{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:19:28Z","timestamp":1789676368939,"version":"4.0.1"},"reference-count":141,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T00:00:00Z","timestamp":1692489600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"JPL\u2019s lab","award":["PID2020-118527RB-I00"],"award-info":[{"award-number":["PID2020-118527RB-I00"]}]},{"name":"JPL\u2019s lab","award":["PDC2021-121735-I00"],"award-info":[{"award-number":["PDC2021-121735-I00"]}]},{"name":"JPL\u2019s lab","award":["CSI234P18"],"award-info":[{"award-number":["CSI234P18"]}]},{"name":"JPL\u2019s lab","award":["CSI144P20"],"award-info":[{"award-number":["CSI144P20"]}]},{"name":"MCIN\/AEI\/10.13039\/501100011039","award":["PID2020-118527RB-I00"],"award-info":[{"award-number":["PID2020-118527RB-I00"]}]},{"name":"MCIN\/AEI\/10.13039\/501100011039","award":["PDC2021-121735-I00"],"award-info":[{"award-number":["PDC2021-121735-I00"]}]},{"name":"MCIN\/AEI\/10.13039\/501100011039","award":["CSI234P18"],"award-info":[{"award-number":["CSI234P18"]}]},{"name":"MCIN\/AEI\/10.13039\/501100011039","award":["CSI144P20"],"award-info":[{"award-number":["CSI144P20"]}]},{"name":"European Union Next Generation EU\/PRTR","award":["PID2020-118527RB-I00"],"award-info":[{"award-number":["PID2020-118527RB-I00"]}]},{"name":"European Union Next Generation EU\/PRTR","award":["PDC2021-121735-I00"],"award-info":[{"award-number":["PDC2021-121735-I00"]}]},{"name":"European Union Next Generation EU\/PRTR","award":["CSI234P18"],"award-info":[{"award-number":["CSI234P18"]}]},{"name":"European Union Next Generation EU\/PRTR","award":["CSI144P20"],"award-info":[{"award-number":["CSI144P20"]}]},{"name":"Regional Government of Castile and Le\u00f3n","award":["PID2020-118527RB-I00"],"award-info":[{"award-number":["PID2020-118527RB-I00"]}]},{"name":"Regional Government of Castile and Le\u00f3n","award":["PDC2021-121735-I00"],"award-info":[{"award-number":["PDC2021-121735-I00"]}]},{"name":"Regional Government of Castile and Le\u00f3n","award":["CSI234P18"],"award-info":[{"award-number":["CSI234P18"]}]},{"name":"Regional Government of Castile and Le\u00f3n","award":["CSI144P20"],"award-info":[{"award-number":["CSI144P20"]}]},{"name":"FPU fellowship (MINECO\/FEDER)","award":["PID2020-118527RB-I00"],"award-info":[{"award-number":["PID2020-118527RB-I00"]}]},{"name":"FPU fellowship (MINECO\/FEDER)","award":["PDC2021-121735-I00"],"award-info":[{"award-number":["PDC2021-121735-I00"]}]},{"name":"FPU fellowship (MINECO\/FEDER)","award":["CSI234P18"],"award-info":[{"award-number":["CSI234P18"]}]},{"name":"FPU fellowship (MINECO\/FEDER)","award":["CSI144P20"],"award-info":[{"award-number":["CSI144P20"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>GRB2-associated binder 1 (GAB1) is the inaugural member of the GAB\/DOS family of pleckstrin homology (PH) domain-containing proteins. Upon receiving various stimuli, GAB1 transitions from the cytoplasm to the membrane where it is phosphorylated by a range of kinases. This event recruits SH2 domain-containing proteins like SHP2, PI3K\u2019s p85 subunit, CRK, and others, thereby activating distinct signaling pathways, including MAPK, PI3K\/AKT, and JNK. GAB1-deficient embryos succumb in utero, presenting with developmental abnormalities in the heart, placenta, liver, skin, limb, and diaphragm myocytes. Oncogenic mutations have been identified in the context of cancer. GAB1 expression levels are disrupted in various tumors, and elevated levels in patients often portend a worse prognosis in multiple cancer types. This review focuses on GAB1\u2019s influence on cellular transformation particularly in proliferation, evasion of apoptosis, metastasis, and angiogenesis\u2014each of these processes being a cancer hallmark. GAB1 also modulates the resistance\/sensitivity to antitumor therapies, making it a promising target for future anticancer strategies.<\/jats:p>","DOI":"10.3390\/cancers15164179","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T01:46:56Z","timestamp":1692582416000},"page":"4179","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["The Role of GAB1 in Cancer"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6820-215X","authenticated-orcid":false,"given":"Manuel Jes\u00fas","family":"P\u00e9rez-Baena","sequence":"first","affiliation":[{"name":"Instituto de Biolog\u00eda Molecular y Celular del C\u00e1ncer (IBMCC-CIC), Universidad de Salamanca\/CSIC, 37007 Salamanca, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria de Salamanca (IBSAL), 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Josu\u00e9","family":"Cordero-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Interna, Complejo Asistencial de Zamora, 49022 Zamora, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2400-624X","authenticated-orcid":false,"given":"Jes\u00fas","family":"P\u00e9rez-Losada","sequence":"additional","affiliation":[{"name":"Instituto de Biolog\u00eda Molecular y Celular del C\u00e1ncer (IBMCC-CIC), Universidad de Salamanca\/CSIC, 37007 Salamanca, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria de Salamanca (IBSAL), 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Holgado-Madruga","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Biosanitaria de Salamanca (IBSAL), 37007 Salamanca, Spain"},{"name":"Departamento de Fisiolog\u00eda y Farmacolog\u00eda, Universidad de Salamanca, 37007 Salamanca, Spain"},{"name":"Instituto de Neurociencias de Castilla y Le\u00f3n (INCyL), 37007 Salamanca, Spain"},{"name":"Virtual Institute for Good Health and Well Being (GLADE), European Campus of City Universities (EC2U), 86073 Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,20]]},"reference":[{"key":"ref_1","first-page":"179","article-title":"The IRS-Signaling System: A Network of Docking Proteins That Mediate Insulin and Cytokine Action","volume":"228","author":"White","year":"1998","journal-title":"Curr. 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