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Kirschstein National Research Service","award":["236564\/H10"],"award-info":[{"award-number":["236564\/H10"]}]},{"name":"Ruth L. Kirschstein National Research Service","award":["UW2013-6397"],"award-info":[{"award-number":["UW2013-6397"]}]},{"name":"Ruth L. Kirschstein National Research Service","award":["JTC 2012"],"award-info":[{"award-number":["JTC 2012"]}]},{"name":"Ruth L. Kirschstein National Research Service","award":["UM-2010-4867"],"award-info":[{"award-number":["UM-2010-4867"]}]},{"name":"Ruth L. Kirschstein National Research Service","award":["UM-2012-5653"],"award-info":[{"award-number":["UM-2012-5653"]}]},{"name":"Ruth L. Kirschstein National Research Service","award":["00005739"],"award-info":[{"award-number":["00005739"]}]},{"name":"Ruth L. Kirschstein National Research Service","award":["2016\/1620"],"award-info":[{"award-number":["2016\/1620"]}]},{"name":"Ruth L. Kirschstein National Research Service","award":["01KT1503"],"award-info":[{"award-number":["01KT1503"]}]},{"name":"Ruth L. Kirschstein National Research Service","award":["01KD2101D"],"award-info":[{"award-number":["01KD2101D"]}]},{"name":"Ruth L. Kirschstein National Research Service","award":["T32 HG008962"],"award-info":[{"award-number":["T32 HG008962"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Colorectal cancer (CRC) is increasingly recognized as a heterogeneous disease. No studies have prospectively examined associations of blood metabolite concentrations with all-cause mortality in patients with colon and rectal cancer separately. Targeted metabolomics (Biocrates AbsoluteIDQ p180) and pathway analyses (MetaboAnalyst 4.0) were performed on pre-surgery collected plasma from 674 patients with non-metastasized (stage I\u2013III) colon (n = 394) or rectal cancer (n = 283). Metabolomics data and covariate information were received from the international cohort consortium MetaboCCC. Cox proportional hazards models were computed to investigate associations of 148 metabolite levels with all-cause mortality adjusted for age, sex, tumor stage, tumor site (whenever applicable), and cohort; the false discovery rate (FDR) was used to account for multiple testing. A total of 93 patients (14%) were deceased after an average follow-up time of 4.4 years (60 patients with colon cancer and 33 patients with rectal cancer). After FDR adjustment, higher plasma creatinine was associated with a 39% increase in all-cause mortality in patients with rectal cancer. HR: 1.39, 95% CI 1.23\u20131.72, pFDR = 0.03; but not colon cancer: pFDR = 0.96. Creatinine is a breakdown product of creatine phosphate in muscle and may reflect changes in skeletal muscle mass. The starch and sucrose metabolisms were associated with increased all-cause mortality in colon cancer but not in rectal cancer. Genes in the starch and sucrose metabolism pathways were previously linked to worse clinical outcomes in CRC. In summary, our findings support the hypothesis that colon and rectal cancer have different etiological and clinical outcomes that need to be considered for targeted treatments.<\/jats:p>","DOI":"10.3390\/cancers15133391","type":"journal-article","created":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T01:15:47Z","timestamp":1688001347000},"page":"3391","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Higher Plasma Creatinine Is Associated with an Increased Risk of Death in Patients with Non-Metastatic Rectal but Not Colon Cancer: Results from an International Cohort Consortium"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2030-9676","authenticated-orcid":false,"given":"Jennifer","family":"Ose","sequence":"first","affiliation":[{"name":"Huntsman Cancer Institute, Salt Lake City, UT 84112, USA"},{"name":"Department of Population Health Sciences, University of Utah, Salt Lake City, UT 84112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8085-2072","authenticated-orcid":false,"given":"Biljana","family":"Gigic","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplantation Surgery, University of Heidelberg, 69117 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Brezina","sequence":"additional","affiliation":[{"name":"Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, 23, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengda","family":"Lin","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute, Salt Lake City, UT 84112, USA"},{"name":"Department of Population Health Sciences, University of Utah, Salt Lake City, UT 84112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita R.","family":"Peoples","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute, Salt Lake City, UT 84112, USA"},{"name":"Department of Population Health Sciences, University