{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T03:21:11Z","timestamp":1778988071243,"version":"3.51.4"},"reference-count":60,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T00:00:00Z","timestamp":1689120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Cancer Institute of the National Institutes of Health","award":["R01-CA132946"],"award-info":[{"award-number":["R01-CA132946"]}]},{"name":"National Cancer Institute of the National Institutes of Health","award":["SAP-21-061-01"],"award-info":[{"award-number":["SAP-21-061-01"]}]},{"name":"National Cancer Institute of the National Institutes of Health","award":["T32HG008958"],"award-info":[{"award-number":["T32HG008958"]}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society award\/St. Baldrick\u2019s Foundation","doi-asserted-by":"publisher","award":["R01-CA132946"],"award-info":[{"award-number":["R01-CA132946"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society award\/St. Baldrick\u2019s Foundation","doi-asserted-by":"publisher","award":["SAP-21-061-01"],"award-info":[{"award-number":["SAP-21-061-01"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society award\/St. Baldrick\u2019s Foundation","doi-asserted-by":"publisher","award":["T32HG008958"],"award-info":[{"award-number":["T32HG008958"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Human Genome Research Institute of the National Institutes of Health","doi-asserted-by":"publisher","award":["R01-CA132946"],"award-info":[{"award-number":["R01-CA132946"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Human Genome Research Institute of the National Institutes of Health","doi-asserted-by":"publisher","award":["SAP-21-061-01"],"award-info":[{"award-number":["SAP-21-061-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Human Genome Research Institute of the National Institutes of Health","doi-asserted-by":"publisher","award":["T32HG008958"],"award-info":[{"award-number":["T32HG008958"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Acute myeloid leukemia (AML) is a clonal hematopoietic disease that arises from chromosomal and genetic aberrations in myeloid precursor cells. AML is one of the most common types of acute leukemia in adults; however, it is relatively rare overall, comprising about 1% of all cancers. In the last decade or so, numerous genome-wide association studies (GWAS) have been conducted to screen between hundreds of thousands and millions of variants across many human genomes to discover genetic polymorphisms associated with a particular disease or phenotype. In oncology, GWAS has been performed in almost every commonly occurring cancer. Despite the increasing number of studies published regarding other malignancies, there is a paucity of GWAS studies for AML. In this review article, we will summarize the current status of GWAS in AML.<\/jats:p>","DOI":"10.3390\/cancers15143583","type":"journal-article","created":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T01:52:25Z","timestamp":1689213145000},"page":"3583","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Current Landscape of Genome-Wide Association Studies in Acute Myeloid Leukemia: A Review"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0789-1075","authenticated-orcid":false,"given":"Richard J.","family":"Marrero","sequence":"first","affiliation":[{"name":"Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0411-0007","authenticated-orcid":false,"given":"Jatinder K.","family":"Lamba","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA"},{"name":"University of Florida Health Cancer Center, University of Florida, Gainesville, FL 32610, USA"},{"name":"Center for Pharmacogenomics and Precision Medicine, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,12]]},"reference":[{"key":"ref_1","unstructured":"National Cancer Institute (2023, January 06). 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