{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T11:44:06Z","timestamp":1767008646200,"version":"build-2065373602"},"reference-count":25,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T00:00:00Z","timestamp":1694390400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V111C-162","VGHUST111C-140"],"award-info":[{"award-number":["V111C-162","VGHUST111C-140"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Veterans General Hospitals and University System of Taiwan Joint Research Program","award":["V111C-162","VGHUST111C-140"],"award-info":[{"award-number":["V111C-162","VGHUST111C-140"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>This case-control study investigates the associations between head and neck cancer (HNC), hepatitis B virus (HBV), and hepatitis C virus (HCV) infection. We included 5603 patients who had received a diagnosis of HNC as cases and 16,809 propensity score matching controls. We employed multivariate logistic regression models to evaluate the association of HNC with HBV and HCV infection after taking sociodemographic characteristics and diabetes, hypertension, hyperlipidemia, HPV infection, tobacco use disorder, and alcohol abuse\/alcohol dependence syndrome into considerations. Results show that 7.9% of the total sample had been previously diagnosed with HBV infection, with 9.0% prevalence among cases and 7.6% among controls (p &lt; 0.001). The chi-squared test suggests a significant difference in the prevalence of HCV infection between cases and controls (3.3% vs. 2.7%, p = 0.019). The covariate-adjusted odds ratio (OR) of HBV infection in patients with HNC relative to controls was 1.219 (95% CI = 1.093~1.359). Additionally, the adjusted OR of HCV infection in patients with HNC was 1.221 (95% CI = 1.023~1.457) compared to controls. Furthermore, patients with oropharyngeal cancer were more likely to have HCV infection than controls (adjusted OR = 2.142, 95% CI = 1.171~3.918). Our study provides evidence that suggests a potential association between HBV and HCV infections and the risk of HNC.<\/jats:p>","DOI":"10.3390\/cancers15184510","type":"journal-article","created":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T09:11:18Z","timestamp":1694423478000},"page":"4510","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Associations of Head and Neck Cancer with Hepatitis B Virus and Hepatitis C Virus Infection"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9591-5489","authenticated-orcid":false,"given":"Shih-Han","family":"Hung","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, School of Medicine, Taipei Medical University, Taipei 110, Taiwan"},{"name":"Department of Otolaryngology, Wan Fang Hospital, Taipei 110, Taiwan"},{"name":"International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1276-6292","authenticated-orcid":false,"given":"Tzong-Hann","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Taipei City Hospital, Taipei 110, Taiwan"},{"name":"Department of Speech, Language and Audiology, National Taipei University of Nursing and Health, Taipei 112, Taiwan"},{"name":"Department of Otolaryngology-Head and Neck Surgery, School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"},{"name":"Center of General Education, University of Taipei, Taipei 112, Taiwan"},{"name":"Research Center of Sleep Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen-Fu","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan"},{"name":"Research Center of Sleep Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan"},{"name":"Department of Medical Research, Taipei Veterans General Hospital, Taipei 112, Taiwan"},{"name":"Department of Otolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, Taipei 112, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin-Shyan","family":"Chen","sequence":"additional","affiliation":[{"name":"Research Center of Sleep Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan"},{"name":"Department of Economics, National Taipei University, New Taipei City 112, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4661-959X","authenticated-orcid":false,"given":"Herng-Ching","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Health Care Administration, College of Management, Taipei Medical University, Taipei 110, Taiwan"},{"name":"Research Center of Sleep Medicine, Taipei Medical University Hospital, Taipei 110, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1056\/NEJM199301213280306","article-title":"Head and neck cancer","volume":"328","author":"Vokes","year":"1993","journal-title":"N. 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