{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:11:19Z","timestamp":1790946679901,"version":"4.1.0"},"reference-count":327,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T00:00:00Z","timestamp":1690243200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Ramalingaswami Re-entry fellowship, Department of Biotechnology, Govt. of India to S. Sur","doi-asserted-by":"publisher","award":["BT\/RLF\/Re-entry\/47\/2021"],"award-info":[{"award-number":["BT\/RLF\/Re-entry\/47\/2021"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Ramalingaswami Re-entry fellowship, Department of Biotechnology, Govt. of India to S. Sur","doi-asserted-by":"publisher","award":["DPU\/644-43\/2021"],"award-info":[{"award-number":["DPU\/644-43\/2021"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Intramural Grants, Dr. D. Y. Patil Vidyapeeth (DPU), Pimpri, Pune, India to S. Basu","award":["BT\/RLF\/Re-entry\/47\/2021"],"award-info":[{"award-number":["BT\/RLF\/Re-entry\/47\/2021"]}]},{"name":"Intramural Grants, Dr. D. Y. Patil Vidyapeeth (DPU), Pimpri, Pune, India to S. Basu","award":["DPU\/644-43\/2021"],"award-info":[{"award-number":["DPU\/644-43\/2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Oral cancer (OC) is among the most prevalent cancers in the world. Certain geographical areas are disproportionately affected by OC cases due to the regional differences in dietary habits, tobacco and alcohol consumption. However, conventional therapeutic methods do not yield satisfying treatment outcomes. Thus, there is an urgent need to understand the disease process and to develop diagnostic and therapeutic strategies for OC. In this review, we discuss the role of various types of ncRNAs in OC, and their promising clinical implications as prognostic or diagnostic markers and therapeutic targets. MicroRNA (miRNA), long ncRNA (lncRNA), circular RNA (circRNA), PIWI-interacting RNA (piRNA), and small nucleolar RNA (snoRNA) are the major ncRNA types whose involvement in OC are emerging. Dysregulated expression of ncRNAs, particularly miRNAs, lncRNAs, and circRNAs, are linked with the initiation, progression, as well as therapy resistance of OC via modulation in a series of cellular pathways through epigenetic, transcriptional, post-transcriptional, and translational modifications. Differential expressions of miRNAs and lncRNAs in blood, saliva or extracellular vesicles have indicated potential diagnostic and prognostic importance. In this review, we have summarized all the promising aspects of ncRNAs in the management of OC.<\/jats:p>","DOI":"10.3390\/cancers15153752","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T01:27:32Z","timestamp":1690248452000},"page":"3752","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Non-Coding RNAs in Oral Cancer: Emerging Roles and Clinical Applications"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1432-3823","authenticated-orcid":false,"given":"Saurabh","family":"Dey","sequence":"first","affiliation":[{"name":"Cancer and Translational Research Centre, Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth (DPU), Pimpri, Pune 411033, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6194-875X","authenticated-orcid":false,"given":"Bini","family":"Biswas","sequence":"additional","affiliation":[{"name":"Cancer and Translational Research Centre, Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth (DPU), Pimpri, Pune 411033, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Manoj Appadan","sequence":"additional","affiliation":[{"name":"Cancer and Translational Research Centre, Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth (DPU), Pimpri, Pune 411033, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaladhi","family":"Shah","sequence":"additional","affiliation":[{"name":"Cancer and Translational Research Centre, Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. 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Patil Vidyapeeth (DPU), Pimpri, Pune 411033, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4208-9694","authenticated-orcid":false,"given":"Subhayan","family":"Sur","sequence":"additional","affiliation":[{"name":"Cancer and Translational Research Centre, Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth (DPU), Pimpri, Pune 411033, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. 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