{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:36:00Z","timestamp":1760150160330,"version":"build-2065373602"},"reference-count":39,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T00:00:00Z","timestamp":1697932800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Arbeitsgemeinschaft Gyn\u00e4kologische Endoskopie","award":["LSK Ovar 01"],"award-info":[{"award-number":["LSK Ovar 01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>The demand for fertility-sparing surgery (FSS) has increased in the last decade due to increased maternal age, increased incidence of ovarian malignancies in younger patients, and technical advances in surgery. Data on oncological safety and fertility outcomes of patients with ovarian cancer after laparoscopic FSS are sparse, but some retrospective studies have shown that open FSS may be offered to selected patients. We assessed the role of minimally invasive FSS in comparison with radical surgery (RS) in terms of oncological safety and reproductive outcomes after FSS in this multicenter study. Eighty patients with FIGO stage I\/II ovarian cancer treated with laparoscopic FSS or RS between 01\/2000 and 10\/2018 at the participating centers (comprehensive gynecological cancer centers with minimally invasive surgical expertise) were included in this retrospective analysis of prospectively kept data. Case\u2013control (n = 40 each) matching according to the FIGO stage was performed. Progression-free survival [150 (3\u2013150) and 150 (5\u2013150) months; p = 0.61] and overall survival [36 (3\u2013150) and 50 (1\u2013275) months; p = 0.65] did not differ between the FSS and RS groups. Eight (25.8%) women became pregnant after FSS, resulting in seven (22.5%) deliveries; three (37.5%) patients conceived after in vitro fertilization, and five (62.5%) conceived spontaneously. Laparoscopic FSS seems to be applicable and oncologically safe for patients with early-stage ovarian cancer, with adequate fertility outcomes.<\/jats:p>","DOI":"10.3390\/cancers15205099","type":"journal-article","created":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T07:02:53Z","timestamp":1697958173000},"page":"5099","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Laparoscopic Fertility-Sparing Surgery for Early Ovarian Malignancies"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0741-8664","authenticated-orcid":false,"given":"Julia S. M.","family":"Zimmermann","sequence":"first","affiliation":[{"name":"Department of Gynecology, Obstetrics and Reproductive Medicine, Saarland University Hospital, D-66421 Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauline","family":"Ramisch","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Obstetrics and Reproductive Medicine, Saarland University Hospital, D-66421 Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc P.","family":"Radosa","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Obstetrics and Reproductive Medicine, Saarland University Hospital, D-66421 Homburg, Germany"},{"name":"Department of Gynecology and Obstetrics, Klinikum Bremen Nord, D-28755 Bremen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph G.","family":"Radosa","sequence":"additional","affiliation":[{"name":"Institute and Policlinic of Diagnostic and Interventional Radiology, Medical University, TU Dresden, D-01307 Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Askin C.","family":"Kaya","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Obstetrics and Reproductive Medicine, Saarland University Hospital, D-66421 Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5162-1542","authenticated-orcid":false,"given":"Sara Y.","family":"Brucker","sequence":"additional","affiliation":[{"name":"Department of Gynecology, T\u00fcbingen University Hospital, D-72076 T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7384-2928","authenticated-orcid":false,"given":"Florin A.","family":"Taran","sequence":"additional","affiliation":[{"name":"Department of Gynecology, University Medical Center Freiburg, D-79106 Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uwe A.","family":"Ulrich","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Martin Luther Hospital, Johannesstift Diakonie, D-14193 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Hackethal","sequence":"additional","affiliation":[{"name":"Frauenklinik an der Elbe, D-20457 Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Deeken","sequence":"additional","affiliation":[{"name":"Department of Gynecology, D-66346 P\u00fcttlingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"S\u00fctterlin","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, University Medical Center Mannheim, Heidelberg University, D-68167 Mannheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Tuschy","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, University Medical Center Mannheim, Heidelberg University, D-68167 Mannheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erich-Franz","family":"Solomayer","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Obstetrics and Reproductive Medicine, Saarland University Hospital, D-66421 Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia C.","family":"Radosa","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Obstetrics and Reproductive Medicine, Saarland University Hospital, D-66421 Homburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/S0140-6736(13)62146-7","article-title":"Ovarian cancer","volume":"384","author":"Jayson","year":"2014","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21332","article-title":"Cancer statistics","volume":"66","author":"Siegel","year":"2016","journal-title":"CA-Cancer J. 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