of Utah, Salt Lake City, UT 84112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5717-0673","authenticated-orcid":false,"given":"Pauline P.","family":"Schobert","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute, Salt Lake City, UT 84112, USA"},{"name":"Department of Population Health Sciences, University of Utah, Salt Lake City, UT 84112, USA"},{"name":"School of Medicine, Ludwig-Maximilians University, 80539 Munich, Germany"},{"name":"School of Medicine, Technical University of Munich, 80333 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5329-9507","authenticated-orcid":false,"given":"Andreas","family":"Baierl","sequence":"additional","affiliation":[{"name":"Department of Statistics and Operations Research, University of Vienna, 1, 1010 Wien, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9402-2029","authenticated-orcid":false,"given":"Eline","family":"van Roekel","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, GROW-School of Oncology and Developmental Biology, Maastricht University, 30, 6229 Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2532-1455","authenticated-orcid":false,"given":"Nivonirina","family":"Robinot","sequence":"additional","affiliation":[{"name":"Nutrition and Metabolism Branch, International Agency for Research on Cancer, WHO, 69366 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Gicquiau","sequence":"additional","affiliation":[{"name":"Nutrition and Metabolism Branch, International Agency for Research on Cancer, WHO, 69366 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Achaintre","sequence":"additional","affiliation":[{"name":"Nutrition and Metabolism Branch, International Agency for Research on Cancer, WHO, 69366 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6651-6710","authenticated-orcid":false,"given":"Augustin","family":"Scalbert","sequence":"additional","affiliation":[{"name":"Nutrition and Metabolism Branch, International Agency for Research on Cancer, WHO, 69366 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e4nzel J. B.","family":"van Duijnhoven","sequence":"additional","affiliation":[{"name":"Division of Human Nutrition and Health, Wageningen University & Research, 6708 Wageningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8001-8793","authenticated-orcid":false,"given":"Andreana N.","family":"Holowatyj","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute, Salt Lake City, UT 84112, USA"},{"name":"Department of Population Health Sciences, University of Utah, Salt Lake City, UT 84112, USA"},{"name":"Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA"},{"name":"Vanderbilt-Ingram Cancer Center, Nashville, TN 37232, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9319-5350","authenticated-orcid":false,"given":"Tanja","family":"Gumpenberger","sequence":"additional","affiliation":[{"name":"Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, 23, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4339-3492","authenticated-orcid":false,"given":"Petra","family":"Schrotz-King","sequence":"additional","affiliation":[{"name":"Division of Preventive Oncology, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis B.","family":"Ulrich","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplantation Surgery, University of Heidelberg, 69117 Heidelberg, Germany"},{"name":"Klinik f\u00fcr Allgemein-, Viszeral-, Thorax- und Gef\u00e4\u00dfchirurgie, St\u00e4dtische Kliniken Neuss, 84, 41464 Neuss, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arve","family":"Ulvik","sequence":"additional","affiliation":[{"name":"BEVITAL, 87, 5021 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per-Magne","family":"Ueland","sequence":"additional","affiliation":[{"name":"BEVITAL, 87, 5021 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matty P.","family":"Weijenberg","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, GROW-School of Oncology and Developmental Biology, Maastricht University, 30, 6229 Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Habermann","sequence":"additional","affiliation":[{"name":"Genome Biology, European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9437-3040","authenticated-orcid":false,"given":"Pekka","family":"Keski-Rahkonen","sequence":"additional","affiliation":[{"name":"Nutrition and Metabolism Branch, International Agency for Research on Cancer, WHO, 69366 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9795-1528","authenticated-orcid":false,"given":"Andrea","family":"Gsur","sequence":"additional","affiliation":[{"name":"Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, 23, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7154-8207","authenticated-orcid":false,"given":"Dieuwertje E.","family":"Kok","sequence":"additional","affiliation":[{"name":"Division