{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:42:27Z","timestamp":1790959347795,"version":"4.1.0"},"reference-count":48,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2023,8,26]],"date-time":"2023-08-26T00:00:00Z","timestamp":1693008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University Jaume I (UJI)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Introduction: Epithelial ovarian cancer (EOC) is primarily confined to the peritoneal cavity. When primary complete surgery is not possible, neoadjuvant chemotherapy (NACT) is provided; however, the peritoneum-plasma barrier hinders the drug effect. The intraperitoneal administration of chemotherapy could eliminate residual microscopic peritoneal tumor cells and increase this effect by hyperthermia. Intraperitoneal hyperthermic chemotherapy (HIPEC) after interval cytoreductive surgery could improve outcomes in terms of disease-free survival (DFS) and overall survival (OS). Materials and Methods: A multicenter, retrospective observational study of advanced EOC patients who underwent interval cytoreductive surgery alone (CRSnoH) or interval cytoreductive surgery plus HIPEC (CRSH) was carried out in Spain between 07\/2012 and 12\/2021. A total of 515 patients were selected. Progression-free survival (PFS) and OS analyses were performed. The series of patients who underwent CRSH or CRSnoH was balanced regarding the risk factors using a statistical analysis technique called propensity score matching. Results: A total of 170 patients were included in each subgroup. The complete surgery rate was similar in both groups (79.4% vs. 84.7%). The median PFS times were 16 and 13 months in the CRSH and CRSnoH groups, respectively (Hazard ratio (HR) 0.74; 95% CI, 0.58\u20130.94; p = 0.031). The median OS times were 56 and 50 months in the CRSH and CRSnoH groups, respectively (HR, 0.88; 95% CI, 0.64\u20131.20; p = 0.44). There was no increase in complications in the CRSH group. Conclusion: The addition of HIPEC after interval cytoreductive surgery is safe and increases DFS in advanced EOC patients.<\/jats:p>","DOI":"10.3390\/cancers15174271","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T05:46:47Z","timestamp":1693201607000},"page":"4271","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Neoadjuvant Chemotherapy plus Interval Cytoreductive Surgery with or without Hyperthermic Intraperitoneal Chemotherapy (NIHIPEC) in the Treatment of Advanced Ovarian Cancer: A Multicentric Propensity Score Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3723-8795","authenticated-orcid":false,"given":"Antoni","family":"Llueca","sequence":"first","affiliation":[{"name":"Multidisciplinary Unit of Abdominopelvic Oncology Surgery (MUAPOS), University General Hospital of Castellon, 12004 Castellon, Spain"},{"name":"Oncological Surgery Research Group (OSRG), Department of Medicine, University Jaume I (UJI), 12071 Castellon, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7043-8233","authenticated-orcid":false,"given":"Maria Victoria","family":"Iba\u00f1ez","sequence":"additional","affiliation":[{"name":"Department of Mathematics, IMAC, University Jaume I (UJI), 12071 Castellon, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Cascales","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Hospital Universitario Virgen de la Arrixaca, El Palmar, 30120 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1106-5590","authenticated-orcid":false,"given":"Antonio","family":"Gil-Moreno","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Unit, Department of Gynecology, Hospital Universitari Vall d\u2019Hebron, Universitat Aut\u00f2noma de Barcelona, 08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Bebia","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Unit, Department of Gynecology, Hospital Universitari Vall d\u2019Hebron, Universitat Aut\u00f2noma de Barcelona, 08035 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0613-2261","authenticated-orcid":false,"given":"Jordi","family":"Ponce","sequence":"additional","affiliation":[{"name":"Department of Gynecology, University Hospital of Bellvitge, 08907 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9138-6978","authenticated-orcid":false,"given":"Sergi","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Department of Gynecology, University Hospital of Bellvitge, 08907 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3024-3009","authenticated-orcid":false,"given":"Alvaro","family":"Arjona-Sanchez","sequence":"additional","affiliation":[{"name":"Unit of Surgical Oncology and Pancreatic Surgery, University Hospital Reina