{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:34:26Z","timestamp":1760150066184,"version":"build-2065373602"},"reference-count":64,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT)","award":["2021R1A2C1003898"],"award-info":[{"award-number":["2021R1A2C1003898"]}]},{"name":"Translational R&amp;D Project through Institute for Bio-Medical Convergence, Incheon St. Mary\u2019s Hospital, The Catholic University of Korea","award":["2021R1A2C1003898"],"award-info":[{"award-number":["2021R1A2C1003898"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Cyclin D1, a critical cyclin-dependent kinase (CDK) 4\/6-dependent regulator of G1\/S transition, has attracted much interest as a therapeutic target. The cyclin D1 expression in small intestinal adenocarcinomas (SIACs) has not yet been comprehensively studied, owing to the rarity of this tumor. We investigated the clinicopathological and prognostic significance of the cyclin D1 expression in 232 surgically resected primary SIACs through a multi-institutional study. A high expression of cyclin D1 (cyclin D1High) was detected in 145 SIAC cases (63%), which was significantly higher than that in normal small intestinal mucosa (11%). Cyclin D1High was more commonly found in SIACs with a lower T-category and disease stage and KRAS mutation and predicted better patient survival. Multivariate analysis revealed that cyclin D1High, the absence of retroperitoneal seeding and lymphovascular invasion, and the lower N-category were identified as independent prognostic indicators for patients with SIACs. Specifically, cyclin D1High affected patient survival in the lower stage group (stages I and II). In conclusion, cyclin D1 was commonly overexpressed in SIACs, and cyclin D1High acted as a favorable prognostic indicator in patients with SIACs. These findings in SIACs may, thus, be important to further comprehend the mechanism of cyclin D1 in carcinogenesis and to strategize appropriate patient therapies.<\/jats:p>","DOI":"10.3390\/cancers15205032","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T10:36:56Z","timestamp":1697625416000},"page":"5032","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prognostic Significance of Cyclin D1 Expression in Small Intestinal Adenocarcinoma"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3007-2094","authenticated-orcid":false,"given":"Sun-Young","family":"Jun","sequence":"first","affiliation":[{"name":"Department of Pathology, Incheon St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul 21431, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung-Mo","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kee-Taek","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: The next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1007\/s12253-019-00776-0","article-title":"Prognostic significance of cyclin D1 expression in renal cell carcinoma: A systematic review and meta-analysis","volume":"26","author":"Li","year":"2020","journal-title":"Pathol. Oncol. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"144283","DOI":"10.1016\/j.gene.2019.144283","article-title":"The prognostic value of cyclin D1 expression in the survival of cancer patients: A meta-analysis","volume":"728","author":"Bahrami","year":"2020","journal-title":"Gene"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s10549-017-4294-5","article-title":"High expression of cyclin D1 is associated to high proliferation rate and increased risk of mortality in women with ER-positive but not in ER-negative breast cancers","volume":"164","author":"Ahlin","year":"2017","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1007\/s00432-010-0814-y","article-title":"D-type cyclins in superficial and muscle-invasive bladder urothelial carcinoma: Correlation with clinicopathological data and prognostic significance","volume":"136","author":"Levidou","year":"2010","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"959","DOI":"10.21037\/tlcr.2019.12.01","article-title":"Cyclin D1 expression as a potential prognostic factor in advanced KRAS-mutant non-small cell lung cancer","volume":"8","author":"Luangdilok","year":"2019","journal-title":"Transl. Lung Cancer Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1093\/jnci\/djj334","article-title":"Cyclin D1 overexpression and response to bortezomib treatment in a breast cancer model","volume":"98","author":"Ishii","year":"2006","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_8","unstructured":"(2023, July 06). Cancer Stat Facts: Small Intestine Cancer, Available online: https:\/\/seer.cancer.gov\/statfacts\/html\/smint.html."},{"key":"ref_9","unstructured":"(2023, September 27). Annual Report of Cancer Statistics in Korea in 2020. Available online: http:\/\/ncc.re.kr\/cancerStatsList.ncc?searchKey=total&searchValue=&pageNum=1."},{"key":"ref_10","unstructured":"Carneiro, F., Ochiai, A., Chan, J., Oliva, E., Cheung, N.-Y., Rous, B., Cree, I., and Singh, R. (2019). WHO Classification of Tumours: Digestive System Tumours, IARC. [5th ed.]."