of Human Nutrition and Health, Wageningen University & Research, 6708 Wageningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7641-059X","authenticated-orcid":false,"given":"Cornelia M.","family":"Ulrich","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute, Salt Lake City, UT 84112, USA"},{"name":"Department of Population Health Sciences, University of Utah, Salt Lake City, UT 84112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21708","article-title":"Cancer statistics, 2022","volume":"72","author":"Siegel","year":"2022","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Paschke, S., Jafarov, S., Staib, L., Kreuser, E.D., Maulbecker-Armstrong, C., Roitman, M., Holm, T., Harris, C.C., Link, K.H., and Kornmann, M. (2018). Are Colon and Rectal Cancer Two Different Tumor Entities? A Proposal to Abandon the Term Colorectal Cancer. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19092577"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e165","DOI":"10.1016\/j.clcc.2021.02.007","article-title":"Fusobacterium nucleatum and Clinicopathologic Features of Colorectal Cancer: Results From the ColoCare Study","volume":"20","author":"Eisele","year":"2021","journal-title":"Clin. Color. Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1158\/1055-9965.EPI-22-0092","article-title":"Presurgery Adhesion Molecules and Angiogenesis Biomarkers Are Differently Associated with Outcomes in Colon and Rectal Cancer: Results from the ColoCare Study","volume":"31","author":"Ose","year":"2022","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"987518","DOI":"10.3389\/fonc.2022.987518","article-title":"The prognostic impact of BMI on colorectal cancer is stratified by tumor location","volume":"12","author":"Zhang","year":"2022","journal-title":"Front. Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.ajcnut.2022.11.018","article-title":"Postdiagnostic intake of a more proinflammatory diet is associated with a higher risk of recurrence and all-cause mortality in colorectal cancer survivors","volume":"117","author":"Wesselink","year":"2023","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nrm3314","article-title":"Innovation: Metabolomics: The apogee of the omics trilogy","volume":"13","author":"Patti","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.2217\/fon.12.113","article-title":"Metabolic profiling: Are we en route to better diagnostic tests for cancer?","volume":"8","author":"Gu","year":"2012","journal-title":"Future Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nature11708","article-title":"Metabolic phenotyping in clinical and surgical environments","volume":"491","author":"Nicholson","year":"2012","journal-title":"Nature"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s10858-011-9484-6","article-title":"NMR-based stable isotope resolved metabolomics in systems biochemistry","volume":"49","author":"Fan","year":"2011","journal-title":"J. Biomol. NMR"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.2337\/db09-0580","article-title":"Metabolomics applied to diabetes research: Moving from information to knowledge","volume":"58","author":"Bain","year":"2009","journal-title":"Diabetes"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1021\/ac102981k","article-title":"Expanding coverage of the metabolome for global metabolite profiling","volume":"83","author":"Yanes","year":"2011","journal-title":"Anal. Chem."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Gumpenberger, T., Brezina, S., Keski-Rahkonen, P., Baierl, A., Robinot, N., Leeb, G., Habermann, N., Kok, D.E.G., Scalbert, A., and Ueland, P.M. (2021). Untargeted Metabolomics Reveals Major Differences in the Plasma Metabolome between Colorectal Cancer and Colorectal Adenomas. Metabolites, 11.","DOI":"10.3390\/metabo11020119"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Ose, J., Gigic, B., Brezina, S., Lin, T., Baierl, A., Geijsen, A., van Roekel, E., Robinot, N., Gicquiau, A., and Achaintre, D. (2021). Targeted Plasma Metabolic Profiles and Risk of Recurrence in Stage II and III Colorectal Cancer Patients: Results from an International Cohort Consortium. Metabolites, 11.","DOI":"10.3390\/metabo11030129"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Ritchie, S.A., Ahiahonu, P.W., Jayasinghe, D., Heath, D., Liu, J., Lu, Y., Jin, W., Kavianpour, A., Yamazaki, Y., and Khan, A.M. (2010). Reduced levels of hydroxylated, polyunsaturated ultra long-chain fatty acids in the serum of colorectal cancer patients: Implications for early screening and detection. BMC Med., 8.","DOI":"10.1186\/1741-7015-8-13"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"4844","DOI":"10.1021\/pr9004162","article-title":"Serum metabolite profiling of human colorectal cancer using GC-TOFMS and UPLC-QTOFMS","volume":"8","author":"Qiu","year":"2009","journal-title":"J. Proteome Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1158\/0008-5472.CAN-11-1543","article-title":"Metabolomic NMR fingerprinting to identify and predict survival of patients with metastatic colorectal cancer","volume":"72","author":"Bertini","year":"2012","journal-title":"Cancer Res."