{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:36:25Z","timestamp":1787027785833,"version":"build-2736575974"},"reference-count":38,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T00:00:00Z","timestamp":1695859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Russian Science Fund","award":["22-15-00491"],"award-info":[{"award-number":["22-15-00491"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>In this single-center analysis, we evaluated the trends in 5185 hematopoietic cell transplantations performed between 1990 and 2022. The study group comprised 3237 allogeneic (alloHCT) and 1948 autologous (autoHCT) hematopoietic cell transplantations. In the multivariate analysis, there was an improvement in event-free-survival (EFS) after autoHCT (HR 0.6, 95% CI 0.4\u20130.7, p &lt; 0.0001) due to reduced cumulative incidence of relapse in the last five years (56% in 2010\u20132014 vs. 38% in 2015\u20132022). An improvement in EFS after alloHCT over time was observed (HR 0.33, 95% CI 0.23\u20130.48, p &lt; 0.0001), which was due to reduced non-relapse mortality. No difference in cumulative relapse incidence was observed over the last decade for allografted patients. Survival after autoHCT improved in Hodgkin\u2019s disease (HR 0.1, 95% CI 0.1\u20130.3), multiple myeloma (HR 0.4, 95% CI 0.2\u20130.7) and solid tumors (HR 0.2, 95% CI 0.2\u20130.4), while after alloHCT, improvement was observed in acute myeloid leukemia (HR 0.3, 95% CI 0.1\u20130.5), acute lymphoblastic leukemia (HR 0.2, 95% CI 0.1\u20130.5), Hodgkin\u2019s disease (HR 0.1, 95% CI 0.0\u20130.4), non-Hodgkin\u2019s lymphomas and chronic lymphocytic leukemia (HR 0.2, 95% CI 0.0\u20130.6), inborn diseases (HR 0.2, 95% CI 0.2\u20130.4) and acquired aplastic anemia with matched related donors and matched unrelated donors (HR 0.3, 95% CI 0.2\u20130.8).<\/jats:p>","DOI":"10.3390\/cancers15194758","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T07:50:26Z","timestamp":1695887426000},"page":"4758","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Trends in Outcome of Hematopoietic Stem Cell Transplantation: 5000 Transplantations and 30 Years of Single-Center Experience"],"prefix":"10.3390","volume":"15","author":[{"given":"Ludmila Stepanovna","family":"Zubarovskaya","sequence":"first","affiliation":[{"name":"RM Gorbacheva Research Institute, Pavlov University, 197022 Saint-Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan Sergeevich","family":"Moiseev","sequence":"additional","affiliation":[{"name":"RM Gorbacheva Research Institute, Pavlov University, 197022 Saint-Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Dmidrievna","family":"Vladovskaya","sequence":"additional","affiliation":[{"name":"RM Gorbacheva Research Institute, Pavlov University, 197022 Saint-Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia Borisovna","family":"Mikhailova","sequence":"additional","affiliation":[{"name":"RM Gorbacheva Research Institute, Pavlov University, 197022 Saint-Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena Vladislavovna","family":"Morozova","sequence":"additional","affiliation":[{"name":"RM Gorbacheva Research Institute, Pavlov University, 197022 Saint-Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatyana Alexandrovna","family":"Bykova","sequence":"additional","affiliation":[{"name":"RM Gorbacheva Research Institute, Pavlov University, 197022 Saint-Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulia Yurievna","family":"Vlasova","sequence":"additional","affiliation":[{"name":"RM Gorbacheva Research Institute, Pavlov University, 197022 Saint-Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olesya Vladimirovna","family":"Paina","sequence":"additional","affiliation":[{"name":"RM Gorbacheva Research Institute, Pavlov University, 197022 Saint-Petersburg, 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Georgievna","family":"Volkova","sequence":"additional","affiliation":[{"name":"RM Gorbacheva Research Institute, Pavlov University, 197022 Saint-Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander Leonidovich","family":"Alyansky","sequence":"additional","affiliation":[{"name":"RM Gorbacheva Research Institute, Pavlov University, 197022 Saint-Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitrii Eduardovich","family":"Pevtcov","sequence":"additional","affiliation":[{"name":"RM Gorbacheva Research Institute, Pavlov University, 197022 Saint-Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia Evgenievna","family":"Ivanova","sequence":"additional","affiliation":[{"name":"RM Gorbacheva Research Institute, Pavlov University, 197022 Saint-Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena 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