{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:32:52Z","timestamp":1760149972853,"version":"build-2065373602"},"reference-count":106,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T00:00:00Z","timestamp":1695859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Barrett\u2019s oesophagus is a pathological condition whereby the normal oesophageal squamous mucosa is replaced by specialised, intestinal-type metaplasia, which is strongly linked to chronic gastro-oesophageal reflux. A correct endoscopic and histological diagnosis is pivotal in the management of Barrett\u2019s oesophagus to identify patients who are at high risk of progression to neoplasia. The presence and grade of dysplasia and the characteristics of visible lesions within the mucosa of Barrett\u2019s oesophagus are both important to guide the most appropriate endoscopic therapy. In this review, we provide an overview on the management of Barrett\u2019s oesophagus, with a particular focus on recent advances in the diagnosis and recommendations for endoscopic therapy to reduce the risk of developing oesophageal adenocarcinoma.<\/jats:p>","DOI":"10.3390\/cancers15194776","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T07:50:26Z","timestamp":1695887426000},"page":"4776","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Endoscopic Management of Dysplastic Barrett\u2019s Oesophagus and Early Oesophageal Adenocarcinoma"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3323-7744","authenticated-orcid":false,"given":"Leonardo Henry","family":"Eusebi","sequence":"first","affiliation":[{"name":"Gastroenterology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy"},{"name":"Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Telese","sequence":"additional","affiliation":[{"name":"Digestive Disease and Surgery Institute Cleveland Clinic, London SW1X 7HY, UK"},{"name":"Division of Surgery and Interventional Science, University College London, London NW1 2BU, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Castellana","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy"},{"name":"Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rengin Melis","family":"Engin","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy"},{"name":"Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2058-3162","authenticated-orcid":false,"given":"Benjamin","family":"Norton","sequence":"additional","affiliation":[{"name":"Digestive Disease and Surgery Institute Cleveland Clinic, London SW1X 7HY, UK"},{"name":"Department of Gastroenterology, University College London Hospital (UCLH), London NW1 2BU, UK"},{"name":"Centre for Obesity Research, Department of Medicine, Rayne Institute, University College London, London NW1 2BU, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Apostolis","family":"Papaefthymiou","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University College London Hospital (UCLH), London NW1 2BU, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9949-8619","authenticated-orcid":false,"given":"Rocco Maurizio","family":"Zagari","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy"},{"name":"Esophagus and Stomach Organic Diseases Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rehan","family":"Haidry","sequence":"additional","affiliation":[{"name":"Digestive Disease and Surgery Institute Cleveland Clinic, London SW1X 7HY, UK"},{"name":"Division of Surgery and Interventional Science, University College London, London NW1 2BU, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/ajg.2015.322","article-title":"Acg Clinical Guideline: Diagnosis and Management of Barrett\u2019s Esophagus","volume":"111","author":"Shaheen","year":"2016","journal-title":"Am. J. Gastroenterol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.gde.2012.08.001","article-title":"Barrett\u2019s Metaplasia as a Paradigm for Understanding the Development of Cancer","volume":"22","author":"Burke","year":"2012","journal-title":"Curr. Opin. Genet. Dev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/0016-5085(87)90847-X","article-title":"Barrett\u2019s Esophagus. A Prevalent, Occult Complication of Gastroesophageal Reflux