol. Cell Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.freeradbiomed.2021.06.013","article-title":"DNA damage and oxidant stress activate p53 through differential upstream signaling pathways","volume":"172","author":"Shi","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.tibs.2016.04.004","article-title":"SOD2 and the Mitochondrial UPR: Partners Regulating Cellular Phenotypic Transitions","volume":"41","author":"He","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/s41590-022-01132-2","article-title":"Immunogenic cell stress and death","volume":"23","author":"Kroemer","year":"2022","journal-title":"Nat. Immunol."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/15\/12\/3204\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:56:02Z","timestamp":1760126162000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/15\/12\/3204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,15]]},"references-count":39,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,6]]}},"alternative-id":["cancers15123204"],"URL":"https:\/\/doi.org\/10.3390\/cancers15123204","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,15]]}}}