{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:24:16Z","timestamp":1763018656261,"version":"build-2065373602"},"reference-count":79,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T00:00:00Z","timestamp":1690416000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Centre Fran\u00e7ois Baclesse, Caen"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: Knowledge about the precise effects of radiotherapy on hypothalamo-pituitary functions is limited. Reduction of side effects is a major goal of advanced radiotherapy modalities. We assessed strategies for monitoring and replacement of hormone deficiencies in irradiated patients. Methods: A search strategy was systematically conducted on PubMed\u00ae. Additional articles were retrieved to describe endocrine mechanisms. Results: 45 studies were evaluated from 2000 to 2022. They were predominantly retrospective and highly heterogeneous concerning patient numbers, tumor types, radiotherapy technique and follow-up. Endocrine deficiencies occurred in about 40% of patients within a median follow-up of 5.6 years without a clear difference between radiotherapy modalities. Somatotropic and thyrotropic axes were, respectively, the most and least radiosensitive. Conclusions: Current pituitary gland dose constraints may underestimate radiation-induced endocrine deficiencies, thus impairing quality of life. Little difference might be expected between radiation techniques for PG tumors. For non-PG tumors, dose constraints should be applied more systematically.<\/jats:p>","DOI":"10.3390\/cancers15153820","type":"journal-article","created":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T02:08:00Z","timestamp":1690510080000},"page":"3820","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects on the Hypothalamo-Pituitary Axis in Patients with CNS or Head and Neck Tumors following Radiotherapy"],"prefix":"10.3390","volume":"15","author":[{"given":"Jordan","family":"Bouter","sequence":"first","affiliation":[{"name":"Radiotherapy Department, Centre Fran\u00e7ois Baclesse, Avenue du G\u00e9n\u00e9ral Harris, 14000 Caen, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Reznik","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, University Hospital of Caen, Avenue de la C\u00f4te de Nacre, 14033 Caen, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4755-496X","authenticated-orcid":false,"given":"Juliette","family":"Thariat","sequence":"additional","affiliation":[{"name":"Radiotherapy Department, Centre Fran\u00e7ois Baclesse, Avenue du G\u00e9n\u00e9ral Harris, 14000 Caen, France"},{"name":"Corpuscular Physics Laboratory, ENSICAEN, Boulevard Mar\u00e9chal Juin, 14050 Caen, France"},{"name":"Unicaen\u2014Normandie Universit\u00e9, 14050 Caen, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0140-6736(90)91812-O","article-title":"Premature Mortality Due to Cardiovascular Disease in Hypopituitarism","volume":"336","author":"Bengtsson","year":"1990","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0140-6736(00)04006-X","article-title":"Association between Premature Mortality and Hypopituitarism","volume":"357","author":"Tomlinson","year":"2001","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1210\/er.2018-00005","article-title":"Pituitary Diseases and Bone","volume":"39","author":"Mazziotti","year":"2018","journal-title":"Endocr. 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