{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:23:36Z","timestamp":1760149416932,"version":"build-2065373602"},"reference-count":53,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T00:00:00Z","timestamp":1691020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ArcticNet Network of Centres of Excellence of Canada","award":["MOP115031","IPH108285","90386","201201159"],"award-info":[{"award-number":["MOP115031","IPH108285","90386","201201159"]}]},{"name":"Canadian Institutes for Health Research","award":["MOP115031","IPH108285","90386","201201159"],"award-info":[{"award-number":["MOP115031","IPH108285","90386","201201159"]}]},{"DOI":"10.13039\/501100000146","name":"Alberta Innovates Health Solutions","doi-asserted-by":"publisher","award":["MOP115031","IPH108285","90386","201201159"],"award-info":[{"award-number":["MOP115031","IPH108285","90386","201201159"]}],"id":[{"id":"10.13039\/501100000146","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Alberta Heritage Foundation for Medical Research","award":["MOP115031","IPH108285","90386","201201159"],"award-info":[{"award-number":["MOP115031","IPH108285","90386","201201159"]}]},{"name":"Canadian North airlines and Olympus Canada","award":["MOP115031","IPH108285","90386","201201159"],"award-info":[{"award-number":["MOP115031","IPH108285","90386","201201159"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Community-driven projects have characterized Helicobacter pylori (Hp) infection in Indigenous communities in the Northwest Territories (NT) and Yukon (YT), Canada. These projects address concerns about the frequent diagnosis of Hp infection among community members and its relation to gastric cancer deaths, perceived to occur with alarming frequency in this region. Projects included breath-test screening for Hp infection, gastroscopy with gastric biopsies, and treatment to eliminate Hp infection. Previous project results showed a high prevalence of stomach pathologies associated with increased cancer risk among Hp-positive participants at baseline. This analysis describes changes in precancerous gastric pathologies in project participants who had gastroscopy before baseline treatment during 2008\u20132013 and again in 2017. Throughout the study period, the same pathologist graded Hp density, active gastritis, chronic gastritis, atrophic gastritis, and intestinal metaplasia using the updated Sydney System. Of 310 participants from three communities with baseline pathology data, 69 had follow-up pathology data. Relative to baseline, the prevalence of Hp infection and precancerous gastric pathology was substantially lower at follow-up; most participants who were Hp-positive at baseline and Hp-negative at follow-up had reduced severity of active, chronic, and\/or atrophic gastritis at follow-up. Though follow-up numbers are small, these results yield evidence that successful Hp treatment has the potential to reduce the risk of gastric cancer in Arctic Indigenous communities.<\/jats:p>","DOI":"10.3390\/cancers15153950","type":"journal-article","created":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T11:13:06Z","timestamp":1691061186000},"page":"3950","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Changes in Gastric Pathology after H. pylori Treatment in Community-Driven Research Aimed at Gastric Cancer Prevention"],"prefix":"10.3390","volume":"15","author":[{"given":"Ting","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Medicine, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB T6G 2X8, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Safwat","family":"Girgis","sequence":"additional","affiliation":[{"name":"Department of Lab Medicine & Pathology, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB T6G 2X8, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiu-Ju","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB T6G 2X8, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Assi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB T6G 2X8, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharine","family":"Fagan-Garcia","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB T6G 2X8, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taylor","family":"Cromarty","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB T6G 2X8, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Munday","sequence":"additional","affiliation":[{"name":"Susie Husky Health Centre, Aklavik, NT X0E 0A0, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen J.","family":"Goodman","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB T6G 2X8, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sander","family":"Veldhuyzen van Zanten","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB T6G 2X8, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the CANHelp Working Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0168-1605(99)00160-9","article-title":"Helicobacter pylori: Characteristics, pathogenicity, detection methods and mode of transmission implicating foods and water","volume":"53","author":"Velazquez","year":"1999","journal-title":"Int. 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