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s11864-023-01058-3","article-title":"Progress in the treatment of small intestine cancer","volume":"24","author":"Symons","year":"2023","journal-title":"Curr. Treat. Options Oncol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1097\/DCR.0000000000000562","article-title":"Treatment and survival of small-bowel adenocarcinoma in the United States: A comparison with colon cancer","volume":"59","author":"Young","year":"2016","journal-title":"Dis. Colon Rectum"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/ajcp\/aqz136","article-title":"Prognostic significance of stromal and intraepithelial tumor-infiltrating lymphocytes in small intestinal adenocarcinoma","volume":"153","author":"Jun","year":"2020","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1097\/PAS.0000000000001668","article-title":"Tumor microenvironmental prognostic risk in primary operable small intestinal adenocarcinoma","volume":"45","author":"Jun","year":"2021","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/modpathol.2016.40","article-title":"Clinicopathologic and prognostic associations of KRAS and BRAF mutations in small intestinal adenocarcinoma","volume":"29","author":"Jun","year":"2016","journal-title":"Mod. Pathol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.6004\/jnccn.2019.0043","article-title":"Small bowel adenocarcinoma, version 1.2020, NCCN clinical practice guidelines in oncology","volume":"17","author":"Benson","year":"2019","journal-title":"J. Natl. Compr. Canc. Netw."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Li, Y., Wei, J., Xu, C., Zhao, Z., and You, T. (2014). Prognostic significance of cyclin D1 expression in colorectal cancer: A meta-analysis of observational studies. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0094508"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Jun, S.Y., Kim, J., Yoon, N., Maeng, L.S., and Byun, J.H. (2023). Prognostic potential of cyclin D1 expression in colorectal cancer. J. Clin. Med., 12.","DOI":"10.3390\/jcm12020572"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"757120","DOI":"10.3389\/fphar.2021.757120","article-title":"Cyclin-dependent kinase inhibitors and their therapeutic potential in colorectal cancer treatment","volume":"12","author":"Thoma","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"39595","DOI":"10.18632\/oncotarget.9153","article-title":"Efficacy of the combination of MEK and CDK4\/6 inhibitors in vitro and in vivo in KRAS mutant colorectal cancer models","volume":"7","author":"Lee","year":"2016","journal-title":"Oncotarget"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/onc.2017.384","article-title":"RAF inhibitor LY3009120 sensitizes RAS or BRAF mutant cancer to CDK4\/6 inhibition by abemaciclib via superior inhibition of phospho-RB and suppression of cyclin D1","volume":"37","author":"Chen","year":"2018","journal-title":"Oncogene"},{"key":"ref_22","first-page":"1101","article-title":"Abnormalities in the expression of cell cycle-related proteins in tumors of the small bowel","volume":"8","author":"Arber","year":"1999","journal-title":"Cancer Epidemiol Biomark. Prev."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Jun, S.Y., Chung, J.Y., Yoon, N., Jung, E.S., Oh, Y.H., and Hong, S.M. (2020). Tumor budding and poorly differentiated clusters in small intestinal adenocarcinoma. Cancers, 12.","DOI":"10.3390\/cancers12082199"},{"key":"ref_24","unstructured":"Edge, S.B., Greene, F.L., Schilsky, R.L., Gaspar, L.E., Washington, M.K., Sullivan, D.C., Brookland, R.K., Brierley, J.D., Balch, C.M., and Campton, C.C. (2017). AJCC Cancer Staging Manual, Springer Nature. [8th ed.]."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1097\/01.pas.0000126054.95798.94","article-title":"Consistent immunostaining for cyclin D1 can be achieved on a routine basis using a newly available rabbit monoclonal antibody","volume":"28","author":"Cheuk","year":"2004","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1097\/01.pai.0000137685.57687.1f","article-title":"SP4, a novel anti-cyclin D1 rabbit monoclonal antibody, is a highly sensitive probe for identifying mantle cell lymphomas bearing the t(11;14)(q13;q32) translocation","volume":"13","author":"Pruneri","year":"2005","journal-title":"Appl. Immunohistochem. Mol. Morphol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1309\/TYE7K2CQMQ707FRT","article-title":"Antibody selection in immunohistochemical detection of cyclin D1 in mantle cell lymphoma","volume":"124","author":"Torlakovic","year":"2005","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1593\/tlo.12220","article-title":"Expression of cyclin D1 is associated with \u03b2-catenin expression and correlates with good prognosis in colorectal adenocarcinoma","volume":"5","author":"Jang","year":"2012","journal-title":"Transl. Oncol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"4431","DOI":"10.1158\/1078-0432.CCR-08-3330","article-title":"A cohort study of cyclin D1 expression and prognosis in 602 colon cancer cases","volume":"15","author":"Ogino","year":"2009","journal-title":"Clin. Cancer Res."