{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:29:33Z","timestamp":1790422173291,"version":"4.1.0"},"reference-count":38,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T00:00:00Z","timestamp":1694736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"German Federal Joint Committee","award":["01VSF17020"],"award-info":[{"award-number":["01VSF17020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>(1) Background: The WiZen study is the largest study so far to analyze the effect of the certification of designated cancer centers on survival in Germany. This certification program is provided by the German Cancer Society (GCS) and represents one of the largest oncologic certification programs worldwide. Currently, about 50% of colorectal cancer patients in Germany are treated in certified centers. (2) Methods: All analyses are based on population-based clinical cancer registry data of 47.440 colorectal cancer (ICD-10-GM C18\/C20) patients treated between 2009 and 2017. The primary outcome was 5-year overall survival (OAS) after treatment at certified cancer centers compared to treatment at other hospitals; the secondary endpoint was recurrence-free survival. Statistical methods included Kaplan\u2013Meier analysis and multivariable Cox regression. (3) Results: Treatment at certified hospitals was associated with significant advantages concerning 5-year overall survival (HR 0.92, 95% CI 0.89, 0.96, adjusted for a broad range of confounders) for colon cancer patients. Concentrating on UICC stage I\u2013III patients, for whom curative treatment is possible, the survival benefit was even larger (colon cancer: HR 0.89, 95% CI 0.84, 0.94; rectum cancer: HR 0.91, 95% CI 0.84, 0.97). (4) Conclusions: These results encourage future efforts for further implementation of the certification program. Patients with colorectal cancer should preferably be directed to certified centers.<\/jats:p>","DOI":"10.3390\/cancers15184568","type":"journal-article","created":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T04:06:13Z","timestamp":1694750773000},"page":"4568","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Treatment of Colorectal Cancer in Certified Centers: Results of a Large German Registry Study Focusing on Long-Term Survival"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2057-4904","authenticated-orcid":false,"given":"Vinzenz","family":"V\u00f6lkel","sequence":"first","affiliation":[{"name":"Tumor Center Regensburg, Center of Quality Management and Health Services Research, University of Regensburg, 93053 Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Gerken","sequence":"additional","affiliation":[{"name":"Tumor Center Regensburg, Center of Quality Management and Health Services Research, University of Regensburg, 93053 Regensburg, Germany"},{"name":"Bavarian Cancer Registry, Regional Center Regensburg, Bavarian Health and Food Safety Authority, 93053 Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kees","family":"Kleihues-van Tol","sequence":"additional","affiliation":[{"name":"Arbeitsgemeinschaft Deutscher Tumorzentren e.V. (ADT), 14057 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6922-7148","authenticated-orcid":false,"given":"Olaf","family":"Schoffer","sequence":"additional","affiliation":[{"name":"Center for Evidence-Based Healthcare (ZEGV), Faculty of Medicine, University Hospital Carl Gustav Carus and Carl Gustav Carus, Dresden University of Technology (TU Dresden), 01307 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Bierbaum","sequence":"additional","affiliation":[{"name":"Center for Evidence-Based Healthcare (ZEGV), Faculty of Medicine, University Hospital Carl Gustav Carus and Carl Gustav Carus, Dresden University of Technology (TU Dresden), 01307 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Bobeth","sequence":"additional","affiliation":[{"name":"Center for Evidence-Based Healthcare (ZEGV), Faculty of Medicine, University Hospital Carl Gustav Carus and Carl Gustav Carus, Dresden University of Technology (TU Dresden), 01307 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4662-4156","authenticated-orcid":false,"given":"Martin","family":"Roessler","sequence":"additional","affiliation":[{"name":"Center for Evidence-Based Healthcare (ZEGV), Faculty of Medicine, University Hospital Carl Gustav Carus and Carl Gustav Carus, Dresden University of Technology (TU Dresden), 01307 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4591-1046","authenticated-orcid":false,"given":"Christoph","family":"Reissfelder","sequence":"additional","affiliation":[{"name":"Department of Surgery, Universit\u00e4tsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alois","family":"F\u00fcrst","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Allgemein-, Viszeral-, Thoraxchirurgie und Adipositasmedizin, Caritas Krankenhaus St., 93053 Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Benz","sequence":"additional","affiliation":[{"name":"Arbeitsgemeinschaft Deutscher Tumorzentren e.V. (ADT), 14057 Berlin, Germany"},{"name":"Klinik f\u00fcr Allgemein-, Viszeral-, Thorax- und Kinderchirurgie, 71032 B\u00f6blingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina M.","family":"Rau","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Thoracic Surgery, Hospital of Neumarkt, 92318 Neumarkt in der Oberpfalz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pompiliu","family":"Piso","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Allgemein- und Viszeralchirurgie, Krankenhaus der Barmherzigen Br\u00fcder, 93049 Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Distler","sequence":"additional","affiliation":[{"name":"Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus Dresden, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology (TU Dresden), 01307 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3085-6259","authenticated-orcid":false,"given":"Christian","family":"G\u00fcnster","sequence":"additional","affiliation":[{"name":"WIdO\u2014AOK Research Institute, 10178 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Hansinger","sequence":"additional","affiliation":[{"name":"Tumor Center Regensburg, Center of Quality Management and Health Services Research, University of Regensburg, 93053 Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Center for Evidence-Based Healthcare (ZEGV), Faculty of Medicine, University Hospital Carl Gustav Carus and Carl Gustav Carus, Dresden University of Technology (TU Dresden), 01307 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Klinkhammer-Schalke","sequence":"additional","affiliation":[{"name":"Tumor Center Regensburg, Center of Quality Management and Health Services Research, University of Regensburg, 93053 Regensburg, Germany"},{"name":"Arbeitsgemeinschaft Deutscher Tumorzentren e.V. (ADT), 14057 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,15]]},"reference":[{"key":"ref_1","unstructured":"Wild, C.P., Weiderpass, E., and Stewart, B.W. (2020). World Cancer Report: Cancer Research for Cancer Prevention, World Health Organization. World Cancer Reports."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3322\/caac.21601","article-title":"Colorectal cancer statistics, 2020","volume":"70","author":"Siegel","year":"2020","journal-title":"CA Cancer J. Clin."},{"key":"ref_3","unstructured":"Robert Koch-Institut, and Gesellschaft der Epidemiologischen Krebsregister in Deutschland e.V. (2021). Krebs in Deutschland f\u00fcr 2017\/2018, Zentrum f\u00fcr Krebsregisterdaten. [13th ed.]."},{"key":"ref_4","unstructured":"(2023, June 21). 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