{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:59:42Z","timestamp":1791615582909,"version":"4.3.4"},"reference-count":83,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T00:00:00Z","timestamp":1698537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal e N\u00edvel Superior (CAPES)"},{"name":"Funda\u00e7\u00e3o Amaz\u00f4nia de Amparo a Estudos e Pesquisas (FAPESPA)"},{"name":"Universidade Federal do Par\u00e1 (UFPA)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Cancer is the abnormal proliferation of physiologically inadequate cells. Studies have identified the cardiac pacemaker pocket as a site of rare neoplasms. To evaluate the clinical outcomes, treatment, prognosis, and individualized management of tumors originating in the cardiac pacemaker pocket, a systematic review was conducted using case reports and case series available in the PubMed\/Medline, Science Direct, Cochrane Central, LILACS, and Scientific Electronic Library Online (Scielo) databases. Pacemaker pocket tumors affected patients with a mean age of 72.9 years, with a higher incidence in males (76.9%, n = 10). The average time for neoplasm development was 4.4 years (54.07 months). The most prevalent model was Medtronic (38.4%, n = 5), with titanium (83.3%) being the most common metal composition. Chemotherapy was the most performed procedure among patients (38.4%), followed by radiation therapy (38.4%) and surgical tumor resection (30.7%). Six analyzed cases (46.1%) resulted in death, and four patients (30.7%) achieved a cure. Patients with pacemakers should be routinely evaluated for the occurrence of malignant tumors at the site of device implantation.<\/jats:p>","DOI":"10.3390\/cancers15215206","type":"journal-article","created":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T13:20:07Z","timestamp":1698672007000},"page":"5206","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Malignant Neoplasms Arising in the Cardiac Pacemaker Cavity: A Systematic Review"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0623-8135","authenticated-orcid":false,"given":"Francisco Cezar Aquino de","family":"Moraes","sequence":"first","affiliation":[{"name":"Oncology Research Center, University Hospital Jo\u00e3o de Barros Barreto, Bel\u00e9m 66073-005, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5646-2612","authenticated-orcid":false,"given":"Lucca","family":"Dal Moro","sequence":"additional","affiliation":[{"name":"Department of Medicine, Federal University of Par\u00e1, Bel\u00e9m 66075-110, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1215-8804","authenticated-orcid":false,"given":"Fernando Rocha","family":"Pessoa","sequence":"additional","affiliation":[{"name":"Department of Medicine, Federal University of Par\u00e1, Bel\u00e9m 66075-110, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen Sabrinna dos Rem\u00e9dios","family":"Passos","sequence":"additional","affiliation":[{"name":"Department of Medicine, Federal University of Par\u00e1, Bel\u00e9m 66075-110, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul Ant\u00f4nio Lopes Silva","family":"Campos","sequence":"additional","affiliation":[{"name":"Department of Medicine, Federal University of Par\u00e1, Bel\u00e9m 66075-110, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilma do Socorro Moraes de","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Medicine, Federal University of Par\u00e1, Bel\u00e9m 66075-110, PA, Brazil"},{"name":"Gaspar Vianna State Public Hospital of Clinical Foundation, Bel\u00e9m 66083-106, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Feio","sequence":"additional","affiliation":[{"name":"Oncology Research Center, University Hospital Jo\u00e3o de Barros Barreto, Bel\u00e9m 66073-005, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rommel Mario","family":"Rodr\u00edguez Burbano","sequence":"additional","affiliation":[{"name":"Ot\u00e1vio Lobo Children\u2019s Cancer Hospital, Bel\u00e9m, 66063-005, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1396-3442","authenticated-orcid":false,"given":"Marianne Rodrigues","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Oncology Research Center, University Hospital Jo\u00e3o de Barros Barreto, Bel\u00e9m 66073-005, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ney Pereira Carneiro dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Oncology Research Center, University Hospital Jo\u00e3o de Barros Barreto, Bel\u00e9m 66073-005, PA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,29]]},"reference":[{"key":"ref_1","unstructured":"(2023, June 06). 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