{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T14:18:49Z","timestamp":1789395529059,"version":"build-2803163510"},"reference-count":54,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T00:00:00Z","timestamp":1696464000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute for Health and Care Research (NIHR)","award":["RP-PG-0707-10034"],"award-info":[{"award-number":["RP-PG-0707-10034"]}]},{"name":"National Institute for Health and Care Research (NIHR)","award":["C18281\/A19169"],"award-info":[{"award-number":["C18281\/A19169"]}]},{"name":"Integrative Cancer Epidemiology Programme","award":["RP-PG-0707-10034"],"award-info":[{"award-number":["RP-PG-0707-10034"]}]},{"name":"Integrative Cancer Epidemiology Programme","award":["C18281\/A19169"],"award-info":[{"award-number":["C18281\/A19169"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Cancer-related fatigue (CRF) is a common side-effect of cancer and its treatments. For head and neck cancer (HNC), CRF may exacerbate the symptom burden and poor quality-of-life. Using data from the Head and Neck 5000 prospective clinical cohort, we investigated clinically important CRF over a year post-diagnosis, assessing temporal trends, CRF by HNC site and treatment received, and subgroups at higher risk of CRF. Recruitment was undertaken in 2011\u20132014. Socio-demographic and clinical data, and patient-reported CRF (EORTC QLQ-C30 fatigue subscale score \u226539 of a possible 100) were collected at baseline (pre-treatment) and 4- and 12- months post-baseline. Mixed-effects logistic multivariable regression was used to investigate time trends, compare cancer sites and treatment groups, and identify associations between clinical, socio-demographic and lifestyle variables and CRF. At baseline, 27.8% of 2847 patients scored in the range for clinically important CRF. This was 44.7% at 4 months and 29.6% at 12 months. In the multivariable model, after adjusting for time-point, the odds of having CRF over 12 months were significantly increased in females and current smokers; those with stage 3\/4 disease, comorbidities and multimodal treatment; and those who had depression at baseline. The high prevalence of clinically important CRF indicates the need for additional interventions and supports for affected HNC patients. These findings also identified patient subgroups towards whom such interventions could be targeted.<\/jats:p>","DOI":"10.3390\/cancers15194864","type":"journal-article","created":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T01:07:13Z","timestamp":1696554433000},"page":"4864","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Cancer-Related Fatigue in Head and Neck Cancer Survivors: Longitudinal Findings from the Head and Neck 5000 Prospective Clinical Cohort"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9515-1722","authenticated-orcid":false,"given":"Linda","family":"Sharp","sequence":"first","affiliation":[{"name":"Population Health Sciences Institute, Newcastle University Centre for Cancer, Newcastle University, Newcastle NE1 7RU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura-Jayne","family":"Watson","sequence":"additional","affiliation":[{"name":"Speech & Language Therapy, Sunderland Royal Hospital, South Tyneside and Sunderland NHS Foundation Trust, Sunderland SR4 7TP, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liya","family":"Lu","sequence":"additional","affiliation":[{"name":"Population Health Sciences Institute, Newcastle University Centre for Cancer, Newcastle University, Newcastle NE1 7RU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5870-2094","authenticated-orcid":false,"given":"Sam","family":"Harding","sequence":"additional","affiliation":[{"name":"Speech and Language Therapy Research Unit, Southmead Hospital North Bristol NHS Hospital Trust, Bristol BS10 5NB, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina","family":"Hurley","sequence":"additional","affiliation":[{"name":"Head & Neck 5000 Study, Weston NHS Foundation Trust, University of Bristol, Bristol BS8 1TU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve J.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Head & Neck 5000 Study, Weston NHS Foundation Trust, University of Bristol, Bristol BS8 1TU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4990-302X","authenticated-orcid":false,"given":"Joanne M.","family":"Patterson","sequence":"additional","affiliation":[{"name":"Liverpool Head and Neck Centre, School of Health Science, University of Liverpool, Liverpool L69 3BG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Anderson, G., Ebadi, M., Vo, K., Novak, J., Govindarajan, A., and Amini, A. 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