{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:54:14Z","timestamp":1785153254533,"version":"3.55.0"},"reference-count":25,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2023,8,15]],"date-time":"2023-08-15T00:00:00Z","timestamp":1692057600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: The aim of this study was to evaluate the impact of pathological tumor-free margin distance on survival in SCC patients treated with surgery alone. Methods: This retrospective study included 128 patients with node-negative disease that received no adjuvant treatment. Disease-free and overall survival were analyzed according to pathological tumor-free margin distance. Results: The patients were subclassified into three resection margin category groups: \u201c1 to 3 mm\u201d (n = 42), \u201c&gt;3 to 8 mm\u201d (n = 47) or \u201c&gt;8 mm\u201d (n = 39). Thirty-nine of the 128 patients (30.5%) developed recurrent disease. Median follow-up for disease-free survival (DFS) was 6.49 years (95% CI 5.16 years; 7.62 years), and median follow-up for overall survival (OS) was 6.29 years (95% CI 5.45 years; 7.33 years). The 5-year DFS rate was 0.70 (95% CI: 0.62\u20130.79), and the 5-year OS rate was 0.79 (95% CI: 0.71\u20130.87). Regarding the survival outcome, there were no independent significant differences in either disease-free survival (DFS) (p = 0.300) or overall survival (p = 1.000) among patients within the three tumor-free resection margin categories. Multivariate analyses did not show any statistically significant association between tumor-free resection margin distance and recurrent disease or death, either when analyzed as a categorical variable or when analyzed as a continuous variable. Conclusion: The present study did not show a significant impact of pathological tumor-free resection margin distance following surgery in patients with node-negative SCC of the vulva (that did not receive adjuvant treatment) on disease-free and overall survival.<\/jats:p>","DOI":"10.3390\/cancers15164110","type":"journal-article","created":{"date-parts":[[2023,8,15]],"date-time":"2023-08-15T11:09:44Z","timestamp":1692097784000},"page":"4110","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Tumor-Free Resection Margin Distance in the Surgical Treatment of Node-Negative Squamous Cell Cancer of the Vulva Has No Impact on Survival: Analysis of a Large Patient Cohort in a Tertiary Care Center"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7384-2928","authenticated-orcid":false,"given":"Florin Andrei","family":"Taran","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Medical Center, University of Freiburg, 79106 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6703-8738","authenticated-orcid":false,"given":"Jana","family":"Pasternak","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s Health, Tuebingen University Hospital, 72076 Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Staebler","sequence":"additional","affiliation":[{"name":"Institute of Pathology and Neuropathology, Tuebingen University Hospital, 72076 Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Rohner","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s Health, Tuebingen University Hospital, 72076 Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7343-561X","authenticated-orcid":false,"given":"Felix","family":"Neis","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s Health, Tuebingen University Hospital, 72076 Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8063-2053","authenticated-orcid":false,"given":"Tobias","family":"Engler","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s Health, Tuebingen University Hospital, 72076 Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3622-4340","authenticated-orcid":false,"given":"Ernst","family":"Oberlechner","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s Health, Tuebingen University Hospital, 72076 Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitt","family":"Sch\u00f6nfisch","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s Health, Tuebingen University Hospital, 72076 Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingolf","family":"Juhasz-B\u00f6ss","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Medical Center, University of Freiburg, 79106 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1227-1118","authenticated-orcid":false,"given":"Andreas Daniel","family":"Hartkopf","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s Health, Tuebingen University Hospital, 72076 Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5162-1542","authenticated-orcid":false,"given":"Sara","family":"Brucker","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s Health, Tuebingen University Hospital, 72076 Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina Barbara","family":"Walter","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s Health, Tuebingen University Hospital, 72076 Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,15]]},"reference":[{"key":"ref_1","unstructured":"(2023, June 28). 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