Disease","volume":"92","author":"Winters","year":"1987","journal-title":"Gastroenterology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1111\/jgh.15902","article-title":"Effect of Gastro-Esophageal Reflux Symptoms on the Risk of Barrett\u2019s Esophagus: A Systematic Review and Meta-Analysis","volume":"37","author":"Eusebi","year":"2022","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1136\/gutjnl-2012-304269","article-title":"Update on the Epidemiology of Gastro-Oesophageal Reflux Disease: A Systematic Review","volume":"63","author":"Sweet","year":"2014","journal-title":"Gut"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1136\/gutjnl-2016-313589","article-title":"Global Prevalence of, and Risk Factors for, Gastro-Oesophageal Reflux Symptoms: A Meta-Analysis","volume":"67","author":"Eusebi","year":"2018","journal-title":"Gut"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.gie.2019.05.030","article-title":"Systematic Review and Meta-Analysis of Prevalence and risk factors for Barrett\u2019s Esophagus","volume":"90","author":"Qumseya","year":"2019","journal-title":"Gastrointest. Endosc."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1136\/gutjnl-2020-321365","article-title":"Global Prevalence of Barrett\u2019s Oesophagus and Oesophageal Cancer in Individuals with Gastro-Oesophageal Reflux: A Systematic Review and Meta-Analysis","volume":"70","author":"Eusebi","year":"2021","journal-title":"Gut"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1111\/apt.16585","article-title":"Systematic Review with Meta-Analysis: Association of Helicobacter Pylori Infection with Gastro-Oesophageal Reflux and Its Complications","volume":"54","author":"Zamani","year":"2021","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1111\/apt.16321","article-title":"Systematic Review with Meta-Analysis: Risk Factors for Barrett\u2019s Oesophagus in Individuals with Gastro-Oesophageal Reflux Symptoms","volume":"53","author":"Eusebi","year":"2021","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1136\/gutjnl-2013-305372","article-title":"British Society of Gastroenterology Guidelines on the Diagnosis and Management of Barrett\u2019s Oesophagus","volume":"63","author":"Fitzgerald","year":"2014","journal-title":"Gut"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.gie.2014.01.009","article-title":"Incidence of Esophageal Adenocarcinoma in Barrett\u2019s Esophagus with Low-Grade Dysplasia: A Systematic Review and Meta-Analysis","volume":"79","author":"Singh","year":"2014","journal-title":"Gastrointest. Endosc."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.gie.2007.07.019","article-title":"Incidence of Esophageal Adenocarcinoma in Patients with Barrett\u2019s Esophagus and High-Grade Dysplasia: A Meta-Analysis","volume":"67","author":"Rastogi","year":"2008","journal-title":"Gastrointest. Endosc."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.bpg.2008.02.001","article-title":"When and How to Grade Barrett\u2019s Columnar Metaplasia: The Prague System","volume":"22","author":"Anand","year":"2008","journal-title":"Best. Pract. Res. Clin. Gastroenterol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1001\/jama.2013.226450","article-title":"Barrett Esophagus and Risk of Esophageal Cancer: A Clinical Review","volume":"310","author":"Spechler","year":"2013","journal-title":"JAMA"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1111\/j.1572-0241.2002.05910.x","article-title":"Updated Guidelines for the Diagnosis, Surveillance, and Therapy of Barrett\u2019s Esophagus","volume":"97","author":"Sampliner","year":"2002","journal-title":"Am. J. Gastroenterol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Maione, F., Chini, A., Maione, R., Manigrasso, M., Marello, A., Cassese, G., Gennarelli, N., Milone, M., and De Palma, G.D. (2022). Endoscopic Diagnosis and Management of Barrett\u2019s Esophagus with Low-Grade Dysplasia. Diagnostics, 12.","DOI":"10.3390\/diagnostics12051295"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0016-5107(87)71676-9","article-title":"Early Diagnosis of Columnar-Lined Esophagus: A New Endoscopic Diagnostic Criterion","volume":"33","author":"Mcclave","year":"1987","journal-title":"Gastrointest. Endosc."