{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T15:41:35Z","timestamp":1775749295734,"version":"3.50.1"},"reference-count":33,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian National Institute of Health","award":["ISS20-a4627f16ba39"],"award-info":[{"award-number":["ISS20-a4627f16ba39"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>The aim of this study is to describe the frequency and trend of pregnancy-associated cancer (PAC) in Italy, an increasingly relevant phenomenon due to postponing age at childbirth. To this purpose, a population-based retrospective longitudinal study design based on cohorts of women aged 15\u201349 diagnosed with cancer and concomitant pregnancy is proposed. The study uses 19 population-based Cancer Registries, covering about 22% of Italy, and linked at an individual level with Hospital Discharge Records. A total of 2,861,437 pregnancies and 3559 PAC are identified from 74,165 women of the cohort with a rate of 1.24 PAC per 1000 pregnancies. The most frequent cancer site is breast (24.3%), followed by thyroid (23.9%) and melanoma (14.3%). The most frequent outcome is delivery (53.1%), followed by voluntary termination of pregnancy and spontaneous abortion (both 12.0%). The trend of PAC increased from 2003 to 2015, especially when the outcome is delivery, thus confirming a new attitude of clinicians to manage cancer throughout pregnancy. This represents the first attempt in Italy to describe PAC from Cancer Registries data; the methodology is applicable to other areas with the same data availability. Evidence from this study is addressed to clinicians for improving clinical management of women with PAC.<\/jats:p>","DOI":"10.3390\/cancers15174305","type":"journal-article","created":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T08:51:14Z","timestamp":1693299074000},"page":"4305","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Cancer and Pregnancy: Estimates in Italy from Record-Linkage Procedures between Cancer Registries and the Hospital Discharge Database"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3593-9774","authenticated-orcid":false,"given":"Daniela","family":"Pierannunzio","sequence":"first","affiliation":[{"name":"National Centre for Disease Prevention and Health Promotion, Italian National Institute of Health, 00162 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4754-5385","authenticated-orcid":false,"given":"Alice","family":"Maraschini","sequence":"additional","affiliation":[{"name":"Technical-Scientific Statistical Service, Italian National Institute of Health, 00162 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6168-400X","authenticated-orcid":false,"given":"Tania","family":"Lopez","sequence":"additional","affiliation":[{"name":"National Centre for Disease Prevention and Health Promotion, Italian National Institute of Health, 00162 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4607-2072","authenticated-orcid":false,"given":"Serena","family":"Donati","sequence":"additional","affiliation":[{"name":"National Centre for Disease Prevention and Health Promotion, Italian National Institute of Health, 00162 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosalba","family":"Amodio","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and Cancer Registry Unit, Azienda Ospedaliera Universitaria Policlinico (AOUP), 90127 Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3132-0061","authenticated-orcid":false,"given":"Fortunato","family":"Bianconi","sequence":"additional","affiliation":[{"name":"Area Operativa ICT\u2014PuntoZero Scarl, 06128 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2129-3921","authenticated-orcid":false,"given":"Rossella","family":"Bruni","sequence":"additional","affiliation":[{"name":"AReSS Puglia, 70121 Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marine","family":"Castaing","sequence":"additional","affiliation":[{"name":"Siracusa Cancer Registry, Health Unit of Siracusa, 96100 Siracusa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Cirilli","sequence":"additional","affiliation":[{"name":"Dipartimento di Epidemiologia e Comunicazione del Rischio, AUSL di Modena, 41126 Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Fantaci","sequence":"additional","affiliation":[{"name":"UOS Registro Tumori ASP Trapani, 91100 Trapani, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Guarda","sequence":"additional","affiliation":[{"name":"SC Osservatorio Epidemiologico ATS Valpadana, 46100 Mantova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Iacovacci","sequence":"additional","affiliation":[{"name":"RT LT, Dipartimento di Prevenzione ASL Latina, 04100 Latina, 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Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Rugge","sequence":"additional","affiliation":[{"name":"Surgical Pathology & Cytopathology Unit, Department of Medicine (DIMED), University of Padova, 35128 Padova, Italy"},{"name":"Veneto Tumor Registry (RTV), Veneto Regional Authority, 35132 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Sampietro","sequence":"additional","affiliation":[{"name":"Health Protection Agency of Bergamo (ATS Bergamo), 24121 Bergamo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Scambia","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Universit\u00e0 Cattolica Roma, 00168 Roma, 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