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Nishiumi, S., Kobayashi, T., Ikeda, A., Yoshie, T., Kibi, M., Izumi, Y., Okuno, T., Hayashi, N., Kawano, S., and Takenawa, T. (2012). A novel serum metabolomics-based diagnostic approach for colorectal cancer. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0040459"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1002\/ijc.32146","article-title":"Plasma metabolites associated with colorectal cancer: A discovery-replication strategy","volume":"145","author":"Geijsen","year":"2019","journal-title":"Int. J. Cancer"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Winkels, R.M., Heine-Broring, R.C., van Zutphen, M., van Harten-Gerritsen, S., Kok, D.E., van Duijnhoven, F.J., and Kampman, E. (2014). The COLON study: Colorectal cancer: Longitudinal, Observational study on Nutritional and lifestyle factors that may influence colorectal tumour recurrence, survival and quality of life. BMC Cancer, 14.","DOI":"10.1186\/1471-2407-14-374"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1158\/1055-9965.EPI-13-1144","article-title":"The applicability of the international classification of functioning, disability, and health to study lifestyle and quality of life of colorectal cancer survivors","volume":"23","author":"Bours","year":"2014","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1158\/1055-9965.EPI-18-0773","article-title":"The ColoCare Study: A Paradigm of Transdisciplinary Science in Colorectal Cancer Outcomes","volume":"28","author":"Ulrich","year":"2019","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Gsur, A., Baierl, A., and Brezina, S. (2021). Colorectal Cancer Study of Austria (CORSA): A Population-Based Multicenter Study. Biology, 10.","DOI":"10.3390\/biology10080722"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1021\/acs.analchem.6b02930","article-title":"Interlaboratory Reproducibility of a Targeted Metabolomics Platform for Analysis of Human Serum and Plasma","volume":"89","author":"Siskos","year":"2017","journal-title":"Anal. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Carayol, M., Licaj, I., Achaintre, D., Sacerdote, C., Vineis, P., Key, T.J., Onland Moret, N.C., Scalbert, A., Rinaldi, S., and Ferrari, P. (2015). Reliability of Serum Metabolites over a Two-Year Period: A Targeted Metabolomic Approach in Fasting and Non-Fasting Samples from EPIC. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0135437"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.1002\/ijc.32666","article-title":"Plasma metabolites associated with colorectal cancer stage: Findings from an international consortium","volume":"146","author":"Geijsen","year":"2020","journal-title":"Int. J. Cancer"},{"key":"ref_27","first-page":"93","article-title":"Non-targeted UHPLC-MS metabolomic data processing methods: A comparative investigation of normalisation, missing value imputation, transformation and scaling","volume":"12","author":"Engel","year":"2016","journal-title":"Metab. Off. J. Metab. Soc."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"W388","DOI":"10.1093\/nar\/gkab382","article-title":"MetaboAnalyst 5.0: Narrowing the gap between raw spectra and functional insights","volume":"49","author":"Pang","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e86","DOI":"10.1002\/cpbi.86","article-title":"Using MetaboAnalyst 4.0 for Comprehensive and Integrative Metabolomics Data Analysis","volume":"68","author":"Chong","year":"2019","journal-title":"Curr. Protoc. Bioinform."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"710423","DOI":"10.3389\/fonc.2021.710423","article-title":"Association Between Serum Creatinine Concentrations and Overall Survival in Patients with Colorectal Cancer: A Multi-Center Cohort Study","volume":"11","author":"Yang","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s11306-022-01959-8","article-title":"Changes of serum metabolites levels during neoadjuvant chemoradiation and prediction of the pathological response in locally advanced rectal cancer","volume":"18","author":"Lv","year":"2022","journal-title":"Metabolomics"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Bonilla, D.A., Kreider, R.B., Stout, J.R., Forero, D.A., Kerksick, C.M., Roberts, M.D., and Rawson, E.S. (2021). Metabolic Basis of Creatine in Health and Disease: A Bioinformatics-Assisted Review. Nutrients, 13.","DOI":"10.3390\/nu13041238"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1002\/jor.23598","article-title":"Serum creatinine and albumin predict sarcoma-specific survival in patients with myofibroblastic and fibroblastic sarcomas","volume":"35","author":"Willegger","year":"2017","journal-title":"J. Orthop. