{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T19:51:32Z","timestamp":1772826692556,"version":"3.50.1"},"reference-count":52,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T00:00:00Z","timestamp":1694131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Survivorship Outcomes","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>There is a paucity of research on treatment-related neurotoxicity in older adults with multiple myeloma (MM) treated with high-dose chemotherapy (HDC) and autologous SCT (HDC\/ASCT), despite the increasing use of this regimen. We examined resting state functional connectivity (RSFC), gray matter (GM) volume, neurocognitive function (NF), and proinflammatory cytokines (PCy) in older patients with MM pre- and post-HDC\/ASCT. Eighteen patients underwent MRI, NF tests, and serum PCy measurements prior to HDC\/ASCT, and fifteen patients completed a follow up five-months post-HDC\/ASCT. There were significant decreases in RSFC post-HDC\/ASCT in (1) the central executive network (CEN) involving the left dorsolateral prefrontal cortex and right posterior parietal cortex (p = 0.022) and (2) the CEN involving the right posterior parietal cortex and the salience network involving the right dorsal anterior cingulate cortex (p = 0.029). There were no significant changes in GM or NF, except for improvements in attention (Digit Span Backward, p = 0.03). There were significant increases in several PCy post-HDC\/ASCT (p \u2264 0.05). In conclusion, RSFC decreased in frontal, parietal, and cingulate cortices post-HDC\/ASCT, NF was relatively stable, and several PCy increased. These findings are congruent with other studies in cancer patients and provide supporting evidence for the vulnerability of frontoparietal regions to chemotherapy\u2019s adverse effects.<\/jats:p>","DOI":"10.3390\/cancers15184484","type":"journal-article","created":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T09:09:21Z","timestamp":1694423361000},"page":"4484","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Neuroimaging and Neurocognitive Outcomes in Older Patients with Multiple Myeloma Treated with Chemotherapy and Autologous Stem Cell Transplantation"],"prefix":"10.3390","volume":"15","author":[{"given":"Denise D.","family":"Correa","sequence":"first","affiliation":[{"name":"Department of Neurology, MSKCC\u2014Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"},{"name":"Department of Neurology, Weill Cornell Medical College, New York, NY 10065, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7462-1422","authenticated-orcid":false,"given":"Behroze A.","family":"Vachha","sequence":"additional","affiliation":[{"name":"Department of Radiology, UMass Chan Medical School, Worcester, MA 01665, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond E.","family":"Baser","sequence":"additional","affiliation":[{"name":"Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8252-1372","authenticated-orcid":false,"given":"Adrian","family":"Koch","sequence":"additional","affiliation":[{"name":"Department of Neurology, MSKCC\u2014Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Immune Monitoring Facility, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suril","family":"Gohel","sequence":"additional","affiliation":[{"name":"Department of Heath Informatics, Rutgers University School of Health Professions, Newark, NJ 08854, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Giralt","sequence":"additional","affiliation":[{"name":"Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James C.","family":"Root","sequence":"additional","affiliation":[{"name":"Department of Psychiatry & Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"},{"name":"Departments of Psychiatry, Weill Cornell Medical College, New York, NY 10065, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1634\/theoncologist.2008-0130","article-title":"Clinical patterns and biological correlates of cognitive dysfunction associated with cancer therapy","volume":"13","author":"Dietrich","year":"2008","journal-title":"Oncologist"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.tins.2021.02.003","article-title":"Microglia in Cancer Therapy-Related Cognitive Impairment","volume":"44","author":"Gibson","year":"2021","journal-title":"Trends Neurosci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"S117","DOI":"10.1016\/j.bbi.2012.05.007","article-title":"Frontal gray matter reduction after breast cancer chemotherapy and association with executive symptoms: A replication and extension study","volume":"30","author":"McDonald","year":"2012","journal-title":"Brain Behav. 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