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1111\/j.1572-0241.1998.00324.x","article-title":"Short Segment Barrett\u2019s Esophagus\u2014The Need for Standardization of the Definition and of Endoscopic Criteria","volume":"93","author":"Sharma","year":"1998","journal-title":"Am. J. Gastroenterol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.gtc.2022.06.004","article-title":"Management of Dysplastic Barrett\u2019s Esophagus and Early Esophageal Adenocarcinoma","volume":"51","author":"Cotton","year":"2022","journal-title":"Gastroenterol. Clin. N. Am."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1007\/s10620-020-06615-6","article-title":"Attending Training Courses on Barrett\u2019s Esophagus Improves Adherence to Guidelines: A Survey from the Italian Society of Digestive Endoscopy","volume":"66","author":"Zagari","year":"2021","journal-title":"Dig. Dis. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1053\/j.gastro.2006.08.032","article-title":"The Development and Validation of an Endoscopic Grading System for Barrett\u2019s Esophagus: The Prague C & M Criteria","volume":"131","author":"Sharma","year":"2006","journal-title":"Gastroenterology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1159\/000337198","article-title":"Prevalence of Minimal Change Lesions in Patients with Non-Erosive Reflux Disease: A Case-Control Study","volume":"85","author":"Kim","year":"2012","journal-title":"Digestion"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1097\/MEG.0b013e3283318f69","article-title":"Predictors of Specialized Intestinal Metaplasia in Patients with an Incidental Irregular Z Line","volume":"22","author":"Dickman","year":"2010","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"E18","DOI":"10.1053\/j.gastro.2011.01.031","article-title":"American Gastroenterological Association Technical Review on the Management of Barrett\u2019s Esophagus","volume":"140","author":"Spechler","year":"2011","journal-title":"Gastroenterology"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1055\/s-2001-14427","article-title":"Methylene Blue Staining of Dysplastic and Nondysplastic Barrett\u2019s Esophagus: An in Vivo and Ex Vivo Study","volume":"33","author":"Canto","year":"2001","journal-title":"Endoscopy"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.gie.2008.06.056","article-title":"Diagnostic Yield of Methylene Blue Chromoendoscopy for Detecting Specialized Intestinal Metaplasia and Dysplasia in Barrett\u2019s Esophagus: A Meta-Analysis","volume":"69","author":"Ngamruengphong","year":"2009","journal-title":"Gastrointest. Endosc."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.gie.2007.05.029","article-title":"Chromoendoscopy","volume":"66","author":"Adler","year":"2007","journal-title":"Gastrointest. Endosc."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1067\/mge.2001.114059","article-title":"Enhanced Magnification Endoscopy: A New Technique to Identify Specialized Intestinal Metaplasia in Barrett\u2019s Esophagus","volume":"53","author":"Guelrud","year":"2001","journal-title":"Gastrointest. Endosc."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1016\/S0016-5107(99)70518-3","article-title":"Vital Staining and Barrett\u2019s Esophagus","volume":"49","author":"Canto","year":"1999","journal-title":"Gastrointest. Endosc."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/j.1572-0241.2007.01601.x","article-title":"A Randomized Comparison of Methylene Blue-Directed Biopsy Versus Conventional Four-Quadrant Biopsy for the Detection of Intestinal Metaplasia and Dysplasia in Patients with Long-Segment Barrett\u2019s Esophagus","volume":"103","author":"Horwhat","year":"2008","journal-title":"Am. J. Gastroenterol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0140-6736(03)14026-3","article-title":"Chromoendoscopy with Methylene Blue and Associated DNA Damage in Barrett\u2019s Oesophagus","volume":"362","author":"Olliver","year":"2003","journal-title":"Lancet"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1067\/mge.2001.115728","article-title":"Methylene Blue Chromoendoscopy for Detection of Short-Segment Barrett\u2019s Esophagus","volume":"54","author":"Sharma","year":"2001","journal-title":"Gastrointest. Endosc."