{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:21:52Z","timestamp":1771892512686,"version":"3.50.1"},"reference-count":65,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T00:00:00Z","timestamp":1694476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Instituto de Salud Carlos III FEDER","award":["PI\/00047"],"award-info":[{"award-number":["PI\/00047"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: We aimed to develop and validate a model predicting breast cancer risk for women targeted by breast cancer screening. Method: This retrospective cohort study included 57,411 women screened at least once in BreastScreen Norway during the period from 2007 to 2019. The prediction model included information about age, mammographic density, family history of breast cancer, body mass index, age at menarche, alcohol consumption, exercise, pregnancy, hormone replacement therapy, and benign breast disease. We calculated a 4-year absolute breast cancer risk estimates for women and in risk groups by quartiles. The Bootstrap resampling method was used for internal validation of the model (E\/O ratio). The area under the curve (AUC) was estimated with a 95% confidence interval (CI). Results: The 4-year predicted risk of breast cancer ranged from 0.22\u20137.33%, while 95% of the population had a risk of 0.55\u20132.31%. The thresholds for the quartiles of the risk groups, with 25% of the population in each group, were 0.82%, 1.10%, and 1.47%. Overall, the model slightly overestimated the risk with an E\/O ratio of 1.10 (95% CI: 1.09\u20131.11) and the AUC was 62.6% (95% CI: 60.5\u201365.0%). Conclusions: This 4-year risk prediction model showed differences in the risk of breast cancer, supporting personalized screening for breast cancer in women aged 50\u201369 years.<\/jats:p>","DOI":"10.3390\/cancers15184517","type":"journal-article","created":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T03:54:06Z","timestamp":1694490846000},"page":"4517","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Personalized Breast Cancer Screening: A Risk Prediction Model Based on Women Attending BreastScreen Norway"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2985-3301","authenticated-orcid":false,"given":"Javier","family":"Louro","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Evaluation, Hospital del Mar Medical Research Institute, 08003 Barcelona, Spain"},{"name":"Network for Research on Chronicity, Primary Care, and Health Promotion (RICAPPS), 48902 Barakaldo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Rom\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Evaluation, Hospital del Mar Medical Research Institute, 08003 Barcelona, Spain"},{"name":"Network for Research on Chronicity, Primary Care, and Health Promotion (RICAPPS), 48902 Barakaldo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nataliia","family":"Moshina","sequence":"additional","affiliation":[{"name":"Section for Breast Cancer Screening, Cancer Registry of Norway, 0304 Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla F.","family":"Olstad","sequence":"additional","affiliation":[{"name":"Section for Breast Cancer Screening, Cancer Registry of Norway, 0304 Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marthe","family":"Larsen","sequence":"additional","affiliation":[{"name":"Section for Breast Cancer Screening, Cancer Registry of Norway, 0304 Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3193-1158","authenticated-orcid":false,"given":"Silje","family":"Sagstad","sequence":"additional","affiliation":[{"name":"Section for Breast Cancer Screening, Cancer Registry of Norway, 0304 Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Castells","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Evaluation, Hospital del Mar Medical Research Institute, 08003 Barcelona, Spain"},{"name":"Network for Research on Chronicity, Primary Care, and Health Promotion (RICAPPS), 48902 Barakaldo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0178-8939","authenticated-orcid":false,"given":"Solveig","family":"Hofvind","sequence":"additional","affiliation":[{"name":"Section for Breast Cancer Screening, Cancer Registry of Norway, 0304 Oslo, Norway"},{"name":"Department of Health and Care Sciences, Faculty of Health Sciences, UiT, The Arctic University of Norway, 9037 Troms\u00f8, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1056\/NEJMoa1206809","article-title":"Effect of three decades of screening mammography on breast-cancer incidence","volume":"367","author":"Bleyer","year":"2012","journal-title":"N. 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