},{"key":"ref_30","first-page":"1490","article-title":"The prognostic role of apoptosis mediators in rectal adenocarcinoma","volume":"58","author":"Seicean","year":"2011","journal-title":"Hepato-Gastroenterol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"39","DOI":"10.2298\/ACI0803039S","article-title":"Prognostic value of clinical, pathological and immunohistochemical markers in stage II colon cancer patients","volume":"55","author":"Stor","year":"2008","journal-title":"Acta Chir. Lugosl."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1007\/s10350-005-0202-x","article-title":"The significance of tumor markers for proliferation and apoptosis in predicting survival in colorectal cancer","volume":"48","author":"Hilska","year":"2005","journal-title":"Dis. Colon Rectum"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/path.1053","article-title":"Analysis of key cell-cycle checkpoint proteins in colorectal tumours","volume":"196","author":"McKay","year":"2002","journal-title":"J. Pathol."},{"key":"ref_34","first-page":"27","article-title":"p16, cyclin D1 and Rb expression in colorectal carcinomas: Correlations with clinico-pathological parameters and prognosis","volume":"1","author":"Monig","year":"2008","journal-title":"Mol. Med. Rep."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1158\/1078-0432.CCR-05-1864","article-title":"Profiling markers of prognosis in colorectal cancer","volume":"12","author":"Lyall","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/1097-0215(20001001)88:1<77::AID-IJC12>3.0.CO;2-O","article-title":"Cyclin D1 protein expression and gene polymorphism in colorectal cancer. Aberdeen Colorectal Initiative","volume":"88","author":"McKay","year":"2000","journal-title":"Int. J. Cancer"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/BF02234324","article-title":"Molecular markers are predictors of recurrence and survival in patients with Dukes B and Dukes C colorectal adenocarcinoma","volume":"44","author":"Bhatavdekar","year":"2001","journal-title":"Dis. Colon Rectum"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Bahnassy, A.A., Zekri, A.R., El-Houssini, S., El-Shehaby, A.M., Mahmoud, M.R., Abdallah, S., and El-Serafi, M. (2004). Cyclin A and cyclin D1 as significant prognostic markers in colorectal cancer patients. BMC Gastroentero., 4.","DOI":"10.1186\/1471-230X-4-22"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1245\/ASO.2004.03.095","article-title":"Expression of p27 in residual rectal cancer after preoperative chemoradiation predicts long-term outcome","volume":"11","author":"Moore","year":"2004","journal-title":"Ann. Surg. Oncol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1002\/1097-0215(20010920)95:5<302::AID-IJC1052>3.0.CO;2-#","article-title":"Subcellular localisation of cyclin D1 protein in colorectal tumours is associated with p21(WAF1\/CIP1) expression and correlates with patient survival","volume":"95","author":"Holland","year":"2001","journal-title":"Int. J. Cancer"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1159\/000011849","article-title":"Cyclin D1 overexpression and prognosis in colorectal adenocarcinoma","volume":"55","author":"Maeda","year":"1998","journal-title":"Oncology"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/(SICI)1097-0215(19970620)74:3<310::AID-IJC13>3.0.CO;2-F","article-title":"Overexpression of cyclin D1 and p53 associated with disease recurrence in colorectal adenocarcinoma","volume":"74","author":"Maeda","year":"1997","journal-title":"Int. J. Cancer"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/jso.23243","article-title":"Co-existence of cyclin D1 and vascular endothelial growth factor protein expression is a poor prognostic factor for UICC stage I-III colorectal cancer patients after curative resection","volume":"107","author":"Tsai","year":"2013","journal-title":"J. Surg. Oncol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"S682","DOI":"10.1245\/s10434-012-2216-7","article-title":"Cell cycle proteins predict recurrence in stage II and III colon cancer","volume":"19","author":"Belt","year":"2012","journal-title":"Ann. Surg. Oncol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00384-010-1090-7","article-title":"Expression of phosphorylated Stat5 predicts expression of cyclin D1 and correlates with poor prognosis of colonic adenocarcinoma","volume":"26","author":"Mao","year":"2011","journal-title":"Int. J. Colorectal Dis."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s00384-009-0725-z","article-title":"Elevated expressions of MMP7, TROP2, and survivin are associated with survival, disease recurrence, and liver metastasis of colon cancer","volume":"24","author":"Fang","year":"2009","journal-title":"Int. J. Color. Dis."