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1053\/j.gastro.2008.03.019","article-title":"Prospective, Controlled Tandem Endoscopy Study of Narrow Band Imaging for Dysplasia Detection in Barrett\u2019s Esophagus","volume":"135","author":"Wolfsen","year":"2008","journal-title":"Gastroenterology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1111\/jgh.15577","article-title":"Diagnostic Accuracy of Narrow-Band Imaging Endoscopy with Targeted Biopsies Compared with Standard Endoscopy with Random Biopsies in Patients with Barrett\u2019s Esophagus: A Systematic Review and Meta-Analysis","volume":"36","author":"Hajelssedig","year":"2021","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1055\/s-2008-1077596","article-title":"Mucosal Morphology in Barrett\u2019s Esophagus: Interobserver Agreement and Role of Narrow Band Imaging","volume":"40","author":"Curvers","year":"2008","journal-title":"Endoscopy"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.1016\/j.cgh.2022.06.003","article-title":"Aga Clinical Practice Update on New Technology and Innovation for Surveillance and Screening in Barrett\u2019s Esophagus: Expert Review","volume":"20","author":"Muthusamy","year":"2022","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.gie.2011.04.004","article-title":"Real-Time Increased Detection of Neoplastic Tissue in Barrett\u2019s Esophagus with Probe-Based Confocal Laser Endomicroscopy: Final Results of an International Multicenter, Prospective, Randomized, Controlled Trial","volume":"74","author":"Sharma","year":"2011","journal-title":"Gastrointest. Endosc."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1111\/jgh.13267","article-title":"A Meta-Analysis of Confocal Laser Endomicroscopy for the Detection of Neoplasia in Patients with Barrett\u2019s Esophagus","volume":"31","author":"Xiong","year":"2016","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/0046-8177(92)90123-K","article-title":"Distribution of Dysplasias and Early Invasive Carcinoma in Barrett\u2019s Esophagus","volume":"23","author":"Mcardle","year":"1992","journal-title":"Hum. Pathol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.cgh.2008.12.027","article-title":"Adherence to Biopsy Guidelines for Barrett\u2019s Esophagus Surveillance in the Community Setting in the United States","volume":"7","author":"Abrams","year":"2009","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1136\/gut.47.2.251","article-title":"The Vienna Classification of Gastrointestinal Epithelial Neoplasia","volume":"47","author":"Schlemper","year":"2000","journal-title":"Gut"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1136\/gut.51.1.130","article-title":"Gastrointestinal Epithelial Neoplasia: Vienna Revisited","volume":"51","author":"Dixon","year":"2002","journal-title":"Gut"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1056\/NEJM197608262950904","article-title":"The Histologic Spectrum of Barrett\u2019s Esophagus","volume":"295","author":"Paull","year":"1976","journal-title":"N. Engl. J. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1056\/NEJMra1314704","article-title":"Barrett\u2019s Esophagus","volume":"371","author":"Spechler","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1111\/j.1572-0241.2000.02002.x","article-title":"Safety of a Systematic Endoscopic Biopsy Protocol in Patients with Barrett\u2019s Esophagus","volume":"95","author":"Levine","year":"2000","journal-title":"Am. J. Gastroenterol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1136\/gutjnl-2017-314135","article-title":"Revised British Society of Gastroenterology Recommendation on the Diagnosis and Management of Barrett\u2019s Oesophagus with Low-Grade Dysplasia","volume":"67","author":"Fitzgerald","year":"2018","journal-title":"Gut"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1055\/s-0042-122140","article-title":"Endoscopic Management of Barrett\u2019s Esophagus: European Society of Gastrointestinal Endoscopy (Esge) Position Statement","volume":"49","author":"Weusten","year":"2017","journal-title":"Endoscopy"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1053\/j.gastro.2019.09.051","article-title":"Aga Clinical Practice Update on Endoscopic Treatment of Barrett\u2019s Esophagus with Dysplasia and\/or Early Cancer: Expert