{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:43:10Z","timestamp":1787503390587,"version":"build-2736575974"},"reference-count":36,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T00:00:00Z","timestamp":1698710400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81802456"],"award-info":[{"award-number":["81802456"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2020JQ-545"],"award-info":[{"award-number":["2020JQ-545"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2023-JC-YB-750"],"award-info":[{"award-number":["2023-JC-YB-750"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["YXJLRH2022063"],"award-info":[{"award-number":["YXJLRH2022063"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation Program of Shaanxi Province of China","award":["81802456"],"award-info":[{"award-number":["81802456"]}]},{"name":"Natural Science Foundation Program of Shaanxi Province of China","award":["2020JQ-545"],"award-info":[{"award-number":["2020JQ-545"]}]},{"name":"Natural Science Foundation Program of Shaanxi Province of China","award":["2023-JC-YB-750"],"award-info":[{"award-number":["2023-JC-YB-750"]}]},{"name":"Natural Science Foundation Program of Shaanxi Province of China","award":["YXJLRH2022063"],"award-info":[{"award-number":["YXJLRH2022063"]}]},{"name":"Basic-Clinical Medical Fusion Innovation Project of Xi\u2019an Jiaotong University","award":["81802456"],"award-info":[{"award-number":["81802456"]}]},{"name":"Basic-Clinical Medical Fusion Innovation Project of Xi\u2019an Jiaotong University","award":["2020JQ-545"],"award-info":[{"award-number":["2020JQ-545"]}]},{"name":"Basic-Clinical Medical Fusion Innovation Project of Xi\u2019an Jiaotong University","award":["2023-JC-YB-750"],"award-info":[{"award-number":["2023-JC-YB-750"]}]},{"name":"Basic-Clinical Medical Fusion Innovation Project of Xi\u2019an Jiaotong University","award":["YXJLRH2022063"],"award-info":[{"award-number":["YXJLRH2022063"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>DHX37, a member of the DEAD\/H-box RNA helicase family, has been implicated in various diseases, including tumors. However, the biological characteristics and prognostic significance of DHX37 in HCC remain unclear. In this study, we use R software 3.6.3 and multiple bioinformatics analysis tools, such as GDSC, HPA, STRING, TISCH, and TIMER2, to analyze the characterization and function of DHX37 in HCC. In addition, Western blot (WB) and immunohistochemistry (IHC) based on clinical samples validated some of the findings. DHX37 was more highly expressed in HCC samples compared to adjacent non-tumor tissues. Higher DHX37 expression is correlated with various clinicopathological characteristics in HCC, including AFP, adjacent hepatic tissue inflammation, histologic grade, T stage, and pathologic stage. Survival analysis revealed that the high DHX37 group had significantly shorter overall survival (OS), progress-free interval (PFI), and disease-specific survival (DSS) compared to the low DHX37 group. By analyzing the correlation between DHX37 and the IC50 of chemotherapeutic drugs, the results showed that DHX37 expression level was negatively correlated with the IC50 of 11 chemotherapeutic drugs. Further analysis indicated that DHX37 and its co-expressed genes may play important roles in activating the cell cycle, DNA repair, chemokine signaling pathways, and regulating the immune response, which leads to a poor prognosis in HCC. High expression of DHX37 is an independent risk factor for poor prognosis in HCC, and DHX37 is expected to be a potential target to inhibit tumor progression. Targeting DHX37 may enhance chemotherapeutic drug sensitivity and immunotherapeutic efficacy in HCC.<\/jats:p>","DOI":"10.3390\/cancers15215228","type":"journal-article","created":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T12:48:31Z","timestamp":1698756511000},"page":"5228","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["DHX37 Is a Promising Prognostic Biomarker and a Therapeutic Target for Immunotherapy and Chemotherapy in HCC"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5203-2475","authenticated-orcid":false,"given":"Nanbin","family":"Liu","sequence":"first","affiliation":[{"name":"National and Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, The Second Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an 710004, China"},{"name":"Shaanxi Provincial Clinical Research Center for Hepatic & Splenic Diseases, Xi\u2019an 710004, China"},{"name":"Tumor and Immunology Center of Precision Medicine Institute, Xi\u2019an Jiaotong University, Xi\u2019an 710049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailong","family":"Zhang","sequence":"additional","affiliation":[{"name":"National and Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, The Second Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an 710004, China"},{"name":"Shaanxi Provincial Clinical Research Center for Hepatic & Splenic Diseases, Xi\u2019an 710004, China"},{"name":"Tumor and Immunology Center of Precision Medicine Institute, Xi\u2019an Jiaotong University, Xi\u2019an 710049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunli","family":"Zhang","sequence":"additional","affiliation":[{"name":"National and Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, The Second Affiliated Hospital of Xi\u2019an Jiaotong University, Xi\u2019an 710004, 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