Sofia, 14004 Cordoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Muruzabal","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Complejo Hospitalario de Navarra, 31008 Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5761-5781","authenticated-orcid":false,"given":"Nadia","family":"Veiga","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Complejo Hospitalario de Navarra, 31008 Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6451-1817","authenticated-orcid":false,"given":"Berta","family":"Diaz-Feijoo","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Unit, Clinic Institute of Gynecology, Obstetrics, and Neonatology, Hospital Clinic of Barcelona, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Celada","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Unit, Clinic Institute of Gynecology, Obstetrics, and Neonatology, Hospital Clinic of Barcelona, Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Gilabert-Estelles","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University General Hospital of Valencia, 46014 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Aghababyan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University General Hospital of Valencia, 46014 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Lacueva","sequence":"additional","affiliation":[{"name":"Unit of Peritoneal Carcinomatosis, Department of General Surgery, University General Hospital of Elche, 03203 Elche, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Calero","sequence":"additional","affiliation":[{"name":"Unit of Peritoneal Carcinomatosis, Department of General Surgery, University General Hospital of Elche, 03203 Elche, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0565-3791","authenticated-orcid":false,"given":"Juan Jose","family":"Segura","sequence":"additional","affiliation":[{"name":"Hepatobiliopancreatic Surgery and Peritoneal Oncology Surgery Unit, General Surgery and Digestive System Department, Son Espases University Hospital, 07120 Palma de Mallorca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Maiocchi","sequence":"additional","affiliation":[{"name":"Multidisciplinary Unit of Abdominopelvic Oncology Surgery (MUAPOS), University General Hospital of Castellon, 12004 Castellon, Spain"},{"name":"Department of General Surgery, University General Hospital of Castellon, 12004 Castellon, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Llorca","sequence":"additional","affiliation":[{"name":"Multidisciplinary Unit of Abdominopelvic Oncology Surgery (MUAPOS), University General Hospital of Castellon, 12004 Castellon, Spain"},{"name":"Department of General Surgery, University General Hospital of Castellon, 12004 Castellon, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Villarin","sequence":"additional","affiliation":[{"name":"Multidisciplinary Unit of Abdominopelvic Oncology Surgery (MUAPOS), University General Hospital of Castellon, 12004 Castellon, Spain"},{"name":"Department of General Surgery, University General Hospital of Castellon, 12004 Castellon, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2533-7983","authenticated-orcid":false,"given":"Maria Teresa","family":"Climent","sequence":"additional","affiliation":[{"name":"Multidisciplinary Unit of Abdominopelvic Oncology Surgery (MUAPOS), University General Hospital of Castellon, 12004 Castellon, Spain"},{"name":"Oncological Surgery Research Group (OSRG), Department of Medicine, University Jaume I (UJI), 12071 Castellon, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katty","family":"Delgado","sequence":"additional","affiliation":[{"name":"Multidisciplinary Unit of Abdominopelvic Oncology Surgery (MUAPOS), University General Hospital of Castellon, 12004 Castellon, Spain"},{"name":"Oncological Surgery Research Group (OSRG), Department of Medicine, University Jaume I (UJI), 12071 Castellon, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7535-057X","authenticated-orcid":false,"given":"Anna","family":"Serra","sequence":"additional","affiliation":[{"name":"Multidisciplinary Unit of Abdominopelvic Oncology Surgery (MUAPOS), University General Hospital of Castellon, 12004 Castellon, Spain"},{"name":"Oncological Surgery Research Group (OSRG), Department of Medicine, University Jaume I (UJI), 12071 Castellon, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Gomez-Quiles","sequence":"additional","affiliation":[{"name":"Multidisciplinary Unit of Abdominopelvic Oncology Surgery (MUAPOS), University General Hospital of Castellon, 12004 Castellon, Spain"},{"name":"Department of General Surgery, University General Hospital of Castellon, 12004 Castellon, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Llueca","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Joan XXIII University Hospital of Tarragona, 43005 Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of Spain GOG and GECOP Working 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Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.2147\/OTT.S147559","article-title":"Peritoneal carcinomatosis index as a predictor of diaphragmatic involvement in stage III and IV ovarian cancer","volume":"11","author":"Llueca","year":"2018","journal-title":"OncoTargets Ther."