Review","volume":"158","author":"Sharma","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"559","DOI":"10.14309\/ajg.0000000000001680","article-title":"Diagnosis and Management of Barrett\u2019s Esophagus: An Updated Acg Guideline","volume":"117","author":"Shaheen","year":"2022","journal-title":"Am. J. Gastroenterol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1136\/gutjnl-2016-311715","article-title":"Asia-Pacific Consensus on the Management of Gastro-Oesophageal Reflux Disease: An Update Focusing on Refractory Reflux Disease and Barrett\u2019s Oesophagus","volume":"65","author":"Fock","year":"2016","journal-title":"Gut"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"239","DOI":"10.4253\/wjge.v11.i3.239","article-title":"Treatment of High-Grade Dysplasia and Intramucosal Carcinoma Using Radiofrequency Ablation or Endoscopic Mucosal Resection + Radiofrequency Ablation: Meta-Analysis and Systematic Review","volume":"11","author":"Maahs","year":"2019","journal-title":"World J. Gastrointest. Endosc."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1055\/a-1811-7025","article-title":"Endoscopic Submucosal Dissection for Superficial Gastrointestinal Lesions: European Society of Gastrointestinal Endoscopy (Esge) Guideline\u2014Update 2022","volume":"54","author":"Bastiaansen","year":"2022","journal-title":"Endoscopy"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Vantanasiri, K., and Iyer, P.G. (2022). State-of-the-Art Management of Dysplastic Barrett\u2019s Esophagus. Gastroenterol. Rep., 10.","DOI":"10.1093\/gastro\/goac068"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/ajg.2012.78","article-title":"The Risk of Lymph-Node Metastases in Patients with High-Grade Dysplasia or Intramucosal Carcinoma in Barrett\u2019s Esophagus: A Systematic Review","volume":"107","author":"Dunbar","year":"2012","journal-title":"Am. J. Gastroenterol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1016\/j.cgh.2014.04.010","article-title":"Complete Endoscopic Mucosal Resection Is Effective and Durable Treatment for Barrett\u2019s-Associated Neoplasia","volume":"12","author":"Konda","year":"2014","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1067\/mge.2003.339","article-title":"A Prospective Randomized Trial of Two Different Endoscopic Resection Techniques for Early Stage Cancer of the Esophagus","volume":"58","author":"May","year":"2003","journal-title":"Gastrointest. Endosc."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.gie.2013.08.005","article-title":"Endotherapy versus Surgery for Early Neoplasia in Barrett\u2019s Esophagus: A Meta-Analysis","volume":"79","author":"Wu","year":"2014","journal-title":"Gastrointest. Endosc."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1055\/a-1658-7554","article-title":"Extending Treatment Criteria for Barrett\u2019s Neoplasia: Results of a Nationwide Cohort of 138 Endoscopic Submucosal Dissection Procedures","volume":"54","author":"Verheij","year":"2022","journal-title":"Endoscopy"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1136\/gutjnl-2015-310126","article-title":"A Randomised Trial of Endoscopic Submucosal Dissection versus Endoscopic Mucosal Resection for Early Barrett\u2019s Neoplasia","volume":"66","author":"Terheggen","year":"2017","journal-title":"Gut"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.cgh.2020.11.017","article-title":"Comparative Outcomes of Cap Assisted Endoscopic Resection and Endoscopic Submucosal Dissection in Dysplastic Barrett\u2019s Esophagus","volume":"20","author":"Codipilly","year":"2022","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.bpg.2018.11.003","article-title":"Endoscopic Management of Dysplasia and Early Oesophageal Cancer","volume":"36\u201337","author":"Zeki","year":"2018","journal-title":"Best. Pract. Res. Clin. Gastroenterol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1001\/jama.2014.2511","article-title":"Radiofrequency Ablation vs. Endoscopic Surveillance for Patients with Barrett Esophagus and Low-Grade Dysplasia: A Randomized Clinical Trial","volume":"311","author":"Phoa","year":"2014","journal-title":"JAMA"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.gie.2020.03.3756","article-title":"Radiofrequency Ablation for Low-Grade Dysplasia in Barrett\u2019s Esophagus: Long-Term Outcome of A Randomized Trial","volume":"92","author":"Pouw","year":"2020","journal-title":"Gastrointest. Endosc."