{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:14:38Z","timestamp":1777709678056,"version":"3.51.4"},"reference-count":31,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T00:00:00Z","timestamp":1694995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical University of Lodz","award":["503\/5-061-02\/503-51-001-18"],"award-info":[{"award-number":["503\/5-061-02\/503-51-001-18"]}]},{"name":"Medical University of Lodz","award":["503\/5-061-02\/503-51-001-17"],"award-info":[{"award-number":["503\/5-061-02\/503-51-001-17"]}]},{"name":"Medical University of Lodz","award":["503\/5-061-02\/503-51-002-18"],"award-info":[{"award-number":["503\/5-061-02\/503-51-002-18"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>The aim of this paper was to characterise the isotopic composition of oral squamous cell carcinoma (OSCC) specimens of different areas of the oral cavity. Secondly, we assessed whether there was a correlation between clinical stages of OSCC and isotopic abundance. The IRMS procedure was performed on 124 samples derived from 31 patients with OSCC of 15 N and 13 C to assess the isotopic composition. From each individual, four samples from the tumour, two from the margins, and two samples of healthy oral mucous membranes were derived. The two samples from the tumour and two samples from the margin were additionally subjected to histopathological assessment. Then, statistical analysis was conducted. Tumour infiltration tissues of the lower lip were characterised by higher mean \u03b413C values compared to samples derived from cancers of the other oral cavity regions (\u221223.82 \u00b1 1.21 vs. \u221222.67 \u00b1 1.35); (p = 0.04). The mean percentage of nitrogen content in tumour tissues was statistically higher in patients with the most advanced cancers (11.89 \u00b1 0.03%) versus the group of patients with II and III stage cancers (11.12 \u00b1 0.02%); (p = 0.04). In patients at stage IV, the mean \u03b413C value in the cancer samples equalled \u221222.69 \u00b1 1.42 and was lower than that in patients at less severe clinical stages (p = 0.04). Lower lip cancer tissues differed in the isotopic abundance of carbon in comparison with tissues derived from the group of combined samples from other locations. Values of \u03b413C observed in specimens derived from lower lip cancers were similar to those observed in healthy oral mucous membranes. Cancer tissues obtained from patients in the last stage of OSCC had a different isotopic composition in comparison with those obtained from earlier stages. To confirm these observations, further research on larger groups of patients is needed.<\/jats:p>","DOI":"10.3390\/cancers15184610","type":"journal-article","created":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T05:59:06Z","timestamp":1695016746000},"page":"4610","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Oral Cavity Cancer Tissues Differ in Isotopic Composition Depending on Location and Staging"],"prefix":"10.3390","volume":"15","author":[{"given":"Katarzyna","family":"Bogusiak","sequence":"first","affiliation":[{"name":"Department of Maxillofacial Surgery, Medical University of Lodz, 113 \u017beromskiego, 90-549 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9200-2828","authenticated-orcid":false,"given":"Marcin","family":"Kozakiewicz","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery, Medical University of Lodz, 113 \u017beromskiego, 90-549 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4651-7489","authenticated-orcid":false,"given":"Aleksandra","family":"Puch","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery, Medical University of Lodz, 113 \u017beromskiego, 90-549 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rados\u0142aw","family":"Mostowski","sequence":"additional","affiliation":[{"name":"Institute of Food Technology and Analysis, Faculty of Biotechnology and Food Sciences, Lodz University of Technology, 4\/10 Stefanowskiego, 90-924 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3091-8387","authenticated-orcid":false,"given":"Piotr","family":"Paneth","sequence":"additional","affiliation":[{"name":"Institute of Applied Radiation Chemistry, Lodz University of Technology, 116 \u017beromskiego, 90-924 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f3zef","family":"Kobos","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Medical University of Lodz, 7\/9 \u017beligowskiego, 90-752 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Tea, I., De Luca, A., Schiphorst, A.M., Grand, M., Barill\u00e9-Nion, S., Miralli\u00e9, E., Drui, D., Krempf, M., Hankard, R., and Tcherkez, G. 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