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/978-1-4613-1247-5_4","article-title":"Peritoneal-Plasma Barrier","volume":"82","author":"Jacquet","year":"1996","journal-title":"Cancer Treat Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1093\/ndt\/gfn055","article-title":"Distributed model of peritoneal transport: Implications of the endothelial glycocalyx","volume":"23","author":"Flessner","year":"2008","journal-title":"Nephrol. Dial. Transpl."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.ejso.2011.04.007","article-title":"Impact of Surgical and Clinical Factors on the Pharmacology of Intraperitoneal Doxorubicin in 145 Patients with Peritoneal Carcinomatosis","volume":"37","author":"Sugarbaker","year":"2011","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"72","DOI":"10.2174\/157016309787581084","article-title":"Using Pharmacologic Data to Plan Clinical Treatments for Patients with Peritoneal Surface Malignancy","volume":"6","author":"Speeten","year":"2009","journal-title":"Curr. Drug Discov. Technol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/bjc.2014.602","article-title":"Pharmacokinetics of Concomitant Cisplatin and Paclitaxel Administered by Hyperthermic Intraperitoneal Chemotherapy to Patients with Peritoneal Carcinomatosis from Epithelial Ovarian Cancer","volume":"112","author":"Ansaloni","year":"2015","journal-title":"Br. J. Cancer"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1016\/j.ejca.2008.07.038","article-title":"Hyperthermia Adds to Chemotherapy","volume":"44","author":"Issels","year":"2008","journal-title":"Eur. J. Cancer"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"525","DOI":"10.5301\/tj.5000623","article-title":"1st Evidence-Based Italian Consensus Conference on Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Carcinosis from Ovarian Cancer","volume":"103","author":"Cavaliere","year":"2017","journal-title":"Tumori. J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1097\/IGC.0b013e31824d836c","article-title":"Evaluation of Extensive Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Patients with Advanced Epithelial Ovarian Cancer","volume":"22","author":"Ansaloni","year":"2012","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1097\/IGC.0000000000000664","article-title":"Heated IntraPEritoneal Chemotherapy (HIPEC) for Patients with Recurrent Ovarian Cancer: A Systematic Literature Review","volume":"26","author":"Hotouras","year":"2016","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3802\/jgo.2015.26.1.54","article-title":"Hyperthermic Intraperitoneal Chemotherapy with Cisplatin and Paclitaxel in Advanced Ovarian Cancer: A Multicenter Prospective Observational Study","volume":"26","author":"Coccolini","year":"2015","journal-title":"J. Gynecol. Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Llueca, M., Iba\u00f1ez, M.V., Climent, M.T., Serra, A., and Llueca, A. (2023). Effectiveness of Hyperthermic Intraperitoneal Chemotherapy Associated with Cytoreductive Surgery in the Treatment of Advanced Ovarian Cancer: Systematic Review and Meta-Analysis. J. Pers. Med., 13.","DOI":"10.3390\/jpm13020258"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1056\/NEJMoa1708618","article-title":"Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer","volume":"378","author":"Koole","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1245\/s10434-021-11087-7","article-title":"Cytoreductive Surgery with or without HIPEC after Neoadjuvant Chemotherapy in Ovarian Cancer: A Phase 3 Clinical Trial","volume":"29","author":"Antonio","year":"2022","journal-title":"Ann. Surg. Oncol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1001\/jamasurg.2022.0143","article-title":"Survival after Hyperthermic Intraperitoneal Chemotherapy and Primary or Interval Cytoreductive Surgery in Ovarian Cancer: A Randomized Clinical Trial","volume":"157","author":"Lim","year":"2022","journal-title":"JAMA Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1097\/00000658-199502000-00002","article-title":"Prognostic