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S0016-5107(92)70536-7","article-title":"Laser-Induced Transient Regression of Barrett\u2019s Epithelium","volume":"38","author":"Brandt","year":"1992","journal-title":"Gastrointest. Endosc."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/BF01307557","article-title":"Regression of Barrett\u2019s Esophagus by Laser Ablation in an Anacid Environment","volume":"38","author":"Sampliner","year":"1993","journal-title":"Dig. Dis. Sci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1016\/0016-5085(93)90646-T","article-title":"Restoration of Squamous Mucosa after Ablation of Barrett\u2019s Esophageal Epithelium","volume":"104","author":"Berenson","year":"1993","journal-title":"Gastroenterology"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0016-5107(93)70017-6","article-title":"Photodynamic Therapy for Treatment of Early Adenocarcinoma in Barrett\u2019s Esophagus","volume":"39","author":"Overholt","year":"1993","journal-title":"Gastrointest. Endosc."},{"key":"ref_69","first-page":"1719","article-title":"Photodynamic Therapy for Barrett\u2019s Esophagus: Clinical Update","volume":"91","author":"Overholt","year":"1996","journal-title":"Am. J. Gastroenterol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1055\/s-2007-1004302","article-title":"Treatment of Barrett\u2019s Esophagus By Endoscopic Argon Plasma Coagulation","volume":"29","author":"Dumoulin","year":"1997","journal-title":"Endoscopy"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/S0016-5107(96)70004-4","article-title":"Reversal of Barrett\u2019s Esophagus with Acid Suppression and Multipolar Electrocoagulation: Preliminary Results","volume":"44","author":"Sampliner","year":"1996","journal-title":"Gastrointest. Endosc."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1053\/j.gastro.2004.04.010","article-title":"A Critical Review of the Diagnosis and Management of Barrett\u2019s Esophagus: The Aga Chicago Workshop","volume":"127","author":"Sharma","year":"2004","journal-title":"Gastroenterology"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1111\/j.1572-0241.2008.01835.x","article-title":"Updated Guidelines 2008 for the Diagnosis, Surveillance and Therapy of Barrett\u2019s Esophagus","volume":"103","author":"Wang","year":"2008","journal-title":"Am. J. Gastroenterol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1053\/j.gastro.2011.01.031","article-title":"American Gastroenterological Association Medical Position Statement on the Management of Barrett\u2019s Esophagus","volume":"140","author":"Spechler","year":"2011","journal-title":"Gastroenterology"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Luigiano, C., Iabichino, G., Eusebi, L.H., Arena, M., Consolo, P., Morace, C., Opocher, E., and Mangiavillano, B. (2016). Outcomes of Radiofrequency Ablation for Dysplastic Barrett\u2019s Esophagus: A Comprehensive Review. Gastroenterol. Res. Pract., 2016.","DOI":"10.1155\/2016\/4249510"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1056\/NEJMoa0808145","article-title":"Radiofrequency Ablation in Barrett\u2019s Esophagus with Dysplasia","volume":"360","author":"Shaheen","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1053\/j.gastro.2013.03.045","article-title":"Radiofrequency Ablation and Endoscopic Mucosal Resection for Dysplastic Barrett\u2019s Esophagus and Early Esophageal Adenocarcinoma: Outcomes of the Uk National Halo Rfa Registry","volume":"145","author":"Haidry","year":"2013","journal-title":"Gastroenterology"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1136\/gutjnl-2014-308501","article-title":"Improvement over Time in Outcomes for Patients Undergoing Endoscopic Therapy for Barrett\u2019s Oesophagus-Related Neoplasia: 6-Year Experience from the First 500 Patients Treated in the Uk Patient Registry","volume":"64","author":"Haidry","year":"2015","journal-title":"Gut"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1136\/gutjnl-2020-322082","article-title":"Endoscopic Radiofrequency Ablation or Surveillance in Patients with Barrett\u2019s Oesophagus with Confirmed Low-Grade Dysplasia: A Multicentre Randomised Trial","volume":"70","author":"Barret","year":"2021","journal-title":"Gut"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Wang, Y., Ma, B., Yang, S., Li, W., and Li, P. (2022). Efficacy and Safety of Radiofrequency Ablation vs. Endoscopic Surveillance for Barrett\u2019s Esophagus with Low-Grade Dysplasia: Meta-Analysis of Randomized Controlled Trials. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.801940"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0016-5085(88)80001-5","article-title":"Double-Blind Controlled Trial of the Garren-Edwards Gastric Bubble: An Adjunctive Treatment for Exogenous Obesity","volume":"95","author":"Benjamin","year":"1988","journal-title":"Gastroenterology"},{"key":"ref_82","first-page":"345","article-title":"Clinical Adverse Events and Device Failures for the Barrx\u2122 Radiofrequency Ablation Catheter System: A Maude Database Analysis","volume":"35","author":"Dubrouskaya","year":"2022","journal-title":"Ann. Gastroenterol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1111\/j.1572-0241.2006.00709.x","article-title":"Ablation of Nonneoplastic Barrett\u2019s Mucosa Using Argon Plasma Coagulation with Concomitant Esomeprazole Therapy (Apbanex): A Prospective Multicenter Evaluation","volume":"101","author":"Manner","year":"2006","journal-title":"Am. J. Gastroenterol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.gie.2018.07.031","article-title":"Radiofrequency Ablation Compared with Argon Plasma Coagulation after Endoscopic Resection of High-Grade Dysplasia or Stage T1 Adenocarcinoma in Barrett\u2019s Esophagus: A Randomized Pilot Study (Bride)","volume":"89","author":"Peerally","year":"2019","journal-title":"Gastrointest. Endosc."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1177\/2050640614544315","article-title":"The Tissue Effect of Argon-Plasma Coagulation with Prior Submucosal Injection (Hybrid-Apc) Versus Standard Apc: A Randomized Ex-Vivo Study","volume":"2","author":"Manner","year":"2014","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1007\/s00464-015-4336-1","article-title":"Efficacy and Safety of Hybrid-Apc for the Ablation of Barrett\u2019s Esophagus","volume":"30","author":"Manner","year":"2016","journal-title":"Surg. Endosc."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"110","DOI":"10.14309\/ajg.0000000000001539","article-title":"Hybrid Apc in Combination with Resection for the Endoscopic Treatment of Neoplastic Barrett\u2019s Esophagus: A Prospective, Multicenter Study","volume":"117","author":"Knabe","year":"2022","journal-title":"Am. J. Gastroenterol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"38","DOI":"10.5946\/ce.2022.179","article-title":"Hybrid Argon Plasma Coagulation in Barrett\u2019s Esophagus: A Systematic Review and Meta-Analysis","volume":"56","author":"Shah","year":"2023","journal-title":"Clin. Endosc."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1055\/a-1119-1030","article-title":"Successful Treatment of Refractory Barrett\u2019s Neoplasia with Hybrid Argon Plasma Coagulation: A Case Series","volume":"52","author":"Trindade","year":"2020","journal-title":"Endoscopy"},{"key":"ref_90","first-page":"169","article-title":"Efficacy of the Cryoballoon Focal Ablation System for the Eradication of Dysplastic Barrett\u2019s Esophagus Islands","volume":"49","author":"Meijer","year":"2017","journal-title":"Endoscopy"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.14309\/ajg.0000000000000822","article-title":"Multifocal Cryoballoon Ablation for Eradication of Barrett\u2019s Esophagus-Related Neoplasia: A Prospective Multicenter Clinical Trial","volume":"115","author":"Canto","year":"2020","journal-title":"Am. J. Gastroenterol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"E172","DOI":"10.1055\/a-1067-4520","article-title":"Safety and Effectiveness of Balloon Cryoablation for Treatment of Barrett\u2019s Associated Neoplasia: Systematic Review and Meta-Analysis","volume":"8","author":"Westerveld","year":"2020","journal-title":"Endosc. Int. Open"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.gie.2021.09.037","article-title":"Comparative Outcomes of Radiofrequency Ablation and Cryoballoon Ablation in Dysplastic Barrett\u2019s Esophagus: A Propensity Score-Matched Cohort Study","volume":"95","author":"Agarwal","year":"2022","journal-title":"Gastrointest. Endosc."