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1477-7819-4-5","article-title":"Cyclin D1 and Rb protein expression and their correlation with prognosis in patients with colon cancer","volume":"4","author":"Kouraklis","year":"2006","journal-title":"World J. Surg. Oncol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1136\/jcp.2004.020347","article-title":"Expression and gene amplification of primary (A, B1, D1, D3, and E) and secondary (C and H) cyclins in colon adenocarcinomas and correlation with patient outcome","volume":"58","author":"Bondi","year":"2005","journal-title":"J. Clin. Pathol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1600-0463.2004.apm1120109.x","article-title":"Expression of non-membranous beta-catenin and gamma-catenin, c-Myc and cyclin D1 in relation to patient outcome in human colon adenocarcinomas","volume":"112","author":"Bondi","year":"2004","journal-title":"APMIS"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"177","DOI":"10.4103\/ijabmr.ijabmr_416_21","article-title":"ROC-analysis derived immunohistochemical p53 cut-off scores as an adjunct to routine histopathology for better diagnostic compartmentalisation of cervical lesions","volume":"12","author":"Shukla","year":"2022","journal-title":"Int. J. Appl. Basic Med. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1038\/modpathol.3800621","article-title":"Cyclin D1 protein overexpression and CCND1 amplification in breast carcinomas: An immunohistochemical and chromogenic in situ hybridisation analysis","volume":"19","author":"Savage","year":"2006","journal-title":"Mod. Pathol."},{"key":"ref_52","first-page":"953","article-title":"Stable overexpression of cyclin D1 in a human mammary epithelial cell line prolongs the S-phase and inhibits growth","volume":"10","author":"Han","year":"1995","journal-title":"Oncogene"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0896-6273(94)90276-3","article-title":"Analysis of cell cycle-related gene expression in postmitotic neurons: Selective induction of cyclin D1 during programmed cell death","volume":"12","author":"Freeman","year":"1994","journal-title":"Neuron"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1006\/excr.1995.1080","article-title":"Overexpression of cyclin D1 blocks proliferation of normal diploid fibroblasts","volume":"217","author":"Atadja","year":"1995","journal-title":"Exp. Cell Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/nrc3090","article-title":"Cyclin D as a therapeutic target in cancer","volume":"11","author":"Musgrove","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"8773","DOI":"10.1007\/s13277-015-3620-y","article-title":"Association of CCND1 overexpression with KRAS and PTEN alterations in specific subtypes of non-small cell lung carcinoma and its influence on patients\u2019 outcome","volume":"36","author":"Dragoj","year":"2015","journal-title":"Tumor Biol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1158\/1940-6207.CAPR-10-0376","article-title":"Bexarotene plus erlotinib suppress lung carcinogenesis independent of KRAS mutations in two clinical trials and transgenic models","volume":"4","author":"Dragnev","year":"2011","journal-title":"Cancer Prev. Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1158\/1078-0432.CCR-15-0829","article-title":"Sensitivity of KRAS-mutant colorectal cancers to combination therapy that cotargets MEK and CDK4\/6","volume":"22","author":"Ziemke","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"4826","DOI":"10.1038\/onc.2010.238","article-title":"Acquired radioresistance of human tumor cells by DNA-PK\/AKT\/GSK3beta-mediated cyclin D1 overexpression","volume":"29","author":"Shimura","year":"2010","journal-title":"Oncogene"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"6075","DOI":"10.1158\/1078-0432.CCR-04-2419","article-title":"Overexpression of cyclin D1 promotes tumor cell growth and confers resistance to cisplatin-mediated apoptosis in an elastase-myc transgene-expressing pancreatic tumor cell line","volume":"11","author":"Biliran","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/nrc2713","article-title":"Biological determinants of endocrine resistance in breast cancer","volume":"9","author":"Musgrove","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"7764","DOI":"10.1158\/1078-0432.CCR-04-0012","article-title":"Deregulated cyclin D1 expression is associated with decreased efficacy of the selective epidermal growth factor receptor tyrosine kinase inhibitor gefitinib in head and neck squamous cell carcinoma cell lines","volume":"10","author":"Kalish","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2876","DOI":"10.1158\/1535-7163.MCT-08-0431","article-title":"Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E-mutated melanomas","volume":"7","author":"Smalley","year":"2008","journal-title":"Mol. Cancer Ther."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1158\/1078-0432.CCR-07-4122","article-title":"Cyclin D1 expression in breast cancer patients receiving adjuvant tamoxifen-based therapy","volume":"14","author":"Rudas","year":"2008","journal-title":"Clin. Cancer Res."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/15\/20\/5032\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:08:48Z","timestamp":1760130528000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/15\/20\/5032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,18]]},"references-count":64,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["cancers15205032"],"URL":"https:\/\/doi.org\/10.3390\/cancers15205032","relation":{},"ISSN":["2072-6694"],"issn-type":[{"type":"electronic","value":"2072-6694"}],"subject":[],"published":{"date-parts":[[2023,10,18]]}}}