Features of 51 Colorectal and 130 Appendiceal Cancer Patients with Peritoneal Carcinomatosis Treated by Cytoreductive Surgery and Intraperitoneal Chemotherapy","volume":"221","author":"Sugarbaker","year":"1995","journal-title":"Ann. Surg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"333","DOI":"10.2147\/IJWH.S198355","article-title":"A Radiologic-Laparoscopic Model to Predict Suboptimal (or Complete and Optimal) Debulking Surgery in Advanced Ovarian Cancer: A Pilot Study","volume":"11","author":"Llueca","year":"2019","journal-title":"Int. J. Womens Health"},{"key":"ref_19","first-page":"518","article-title":"Proposed Classification of Complications of Surgery with Examples of Utility in Cholecystectomy\u2014PubMed","volume":"111","author":"Clavien","year":"1992","journal-title":"Surgery"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Anderson-Cook, C.M., and Anderson-Cook, M.C. (2005). Experimental and Quasi-Experimental Designs for Generalized Causal Inference. William R. Shadish, Thomas D. Cook, and Donald T. Campbell. J. Am. Stat Assoc., 100, Available online: https:\/\/EconPapers.repec.org\/RePEc:bes:jnlasa:v:100:y:2005:p:708-708.","DOI":"10.1198\/jasa.2005.s22"},{"key":"ref_21","unstructured":"R Core Team (2021). R: A Language and Environment for Statistical Computing, R Core Team."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v042.i08","article-title":"MatchIt: Nonparametric Preprocessing for Parametric Causal Inference","volume":"42","author":"Ho","year":"2011","journal-title":"J. Stat. Softw."},{"key":"ref_23","unstructured":"Noah, G. (2022, July 07). Covariate Balance Tables and Plots. R Package Version 4.3.1. Available online: https:\/\/CRAN.R-project.org\/package=cobalt."},{"key":"ref_24","unstructured":"Therneau, T.M., and Grambsch, P.M. (2022, January 16). A Package for Survival Analysis in S, Version 2.38. Modeling Survival Data: Extending the Cox Model. Available online: http:\/\/cran.r-project.org\/package=survival."},{"key":"ref_25","unstructured":"M\u00f6llenhoff, K., and Tresch, A. (2022, January 16). Survival Analysis under Non-Proportional Hazards: Investigating Non-Inferiority or Equivalence in Time-to-Event Data. 14 September 2020. Available online: http:\/\/arxiv.org\/abs\/2009.06699."},{"key":"ref_26","unstructured":"Alboukadel, K. (2022, January 16). Drawing Survival Curves Using \u201cggplot2\u201d. [R Package Survminer Version 0.4.9]. 9 Mar 2021. Available online: https:\/\/CRAN.R-project.org\/package=survminer."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1200\/JCO.2007.13.1953","article-title":"Tumor Residual after Surgical Cytoreduction in Prediction of Clinical Outcome in Stage IV Epithelial Ovarian Cancer: A Gynecologic Oncology Group Study","volume":"26","author":"Winter","year":"2008","journal-title":"J. Clin. Oncol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1056\/NEJMoa052985","article-title":"Intraperitoneal Cisplatin and Paclitaxel in Ovarian Cancer","volume":"354","author":"Armstrong","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1080\/02656736.2017.1279757","article-title":"Targeting Therapy-Resistant Cancer Stem Cells by Hyperthermia","volume":"33","author":"Oei","year":"2017","journal-title":"Int. J. Hyperth."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1136\/ijgc-2020-001231","article-title":"Primary Cytoreductive Surgery with or without Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for FIGO Stage III Epithelial Ovarian Cancer: OVHIPEC-2, a Phase III Randomized Clinical Trial","volume":"30","author":"Koole","year":"2020","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1245\/s10434-014-4157-9","article-title":"Cytoreductive Surgery and HIPEC in Recurrent Epithelial Ovarian Cancer: A Prospective Randomized Phase III Study","volume":"22","author":"Spiliotis","year":"2015","journal-title":"Ann. Surg. Oncol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ygyno.2007.03.019","article-title":"Treatment of Ovarian Cancer with Paclitaxel- or Carboplatin-Based Intraperitoneal Hyperthermic Chemotherapy during Secondary Surgery","volume":"106","author":"Bae","year":"2007","journal-title":"Gynecol. Oncol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1530\/rep.1.01128","article-title":"Quantification of Healthy Follicles in the Neonatal and Adult Mouse Ovary: Evidence for Maintenance of Primordial Follicle Supply","volume":"132","author":"Kerr","year":"2006","journal-title":"Reproduction"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S0025-6196(11)61196-8","article-title":"Current Management Strategies for Ovarian Cancer","volume":"82","author":"Aletti","year":"2007","journal-title":"Mayo Clin. Proc."