{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:27:31Z","timestamp":1760149651236,"version":"build-2065373602"},"reference-count":30,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2023,8,15]],"date-time":"2023-08-15T00:00:00Z","timestamp":1692057600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Prostate motion (standard deviation, range of motion, and diffusion coefficient) was calculated from 4D ultrasound data of 1791 fractions of radiation therapy in N = 100 patients. The inner diameter of the lesser pelvis was obtained from transversal slices through the pubic symphysis in planning CTs. On the lateral and craniocaudal axes, motility increases significantly (t-test, p &lt; 0.005) with the inner diameter of the lesser pelvis. A diameter of &gt;106 mm (ca. 6th decile) is a good predictor for high prostate intrafraction motion (ca. 9th decile). The corresponding area under the receiver operator curve (AUROC) is 80% in the lateral direction, 68% to 80% in the craniocaudal direction, and 62% to 70% in the vertical direction. On the lateral x-axis, the proposed test is 100% sensitive and has a 100% negative predictive value for all three characteristics (standard deviation, range of motion, and diffusion coefficient). On the craniocaudal z-axis, the proposed test is 79% to 100% sensitive and reaches 95% to 100% negative predictive value. On the vertical axis, the proposed test still delivers 98% negative predictive value but is not particularly sensitive. Overall, the proposed predictor is able to help identify patients at risk of high prostate motion based on a single planning CT.<\/jats:p>","DOI":"10.3390\/cancers15164103","type":"journal-article","created":{"date-parts":[[2023,8,15]],"date-time":"2023-08-15T11:09:44Z","timestamp":1692097784000},"page":"4103","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Planning CT Identifies Patients at Risk of High Prostate Intrafraction Motion"],"prefix":"10.3390","volume":"15","author":[{"given":"Hendrik","family":"Ballhausen","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, LMU University Hospital, LMU Munich, 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7312-8350","authenticated-orcid":false,"given":"Minglun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, LMU University Hospital, LMU Munich, 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elia","family":"Lombardo","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, LMU University Hospital, LMU Munich, 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Landry","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, LMU University Hospital, LMU Munich, 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claus","family":"Belka","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, LMU University Hospital, LMU Munich, 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/1097-0142(197508)36:2+<723::AID-CNCR2820360817>3.0.CO;2-Y","article-title":"External beam radiation therapy of primary carcinoma of the prostate","volume":"36","author":"Bagshaw","year":"1975","journal-title":"Cancer"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Terlizzi, M., Limkin, E.J., Moukasse, Y., and Blanchard, P. (2022). Adjuvant or Salvage Radiation Therapy for Prostate Cancer after Prostatectomy: Current Status, Controversies and Perspectives. Cancers, 14.","DOI":"10.3390\/cancers14071688"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Kissel, M., Cr\u00e9hange, G., and Graff, P. (2022). Stereotactic Radiation Therapy versus Brachytherapy: Relative Strengths of Two Highly Efficient Options for the Treatment of Localized Prostate Cancer. Cancers, 14.","DOI":"10.3390\/cancers14092226"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.ijrobp.2007.10.049","article-title":"Consequences of Intrafraction Prostate Motion","volume":"71","author":"Haisen","year":"2008","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Faccenda, V., Panizza, D., Daniotti, M.C., Pellegrini, R., Trivellato, S., Caricato, P., Lucchini, R., De Ponti, E., and Arcangeli, S. (2023). Dosimetric Impact of Intrafraction Prostate Motion and Interfraction Anatomical Changes in Dose-Escalated Linac-Based SBRT. Cancers, 15.","DOI":"10.3390\/cancers15041153"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.ijrobp.2005.12.033","article-title":"Influence of intrafraction motion on margins for prostate radiotherapy","volume":"65","author":"Litzenberg","year":"2006","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e13707","DOI":"10.1002\/acm2.13707","article-title":"Evaluation of internal margins for prostate for step and shoot intensity-modulated radiation therapy and volumetric modulated arc therapy using different margin formulas","volume":"23","author":"Higuchi","year":"2022","journal-title":"J. Appl. Clin. Med. Phys."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0360-3016(02)02738-4","article-title":"Intrafraction prostate motion during IMRT for prostate cancer","volume":"53","author":"Huang","year":"2002","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.radonc.2010.01.010","article-title":"Intra-fraction prostate displacement in radiotherapy estimated from pre- and post-treatment imaging of patients with implanted fiducial markers","volume":"95","author":"Kron","year":"2010","journal-title":"Radiother. Oncol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.ijrobp.2011.12.035","article-title":"Inter- and intrafraction uncertainty in prostate bed image-guided radiotherapy","volume":"84","author":"Huang","year":"2012","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"308","DOI":"10.21037\/tau.2017.12.37","article-title":"Image-guided radiotherapy for prostate cancer","volume":"7","author":"Dang","year":"2018","journal-title":"Transl. Androl. Urol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1055\/s-2007-980118","article-title":"Image-guided radiotherapy for prostate cancer","volume":"38","author":"Lohr","year":"2007","journal-title":"Aktuelle Urol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.tipsro.2018.01.003","article-title":"Reduction of intra-fraction prostate motion\u2014Determining optimal bladder volume and filling for prostate radiotherapy using daily 4D TPUS and CBCT","volume":"5","author":"Pang","year":"2018","journal-title":"Tech. Innov. Patient Support Radiat. Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/j.ijrobp.2010.08.052","article-title":"Real-time study of prostate intrafraction motion during external beam radiotherapy with daily endorectal balloon","volume":"81","author":"Both","year":"2011","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.ijrobp.2011.07.028","article-title":"An endorectal balloon reduces intrafraction prostate motion during radiotherapy","volume":"83","author":"Smeenk","year":"2012","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/acm2.12051","article-title":"A comparison between hydrogel spacer and endorectal balloon: An analysis of intrafraction prostate motion during proton therapy","volume":"18","author":"Hedrick","year":"2017","journal-title":"J. Appl. Clin. Med. Phys."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1007\/s00066-018-1286-2","article-title":"Shorter treatment times reduce the impact of intra-fractional motion: A real-time 4DUS study comparing VMAT vs. step-and-shoot IMRT for prostate cancer","volume":"194","author":"Ballhausen","year":"2018","journal-title":"Strahlenther. Onkol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/j.ijrobp.2006.10.026","article-title":"Multi-institutional clinical experience with the Calypso system in localization and continuous, real-time monitoring of the prostate gland during external radiotherapy","volume":"67","author":"Kupelian","year":"2007","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.radi.2017.07.003","article-title":"Intrafraction monitoring of prostate motion during radiotherapy using the Clarity\u00ae Autoscan Transperineal Ultrasound (TPUS) system","volume":"23","author":"Richardson","year":"2017","journal-title":"Radiography"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.ijrobp.2018.01.040","article-title":"Determination of Intrafraction Prostate Motion During External Beam Radiation Therapy with a Transperineal 4-Dimensional Ultrasound Real-Time Tracking System","volume":"101","author":"Sihono","year":"2018","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.zemedi.2019.12.004","article-title":"Evaluation of intrafraction prostate motion tracking using the Clarity Autoscan system for safety margin validation","volume":"30","author":"Richter","year":"2020","journal-title":"Z. Med. Phys."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41597-019-0280-6","article-title":"The ProMotion LMU dataset, prostate intra-fraction motion recorded by transperineal ultrasound","volume":"6","author":"Ballhausen","year":"2019","journal-title":"Sci. Data"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/s41597-022-01583-0","article-title":"The ProMotion LMU dataset (2022 edition), prostate intra-fraction motion recorded by transperineal ultrasound","volume":"9","author":"Ballhausen","year":"2022","journal-title":"Sci. Data"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1088\/0031-9155\/58\/7\/2413","article-title":"The random walk model of intrafraction movement","volume":"58","author":"Ballhausen","year":"2013","journal-title":"Phys. Med. Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1088\/0031-9155\/60\/2\/549","article-title":"Intra-fraction motion of the prostate is a random walk","volume":"60","author":"Ballhausen","year":"2015","journal-title":"Phys. Med. Biol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/s12094-018-1960-y","article-title":"Impact of rectum and bladder anatomy in intrafractional prostate motion during hypofractionated radiation therapy","volume":"21","author":"Roch","year":"2019","journal-title":"Clin. Transl. Oncol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.clon.2016.09.019","article-title":"Real-time image-guided adaptive-predictive prostate radiotherapy using rectal diameter as a predictor of motion","volume":"29","author":"Oates","year":"2017","journal-title":"Clin. Oncol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.media.2017.03.001","article-title":"Population model of bladder motion and deformation based on dominant eigenmodes and mixed-effects models in prostate cancer radiotherapy","volume":"38","author":"Rios","year":"2017","journal-title":"Med. Image Anal."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"960928","DOI":"10.1155\/2014\/960928","article-title":"Validation of planning target volume margins by analyzing intrafractional localization errors for 14 prostate cancer patients based on three-dimensional cross-correlation between the prostate images of planning CT and intrafraction cone-beam CT during volumetric modulated arc therapy","volume":"2014","author":"Shiraishi","year":"2014","journal-title":"BioMed Res. Int."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s13246-023-01242-7","article-title":"Intrafraction motion during CyberKnife\u00ae prostate SBRT: Impact of imaging frequency and patient factors","volume":"46","author":"Rose","year":"2023","journal-title":"Phys. Eng. Sci. 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