{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T01:17:50Z","timestamp":1768871870307,"version":"3.49.0"},"reference-count":39,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T00:00:00Z","timestamp":1695513600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: maxillary bone invasion (MBI) is not uncommon in hard palate or upper alveolus (HP\/UA) cancer; however, there have been relatively few reports about the MBI of HP\/UA cancer. Patients and Methods: this was a multi-center retrospective study, enrolling 144 cases of HP\/UA cancer. MBI was defined by surgical pathology or radiology follow-up. The multiple prediction models for MBI were developed in total cases and in cases having primary bone resection, using clinical and radiological variables. Results: computerized tomography (CT) alone predicted MBI, with an area under receiver operating curve (AUC) of 0.779 (95% confidence interval (CI) = 0.712\u20130.847). The AUC was increased in a model that combined tumor dimensions and clinical factors (male sex and nodal metastasis) (0.854 (95%CI = 0.790\u20130.918)). In patients who underwent 18fluorodeoxyglucose positron emission tomography\/CT (PET\/CT), the discrimination performance of a model including the maximal standardized uptake value (SUVmax) had an AUC of 0.911 (95%CI = 0.847\u20130.975). The scoring system using CT finding, tumor dimension, and clinical factors, with\/without PET\/CT SUVmax clearly distinguished low-, intermediate-, and high-risk groups for MBI. Conclusion: using information from CT, tumor dimension, clinical factors, and the SUVmax value, the MBI of HP\/UA cancer can be predicted with a relatively high discrimination performance.<\/jats:p>","DOI":"10.3390\/cancers15194699","type":"journal-article","created":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T10:48:31Z","timestamp":1695552511000},"page":"4699","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prediction of Maxillary Bone Invasion in Hard Palate\/Upper Alveolus Cancer: A Multi-Center Retrospective Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0962-0594","authenticated-orcid":false,"given":"Nayeon","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul 06351, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9047-4896","authenticated-orcid":false,"given":"Jeon Yeob","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Ajou University Hospital, Ajou University School of Medicine, Suwon 16499, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min-Ji","family":"Kim","sequence":"additional","affiliation":[{"name":"Biomedical Statistics Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul 06351, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5861-7386","authenticated-orcid":false,"given":"Sung Seok","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Ulsan University School of Medicine, Asan Medical Center, Seoul 05505, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Ho","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Ulsan University School of Medicine, Asan Medical Center, Seoul 05505, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4652-0573","authenticated-orcid":false,"given":"Han-Sin","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul 06351, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4460","DOI":"10.1002\/cncr.26032","article-title":"The prognostic and staging implications of bone invasion in oral squamous cell carcinoma","volume":"117","author":"Ebrahimi","year":"2011","journal-title":"Cancer"},{"key":"ref_2","unstructured":"Edge, S.B., Byrd, D.R., Compton, C.C., Fritz, A.G., Greene, F.L., and Trotti, A. 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