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Mu\u00f1oz-Galv\u00e1n, S., and Carnero, A. (2020). Targeting Cancer Stem Cells to Overcome Therapy Resistance in Ovarian Cancer. Cells, 9.","DOI":"10.3390\/cells9061402"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00005-008-0023-4","article-title":"Cancer Stem Cells as Targets for Cancer Therapy: Selected Cancers as Examples","volume":"56","author":"Paranjothy","year":"2008","journal-title":"Arch. Immunol. Ther. Exp."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.cell.2007.10.054","article-title":"let-7 Regulates Self Renewal and Tumorigenicity of Breast Cancer Cells","volume":"131","author":"Yu","year":"2007","journal-title":"Cell"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1159\/000313823","article-title":"Residual Cancer Stem Cells after Interval Cytoreductive Surgery Following Neoadjuvant Chemotherapy Could Result in Poor Treatment Outcomes for Ovarian Cancer","volume":"33","author":"Lim","year":"2010","journal-title":"Onkologie"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Tate, S., Nishikimi, K., Kato, K., Matsuoka, A., Kambe, M., Kiyokawa, T., and Shozu, M. (2020). Microscopic Diseases Remain in Initial Disseminated Sites after Neoadjuvant Chemotherapy for Stage III\/IV Ovarian, Tubal, and Primary Peritoneal Cancer. J. Gynecol. Oncol., 31.","DOI":"10.3802\/jgo.2020.31.e34"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1200\/JCO.1995.13.7.1589","article-title":"Assessment of Dose-Intensive Therapy in Suboptimally Debulked Ovarian Cancer: A Gynecologic Oncology Group Study","volume":"13","author":"McGuire","year":"1995","journal-title":"J. Clin. Oncol."},{"key":"ref_41","first-page":"45","article-title":"Chemotherapy for Intraperitoneal Use: A Review of Hyperthermic Intraperitoneal Chemotherapy and Early Post-Operative Intraperitoneal Chemotherapy","volume":"7","author":"Goodman","year":"2016","journal-title":"J. Gastrointest. Oncol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Tattersall, A., Ryan, N., Wiggans, A.J., Rogozi\u0144ska, E., and Morrison, J. (2022). Poly(ADP-Ribose) Polymerase (PARP) Inhibitors for the Treatment of Ovarian Cancer. Cochrane Database Syst. Rev., 2.","DOI":"10.1002\/14651858.CD007929.pub4"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1002\/jcp.24302","article-title":"Hyperthermia Inhibits Homologous Recombination Repair and Sensitizes Cells to Ionizing Radiation in a Time- and Temperature-Dependent Manner","volume":"228","author":"Genet","year":"2013","journal-title":"J. Cell Physiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"9851","DOI":"10.1073\/pnas.1101053108","article-title":"Mild Hyperthermia Inhibits Homologous Recombination, Induces BRCA2 Degradation, and Sensitizes Cancer Cells to Poly (ADP-Ribose) Polymerase-1 Inhibition","volume":"108","author":"Krawczyk","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Llueca, A., Serra, A., Climent, M.T., Segarra, B., Maazouzi, Y., Soriano, M., and Escrig, J. (2020). Outcome Quality Standards in Advanced Ovarian Cancer Surgery. World J. Surg. Oncol., 18.","DOI":"10.1186\/s12957-020-02064-7"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Climent, M.T., Serra, A., Gilabert-estell\u00e9s, J., Gilabert-aguilar, J., and Llueca, A. (2021). Comparison of Peritoneal Carcinomatosis Scoring Methods in Predicting Resectability and Prognosis in Gynecologic Malignancies. J. Clin. Med., 10.","DOI":"10.3390\/jcm10122553"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"161","DOI":"10.2147\/IJWH.S190493","article-title":"Predictive model for major complications after extensive abdominal surgery in primary advanced ovarian cancer","volume":"11","author":"Llueca","year":"2019","journal-title":"Int. J. Womens Health"},{"key":"ref_48","first-page":"256","article-title":"Hyperthermic Intraperitoneal Chemotherapy Added to the Treatment of Ovarian Cancer. A Review of Achieved Results and Complications","volume":"31","author":"Dovern","year":"2010","journal-title":"Eur. J. Gynaecol. Oncol."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/15\/17\/4271\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:39:30Z","timestamp":1760128770000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/15\/17\/4271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,26]]},"references-count":48,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["cancers15174271"],"URL":"https:\/\/doi.org\/10.3390\/cancers15174271","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,26]]}}}