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3895","DOI":"10.12659\/MSM.906867","article-title":"Basic Parameters of Blood Count, Serum Sodium, and Creatinine as Prognostic Factors for Renal Cell Carcinoma at Five-Year Follow-Up","volume":"24","author":"Zyczkowski","year":"2018","journal-title":"Med. Sci. Monit."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"5127","DOI":"10.21873\/anticanres.12834","article-title":"Prognostic Value of Serum Creatinine Levels in Patients with Epithelial Ovarian Cancer","volume":"38","author":"Lafleur","year":"2018","journal-title":"Anticancer Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"348","DOI":"10.2215\/CJN.02870707","article-title":"Influence of muscle mass and physical activity on serum and urinary creatinine and serum cystatin C","volume":"3","author":"Baxmann","year":"2008","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"4850","DOI":"10.3748\/wjg.v25.i33.4850","article-title":"Neoadjuvant radiotherapy for rectal cancer management","volume":"25","author":"Feeney","year":"2019","journal-title":"World J. Gastroenterol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1002\/mus.25966","article-title":"Oxaliplatin induces muscle loss and muscle-specific molecular changes in Mice","volume":"57","author":"Feather","year":"2018","journal-title":"Muscle Nerve"},{"key":"ref_39","first-page":"56","article-title":"Impaired Metabolic Pathways Related to Colorectal Cancer Progression and Therapeutic Implications","volume":"49","author":"Qiu","year":"2020","journal-title":"Iran J. Public Health"},{"key":"ref_40","first-page":"1887","article-title":"Resistant starch prevents tumorigenesis of dimethylhydrazine-induced colon tumors via regulation of an ER stress-mediated mitochondrial apoptosis pathway","volume":"41","author":"Wang","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2939087","DOI":"10.1155\/2016\/2939087","article-title":"Use of Carnosine for Oxidative Stress Reduction in Different Pathologies","volume":"2016","author":"Prokopieva","year":"2016","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Prakash, M.D., Fraser, S., Boer, J.C., Plebanski, M., de Courten, B., and Apostolopoulos, V. (2021). Anti-Cancer Effects of Carnosine-A Dipeptide Molecule. Molecules, 26.","DOI":"10.3390\/molecules26061644"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3892\/ol.2021.13162","article-title":"Carnosine suppresses human colorectal cancer cell proliferation by inducing necroptosis and autophagy and reducing angiogenesis","volume":"23","author":"Hsieh","year":"2022","journal-title":"Oncol. Lett."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1179\/016164109X12518779082237","article-title":"Carnosine inhibits ATP production in cells from malignant glioma","volume":"32","author":"Renner","year":"2010","journal-title":"Neurol Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1476-4598-13-14","article-title":"beta-alanine suppresses malignant breast epithelial cell aggressiveness through alterations in metabolism and cellular acidity in vitro","volume":"13","author":"Vaughan","year":"2014","journal-title":"Mol. Cancer"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"27155","DOI":"10.1074\/jbc.M704408200","article-title":"Anti-inflammatory effects of phosphatidylcholine","volume":"282","author":"Treede","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"van Roekel, E.H., Trijsburg, L., Assi, N., Carayol, M., Achaintre, D., Murphy, N., Rinaldi, S., Schmidt, J.A., Stepien, M., and Kaaks, R. (2018). Circulating metabolites associated with alcohol intake in the european prospective investigation into cancer and nutrition cohort. Nutrients, 10.","DOI":"10.3390\/nu10050654"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e276","DOI":"10.1038\/tp.2013.55","article-title":"Alcohol-induced metabolomic differences in humans","volume":"3","author":"Jaremek","year":"2013","journal-title":"Transl. Psychiatry"}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/15\/13\/3391\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:02:48Z","timestamp":1760126568000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/15\/13\/3391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,28]]},"references-count":48,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2023,7]]}},"alternative-id":["cancers15133391"],"URL":"https:\/\/doi.org\/10.3390\/cancers15133391","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,28]]}}}