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.gie.2022.06.017","article-title":"Comparison of Focal Cryoballoon Ablation with 10- and 8-Second Doses for Treatment of Barrett\u2019s Esophagus-Related Neoplasia: Results from A Prospective European Multicenter Study (with Video)","volume":"96","author":"Frederiks","year":"2022","journal-title":"Gastrointest. Endosc."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1055\/a-1381-7562","article-title":"Novel Cryoballoon 180\u00b0 Ablation System for Treatment of Barrett\u2019s Esophagus-Related Neoplasia: A First-in-Human Study","volume":"54","author":"Overwater","year":"2022","journal-title":"Endoscopy"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1055\/a-1024-3967","article-title":"A Novel Cryoballoon Ablation System for Eradication of Dysplastic Barrett\u2019s Esophagus: A First-In-Human Feasibility Study","volume":"52","author":"Overwater","year":"2020","journal-title":"Endoscopy"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1055\/a-1765-7197","article-title":"Threshold Evaluation for Optimal Number of Endoscopic Treatment Sessions to Achieve Complete Eradication of Barrett\u2019s Metaplasia","volume":"54","author":"Mittal","year":"2022","journal-title":"Endoscopy"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1055\/a-1521-6318","article-title":"Incidence and Outcomes of Poor Healing and Poor Squamous Regeneration after Radiofrequency Ablation Therapy for Early Barrett\u2019s Neoplasia","volume":"54","author":"Frederiks","year":"2022","journal-title":"Endoscopy"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1016\/j.cgh.2022.02.057","article-title":"Development and External Validation of A Model to Predict Complex Treatment after Radiofrequency Ablation for Barrett\u2019s Esophagus with Early Neoplasia","volume":"20","author":"Nieuwenhuis","year":"2022","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.gie.2022.02.016","article-title":"Endoscopic Eradication Therapy for Barrett\u2019s Esophagus-Related Neoplasia: A Final 10-Year Report from the Uk National Halo Radiofrequency Ablation Registry","volume":"96","author":"Wolfson","year":"2022","journal-title":"Gastrointest. Endosc."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"E1053","DOI":"10.1055\/a-1858-0945","article-title":"Comparative Cost-Effectiveness of Three Post-Radiofrequency Ablation Surveillance Intervals for Barrett\u2019s Esophagus","volume":"10","author":"Menon","year":"2022","journal-title":"Endosc. Int. Open"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1053\/j.gastro.2022.03.020","article-title":"Dysplastic Recurrence after Successful Treatment for Early Barrett\u2019s Neoplasia: Development and Validation of a Prediction Model","volume":"163","author":"Nieuwenhuis","year":"2022","journal-title":"Gastroenterology"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Verheij, E.P.D., Van Munster, S.N., Nieuwenhuis, E.A., Cotton, C.C., Weusten, B.L.A.M., Alvarez Herrero, L., Alkhalaf, A., Schenk, B.E., Schoon, E.J., and Curvers, W. (2022). All-Cause Mortality after Successful Endoscopic Eradication Therapy for Barrett\u2019s Related Neoplasia in a Nationwide Cohort of 1154 Patients. Endoscopy, 54.","DOI":"10.1055\/s-0042-1744783"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1136\/gutjnl-2015-309298","article-title":"Multimodality Endoscopic Eradication for Neoplastic Barrett Oesophagus: Results of an European Multicentre Study (Euro-Ii)","volume":"65","author":"Phoa","year":"2016","journal-title":"Gut"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1111\/jgh.14580","article-title":"Efficacy and Safety of Steroid in the Prevention of Esophageal Stricture after Endoscopic Submucosal Dissection: A Network Meta-Analysis","volume":"34","author":"Yang","year":"2019","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.gie.2020.11.026","article-title":"Impact of Topical Budesonide on Prevention of Esophageal Stricture after Mucosal Resection","volume":"93","author":"Bartel","year":"2021","journal-title":"Gastrointest. 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